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Ellen Covey - One of the best experts on this subject based on the ideXlab platform.
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A Neuroethological Theory of the Operation of the Inferior Colliculus; pp. 323–336
Brain Behavior and Evolution, 1996Co-Authors: John H Casseday, Ellen CoveyAbstract:A general statement of the function of the Inferior Colliculus is lacking, even after more than three decades of electrophysiological investigation. A neuroethological theory is proposed that accounts for a large and diverse body of evidence. Although aimed at characterizing the Inferior Colliculus in mammals, the theory also applies generally to the auditory midbrain in vertebrates. The theory has two hypotheses: (1) Tuning processes in the Inferior Colliculus are related to the biological importance of sounds. (2) There is a change in timing properties at the Inferior Colliculus, from rapid input to slowed output; this transformation is related to the timing of specific behaviors. Expressed in neuroethological terms, at least some neurons in the Inferior Colliculus are tuned to sign-stimuli, and the processing of these sign stimuli triggers fixed action patterns for hunting, escape or vocal communication. The resulting temporal transformation adjusts the pace of sensory input to the pace of behavior. Evidence for the theory comes from anatomical, neurophysiological and behavioral studies and includes: (1) massive convergence of parallel auditory pathways at the Inferior Colliculus, (2) interaction of the Inferior Colliculus with motor systems, (3) tuning of auditory midbrain neurons to biologically important sounds, (4) the slow pace of neural processing at the Inferior Colliculus, (5) the slow pace of motor output. The theory has the following implications. Neurons in the Inferior Colliculus are filters for sounds that require immediate action, such as certain sounds made by prey, predators or conspecifics. Neural processing in the Inferior Colliculus is species specific, resulting in filtering for these kinds of sounds. Specific action patterns should be correlated with the activity of neurons in the Inferior Colliculus. Motor activites may modify neural processing in Inferior Colliculus neurons. The rate at which information is transmitted to the thalamus is regulated by the Inferior Colliculus.
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A neuroethological theory of the operation of the Inferior Colliculus.
Brain behavior and evolution, 1996Co-Authors: John H Casseday, Ellen CoveyAbstract:A general statement of the function of the Inferior Colliculus is lacking, even after more than three decades of electrophysiological investigation. A neuroethological theory is proposed that accounts
John H Casseday - One of the best experts on this subject based on the ideXlab platform.
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A Neuroethological Theory of the Operation of the Inferior Colliculus; pp. 323–336
Brain Behavior and Evolution, 1996Co-Authors: John H Casseday, Ellen CoveyAbstract:A general statement of the function of the Inferior Colliculus is lacking, even after more than three decades of electrophysiological investigation. A neuroethological theory is proposed that accounts for a large and diverse body of evidence. Although aimed at characterizing the Inferior Colliculus in mammals, the theory also applies generally to the auditory midbrain in vertebrates. The theory has two hypotheses: (1) Tuning processes in the Inferior Colliculus are related to the biological importance of sounds. (2) There is a change in timing properties at the Inferior Colliculus, from rapid input to slowed output; this transformation is related to the timing of specific behaviors. Expressed in neuroethological terms, at least some neurons in the Inferior Colliculus are tuned to sign-stimuli, and the processing of these sign stimuli triggers fixed action patterns for hunting, escape or vocal communication. The resulting temporal transformation adjusts the pace of sensory input to the pace of behavior. Evidence for the theory comes from anatomical, neurophysiological and behavioral studies and includes: (1) massive convergence of parallel auditory pathways at the Inferior Colliculus, (2) interaction of the Inferior Colliculus with motor systems, (3) tuning of auditory midbrain neurons to biologically important sounds, (4) the slow pace of neural processing at the Inferior Colliculus, (5) the slow pace of motor output. The theory has the following implications. Neurons in the Inferior Colliculus are filters for sounds that require immediate action, such as certain sounds made by prey, predators or conspecifics. Neural processing in the Inferior Colliculus is species specific, resulting in filtering for these kinds of sounds. Specific action patterns should be correlated with the activity of neurons in the Inferior Colliculus. Motor activites may modify neural processing in Inferior Colliculus neurons. The rate at which information is transmitted to the thalamus is regulated by the Inferior Colliculus.
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A neuroethological theory of the operation of the Inferior Colliculus.
Brain behavior and evolution, 1996Co-Authors: John H Casseday, Ellen CoveyAbstract:A general statement of the function of the Inferior Colliculus is lacking, even after more than three decades of electrophysiological investigation. A neuroethological theory is proposed that accounts
Ann M Thompson - One of the best experts on this subject based on the ideXlab platform.
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Inferior Colliculus projections to pontine nuclei in guinea pig
Brain Research, 2006Co-Authors: Ann M ThompsonAbstract:The present study examined the neural projection from the Inferior Colliculus to the pontine nuclei in guinea pig. This projection has been reported in other animals, and our goal was to establish the projection in guinea pig, a commonly used auditory model. Ultimately, we wanted to determine if the pontine nuclei could be a component of the descending auditory system from the Inferior Colliculus to the cochlear nucleus. The anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L) was injected into one Inferior Colliculus of 10 animals and the pontine nuclei examined under a light microscope to detect PHA-L-labeled fibers. PHA-L-labeled fibers were observed in the ipsilateral pontine nuclei in 70% of the animals. While the majority of labeled fibers were smooth in appearance, a few fibers with en passant type varicosities (indicating synapses) were observed in the dorsolateral area of the pontine nuclei, adjacent to the lateral lemniscus. These findings do not support a robust projection from the Inferior Colliculus to the pontine nuclei in guinea pig. This is in opposition to findings in bat in which the projection may play a major role in modulating responses to sound.
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Serotonin in the Inferior Colliculus.
Hearing research, 2002Co-Authors: Laura M Hurley, Ann M Thompson, George D. PollakAbstract:It has been recognized for some time that serotonin fibers originating in raphe nuclei are present in the Inferior colliculi of all mammalian species studied. More recently, serotonin has been found to modulate the responses of single Inferior Colliculus neurons to many types of auditory stimuli, ranging from simple tone bursts to complex species-specific vocalizations. The effects of serotonin are often quite strong, and for some neurons are also highly specific. A dramatic illustration of this is that serotonin can change the selectivity of some neurons for sounds, including species-specific vocalizations. These results are discussed in light of several theories on the function of serotonin in the IC, and of outstanding issues that remain to be addressed.
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Relationship of descending Inferior Colliculus projections to olivocochlear neurons.
The Journal of comparative neurology, 1993Co-Authors: Ann M Thompson, Glenn C. ThompsonAbstract:With the objective of defining the relationship of descending Inferior Colliculus projections to the olivocochlear system in the guinea pig, Inferior Colliculus neurons were anterogradely labeled with Phaseolus vulgaris-leucoagglutinin and olivocochlear neurons were retrogradely labeled with horseradish peroxidase in the same brain sections. Inferior Colliculus neurons were found to project to many nuclei and regions of the hindbrain where olivocochlear neurons reside. The most substantial of these descending projections was to the ipsilateral medioventral periolivary region. Fewer descending projections terminated in the ipsilateral ventral nucleus of the lateral lemniscus, superior paraolivary nucleus, and rostral periolivary region; and even fewer ipsilateral projections terminated in the area surrounding the lateral superior olive, caudal periolivary region, and the lateroventral periolivary region. Descending neurons of the Inferior Colliculus also project to the contralateral hindbrain first via the lateral lemniscus and then the trapezoid body, to terminate in the contralateral medioventral periolivary region, superior paraolivary nucleus, rostral periolivary region, and the ventral nucleus of the lateral lemniscus. In addition to the projections into these regions that contain olivocochlear neurons, there are varicosities of Inferior Colliculus neurons that appear to contact the olivocochlear neurons themselves, both ipsilaterally and contralaterally, especially, but not only, in the ipsilateral medioventral periolivary region. We therefore conclude that descending Inferior Colliculus neurons do provide input to olivocochlear neurons and that the input is not limited to olivocochlear neurons of the ipsilateral medioventral periolivary region. However, given the robust nature of the projection to the ipsilateral medioventral periolivary region and the paucity of contacts observed in that region, we also conclude that the olivocochlear neuron is not the major target of descending Inferior Colliculus projections. © 1993 Wiley-Liss, Inc.
Piyarat Govitrapong - One of the best experts on this subject based on the ideXlab platform.
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Relationship of opioid receptors with GABAergic neurons in the rat Inferior Colliculus.
The European journal of neuroscience, 2006Co-Authors: Walaiporn Tongjaroenbuangam, N Jongkamonwiwat, Pansiri Phansuwan-pujito, Hilary Dodson, Andrew Forge, Stefano O. Casalotti, Piyarat GovitrapongAbstract:The Inferior Colliculus is a critical structure for processing auditory information and receives ascending and descending synaptic auditory projections. In addition to GABAergic and glutamatergic innervations, other neurotransmitter systems are also reported in the Inferior Colliculus, including opioid peptides. In the present study, the relative distribution of each type of opioid receptor, mu (MOR), delta (DOR) and kappa (KOR) within GABAergic neurons in the Inferior Colliculus was examined. GABA immunoreactivity was expressed by small, medium and large neurons and distributed in the central nucleus and the pericentral nucleus of the Inferior Colliculus. Immunostaining for MOR, DOR and KOR receptors was found in both disc-shaped cells and stellate cells. Punctiform beta-endorphin immunolabelling was observed in the proximity of GABA-positive neurons. Co-localization of GABA and MOR receptors was observed in neurons and nerve terminals in the central nucleus, dorsal cortex and external cortex of the Inferior Colliculus. Quantification of the co-localization patterns determined that a higher proportion of GABA neurons was associated with MOR receptors compared with KOR or DOR receptors.
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Opioid modulation of GABA release in the rat Inferior Colliculus
BMC neuroscience, 2004Co-Authors: Walaiporn Tongjaroenbungam, N Jongkamonwiwat, Joanna R. Cunningham, Pansiri Phansuwan-pujito, Hilary Dodson, Andrew Forge, Piyarat Govitrapong, Stefano O. CasalottiAbstract:The Inferior Colliculus, which receives almost all ascending and descending auditory signals, plays a crucial role in the processing of auditory information. While the majority of the recorded activities in the Inferior Colliculus are attributed to GABAergic and glutamatergic signalling, other neurotransmitter systems are expressed in this brain area including opiate peptides and their receptors which may play a modulatory role in neuronal communication. Using a perfusion protocol we demonstrate that morphine can inhibit KCl-induced release of [3H]GABA from rat Inferior Colliculus slices. DAMGO ([D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin) but not DADLE ([D-Ala2, D-Leu5]-enkephalin or U69593 has the same effect as morphine indicating that micro rather than delta or kappa opioid receptors mediate this action. [3H]GABA release was diminished by 16%, and this was not altered by the protein kinase C inhibitor bisindolylmaleimide I. Immunostaining of Inferior Colliculus cryosections shows extensive staining for glutamic acid decarboxylase, more limited staining for micro opiate receptors and relatively few neurons co-stained for both proteins. The results suggest that micro-opioid receptor ligands can modify neurotransmitter release in a sub population of GABAergic neurons of the Inferior Colliculus. This could have important physiological implications in the processing of hearing information and/or other functions attributed to the Inferior Colliculus such as audiogenic seizures and aversive behaviour.
Stefano O. Casalotti - One of the best experts on this subject based on the ideXlab platform.
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Relationship of opioid receptors with GABAergic neurons in the rat Inferior Colliculus.
The European journal of neuroscience, 2006Co-Authors: Walaiporn Tongjaroenbuangam, N Jongkamonwiwat, Pansiri Phansuwan-pujito, Hilary Dodson, Andrew Forge, Stefano O. Casalotti, Piyarat GovitrapongAbstract:The Inferior Colliculus is a critical structure for processing auditory information and receives ascending and descending synaptic auditory projections. In addition to GABAergic and glutamatergic innervations, other neurotransmitter systems are also reported in the Inferior Colliculus, including opioid peptides. In the present study, the relative distribution of each type of opioid receptor, mu (MOR), delta (DOR) and kappa (KOR) within GABAergic neurons in the Inferior Colliculus was examined. GABA immunoreactivity was expressed by small, medium and large neurons and distributed in the central nucleus and the pericentral nucleus of the Inferior Colliculus. Immunostaining for MOR, DOR and KOR receptors was found in both disc-shaped cells and stellate cells. Punctiform beta-endorphin immunolabelling was observed in the proximity of GABA-positive neurons. Co-localization of GABA and MOR receptors was observed in neurons and nerve terminals in the central nucleus, dorsal cortex and external cortex of the Inferior Colliculus. Quantification of the co-localization patterns determined that a higher proportion of GABA neurons was associated with MOR receptors compared with KOR or DOR receptors.
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Opioid modulation of GABA release in the rat Inferior Colliculus
BMC neuroscience, 2004Co-Authors: Walaiporn Tongjaroenbungam, N Jongkamonwiwat, Joanna R. Cunningham, Pansiri Phansuwan-pujito, Hilary Dodson, Andrew Forge, Piyarat Govitrapong, Stefano O. CasalottiAbstract:The Inferior Colliculus, which receives almost all ascending and descending auditory signals, plays a crucial role in the processing of auditory information. While the majority of the recorded activities in the Inferior Colliculus are attributed to GABAergic and glutamatergic signalling, other neurotransmitter systems are expressed in this brain area including opiate peptides and their receptors which may play a modulatory role in neuronal communication. Using a perfusion protocol we demonstrate that morphine can inhibit KCl-induced release of [3H]GABA from rat Inferior Colliculus slices. DAMGO ([D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin) but not DADLE ([D-Ala2, D-Leu5]-enkephalin or U69593 has the same effect as morphine indicating that micro rather than delta or kappa opioid receptors mediate this action. [3H]GABA release was diminished by 16%, and this was not altered by the protein kinase C inhibitor bisindolylmaleimide I. Immunostaining of Inferior Colliculus cryosections shows extensive staining for glutamic acid decarboxylase, more limited staining for micro opiate receptors and relatively few neurons co-stained for both proteins. The results suggest that micro-opioid receptor ligands can modify neurotransmitter release in a sub population of GABAergic neurons of the Inferior Colliculus. This could have important physiological implications in the processing of hearing information and/or other functions attributed to the Inferior Colliculus such as audiogenic seizures and aversive behaviour.