The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform
Francisco Mercado-calderon - One of the best experts on this subject based on the ideXlab platform.
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The evaluation of 1-hydroxypyrene as a bioindicator of Industrial Exposure to polycyclic aromatic hydrocarbons
Salud publica de Mexico, 1993Co-Authors: Francisco Mercado-calderonAbstract:One hundred and twenty-two workers (16 from a coke production plant, 106 from a graphite electrode manufacturing plant) agreed to participate in this study designed to evaluate the relationship between the Exposure to polycyclic aromatic hydrocarbons (PAHS) and the urinary excretion of 1-hydroxypyrene (1-HOP), the main metabolite of pyrene. The results show that the concentration of pyrene in air is highly correlated with total PAHS amount (r = 0.083, p < 0.001), with a the correlation coefficient between 1-HOP and total PAHS of r = 0.72 (p < 0.001). The biological half life of the 1-HOP was determined (18 hrs) and the non interference of smoking habits in relation to 1-HOP urinary was established, concluding that 1-HOP is a suitable bioindicator of the occupational Exposure to PAHS.
Elizabeth A Martin - One of the best experts on this subject based on the ideXlab platform.
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an organizational approach for the assessment of dna adduct data in risk assessment case studies for aflatoxin b1 tamoxifen and vinyl chloride
Critical Reviews in Toxicology, 2014Co-Authors: Lynn H Pottenger, Larry S Andrews, Ammie N Bachman, Peter J Boogaard, Jean Cadet, Michelle R Embry, Peter B Farmer, Matthew W Himmelstein, Annie M Jarabek, Elizabeth A MartinAbstract:AbstractThe framework analysis previously presented for using DNA adduct information in the risk assessment of chemical carcinogens was applied in a series of case studies which place the adduct information into context with the key events in carcinogenesis to determine whether they could be used to support a mutagenic mode of action (MOA) for the examined chemicals. Three data-rich chemicals, aflatoxin B1 (AFB1), tamoxifen (Tam) and vinyl chloride (VCl) were selected for this exercise. These chemicals were selected because they are known human carcinogens and have different characteristics: AFB1 forms a unique adduct and human Exposure is through contaminated foods; Tam is a pharmaceutical given to women so that the dose and duration of Exposure are known, forms unique adducts in rodents, and has both estrogenic and genotoxic properties; and VCl, to which there is Industrial Exposure, forms a number of adducts that are identical to endogenous adducts found in unexposed people. All three chemicals produce...
Lynn H Pottenger - One of the best experts on this subject based on the ideXlab platform.
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an organizational approach for the assessment of dna adduct data in risk assessment case studies for aflatoxin b1 tamoxifen and vinyl chloride
Critical Reviews in Toxicology, 2014Co-Authors: Lynn H Pottenger, Larry S Andrews, Ammie N Bachman, Peter J Boogaard, Jean Cadet, Michelle R Embry, Peter B Farmer, Matthew W Himmelstein, Annie M Jarabek, Elizabeth A MartinAbstract:AbstractThe framework analysis previously presented for using DNA adduct information in the risk assessment of chemical carcinogens was applied in a series of case studies which place the adduct information into context with the key events in carcinogenesis to determine whether they could be used to support a mutagenic mode of action (MOA) for the examined chemicals. Three data-rich chemicals, aflatoxin B1 (AFB1), tamoxifen (Tam) and vinyl chloride (VCl) were selected for this exercise. These chemicals were selected because they are known human carcinogens and have different characteristics: AFB1 forms a unique adduct and human Exposure is through contaminated foods; Tam is a pharmaceutical given to women so that the dose and duration of Exposure are known, forms unique adducts in rodents, and has both estrogenic and genotoxic properties; and VCl, to which there is Industrial Exposure, forms a number of adducts that are identical to endogenous adducts found in unexposed people. All three chemicals produce...
Gisela Witz - One of the best experts on this subject based on the ideXlab platform.
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Structure-Activity Relationships of Acrylate Esters: Reactivity Towards Glutathione and Hydrolysis by Carboxylesterase in Vitro
Advances in Experimental Medicine and Biology, 1991Co-Authors: T. J. Mccarthy, Gisela WitzAbstract:Acrylate esters are high volume, versatile chemicals in the plastics industry. Long)term Industrial Exposure to these esters has caused contact hypersensitivity and dermatitis, while laboratory studies have shown these esters to be strong irritants, sensitizers, clastogens, and some have been shown to be weak carcinogens (Andrews and Clary, 1986). Numerous members make up this class of chemicals sharing an α, β- unsaturated ester structure. The individual members differ from each other due to structural features added onto the α, β-unsaturated ester.
Bette Meek - One of the best experts on this subject based on the ideXlab platform.
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nonoccupational Exposure to chrysotile asbestos and the risk of lung cancer
The New England Journal of Medicine, 1998Co-Authors: Michel Camus, Jack Siemiatycki, Bette MeekAbstract:Background Heavy Industrial Exposure to asbestos causes lung cancer and mesothelioma, but it remains unknown whether much lower environmental Exposure to asbestos also causes these cancers. Nevertheless, regulatory agencies, including the Environmental Protection Agency (EPA), have assessed the risk of lung cancer by extrapolating known risks from past Industrial Exposure to asbestos to today's much lower environmental asbestos levels (roughly 100,000 times lower). We also tested the EPA's model for predicting the risk of asbestos-induced lung cancer in a population of women with relatively high levels of nonoccupational Exposure to asbestos. Methods Mortality among women in 2 chrysotile-asbestos–mining areas of the province of Quebec was compared with mortality among women in 60 control areas, and age-standardized mortality ratios were derived. With the help of an expert panel, we estimated past Exposure to asbestos among women in the mining areas and used these data with the EPA's model to predict the r...
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Nonoccupational Exposure to chrysotile asbestos and the risk of lung cancer.
The New England journal of medicine, 1998Co-Authors: Michel Camus, Jack Siemiatycki, Bette MeekAbstract:Background Heavy Industrial Exposure to asbestos causes lung cancer and mesothelioma, but it remains unknown whether much lower environmental Exposure to asbestos also causes these cancers. Nevertheless, regulatory agencies, including the Environmental Protection Agency (EPA), have assessed the risk of lung cancer by extrapolating known risks from past Industrial Exposure to asbestos to today's much lower environmental asbestos levels (roughly 100,000 times lower). We also tested the EPA's model for predicting the risk of asbestos-induced lung cancer in a population of women with relatively high levels of nonoccupational Exposure to asbestos. Methods Mortality among women in 2 chrysotile-asbestos–mining areas of the province of Quebec was compared with mortality among women in 60 control areas, and age-standardized mortality ratios were derived. With the help of an expert panel, we estimated past Exposure to asbestos among women in the mining areas and used these data with the EPA's model to predict the r...