The Experts below are selected from a list of 1203 Experts worldwide ranked by ideXlab platform
Antonio C. B. Burtoloso - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of (−)-Indolizidine 167B via an unusual Wolff rearrangement from an α,β-unsaturated diazoketone
Tetrahedron Letters, 2012Co-Authors: Vagner D. Pinho, Antonio C. B. BurtolosoAbstract:Abstract A concise synthesis of the (−)-Indolizidine Alkaloid 167B and two formal syntheses of (−)-Indolizidine 209D and (−)-coniceine are described in just three steps from an α,β-unsaturated diazoketone, via an unusual photochemical Wolff rearrangement. Preparation of the unsaturated diazoketone is straightforward from N -Cbz-prolinal and a 3-diazo-2-oxopropylphosphonate, employing a Horner–Wadsworth–Emmons reaction. The strategy should be feasible and easily adaptable to the synthesis of other Indolizidine Alkaloids and analogues.
Satoshi ōmura - One of the best experts on this subject based on the ideXlab platform.
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absolute configuration of iminimycin b a new Indolizidine Alkaloid from streptomyces griseus os 3601
Tetrahedron Letters, 2016Co-Authors: Takuji Nakashima, Rei Miyano, Masato Iwatsuki, Tatsuya Shirahata, Yoshinori Kobayashi, Kazuro Shiomi, George A Petersson, Yōko Takahashi, Hirotaka Matsuo, Satoshi ōmuraAbstract:Abstract Iminimycin B, a novel indolizine Alkaloid featuring a rare pyridinium, was isolated from the cultured broth of a streptomycin-producing strain, Streptomyces griseus OS-3601, through a physicochemical screening method. Its structure was elucidated on the basis of mass and NMR analyses. Stereochemical assignment of iminimycin B was archived by NMR studies, electronic circular dichroism (ECD) analysis, and advanced Marfey’s method.
Takuji Nakashima - One of the best experts on this subject based on the ideXlab platform.
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Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601
The Journal of Antibiotics, 2016Co-Authors: Takuji Nakashima, Rei Miyano, Masato Iwatsuki, Tatsuya Shirahata, Toru Kimura, Yukihiro Asami, Yoshinori Kobayashi, Kazuro Shiomi, George A Petersson, Yōko TakahashiAbstract:A new natural product, designated iminimycin A, was isolated from the cultured broth of a streptomycin-producing microbial strain, Streptomyces griseus OS-3601, via a physicochemical screening method using HP-20, silica gel and ODS column chromatographies and subsequent preparative HPLC. Iminimycin A is an Indolizidine Alkaloid, containing of an unusual iminium group and a cyclopropane ring with a triene side chain. The absolute configuration of iminimycin A was elucidated by NMR studies and electronic circular dichroism analysis. Iminimycin A shows anti-bacterial activity against Bacillus subtilis , Kocuria rhizophila and Xanthomonas campestris pv. orizae , and cytotoxic activity against HeLa S3 and Jurkat cells with IC_50 values of 43 and 36 μ M , respectively.
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absolute configuration of iminimycin b a new Indolizidine Alkaloid from streptomyces griseus os 3601
Tetrahedron Letters, 2016Co-Authors: Takuji Nakashima, Rei Miyano, Masato Iwatsuki, Tatsuya Shirahata, Yoshinori Kobayashi, Kazuro Shiomi, George A Petersson, Yōko Takahashi, Hirotaka Matsuo, Satoshi ōmuraAbstract:Abstract Iminimycin B, a novel indolizine Alkaloid featuring a rare pyridinium, was isolated from the cultured broth of a streptomycin-producing strain, Streptomyces griseus OS-3601, through a physicochemical screening method. Its structure was elucidated on the basis of mass and NMR analyses. Stereochemical assignment of iminimycin B was archived by NMR studies, electronic circular dichroism (ECD) analysis, and advanced Marfey’s method.
Vagner D. Pinho - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of (−)-Indolizidine 167B via an unusual Wolff rearrangement from an α,β-unsaturated diazoketone
Tetrahedron Letters, 2012Co-Authors: Vagner D. Pinho, Antonio C. B. BurtolosoAbstract:Abstract A concise synthesis of the (−)-Indolizidine Alkaloid 167B and two formal syntheses of (−)-Indolizidine 209D and (−)-coniceine are described in just three steps from an α,β-unsaturated diazoketone, via an unusual photochemical Wolff rearrangement. Preparation of the unsaturated diazoketone is straightforward from N -Cbz-prolinal and a 3-diazo-2-oxopropylphosphonate, employing a Horner–Wadsworth–Emmons reaction. The strategy should be feasible and easily adaptable to the synthesis of other Indolizidine Alkaloids and analogues.
Yōko Takahashi - One of the best experts on this subject based on the ideXlab platform.
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Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601
The Journal of Antibiotics, 2016Co-Authors: Takuji Nakashima, Rei Miyano, Masato Iwatsuki, Tatsuya Shirahata, Toru Kimura, Yukihiro Asami, Yoshinori Kobayashi, Kazuro Shiomi, George A Petersson, Yōko TakahashiAbstract:A new natural product, designated iminimycin A, was isolated from the cultured broth of a streptomycin-producing microbial strain, Streptomyces griseus OS-3601, via a physicochemical screening method using HP-20, silica gel and ODS column chromatographies and subsequent preparative HPLC. Iminimycin A is an Indolizidine Alkaloid, containing of an unusual iminium group and a cyclopropane ring with a triene side chain. The absolute configuration of iminimycin A was elucidated by NMR studies and electronic circular dichroism analysis. Iminimycin A shows anti-bacterial activity against Bacillus subtilis , Kocuria rhizophila and Xanthomonas campestris pv. orizae , and cytotoxic activity against HeLa S3 and Jurkat cells with IC_50 values of 43 and 36 μ M , respectively.
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absolute configuration of iminimycin b a new Indolizidine Alkaloid from streptomyces griseus os 3601
Tetrahedron Letters, 2016Co-Authors: Takuji Nakashima, Rei Miyano, Masato Iwatsuki, Tatsuya Shirahata, Yoshinori Kobayashi, Kazuro Shiomi, George A Petersson, Yōko Takahashi, Hirotaka Matsuo, Satoshi ōmuraAbstract:Abstract Iminimycin B, a novel indolizine Alkaloid featuring a rare pyridinium, was isolated from the cultured broth of a streptomycin-producing strain, Streptomyces griseus OS-3601, through a physicochemical screening method. Its structure was elucidated on the basis of mass and NMR analyses. Stereochemical assignment of iminimycin B was archived by NMR studies, electronic circular dichroism (ECD) analysis, and advanced Marfey’s method.