The Experts below are selected from a list of 636 Experts worldwide ranked by ideXlab platform
Ikyon Kim - One of the best experts on this subject based on the ideXlab platform.
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construction of benzo fused Indolizines pyrrolo 1 2 a quinolines via alkyne carbonyl metathesis
ChemInform, 2016Co-Authors: Maloy Nayak, Ikyon KimAbstract:The strategic use of a sequential Sonogashira coupling/intramolecular alkyne–carbonyl metathesis process for the synthesis of a pyridine ring from 1-(2-haloaryl)-1H-pyrrole-2-carbaldehydes allowed ready access to diverse novel benzo-fused Indolizines, pyrrolo[1,2-a]quinolines, in good to excellent yields. As a hybrid structure of indolizine and quinoline, the resulting scaffold has an acyl substituent at the C5 position, which is difficult to make by any other known approaches.
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Domino Knoevenagel Condensation/Intramolecular Aldol Cyclization Route to Diverse Indolizines with Densely Functionalized Pyridine Units
2016Co-Authors: Myungock Kim, Youngeun Jung, Ikyon KimAbstract:A highly efficient [4 + 2] annulation route to polysubstituted Indolizines is described employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as a key step. Construction of pyridine rings in indolizine skeleton was rapidly achieved from several pyrrole-2-carboxaldehydes in good to excellent yields, leading to Indolizines with various substituents at the 5, 6, and 7 positions depending on the reacting active methylene partners
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domino knoevenagel condensation intramolecular aldol cyclization route to diverse Indolizines with densely functionalized pyridine units
Journal of Organic Chemistry, 2013Co-Authors: Myungock Kim, Youngeun Jung, Ikyon KimAbstract:A highly efficient [4 + 2] annulation route to polysubstituted Indolizines is described employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as a key step. Construction of pyridine rings in indolizine skeleton was rapidly achieved from several pyrrole-2-carboxaldehydes in good to excellent yields, leading to Indolizines with various substituents at the 5, 6, and 7 positions depending on the reacting active methylene partners.
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Cycloaromatization Approach to Polysubstituted Indolizines from 2‑Acetylpyrroles: Decoration of the Pyridine Unit
2013Co-Authors: Jin Ho Lee, Ikyon KimAbstract:A new synthetic route to Indolizines with various substituents on the pyridine moiety was developed by utilizing a facile cycloaromatization of 2-acetylpyrrole derivatives. Without isolation, the resulting intermediates were allowed to react with various electrophiles to afford a range of Indolizines. In particular, Suzuki–Miyaura cross-coupling of O-triflates with (hetero)arylboronic acids permitted introduction of diverse substituents at the C8 position of an indolizine skeleton
Yuanhong Liu - One of the best experts on this subject based on the ideXlab platform.
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gold i catalyzed cascade hydroarylation cycloaromatization to Indolizines via pyridine ring construction
Journal of Organic Chemistry, 2016Co-Authors: Xin Xie, Yuanhong LiuAbstract:An efficient and atom-economic method for the synthesis of multisubstituted Indolizines via gold-catalyzed cascade hydroarylation/cycloaromatization reaction of α-(N-pyrrolyl)ketones with alkynes is described. The reaction is realized through the construction of the pyridine ring of Indolizines, which allows the regioselective incorporation of a wide range of functionalities on the pyridine unit.
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Gold(I)-Catalyzed Cascade Hydroarylation/Cycloaromatization to Indolizines via Pyridine Ring Construction
2016Co-Authors: Xin Xie, Yuanhong LiuAbstract:An efficient and atom-economic method for the synthesis of multisubstituted Indolizines via gold-catalyzed cascade hydroarylation/cycloaromatization reaction of α-(N-pyrrolyl)ketones with alkynes is described. The reaction is realized through the construction of the pyridine ring of Indolizines, which allows the regioselective incorporation of a wide range of functionalities on the pyridine unit
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palladium catalyzed highly efficient synthesis of functionalized Indolizines via cross coupling cycloisomerization cascade
ChemInform, 2015Co-Authors: Yuanhong Liu, Liangwei Zhang, Dayong ZhangAbstract:A wide range of 1,3-disubstituted Indolizines are obtained by Pd-catalyzed reaction of 3-(2-pyridyl) propargyl carbonates with organoboronic acids.
Hua Cao - One of the best experts on this subject based on the ideXlab platform.
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one pot regiospecific synthesis of Indolizines a solvent free metal free three component reaction of 2 pyridin 2 yl acetates ynals and alcohols or thiols
Organic Letters, 2018Co-Authors: Daji Yang, Huiyi Feng, Hua CaoAbstract:A novel approach for the synthesis of Indolizines from 2-(pyridin-2-yl)acetates, ynals, and alcohols or thiols has been developed. This MCR (multicomponent reaction) that proceeds under the solvent- and metal-free conditions has provided a straightforward path to construct Indolizines. Furthermore, this reaction demonstrates other attractive features such as widely available starting materials, mild conditions, good functional group tolerance, and high efficiency.
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Transition-Metal-Free Regioselective Cross-Coupling: Controlled Synthesis of Mono- or Dithiolation Indolizines
2018Co-Authors: Zhiyu Chen, Hua Cao, Hong ZhaoAbstract:An efficient transition-metal-free regioselective C–H/S–H cross-coupling of Indolizines with thiols has been developed for the first time to describe a workable route to indolizine thioethers. This finding provides a new method and more straightforward pathway for controllable synthesis of mono- or dithiolation Indolizines that are otherwise difficult to obtain by the literature methods. The reaction exhibits good functional group tolerance and high efficiency and affords the products in good to excellent yields
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One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal-Free, Three-Component Reaction of 2‑(Pyridin-2-yl)acetates, Ynals, and Alcohols or Thiols
2018Co-Authors: Daji Yang, Huiyi Feng, Hua CaoAbstract:A novel approach for the synthesis of Indolizines from 2-(pyridin-2-yl)acetates, ynals, and alcohols or thiols has been developed. This MCR (multicomponent reaction) that proceeds under the solvent- and metal-free conditions has provided a straightforward path to construct Indolizines. Furthermore, this reaction demonstrates other attractive features such as widely available starting materials, mild conditions, good functional group tolerance, and high efficiency
Myungock Kim - One of the best experts on this subject based on the ideXlab platform.
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Domino Knoevenagel Condensation/Intramolecular Aldol Cyclization Route to Diverse Indolizines with Densely Functionalized Pyridine Units
2016Co-Authors: Myungock Kim, Youngeun Jung, Ikyon KimAbstract:A highly efficient [4 + 2] annulation route to polysubstituted Indolizines is described employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as a key step. Construction of pyridine rings in indolizine skeleton was rapidly achieved from several pyrrole-2-carboxaldehydes in good to excellent yields, leading to Indolizines with various substituents at the 5, 6, and 7 positions depending on the reacting active methylene partners
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domino knoevenagel condensation intramolecular aldol cyclization route to diverse Indolizines with densely functionalized pyridine units
Journal of Organic Chemistry, 2013Co-Authors: Myungock Kim, Youngeun Jung, Ikyon KimAbstract:A highly efficient [4 + 2] annulation route to polysubstituted Indolizines is described employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as a key step. Construction of pyridine rings in indolizine skeleton was rapidly achieved from several pyrrole-2-carboxaldehydes in good to excellent yields, leading to Indolizines with various substituents at the 5, 6, and 7 positions depending on the reacting active methylene partners.
Yixia Jia - One of the best experts on this subject based on the ideXlab platform.
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indolizine synthesis via oxidative cross coupling cyclization of alkenes and 2 pyridin 2 yl acetate derivatives
ChemInform, 2015Co-Authors: Renrong Liu, Jianjun Hong, Jianrong Gao, Yixia JiaAbstract:A novel access to various Indolizines via copper/I2-mediated oxidative cross-coupling/cyclization of 2-(pyridin-2-yl)acetate derivatives and simple olefins is given.
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indolizine synthesis via oxidative cross coupling cyclization of alkenes and 2 pyridin 2 yl acetate derivatives
Organic Letters, 2015Co-Authors: Renrong Liu, Jianjun Hong, Jianrong Gao, Yixia JiaAbstract:A novel copper/I2-mediated oxidative cross-coupling/cyclization of 2-(pyridin-2-yl)acetate derivatives and simple olefins is developed, which provides a straightforward and efficient access to structural diversely Indolizines. A series of 1,3-di- and 1,2,3-trisubstituted Indolizines are easily synthesized in modest to excellent yields.
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Indolizine Synthesis via Oxidative Cross-Coupling/Cyclization of Alkenes and 2‑(Pyridin-2-yl)acetate Derivatives
2015Co-Authors: Renrong Liu, Jianjun Hong, Jianrong Gao, Yixia JiaAbstract:A novel copper/I2-mediated oxidative cross-coupling/cyclization of 2-(pyridin-2-yl)acetate derivatives and simple olefins is developed, which provides a straightforward and efficient access to structural diversely Indolizines. A series of 1,3-di- and 1,2,3-trisubstituted Indolizines are easily synthesized in modest to excellent yields