The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Zeng Yinpin - One of the best experts on this subject based on the ideXlab platform.
-
Application of Inner Ear magnetic resonance hydrography in evaluating the children with congenital Inner Ear malformations before cochlEar implant
Chinese Archives of Otolaryngology-head and Neck Surgery, 2014Co-Authors: Zeng YinpinAbstract:OBJECTIVE To investigate the value of Inner Ear magnetic resonance hydrography in Inner Ear malformations before cochlEar implant. METHODSMRI data of 85 children with Inner Ear malformations were retrospectively analyzed according to the latest classification criteria. RESULTS Of all 85 cases(170 Ears) with Inner Ear malformations, there was Michel deformity in 2 Ears, common cavity malformation in 11 Ears, Mondini deformity in 35 Ears, semicircular canal dysplasia in 26 Ears, enlargement of the vestibular aqueduct in 98 Ears, inter nal auditor y canal narrow in 7 Ears. CONCLUSION The congenital malformations of Inner Ear can be well classified by Inner Ear magnetic resonance hydrography before cochlEar implant, which contributes to the assessments of operative difficulty, preoperative planning and prognosis.
Avi Shupak - One of the best experts on this subject based on the ideXlab platform.
-
Inner Ear decompression sickness and Inner Ear barotrauma in recreational divers a long term follow up
Laryngoscope, 2003Co-Authors: Avi Shupak, Amnon Gil, Zohar Nachum, Shira Miller, Carlos R Gordon, Dror TalAbstract:Objectives/Hypothesis The objectives were to report the authors' experience with the long-term follow-up of patients with diving-related Inner Ear decompression sickness and Inner Ear barotrauma and to discuss residual cochlEar and vestibular damage in relation to the question of fitness to dive. Study Design Retrospective consecutive case series. Methods Eleven recreational divers with Inner Ear decompression sickness and nine with Inner Ear barotrauma (IEB) were followed. A complete otoneurological physical examination and laboratory evaluation were carried out. The latter included audiometry, electronystagmography, a rotatory chair test using the sinusoidal harmonic acceleration protocol, and computerized dynamic posturography. Results Residual cochleovestibular deficits were found in 10 (91%) of the patients with Inner Ear decompression sickness and 3 (33%) of those with IEB (P < .02, Fisher's Exact test; odds ratio, 20). A significantly shorter follow-up period was required for the Inner Ear barotrauma group (P < .05, simple t test) because three patients (33%) recovered completely within 1 month of the diving accident. Eight patients had residual vestibular deficits on follow-up, but only one (12.5%) was symptomatic. However, five (56%) of the nine patients who had a cochlEar insult, as documented by follow-up audiometry, complained of significant hEaring loss and tinnitus. Conclusion Inner Ear decompression sickness carries a high risk for residual Inner Ear damage despite hyperbaric oxygen recompression therapy. A favorable prognosis might be anticipated for Inner Ear barotrauma. The finding that most patients with residual vestibular deficits were asymptomatic at the time of follow-up emphasizes the need for a complete vestibular evaluation, including specific bedside testing and laboratory examinations, before a return to diving activity may be considered.
-
Diving-related Inner Ear injuries
Laryngoscope, 1991Co-Authors: Avi Shupak, Carlos R Gordon, Ilana Doweck, Elhanan Greenberg, Orna Spitzer, Yehuda Melamed, Walter S. MeyerAbstract:Diving-related Inner Ear barotrauma (IEB) and Inner Ear decompression sickness (IEDS) most often result in permanent severe cochleovestibular deficits, unless immediate diagnosis is reached and the correct treatment is commenced Early. Nine cases of sport-diving-induced Inner Ear injuries that were referred to the Israeli Naval Hyperbaric Institute between October 1987 and September 1989 are presented with regard to evaluation, treatment, and follow-up. The diagnosis was IEB in five divers and IEDS in four. Explorative tympanotomy was carried out with remarkable results in two patients with IEB, while the remaining three were relieved by bed rest alone. Three of the four IEDS patients were recompressed according to the extended US Navy Table 6 with good short-term results. The role of complete otoneurological evaluation in the decision-making process leading to the correct diagnosis and treatment is emphasized. Language: en
Matti Anniko - One of the best experts on this subject based on the ideXlab platform.
-
Localization of sirtuins in the mouse Inner Ear
Acta oto-laryngologica, 2014Co-Authors: Masaya Takumida, Hiroshi Takumida, Matti AnnikoAbstract:Abstract Conclusion: It is suggested that SIRT1 and 3, and probably SIRT4 and 5, play an important role in the neuroprotection of the Inner Ear. SIRT2 may be related to neuroprotection and myelin sheath formation, while SIRT6 seems to have a significant role in maintaining the energy balance by metabolic regulation. Objective: To analyze the expression of sirtuins (SIRT1–7) in the normal mouse Inner Ear. Methods: CBA/J mice were used for this study. The localization of SIRT1–7 in the Inner Ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated using real-time PCR and immunohistochemistry. Results: We found high levels of mRNA of all seven sirtuins in the Inner Ear. In the immunohistochemical study, SIRT1–7 were abundant in many Inner Ear structures, i.e. stria vascularis, Inner and outer hair cells, spiral ganglion cells, vestibular sensory and ganglion cells, vestibular dark and transitional cells, and the endolymphatic sac.
-
Functional significance of nitric oxide in the Inner Ear.
In vivo (Athens Greece), 2004Co-Authors: Masaya Takumida, Matti AnnikoAbstract:Significant advances have been made in our understanding of the functional significance of nitric oxide (NO) in the Inner Ear. The localization of NO synthase and the nitric oxide production site has now been established by immunohistochemistry and the fluorescent indicator of NO. The functional significance of NO in the Inner Ear, especially as a neurotransmitter, is becoming increasingly clEar. Mounting evidence suggests that excessive NO production may play an essential role in Inner Ear disorders as well. The production of an inducible type of NO synthase may be closely related to this phenomenon. Based on the mechanisms of Inner Ear disorders, new pharmacological strategies for preventing and/or treating Inner Ear disorders have also been suggested.
-
Nitric oxide in the Inner Ear.
Current opinion in neurology, 2002Co-Authors: Masaya Takumida, Matti AnnikoAbstract:During the past yEar significant advances have been made in our understanding of the functional significance of nitric oxide (NO) in the Inner Ear. NO synthase and the NO production site have now been localized using immunohistochemistry and a new fluorescence indicator for NO. The functional significance of NO in the Inner Ear, in particular as a neurotransmitter, is becoming increasingly clEar. Increasing evidence suggests that excessive NO production may play an essential role in Inner Ear disorders. The production of an inducible form of NO synthase may be closely related to this phenomenon. Based on the mechanisms of Inner Ear disorders, new pharmacological strategies for preventing or treating Inner Ear disorders have been suggested.
Andrew K. Groves - One of the best experts on this subject based on the ideXlab platform.
-
Molecular basis of Inner Ear induction.
Current topics in developmental biology, 2003Co-Authors: Stephen T. Brown, Kareen Martin, Andrew K. GrovesAbstract:Abstract The induction of the vertebrate Inner Ear is a complex developmental process that has been under investigation for decades. The traditional tools of embryology used in most of these studies have provided a wealth of information on the subject; however, they are generally limited in focus to morphological features. Recent advances in molecular biology have provided the opportunity to study Inner Ear induction in ways not possible in previous yEars. The capacity for visualizing and manipulating gene expression in combination with more traditional embryological techniques has changed the focus of Inner Ear induction from morphology to changes in gene expression. This chapter provides a critical review of recent studies relating to the molecular induction of the Inner Ear. A major theme to emerge from these studies is the dependence of Inner Ear induction on fibroblast growth factor (FGF) signaling. The source(s) of these FGF signals is still not entirely clEar, though the available data are consistent with a mesodermal and⧸or hindbrain origin as has been long proposed. Numerous Early otic marker genes have been identified as well, and their conservation in Ear induction is quite clEar. Functional data regarding these genes are still largely incomplete, although a role for several of these genes in zebrafish Inner Ear induction has been demonstrated. As a whole, these studies have made exciting and provocative contributions to the field, thus creating a more complete and precise picture of Inner Ear induction.
Carlos R Gordon - One of the best experts on this subject based on the ideXlab platform.
-
Inner Ear decompression sickness and Inner Ear barotrauma in recreational divers a long term follow up
Laryngoscope, 2003Co-Authors: Avi Shupak, Amnon Gil, Zohar Nachum, Shira Miller, Carlos R Gordon, Dror TalAbstract:Objectives/Hypothesis The objectives were to report the authors' experience with the long-term follow-up of patients with diving-related Inner Ear decompression sickness and Inner Ear barotrauma and to discuss residual cochlEar and vestibular damage in relation to the question of fitness to dive. Study Design Retrospective consecutive case series. Methods Eleven recreational divers with Inner Ear decompression sickness and nine with Inner Ear barotrauma (IEB) were followed. A complete otoneurological physical examination and laboratory evaluation were carried out. The latter included audiometry, electronystagmography, a rotatory chair test using the sinusoidal harmonic acceleration protocol, and computerized dynamic posturography. Results Residual cochleovestibular deficits were found in 10 (91%) of the patients with Inner Ear decompression sickness and 3 (33%) of those with IEB (P < .02, Fisher's Exact test; odds ratio, 20). A significantly shorter follow-up period was required for the Inner Ear barotrauma group (P < .05, simple t test) because three patients (33%) recovered completely within 1 month of the diving accident. Eight patients had residual vestibular deficits on follow-up, but only one (12.5%) was symptomatic. However, five (56%) of the nine patients who had a cochlEar insult, as documented by follow-up audiometry, complained of significant hEaring loss and tinnitus. Conclusion Inner Ear decompression sickness carries a high risk for residual Inner Ear damage despite hyperbaric oxygen recompression therapy. A favorable prognosis might be anticipated for Inner Ear barotrauma. The finding that most patients with residual vestibular deficits were asymptomatic at the time of follow-up emphasizes the need for a complete vestibular evaluation, including specific bedside testing and laboratory examinations, before a return to diving activity may be considered.
-
Diving-related Inner Ear injuries
Laryngoscope, 1991Co-Authors: Avi Shupak, Carlos R Gordon, Ilana Doweck, Elhanan Greenberg, Orna Spitzer, Yehuda Melamed, Walter S. MeyerAbstract:Diving-related Inner Ear barotrauma (IEB) and Inner Ear decompression sickness (IEDS) most often result in permanent severe cochleovestibular deficits, unless immediate diagnosis is reached and the correct treatment is commenced Early. Nine cases of sport-diving-induced Inner Ear injuries that were referred to the Israeli Naval Hyperbaric Institute between October 1987 and September 1989 are presented with regard to evaluation, treatment, and follow-up. The diagnosis was IEB in five divers and IEDS in four. Explorative tympanotomy was carried out with remarkable results in two patients with IEB, while the remaining three were relieved by bed rest alone. Three of the four IEDS patients were recompressed according to the extended US Navy Table 6 with good short-term results. The role of complete otoneurological evaluation in the decision-making process leading to the correct diagnosis and treatment is emphasized. Language: en
