The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Thomas H. Leung - One of the best experts on this subject based on the ideXlab platform.
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aging suppresses skin derived circulating sdf1 to promote full thickness Tissue Regeneration
Cell Reports, 2018Co-Authors: Mailyn A. Nishiguchi, Casey A. Spencer, Denis H. Leung, Thomas H. LeungAbstract:Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to blood from young mice by parabiosis counteracts this regenerative capacity. The secreted factor, stromal-derived factor 1 (SDF1), is expressed at higher levels in wounded skin of young mice. Genetic deletion of SDF1 in young skin enhanced Tissue Regeneration. In aged mice, enhancer of zeste homolog 2 (EZH2) and histone H3 lysine 27 trimethylation are recruited to the SDF1 promoter at higher levels, and pharmacologic inhibition of EZH2 restores SDF1 induction and prevents Tissue Regeneration. Similar age-dependent EZH2-mediated SDF1 suppression occurs in human skin. Our findings counter the current dogma that Tissue function invariably declines with age and suggest new therapeutic strategies in regenerative medicine.
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Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration
Elsevier, 2018Co-Authors: Mailyn A. Nishiguchi, Casey A. Spencer, Denis H. Leung, Thomas H. LeungAbstract:Summary: Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to blood from young mice by parabiosis counteracts this regenerative capacity. The secreted factor, stromal-derived factor 1 (SDF1), is expressed at higher levels in wounded skin of young mice. Genetic deletion of SDF1 in young skin enhanced Tissue Regeneration. In aged mice, enhancer of zeste homolog 2 (EZH2) and histone H3 lysine 27 trimethylation are recruited to the SDF1 promoter at higher levels, and pharmacologic inhibition of EZH2 restores SDF1 induction and prevents Tissue Regeneration. Similar age-dependent EZH2-mediated SDF1 suppression occurs in human skin. Our findings counter the current dogma that Tissue function invariably declines with age and suggest new therapeutic strategies in regenerative medicine. : Nishiguchi et al. show that aging promotes full-thickness Tissue Regeneration in mouse skin. Aging modulates chromatin accessibility at the SDF1 gene, and genetic deletion of SDF1 in young skin enhances Tissue Regeneration. Human skin also exhibits age-dependent SDF1 suppression. They identify a rare example where aging improves Tissue function. Keywords: Tissue Regeneration, scar, aging, skin, epigenetics, SDF1, CXCL12, organ regeneratio
Chengtie Wu - One of the best experts on this subject based on the ideXlab platform.
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silicate bioceramics from soft Tissue Regeneration to tumor therapy
Journal of Materials Chemistry B, 2019Co-Authors: Qingqing Yu, Chengtie WuAbstract:Great efforts have been devoted to exploiting silicate bioceramics for various applications in soft Tissue Regeneration, owing to their excellent bioactivity. Based on the inherent ability of silicate bioceramics to repair Tissue, bioactive ions are easily incorporated into silicate bioceramics to endow them with extra biological properties, such as enhanced angiogenesis, antibiosis, enhanced osteogenesis, and antitumor effect, which significantly expands the application of multifunctional silicate bioceramics. Furthermore, silicate nanobioceramics with unique structures have been widely employed for tumor therapy. In recent years, the novel applications of silicate bioceramics for both Tissue Regeneration and tumor therapy have substantially grown. Eliminating the skin tumors first and then repairing the skin wounds has been widely investigated by our groups, which might shed some light on treating other soft Tissue tumor or tumor-induced defects. This review first describes the recent advances made in the development of silicate bioceramics as therapeutic platforms for soft Tissue Regeneration. We then highlight the major silicate nanobioceramics used for tumor therapy. Silicate bioceramics for both soft Tissue Regeneration and tumor therapy are further emphasized. Finally, challenges and future directions of silicate bioceramics stepping into the clinics are discussed. This review will inspire researchers to create the efficient and functional silicate bioceramics needed for Regeneration and tumor therapy of other Tissues.
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mesoporous bioactive glasses as drug delivery and bone Tissue Regeneration platforms
Therapeutic Delivery, 2011Co-Authors: Chengtie Wu, Jiang Chang, Yin XiaoAbstract:The use of mesoporous bioactive glasses (MBG) for drug delivery and bone Tissue Regeneration has grown significantly over the past 5 years. In this article, we highlight recent advances made in the preparation of MBG particles, spheres, fibers and scaffolds. The advantages of MBG for drug delivery and bone scaffold applications are related to this material’s well-ordered mesopore channel structure, superior bioactivity and its capability to deliver both hydrophilic and hydrophobic drugs. A brief forward-looking perspective on the potential clinical applications of MBG in regenerative medicine is also discussed.
Mailyn A. Nishiguchi - One of the best experts on this subject based on the ideXlab platform.
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aging suppresses skin derived circulating sdf1 to promote full thickness Tissue Regeneration
Cell Reports, 2018Co-Authors: Mailyn A. Nishiguchi, Casey A. Spencer, Denis H. Leung, Thomas H. LeungAbstract:Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to blood from young mice by parabiosis counteracts this regenerative capacity. The secreted factor, stromal-derived factor 1 (SDF1), is expressed at higher levels in wounded skin of young mice. Genetic deletion of SDF1 in young skin enhanced Tissue Regeneration. In aged mice, enhancer of zeste homolog 2 (EZH2) and histone H3 lysine 27 trimethylation are recruited to the SDF1 promoter at higher levels, and pharmacologic inhibition of EZH2 restores SDF1 induction and prevents Tissue Regeneration. Similar age-dependent EZH2-mediated SDF1 suppression occurs in human skin. Our findings counter the current dogma that Tissue function invariably declines with age and suggest new therapeutic strategies in regenerative medicine.
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Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration
Elsevier, 2018Co-Authors: Mailyn A. Nishiguchi, Casey A. Spencer, Denis H. Leung, Thomas H. LeungAbstract:Summary: Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to blood from young mice by parabiosis counteracts this regenerative capacity. The secreted factor, stromal-derived factor 1 (SDF1), is expressed at higher levels in wounded skin of young mice. Genetic deletion of SDF1 in young skin enhanced Tissue Regeneration. In aged mice, enhancer of zeste homolog 2 (EZH2) and histone H3 lysine 27 trimethylation are recruited to the SDF1 promoter at higher levels, and pharmacologic inhibition of EZH2 restores SDF1 induction and prevents Tissue Regeneration. Similar age-dependent EZH2-mediated SDF1 suppression occurs in human skin. Our findings counter the current dogma that Tissue function invariably declines with age and suggest new therapeutic strategies in regenerative medicine. : Nishiguchi et al. show that aging promotes full-thickness Tissue Regeneration in mouse skin. Aging modulates chromatin accessibility at the SDF1 gene, and genetic deletion of SDF1 in young skin enhances Tissue Regeneration. Human skin also exhibits age-dependent SDF1 suppression. They identify a rare example where aging improves Tissue function. Keywords: Tissue Regeneration, scar, aging, skin, epigenetics, SDF1, CXCL12, organ regeneratio
Irene De Lazaro - One of the best experts on this subject based on the ideXlab platform.
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non viral tumor free induction of transient cell reprogramming in mouse skeletal muscle to enhance Tissue Regeneration
Molecular Therapy, 2019Co-Authors: Irene De Lazaro, Acelya Yilmazer, Yein Nam, Sara Qubisi, Fazilah Maizatul Abdul Razak, Hans DegensAbstract:Overexpression of Oct3/4, Klf4, Sox2, and c-Myc (OKSM) transcription factors can de-differentiate adult cells in vivo. While sustained OKSM expression triggers tumorigenesis through uncontrolled proliferation of toti- and pluripotent cells, transient reprogramming induces pluripotency-like features and proliferation only temporarily, without teratomas. We sought to transiently reprogram cells within mouse skeletal muscle with a localized injection of plasmid DNA encoding OKSM (pOKSM), and we hypothesized that the generation of proliferative intermediates would enhance Tissue Regeneration after injury. Intramuscular pOKSM administration rapidly upregulated pluripotency (Nanog, Ecat1, and Rex1) and early myogenesis genes (Pax3) in the healthy gastrocnemius of various strains. Mononucleated cells expressing such markers appeared in clusters among myofibers, proliferated only transiently, and did not lead to dysplasia or tumorigenesis for at least 120 days. Nanog was also upregulated in the gastrocnemius when pOKSM was administered 7 days after surgically sectioning its medial head. Enhanced Tissue Regeneration after reprogramming was manifested by the accelerated appearance of centronucleated myofibers and reduced fibrosis. These results suggest that transient in vivo reprogramming could develop into a novel strategy toward the acceleration of Tissue Regeneration after injury, based on the induction of transiently proliferative, pluripotent-like cells in situ. Further research to achieve clinically meaningful functional Regeneration is warranted.
Peter Timashev - One of the best experts on this subject based on the ideXlab platform.
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Skin Tissue Regeneration for burn injury
Stem Cell Research & Therapy, 2019Co-Authors: Anastasia Shpichka, Denis Butnaru, Evgeny A. Bezrukov, Roman B. Sukhanov, Anthony Atala, Vitaliy Burdukovskii, Yuanyuan Zhang, Peter TimashevAbstract:The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction between cell types, cytokines, mediators, the neurovascular system, and matrix remodeling. Tissue Regeneration technology remarkably enhances skin repair via re-epidermalization, epidermal-stromal cell interactions, angiogenesis, and inhabitation of hypertrophic scars and keloids. The success rates of skin healing for burn injuries have significantly increased with the use of various skin substitutes. In this review, we discuss skin replacement with cells, growth factors, scaffolds, or cell-seeded scaffolds for skin Tissue reconstruction and also compare the high efficacy and cost-effectiveness of each therapy. We describe the essentials, achievements, and challenges of cell-based therapy in reducing scar formation and improving burn injury treatment.
