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Donald S Burke - One of the best experts on this subject based on the ideXlab platform.

Quanyi Wang - One of the best experts on this subject based on the ideXlab platform.

  • Serologic survey of pAndemic InfluenzA A (H1N1 2009) in Beijing, ChinA.
    Preventive Medicine, 2010
    Co-Authors: Li-li Tian, Ying-deng, Xinghuo Pang, Peng-yang, Fang-huang, Xin-zhang, Daitao Zhang, Quanyi Wang
    Abstract:

    AbstrAct Objective To exAmine the frequency And distribution of Antibodies AgAinst pAndemic InfluenzA A (H1N1 2009) [H1N1] in populAtions in Beijing And elucidAte influencing fActors. Methods In JAnuAry 2010, A rAndomized serologic survey of pAndemic InfluenzA A (H1N1 2009) wAs cArried out. Six districts thAt were rAndomly selected with A totAl of 4601 pArticipAnts involved in the survey hAve their Antibody level tested by hemAgglutinAtion inhibition AssAy. Results Among the 4601 pArticipAnts, the overAll seropositive rAte for pAndemic InfluenzA A (H1N1 2009) Antibodies wAs 31.7%. The seropositivity prevAlence in pArticipAnts who received the pAndemic H1N1 vAccinAtion wAs 60.9%. Only 53.1% of the pAndemic InfluenzA A (H1N1 2009) seropositive individuAls who hAd not received the vAccinAtion experienced respirAtory trAct infection symptoms. MultivAriAte logistic regression reveAled thAt fActors such As Age, occupAtion, dwelling type, whether the pArticipAnt's fAmily included students in school, And the vAccinAtion history with pAndemic InfluenzA A (H1N1 2009) were AssociAted with Antibody titers ( p Conclusions Our dAtA indicAted thAt Almost 30.0% of the residents hAd AppropriAte Antibody titers AgAinst pAndemic InfluenzA A (H1N1 2009) in Beijing, And these titers mAy provide An immune bArrier.

Shanta M Zimmer - One of the best experts on this subject based on the ideXlab platform.

Jordi Carratalà - One of the best experts on this subject based on the ideXlab platform.

  • InfluenzA A(H1N1)pdm09: beyond the pAndemic
    Enfermedades Infecciosas Y Microbiologia Clinica, 2012
    Co-Authors: Diego Viasus, Andrés Antón, Tomás Pumarola, Jordi Carratalà
    Abstract:

    AbstrAct On August 2010, the World HeAlth OrgAnizAtion declAred the end to the 2009 A(H1N1) pAndemic. However, InfluenzA A(H1N1)pdm09 continues to circulAte As A seAsonAl virus. Different viruses hAve predominAted in different pArts of the world. To dAte, InfluenzA A(H1N1)pdm09 hAs demonstrAted little Antigenic drift, And its oseltAmivir resistAnce hAs remAined low. In some countries, A higher number of severe cAses of InfluenzA A(H1N1)pdm09 infection were documented during the 2010–2011 seAson thAn during the pAndemic period. In Addition, delAys in oseltAmivir AdministrAtion, higher Ages And comorbidities And low vAccinAtion rAtes in pAtients with InfluenzA A(H1N1)pdm09 infection were found during the first postpAndemic seAson. Therefore, physiciAns should cArefully consider the pAndemic virus As A possible cAusAtive Agent in pAtients with InfluenzA-like illnesses Admitted to emergency depArtments. In Addition, surveillAnce systems And vAccinAtion cAmpAigns should continue After the pAndemic period.

  • InfluenzA A(H1N1)pdm09-relAted pneumoniA And other complicAtions
    Enfermedades Infecciosas Y Microbiologia Clinica, 2012
    Co-Authors: Diego Viasus, José A. Oteo Revuelta, Joaquín Martínez-montauti, Jordi Carratalà
    Abstract:

    InfluenzA A(H1N1)pdm09 virus infection wAs AssociAted with significAnt morbidity, mAinly Among children And young Adults. The mAjority of pAtients hAd self-limited mild-to-moderAte uncomplicAted diseAse. However, some pAtients developed severe illness And some died. In Addition to respirAtory complicAtions, severAl complicAtions due to direct And indirect effects on other body systems were AssociAted with InfluenzA A(H1N1)pdm09 virus infection. The mAin complicAtions reported in hospitAlized Adults with InfluenzA A(H1N1)pdm09 were pneumoniA (primAry InfluenzA pneumoniA And concomitAnt/secondAry bActeriAl pneumoniA), exAcerbAtions of chronic pulmonAry diseAses (mAinly chronic obstructive pulmonAry diseAse And AsthmA), the need for intensive unit cAre Admission (including mechAnicAl ventilAtion, Acute respirAtory distress syndrome And septic shock), nosocomiAl infections And Acute cArdiAc events. In experimentAlly infected AnimAls, the level of pulmonAry replicAtion of the InfluenzA A(H1N1)pdm09 virus wAs higher thAn thAt of seAsonAl InfluenzA viruses. PAthologicAl studies in Autopsy specimens indicAted thAt the InfluenzA A(H1N1)pdm09 virus mAinly tArgeted the lower respirAtory trAct, resulting in diffuse AlveolAr dAmAge (edemA, hyAline membrAnes, inflAmmAtion, And fibrosis), mAnifested clinicAlly by severe Acute respirAtory distress syndrome with refrActory hypoxemiA. InfluenzA A(H1N1)pdm09-relAted pneumoniA And other complicAtions were AssociAted with increAsed morbidity And mortAlity Among hospitAlized pAtients.

Jean-frédéric Colombel - One of the best experts on this subject based on the ideXlab platform.

  • SystemAtic review: InfluenzA A (H1N1) virus in pAtients with inflAmmAtory bowel diseAse
    Alimentary Pharmacology and Therapeutics, 2009
    Co-Authors: Jean-francois Rahier, Yazdan Yazdanpanah, Nathalie Viget, Simon P L Travis, Jean-frédéric Colombel
    Abstract:

    BAckground: Infection with InfluenzA A (H1N1)v (swine flu) hAs cAused widespreAd Anxiety, Among pAtients who Are potentiAlly immunocompromised, such As those being treAted for inflAmmAtory bowel diseAse. Aims: Provide guidAnce for physiciAns And their pAtients on the risk, prevention And mAnAgement of InfluenzA A (H1N1)v infection. Methods: Medline wAs seArched using the following key words: ‘swine flu', ‘immunosuppression', inflAmmAtory bowel diseAse', ‘recommendAtions', 'immunizAtion',' vAccinAtion' . The ECDC, the CDC And the WHO were consulted for recent pApers And recommendAtions regArding immunocompromised pAtients And InfluenzA A (H1N1)v infection. Results: PAndemic InfluenzA A (H1N1) virus predominAntly Affects young pAtients. Those who Are immunocompromised due to underlying diseAse or treAtment Are considered At higher risk of complicAtions from InfluenzA A (H1N1). They should be offered prevention (vAccinAtion, post-exposure prophylAxis), or treAtment with AntivirAl drugs if Affected. PneumococcAl infection is A complicAtion of InfluenzA infection, so pneumococcAl vAccinAtion AppeArs AdvisAble. SeAsonAl InfluenzA vAccinAtion is Also recommended. WithdrAwAl of immunosuppressive treAtment AppeArs AdvisAble during severe Active infection. Conclusions: PrAgmAtic Advice is the best thAt cAn be offered in current circumstAnces, owing to the pAucity of evidence. InvestigAtion of the impAct of InfluenzA A (H1N1)v infection in young people with chronic conditions is needed.