The Experts below are selected from a list of 21738 Experts worldwide ranked by ideXlab platform
Yi Hong - One of the best experts on this subject based on the ideXlab platform.
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low Initial Modulus biodegradable polyurethane elastomers for soft tissue regeneration
ACS Applied Materials & Interfaces, 2017Co-Authors: Cancan Xu, Yihui Huang, Liping Tang, Yi HongAbstract:The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low Initial moduli with a J-shaped tensile curve. Suitable synthetic polymer scaffolds require low Initial Modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-e-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer, PVCL–PEG–PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes (PU) with low Initial moduli. The triblock copolymers were varied in chemical components, molecular weights, and hydrophilicities. The mechanical properties of polyurethanes in dry and wet states can be tuned by altering the molecular weights and hydrophilicities of the soft segments. Increasing the length of either PVCL or PEG in the soft segments reduced Initial moduli of the polyurethane films and scaffolds in dry and wet states. The polymer film...
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Low-Initial-Modulus Biodegradable Polyurethane Elastomers for Soft Tissue Regeneration
2016Co-Authors: Yihui Huang, Liping Tang, Yi HongAbstract:The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low Initial moduli with a J-shaped tensile curve. Suitable synthetic polymer scaffolds require low Initial Modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-ε-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer, PVCL–PEG–PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes (PU) with low Initial moduli. The triblock copolymers were varied in chemical components, molecular weights, and hydrophilicities. The mechanical properties of polyurethanes in dry and wet states can be tuned by altering the molecular weights and hydrophilicities of the soft segments. Increasing the length of either PVCL or PEG in the soft segments reduced Initial moduli of the polyurethane films and scaffolds in dry and wet states. The polymer films are found to have good cell compatibility and to support fibroblast growth in vitro. Selected polyurethanes were processed into porous scaffolds by a thermally induced phase-separation technique. The scaffold from PU–PEG1K–PVCL6K had an Initial Modulus of 0.60 ± 0.14 MPa, which is comparable with the Initial Modulus of human myocardium (0.02–0.50 MPa). In vivo mouse subcutaneous implantation of the porous scaffolds showed minimal chronic inflammatory response and intensive cell infiltration, which indicated good tissue compatibility of the scaffolds. Biodegradable polyurethane elastomers with low Initial Modulus and good biocompatibility and processability would be an attractive alternative scaffold material for soft tissue regeneration, especially for heart muscle
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an elastomeric patch electrospun from a blended solution of dermal extracellular matrix and biodegradable polyurethane for rat abdominal wall repair
Tissue Engineering Part C-methods, 2012Co-Authors: Yi Hong, Ryotaro Hashizume, Nicholas J Amoroso, William R Wagner, Keisuke Takanari, Ellen P Brennanpierce, John M FreundAbstract:A biodegradable elastomeric scaffold was created by electrospinning a mixed solution of poly(ester urethane)urea (PEUU) and porcine dermal extracellular matrix (dECM) digest, with PEUU included to provide elasticity, flexibility, and mechanical support and dECM used to enhance bioactivity and biocompatibility. Micrographs and differential scanning calorimetry demonstrated partial miscibility between PEUU and dECM. With greater dECM content, scaffolds were found to possess lower breaking strains and suture retention strength, although Initial Modulus was greater with higher dECM concentrations. The hybrid scaffolds containing 0% to 50% dECM had tensile strengths of 5 to 7 MPa, breaking strains of 138% to 611%, Initial moduli of 3 to 11 Mpa, and suture retention strengths of 35 to 59 MPa. When hydrated, scaffolds were found to contract markedly with 50% dECM content. When used in a rat full-thickness abdominal wall replacement model, no herniation, infection, or tissue adhesion was observed after 4 and 8 we...
Chenxi Ouyang - One of the best experts on this subject based on the ideXlab platform.
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small diameter polyurethane vascular graft reinforced by elastic weft knitted tubular fabric of polyester spandex
Fibers and Polymers, 2008Co-Authors: Fei Zhou, Chenxi OuyangAbstract:Small diameter vascular grafts were fabricated from pure Polyurethane (PU) as well as PU reinforced with a tubular weft-knitted fabric. The tensile properties of the reinforced composite vascular grafts were compared with that of the tubular fabric itself and the pure PU vascular grafts. The elasticity and strength of the reinforced vascular grafts were improved compared with the tubular fabric. Strength of the reinforced vascular grafts was 5–10 times of the strength of the pure PU vascular grafts. Expanding the tubular fabric to increase the inner diameter of the reinforced vascular graft reduced the graft’s strength and Initial Modulus, but the difference was reduced as the PU content was increased. For grafts of the same inner diameter, increasing the PU content increased the thickness and strength of the graft wall, which led to a general increase in the strength and Initial Modulus of the composite vascular grafts.
Cancan Xu - One of the best experts on this subject based on the ideXlab platform.
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low Initial Modulus biodegradable polyurethane elastomers for soft tissue regeneration
ACS Applied Materials & Interfaces, 2017Co-Authors: Cancan Xu, Yihui Huang, Liping Tang, Yi HongAbstract:The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low Initial moduli with a J-shaped tensile curve. Suitable synthetic polymer scaffolds require low Initial Modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-e-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer, PVCL–PEG–PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes (PU) with low Initial moduli. The triblock copolymers were varied in chemical components, molecular weights, and hydrophilicities. The mechanical properties of polyurethanes in dry and wet states can be tuned by altering the molecular weights and hydrophilicities of the soft segments. Increasing the length of either PVCL or PEG in the soft segments reduced Initial moduli of the polyurethane films and scaffolds in dry and wet states. The polymer film...
Yihui Huang - One of the best experts on this subject based on the ideXlab platform.
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low Initial Modulus biodegradable polyurethane elastomers for soft tissue regeneration
ACS Applied Materials & Interfaces, 2017Co-Authors: Cancan Xu, Yihui Huang, Liping Tang, Yi HongAbstract:The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low Initial moduli with a J-shaped tensile curve. Suitable synthetic polymer scaffolds require low Initial Modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-e-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer, PVCL–PEG–PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes (PU) with low Initial moduli. The triblock copolymers were varied in chemical components, molecular weights, and hydrophilicities. The mechanical properties of polyurethanes in dry and wet states can be tuned by altering the molecular weights and hydrophilicities of the soft segments. Increasing the length of either PVCL or PEG in the soft segments reduced Initial moduli of the polyurethane films and scaffolds in dry and wet states. The polymer film...
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Low-Initial-Modulus Biodegradable Polyurethane Elastomers for Soft Tissue Regeneration
2016Co-Authors: Yihui Huang, Liping Tang, Yi HongAbstract:The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low Initial moduli with a J-shaped tensile curve. Suitable synthetic polymer scaffolds require low Initial Modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-ε-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer, PVCL–PEG–PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes (PU) with low Initial moduli. The triblock copolymers were varied in chemical components, molecular weights, and hydrophilicities. The mechanical properties of polyurethanes in dry and wet states can be tuned by altering the molecular weights and hydrophilicities of the soft segments. Increasing the length of either PVCL or PEG in the soft segments reduced Initial moduli of the polyurethane films and scaffolds in dry and wet states. The polymer films are found to have good cell compatibility and to support fibroblast growth in vitro. Selected polyurethanes were processed into porous scaffolds by a thermally induced phase-separation technique. The scaffold from PU–PEG1K–PVCL6K had an Initial Modulus of 0.60 ± 0.14 MPa, which is comparable with the Initial Modulus of human myocardium (0.02–0.50 MPa). In vivo mouse subcutaneous implantation of the porous scaffolds showed minimal chronic inflammatory response and intensive cell infiltration, which indicated good tissue compatibility of the scaffolds. Biodegradable polyurethane elastomers with low Initial Modulus and good biocompatibility and processability would be an attractive alternative scaffold material for soft tissue regeneration, especially for heart muscle
Liping Tang - One of the best experts on this subject based on the ideXlab platform.
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low Initial Modulus biodegradable polyurethane elastomers for soft tissue regeneration
ACS Applied Materials & Interfaces, 2017Co-Authors: Cancan Xu, Yihui Huang, Liping Tang, Yi HongAbstract:The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low Initial moduli with a J-shaped tensile curve. Suitable synthetic polymer scaffolds require low Initial Modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-e-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer, PVCL–PEG–PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes (PU) with low Initial moduli. The triblock copolymers were varied in chemical components, molecular weights, and hydrophilicities. The mechanical properties of polyurethanes in dry and wet states can be tuned by altering the molecular weights and hydrophilicities of the soft segments. Increasing the length of either PVCL or PEG in the soft segments reduced Initial moduli of the polyurethane films and scaffolds in dry and wet states. The polymer film...
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Low-Initial-Modulus Biodegradable Polyurethane Elastomers for Soft Tissue Regeneration
2016Co-Authors: Yihui Huang, Liping Tang, Yi HongAbstract:The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low Initial moduli with a J-shaped tensile curve. Suitable synthetic polymer scaffolds require low Initial Modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-ε-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer, PVCL–PEG–PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes (PU) with low Initial moduli. The triblock copolymers were varied in chemical components, molecular weights, and hydrophilicities. The mechanical properties of polyurethanes in dry and wet states can be tuned by altering the molecular weights and hydrophilicities of the soft segments. Increasing the length of either PVCL or PEG in the soft segments reduced Initial moduli of the polyurethane films and scaffolds in dry and wet states. The polymer films are found to have good cell compatibility and to support fibroblast growth in vitro. Selected polyurethanes were processed into porous scaffolds by a thermally induced phase-separation technique. The scaffold from PU–PEG1K–PVCL6K had an Initial Modulus of 0.60 ± 0.14 MPa, which is comparable with the Initial Modulus of human myocardium (0.02–0.50 MPa). In vivo mouse subcutaneous implantation of the porous scaffolds showed minimal chronic inflammatory response and intensive cell infiltration, which indicated good tissue compatibility of the scaffolds. Biodegradable polyurethane elastomers with low Initial Modulus and good biocompatibility and processability would be an attractive alternative scaffold material for soft tissue regeneration, especially for heart muscle