The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Naoki Kanoh - One of the best experts on this subject based on the ideXlab platform.
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Photo-cross-linked small-molecule affinity matrix as a tool for target identification of bioactive small molecules
Natural product reports, 2016Co-Authors: Naoki KanohAbstract:Covering: up to the end of 2015A photo-cross-linked small-molecule affinity matrix is a unique platform for identifying targets for bioactive small molecules. It utilises a photogenerated carbene species to immobilise a variety of bioactive small molecules on an affinity matrix in a chemo- and site-nonselective manner. Although this platform would seem to run counter to the more typical approach of small-molecule immobilisation on an affinity matrix (i.e., selective coupling), it has been successfully utilised in the past decade to screen protein targets for many bioactive small molecules. This review describes the status of the photo-cross-linking methodology while providing a useful tutorial for academic and Industrial Chemical biologists who are involved or interested in drug target identification.
Sanjay V. Patel - One of the best experts on this subject based on the ideXlab platform.
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Chemicapacitive microsensors for Chemical warfare agent and toxic Industrial Chemical detection
Sensors and Actuators B: Chemical, 2006Co-Authors: Todd E. Mlsna, Sabina Cemalovic, Debra A. Mlsna, Matthew Warburton, Stephen T. Hobson, Sanjay V. PatelAbstract:Detection of Chemical warfare agents and toxic Industrial Chemicals using Microfabrication and microelectromechanical systems (MEMS) chemicapactive sensors is described. Our sensor chips consist of 10 parallel plates or interdigitated capacitors with an absorbant dielectric material to measure the dielectric constant of an array of selectively absorbing materials. The dielectric permittivity of these polymer filled chemicapacitors changes upon adsorption and desorption of the Chemical vapors. Gaseous analytes including Chemical warfare agents (CWAs) and toxic Industrial Chemicals (TICs) have been exposed to our sensors with the results being displayed and discussed below. Sensor performance was characterized through exposure to various CWAs and TICs over a range of concentrations. The limits of detection (LOD) were determined for several Chemicals. © 2006.
Matthew J. Lebaron - One of the best experts on this subject based on the ideXlab platform.
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Global regulatory requirements for mutagenicity assessment in the registration of Industrial Chemicals.
Environmental and molecular mutagenesis, 2017Co-Authors: Nicholas Ball, Matthew J. LebaronAbstract:Mutagenicity is an important toxicological endpoint that requires thorough evaluation during the Industrial Chemical registration process. Regulatory requirements for mutagenicity assessment in registration of Industrial Chemicals vary in geographic regions (and in some cases by intended application). Here we compile the mutagenicity testing requirements for registration of Industrial Chemicals from representative geographic regions (in alphabetical order), that is Australia, Brazil, Canada, China, European Union (EU), India, Japan, South Korea, Taiwan, and United States (US). We further discuss the challenges that industry is facing to meet global regulations, for example, different testing requirements among geographic regions, different strategies in follow-up tests to in vitro positive findings, no-observed-adverse-effect-levels in genetic toxicity testing, and human relevance of mutagenicity. Environ. Mol. Mutagen., 2017. © 2017 Wiley Periodicals, Inc.
Todd E. Mlsna - One of the best experts on this subject based on the ideXlab platform.
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Chemicapacitive microsensors for Chemical warfare agent and toxic Industrial Chemical detection
Sensors and Actuators B: Chemical, 2006Co-Authors: Todd E. Mlsna, Sabina Cemalovic, Debra A. Mlsna, Matthew Warburton, Stephen T. Hobson, Sanjay V. PatelAbstract:Detection of Chemical warfare agents and toxic Industrial Chemicals using Microfabrication and microelectromechanical systems (MEMS) chemicapactive sensors is described. Our sensor chips consist of 10 parallel plates or interdigitated capacitors with an absorbant dielectric material to measure the dielectric constant of an array of selectively absorbing materials. The dielectric permittivity of these polymer filled chemicapacitors changes upon adsorption and desorption of the Chemical vapors. Gaseous analytes including Chemical warfare agents (CWAs) and toxic Industrial Chemicals (TICs) have been exposed to our sensors with the results being displayed and discussed below. Sensor performance was characterized through exposure to various CWAs and TICs over a range of concentrations. The limits of detection (LOD) were determined for several Chemicals. © 2006.
Nicholas Ball - One of the best experts on this subject based on the ideXlab platform.
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Global regulatory requirements for mutagenicity assessment in the registration of Industrial Chemicals.
Environmental and molecular mutagenesis, 2017Co-Authors: Nicholas Ball, Matthew J. LebaronAbstract:Mutagenicity is an important toxicological endpoint that requires thorough evaluation during the Industrial Chemical registration process. Regulatory requirements for mutagenicity assessment in registration of Industrial Chemicals vary in geographic regions (and in some cases by intended application). Here we compile the mutagenicity testing requirements for registration of Industrial Chemicals from representative geographic regions (in alphabetical order), that is Australia, Brazil, Canada, China, European Union (EU), India, Japan, South Korea, Taiwan, and United States (US). We further discuss the challenges that industry is facing to meet global regulations, for example, different testing requirements among geographic regions, different strategies in follow-up tests to in vitro positive findings, no-observed-adverse-effect-levels in genetic toxicity testing, and human relevance of mutagenicity. Environ. Mol. Mutagen., 2017. © 2017 Wiley Periodicals, Inc.
