The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform

Olivier Witschger - One of the best experts on this subject based on the ideXlab platform.

  • characterization of aerosols generated from nine nanomaterial powders reliability with regard to in vivo Inhalation Toxicology studies
    Journal of Nanoparticle Research, 2018
    Co-Authors: Soleiman Bourrous, F Gaielevrel, Olivier Witschger
    Abstract:

    In experimental Toxicology, when simulating human exposure to aerosols in the working environment, Inhalation is the route of administration of choice for evaluating the toxicity of a given material (in aerosol form) in animals. In this context, this work aimed to contribute to the establishment of recommendations concerning the characterization of aerosol tests in Inhalation Toxicology studies. In particular, the work consisted of experimentally characterizing test aerosols using a given generation method to be used for Inhalation Toxicology studies. Nine nanomaterial powders have been investigated (four types of TiO2, two types of SiO2, ZnO, CeO, and BaSO4). The aerosols produced cover the particle size range from a few tens of nanometers up to several micrometers and are mainly composed of aggregates and/or agglomerates. The work carried out shows that generation and characterization of test aerosols for Inhalation Toxicology studies is a complex but essential element of Inhalation studies, for which the conditions required (stability, repeatability, level of concentration) are sometimes difficult to obtain. Moreover, this study highlights the necessity to carry out preliminary tests to ascertain the performances of the chosen devices and their suitability for Inhalation Toxicology.

  • Characterization of aerosols generated from nine nanomaterial powders reliability with regard to in vivo Inhalation Toxicology studies
    Journal of Nanoparticle Research, 2018
    Co-Authors: Soleiman Bourrous, François Gaie-levrel, Olivier Witschger
    Abstract:

    In experimental Toxicology, when simulating human exposure to aerosols in the working environment, Inhalation is the route of administration of choice for evaluating the toxicity of a given material (in aerosol form) in animals. In this context, this work aimed to contribute to the establishment of recommendations concerning the characterization of aerosol tests in Inhalation Toxicology studies. In particular, the work consisted of experimentally characterizing test aerosols using a given generation method to be used for Inhalation Toxicology studies. Nine nanomaterial powders have been investigated (four types of TiO2, two types of SiO2, ZnO, CeO, and BaSO4). The aerosols produced cover the particle size range from a few tens of nanometers up to several micrometers and are mainly composed of aggregates and/or agglomerates. The work carried out shows that generation and characterization of test aerosols for Inhalation Toxicology studies is a complex but essential element of Inhalation studies, for which the conditions required (stability, repeatability, level of concentration) are sometimes difficult to obtain. Moreover, this study highlights the necessity to carry out preliminary tests to ascertain the performances of the chosen devices and their suitability for Inhalation Toxicology. © 2018, Springer Nature B.V.

Soleiman Bourrous - One of the best experts on this subject based on the ideXlab platform.

  • characterization of aerosols generated from nine nanomaterial powders reliability with regard to in vivo Inhalation Toxicology studies
    Journal of Nanoparticle Research, 2018
    Co-Authors: Soleiman Bourrous, F Gaielevrel, Olivier Witschger
    Abstract:

    In experimental Toxicology, when simulating human exposure to aerosols in the working environment, Inhalation is the route of administration of choice for evaluating the toxicity of a given material (in aerosol form) in animals. In this context, this work aimed to contribute to the establishment of recommendations concerning the characterization of aerosol tests in Inhalation Toxicology studies. In particular, the work consisted of experimentally characterizing test aerosols using a given generation method to be used for Inhalation Toxicology studies. Nine nanomaterial powders have been investigated (four types of TiO2, two types of SiO2, ZnO, CeO, and BaSO4). The aerosols produced cover the particle size range from a few tens of nanometers up to several micrometers and are mainly composed of aggregates and/or agglomerates. The work carried out shows that generation and characterization of test aerosols for Inhalation Toxicology studies is a complex but essential element of Inhalation studies, for which the conditions required (stability, repeatability, level of concentration) are sometimes difficult to obtain. Moreover, this study highlights the necessity to carry out preliminary tests to ascertain the performances of the chosen devices and their suitability for Inhalation Toxicology.

  • Characterization of aerosols generated from nine nanomaterial powders reliability with regard to in vivo Inhalation Toxicology studies
    Journal of Nanoparticle Research, 2018
    Co-Authors: Soleiman Bourrous, François Gaie-levrel, Olivier Witschger
    Abstract:

    In experimental Toxicology, when simulating human exposure to aerosols in the working environment, Inhalation is the route of administration of choice for evaluating the toxicity of a given material (in aerosol form) in animals. In this context, this work aimed to contribute to the establishment of recommendations concerning the characterization of aerosol tests in Inhalation Toxicology studies. In particular, the work consisted of experimentally characterizing test aerosols using a given generation method to be used for Inhalation Toxicology studies. Nine nanomaterial powders have been investigated (four types of TiO2, two types of SiO2, ZnO, CeO, and BaSO4). The aerosols produced cover the particle size range from a few tens of nanometers up to several micrometers and are mainly composed of aggregates and/or agglomerates. The work carried out shows that generation and characterization of test aerosols for Inhalation Toxicology studies is a complex but essential element of Inhalation studies, for which the conditions required (stability, repeatability, level of concentration) are sometimes difficult to obtain. Moreover, this study highlights the necessity to carry out preliminary tests to ascertain the performances of the chosen devices and their suitability for Inhalation Toxicology. © 2018, Springer Nature B.V.

Linda Ann Beaupré - One of the best experts on this subject based on the ideXlab platform.

  • Physical and chemical characterization of mn phosphate/sulfate mixture used in an Inhalation Toxicology study.
    Inhalation toxicology, 2004
    Co-Authors: Linda Ann Beaupré, Fariba Salehi, Joseph Zayed, Philippe Plamondon, Gilles L'espérance
    Abstract:

    The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did several Inhalation studies in order to assess the toxicity of each Mn species. The objective of this study is to determine the physical and the chemical characteristics of a mixture of Mn phosphate/sulfate used in one of these Inhalation Toxicology studies. First, the mixture was analyzed by X-ray diffraction in order to obtain the specific peak of Mn phosphate and Mn sulfate. These peaks were used as reference. Second, samples of the mixture were collected on filters in the Inhalation chamber at a concentration level of 3000 microg/m(3). They were analyzed by scanning electron microscopy (SEM), analytical transmission electron microscopy (ATEM), and x-ray energy-dispersive spectrometry (EDS) to show their size, morphology, and chemical composition. Results indicate that 33% of the particles were found to be agglomerated, while free particles accounted for 44% for Mn phosphate and 23% for Mn sulfate.

  • physical and chemical characterization of mn phosphate sulfate mixture used in an Inhalation Toxicology study
    Inhalation Toxicology, 2004
    Co-Authors: Linda Ann Beaupré, Fariba Salehi, Joseph Zayed, Philippe Plamondon, Gilles Lesperance
    Abstract:

    The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did several Inhalation studies in order to assess the toxicity of each Mn species. The objective of this study is to determine the physical and the chemical characteristics of a mixture of Mn phosphate/sulfate used in one of these Inhalation Toxicology studies. First, the mixture was analyzed by X-ray diffraction in order to obtain the specific peak of Mn phosphate and Mn sulfate. These peaks were used as reference. Second, samples of the mixture were collected on filters in the Inhalation chamber at a concentration level of 3000 microg/m(3). They were analyzed by scanning electron microscopy (SEM), analytical transmission electron microscopy (ATEM), and x-ray energy-dispersive spectrometry (EDS) to show their size, morphology, and chemical composition. Results indicate that 33% of the particles were found to be agglomerated, while free particles accounted for 44% for Mn phosphate and 23% for Mn sulfate.

Gilles Lesperance - One of the best experts on this subject based on the ideXlab platform.

  • physical and chemical characterization of mn phosphate sulfate mixture used in an Inhalation Toxicology study
    Inhalation Toxicology, 2004
    Co-Authors: Linda Ann Beaupré, Fariba Salehi, Joseph Zayed, Philippe Plamondon, Gilles Lesperance
    Abstract:

    The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did several Inhalation studies in order to assess the toxicity of each Mn species. The objective of this study is to determine the physical and the chemical characteristics of a mixture of Mn phosphate/sulfate used in one of these Inhalation Toxicology studies. First, the mixture was analyzed by X-ray diffraction in order to obtain the specific peak of Mn phosphate and Mn sulfate. These peaks were used as reference. Second, samples of the mixture were collected on filters in the Inhalation chamber at a concentration level of 3000 microg/m(3). They were analyzed by scanning electron microscopy (SEM), analytical transmission electron microscopy (ATEM), and x-ray energy-dispersive spectrometry (EDS) to show their size, morphology, and chemical composition. Results indicate that 33% of the particles were found to be agglomerated, while free particles accounted for 44% for Mn phosphate and 23% for Mn sulfate.

Gilles L'espérance - One of the best experts on this subject based on the ideXlab platform.

  • Physical and chemical characterization of mn phosphate/sulfate mixture used in an Inhalation Toxicology study.
    Inhalation toxicology, 2004
    Co-Authors: Linda Ann Beaupré, Fariba Salehi, Joseph Zayed, Philippe Plamondon, Gilles L'espérance
    Abstract:

    The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did several Inhalation studies in order to assess the toxicity of each Mn species. The objective of this study is to determine the physical and the chemical characteristics of a mixture of Mn phosphate/sulfate used in one of these Inhalation Toxicology studies. First, the mixture was analyzed by X-ray diffraction in order to obtain the specific peak of Mn phosphate and Mn sulfate. These peaks were used as reference. Second, samples of the mixture were collected on filters in the Inhalation chamber at a concentration level of 3000 microg/m(3). They were analyzed by scanning electron microscopy (SEM), analytical transmission electron microscopy (ATEM), and x-ray energy-dispersive spectrometry (EDS) to show their size, morphology, and chemical composition. Results indicate that 33% of the particles were found to be agglomerated, while free particles accounted for 44% for Mn phosphate and 23% for Mn sulfate.