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Marco Peluso - One of the best experts on this subject based on the ideXlab platform.

  • exocyclic dna adducts in sheep with skeletal fluorosis resident in the proximity of the portoscuso portovesme Industrial Estate on sardinia island italy
    Toxicology Research, 2015
    Co-Authors: Marco Peluso, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Dolores Catelan, Stefano Rocca, Serafina Farigu, A Leoni, Marco Bruzzone, Annibale Biggeri
    Abstract:

    The mechanisms by which fluoride produces its toxic effects are still not clear. Therefore, we conducted a cross-sectional study to evaluate the fluoride-induced toxicity on randomly selected sheep with skeletal fluorosis resident near the large non-ferrous metallurgy Portoscuso-Portovesme Industrial Estate and the Carbonia and Gonnessa towns (control district) with respect to animals from a remote site without Industrial settlements, on Sardinia Island, Italy. We measured the prevalence of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, a biomarker of oxidative stress and lipid peroxidation, in the soft organs of the study animals using the 32P-postlabelling assay. Then, we analysed the association between M1dG adducts and sheep-farm localization. In addition, cadmium and lead levels were measured in the same matrices by mass spectrometry. The histopathology analysis showed that the sheep resident near the Industrial site and in the control district presented typical manifestations of fluorosis. The statistical analyses using log-normal regression models indicated that there was a significant association between exocyclic DNA adducts and skeletal fluorosis. The mean ratios, adjusted for age, of renal and hepatic M1dG for the sheep with fluorosis were 5.09, 95% C.I. 1.67–15.53 and 2.04, 95% C.I. 0.91–4.57, p = 0.009 and p = 0.078, respectively. After stratification for sheep-farm localization, the renal and hepatic levels of M1dG adducts were significantly higher in the sheep resident near the Industrial Estate as compared to controls. Intermediate amounts of DNA damage were observed in the kidney of the sheep living in the control district. As expected, the levels of cadmium and lead were significantly increased in the sheep with fluorosis as compared to controls. Also, the concentrations of heavy metals were driven from the distance of the sheep-farms to the Industrial site. Our results broaden knowledge about the role of exocyclic DNA adducts in the etiology of skeletal fluorosis. Fluoride generated from the non-ferrous metallurgy complexes may increase the intracellular amounts of oxidative stress and ROS within the soft organs. A continuous attack to DNA may contribute to the general decline of cellular functions, ranging from disturbance of DNA metabolism, triggering cell-cycle arrest and apoptosis, to inducing necrosis and cellular degenerative changes.

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M1dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M1dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M1dG. M1dG was decreased in controls reporting to consume 14–17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18–0.69, p< 0.05). Conversely, a non-statistically significant M1dG increment was detected in controls consuming 9–18 servings/week of fried food (MR = 1.33, CI 0.88–2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14–3.10, p < 0.05), but not in workers. M1dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practi...

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M(1)dG. M(1)dG was decreased in controls reporting to consume 14-17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18-0.69, p< 0.05). Conversely, a non-statistically significant M(1)dG increment was detected in controls consuming 9-18 servings/week of fried food (MR = 1.33, CI 0.88-2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14-3.10, p < 0.05), but not in workers. M(1)dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practices should be recommended.

Petcharin Srivatanakul - One of the best experts on this subject based on the ideXlab platform.

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M1dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M1dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M1dG. M1dG was decreased in controls reporting to consume 14–17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18–0.69, p< 0.05). Conversely, a non-statistically significant M1dG increment was detected in controls consuming 9–18 servings/week of fried food (MR = 1.33, CI 0.88–2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14–3.10, p < 0.05), but not in workers. M1dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practi...

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M(1)dG. M(1)dG was decreased in controls reporting to consume 14-17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18-0.69, p< 0.05). Conversely, a non-statistically significant M(1)dG increment was detected in controls consuming 9-18 servings/week of fried food (MR = 1.33, CI 0.88-2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14-3.10, p < 0.05), but not in workers. M(1)dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practices should be recommended.

Marcello Ceppi - One of the best experts on this subject based on the ideXlab platform.

  • exocyclic dna adducts in sheep with skeletal fluorosis resident in the proximity of the portoscuso portovesme Industrial Estate on sardinia island italy
    Toxicology Research, 2015
    Co-Authors: Marco Peluso, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Dolores Catelan, Stefano Rocca, Serafina Farigu, A Leoni, Marco Bruzzone, Annibale Biggeri
    Abstract:

    The mechanisms by which fluoride produces its toxic effects are still not clear. Therefore, we conducted a cross-sectional study to evaluate the fluoride-induced toxicity on randomly selected sheep with skeletal fluorosis resident near the large non-ferrous metallurgy Portoscuso-Portovesme Industrial Estate and the Carbonia and Gonnessa towns (control district) with respect to animals from a remote site without Industrial settlements, on Sardinia Island, Italy. We measured the prevalence of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, a biomarker of oxidative stress and lipid peroxidation, in the soft organs of the study animals using the 32P-postlabelling assay. Then, we analysed the association between M1dG adducts and sheep-farm localization. In addition, cadmium and lead levels were measured in the same matrices by mass spectrometry. The histopathology analysis showed that the sheep resident near the Industrial site and in the control district presented typical manifestations of fluorosis. The statistical analyses using log-normal regression models indicated that there was a significant association between exocyclic DNA adducts and skeletal fluorosis. The mean ratios, adjusted for age, of renal and hepatic M1dG for the sheep with fluorosis were 5.09, 95% C.I. 1.67–15.53 and 2.04, 95% C.I. 0.91–4.57, p = 0.009 and p = 0.078, respectively. After stratification for sheep-farm localization, the renal and hepatic levels of M1dG adducts were significantly higher in the sheep resident near the Industrial Estate as compared to controls. Intermediate amounts of DNA damage were observed in the kidney of the sheep living in the control district. As expected, the levels of cadmium and lead were significantly increased in the sheep with fluorosis as compared to controls. Also, the concentrations of heavy metals were driven from the distance of the sheep-farms to the Industrial site. Our results broaden knowledge about the role of exocyclic DNA adducts in the etiology of skeletal fluorosis. Fluoride generated from the non-ferrous metallurgy complexes may increase the intracellular amounts of oxidative stress and ROS within the soft organs. A continuous attack to DNA may contribute to the general decline of cellular functions, ranging from disturbance of DNA metabolism, triggering cell-cycle arrest and apoptosis, to inducing necrosis and cellular degenerative changes.

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M1dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M1dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M1dG. M1dG was decreased in controls reporting to consume 14–17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18–0.69, p< 0.05). Conversely, a non-statistically significant M1dG increment was detected in controls consuming 9–18 servings/week of fried food (MR = 1.33, CI 0.88–2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14–3.10, p < 0.05), but not in workers. M1dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practi...

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M(1)dG. M(1)dG was decreased in controls reporting to consume 14-17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18-0.69, p< 0.05). Conversely, a non-statistically significant M(1)dG increment was detected in controls consuming 9-18 servings/week of fried food (MR = 1.33, CI 0.88-2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14-3.10, p < 0.05), but not in workers. M(1)dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practices should be recommended.

Roger W. Giese - One of the best experts on this subject based on the ideXlab platform.

  • exocyclic dna adducts in sheep with skeletal fluorosis resident in the proximity of the portoscuso portovesme Industrial Estate on sardinia island italy
    Toxicology Research, 2015
    Co-Authors: Marco Peluso, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Dolores Catelan, Stefano Rocca, Serafina Farigu, A Leoni, Marco Bruzzone, Annibale Biggeri
    Abstract:

    The mechanisms by which fluoride produces its toxic effects are still not clear. Therefore, we conducted a cross-sectional study to evaluate the fluoride-induced toxicity on randomly selected sheep with skeletal fluorosis resident near the large non-ferrous metallurgy Portoscuso-Portovesme Industrial Estate and the Carbonia and Gonnessa towns (control district) with respect to animals from a remote site without Industrial settlements, on Sardinia Island, Italy. We measured the prevalence of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, a biomarker of oxidative stress and lipid peroxidation, in the soft organs of the study animals using the 32P-postlabelling assay. Then, we analysed the association between M1dG adducts and sheep-farm localization. In addition, cadmium and lead levels were measured in the same matrices by mass spectrometry. The histopathology analysis showed that the sheep resident near the Industrial site and in the control district presented typical manifestations of fluorosis. The statistical analyses using log-normal regression models indicated that there was a significant association between exocyclic DNA adducts and skeletal fluorosis. The mean ratios, adjusted for age, of renal and hepatic M1dG for the sheep with fluorosis were 5.09, 95% C.I. 1.67–15.53 and 2.04, 95% C.I. 0.91–4.57, p = 0.009 and p = 0.078, respectively. After stratification for sheep-farm localization, the renal and hepatic levels of M1dG adducts were significantly higher in the sheep resident near the Industrial Estate as compared to controls. Intermediate amounts of DNA damage were observed in the kidney of the sheep living in the control district. As expected, the levels of cadmium and lead were significantly increased in the sheep with fluorosis as compared to controls. Also, the concentrations of heavy metals were driven from the distance of the sheep-farms to the Industrial site. Our results broaden knowledge about the role of exocyclic DNA adducts in the etiology of skeletal fluorosis. Fluoride generated from the non-ferrous metallurgy complexes may increase the intracellular amounts of oxidative stress and ROS within the soft organs. A continuous attack to DNA may contribute to the general decline of cellular functions, ranging from disturbance of DNA metabolism, triggering cell-cycle arrest and apoptosis, to inducing necrosis and cellular degenerative changes.

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M1dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M1dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M1dG. M1dG was decreased in controls reporting to consume 14–17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18–0.69, p< 0.05). Conversely, a non-statistically significant M1dG increment was detected in controls consuming 9–18 servings/week of fried food (MR = 1.33, CI 0.88–2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14–3.10, p < 0.05), but not in workers. M1dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practi...

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M(1)dG. M(1)dG was decreased in controls reporting to consume 14-17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18-0.69, p< 0.05). Conversely, a non-statistically significant M(1)dG increment was detected in controls consuming 9-18 servings/week of fried food (MR = 1.33, CI 0.88-2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14-3.10, p < 0.05), but not in workers. M(1)dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practices should be recommended.

Armelle Munnia - One of the best experts on this subject based on the ideXlab platform.

  • exocyclic dna adducts in sheep with skeletal fluorosis resident in the proximity of the portoscuso portovesme Industrial Estate on sardinia island italy
    Toxicology Research, 2015
    Co-Authors: Marco Peluso, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Dolores Catelan, Stefano Rocca, Serafina Farigu, A Leoni, Marco Bruzzone, Annibale Biggeri
    Abstract:

    The mechanisms by which fluoride produces its toxic effects are still not clear. Therefore, we conducted a cross-sectional study to evaluate the fluoride-induced toxicity on randomly selected sheep with skeletal fluorosis resident near the large non-ferrous metallurgy Portoscuso-Portovesme Industrial Estate and the Carbonia and Gonnessa towns (control district) with respect to animals from a remote site without Industrial settlements, on Sardinia Island, Italy. We measured the prevalence of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, a biomarker of oxidative stress and lipid peroxidation, in the soft organs of the study animals using the 32P-postlabelling assay. Then, we analysed the association between M1dG adducts and sheep-farm localization. In addition, cadmium and lead levels were measured in the same matrices by mass spectrometry. The histopathology analysis showed that the sheep resident near the Industrial site and in the control district presented typical manifestations of fluorosis. The statistical analyses using log-normal regression models indicated that there was a significant association between exocyclic DNA adducts and skeletal fluorosis. The mean ratios, adjusted for age, of renal and hepatic M1dG for the sheep with fluorosis were 5.09, 95% C.I. 1.67–15.53 and 2.04, 95% C.I. 0.91–4.57, p = 0.009 and p = 0.078, respectively. After stratification for sheep-farm localization, the renal and hepatic levels of M1dG adducts were significantly higher in the sheep resident near the Industrial Estate as compared to controls. Intermediate amounts of DNA damage were observed in the kidney of the sheep living in the control district. As expected, the levels of cadmium and lead were significantly increased in the sheep with fluorosis as compared to controls. Also, the concentrations of heavy metals were driven from the distance of the sheep-farms to the Industrial site. Our results broaden knowledge about the role of exocyclic DNA adducts in the etiology of skeletal fluorosis. Fluoride generated from the non-ferrous metallurgy complexes may increase the intracellular amounts of oxidative stress and ROS within the soft organs. A continuous attack to DNA may contribute to the general decline of cellular functions, ranging from disturbance of DNA metabolism, triggering cell-cycle arrest and apoptosis, to inducing necrosis and cellular degenerative changes.

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M1dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M1dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M1dG. M1dG was decreased in controls reporting to consume 14–17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18–0.69, p< 0.05). Conversely, a non-statistically significant M1dG increment was detected in controls consuming 9–18 servings/week of fried food (MR = 1.33, CI 0.88–2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14–3.10, p < 0.05), but not in workers. M1dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practi...

  • fruit and vegetable and fried food consumption and 3 2 deoxy β d erythro pentafuranosyl pyrimido 1 2 α purin 10 3h one deoxyguanosine adduct formation
    Free Radical Research, 2012
    Co-Authors: Marco Peluso, Adisorn Jedpiyawongse, Sara Piro, Suleeporn Sangrajrang, Paolo Boffetta, Armelle Munnia, Roger W. Giese, Marcello Ceppi, Petcharin Srivatanakul
    Abstract:

    Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut Industrial Estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-grilled/barbecued food consumption on M(1)dG. M(1)dG was decreased in controls reporting to consume 14-17 servings/week of fruit and vegetables (mean ratio [MR]= 0.35, CI 0.18-0.69, p< 0.05). Conversely, a non-statistically significant M(1)dG increment was detected in controls consuming 9-18 servings/week of fried food (MR = 1.33, CI 0.88-2.00, p = 0.168). No effect of charcoal-grilled/barbecued food was found. No effect of diet was observed in workers. An association with smoking was observed in controls (MR = 1.88, CI 1.14-3.10, p < 0.05), but not in workers. M(1)dG can induce mutations and/or methylation changes within the promoter regions of cancer-related genes, thus promotion of healthy eating practices should be recommended.