The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Fumio Shiraga - One of the best experts on this subject based on the ideXlab platform.
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efficacy of vitrectomy and Inner Limiting Membrane peeling in age related macular degeneration resistant to anti vascular endothelial growth factor therapy with vitreomacular traction or epiretinal Membrane
Graefes Archive for Clinical and Experimental Ophthalmology, 2016Co-Authors: Shuhei Kimura, Yuki Morizane, Shinji Toshima, Mika Hosogi, Fumiaki Kumase, Mio Hosokawa, Yusuke Shiode, Atsushi Fujiwara, Fumio ShiragaAbstract:Purpose We assessed the efficacy of vitrectomy and Inner Limiting Membrane (ILM) peeling, followed by anti-vascular endothelial growth factor (VEGF) therapy, anti-VEGF-resistant age-related macular degeneration (AMD) due to vitreomacular traction (VMT) or epiretinal Membrane (ERM).
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efficacy of vitrectomy and Inner Limiting Membrane peeling in age related macular degeneration resistant to anti vascular endothelial growth factor therapy with vitreomacular traction or epiretinal Membrane
Graefes Archive for Clinical and Experimental Ophthalmology, 2016Co-Authors: Shuhei Kimura, Yuki Morizane, Shinji Toshima, Mika Hosogi, Fumiaki Kumase, Mio Hosokawa, Yusuke Shiode, Atsushi Fujiwara, Fumio ShiragaAbstract:We assessed the efficacy of vitrectomy and Inner Limiting Membrane (ILM) peeling, followed by anti-vascular endothelial growth factor (VEGF) therapy, anti-VEGF-resistant age-related macular degeneration (AMD) due to vitreomacular traction (VMT) or epiretinal Membrane (ERM). We identified six patients with anti-VEGF-resistant AMD due to VMT or ERM amongst a total of 588 patients with AMD (821 eyes) referred to Okayama University Hospital between February 2012 and May 2014. These patients underwent vitrectomy to release the VMT (4 cases) or remove the ERM (2 cases), along with ILM peeling. The regimen used for intravitreal injections of anti-VEGF reagents after surgery was based on the severity of exudative changes in each patient. Preoperative and postoperative best-corrected visual acuity (BCVA) and central retinal thickness (CRT) measurements were compared. After vitrectomy and ILM peeling, all six patients responded to anti-VEGF therapy, which was then able to maintain dry retinas. Mean BCVA did not improve significantly (0.49 ± 0.28 before vs. 0.43 ± 0.38 after surgery, P = 0.538). However, mean CR was significantly decreased after surgery, from 423 ± 83.5 μm to 257 ± 75.8 μm (P = 0.0078). Vitrectomy and ILM peeling followed by anti-VEGF therapy may be a useful therapeutic option for anti-VEGF-resistant AMD with VMT or ERM.
Shuhei Kimura - One of the best experts on this subject based on the ideXlab platform.
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efficacy of vitrectomy and Inner Limiting Membrane peeling in age related macular degeneration resistant to anti vascular endothelial growth factor therapy with vitreomacular traction or epiretinal Membrane
Graefes Archive for Clinical and Experimental Ophthalmology, 2016Co-Authors: Shuhei Kimura, Yuki Morizane, Shinji Toshima, Mika Hosogi, Fumiaki Kumase, Mio Hosokawa, Yusuke Shiode, Atsushi Fujiwara, Fumio ShiragaAbstract:Purpose We assessed the efficacy of vitrectomy and Inner Limiting Membrane (ILM) peeling, followed by anti-vascular endothelial growth factor (VEGF) therapy, anti-VEGF-resistant age-related macular degeneration (AMD) due to vitreomacular traction (VMT) or epiretinal Membrane (ERM).
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efficacy of vitrectomy and Inner Limiting Membrane peeling in age related macular degeneration resistant to anti vascular endothelial growth factor therapy with vitreomacular traction or epiretinal Membrane
Graefes Archive for Clinical and Experimental Ophthalmology, 2016Co-Authors: Shuhei Kimura, Yuki Morizane, Shinji Toshima, Mika Hosogi, Fumiaki Kumase, Mio Hosokawa, Yusuke Shiode, Atsushi Fujiwara, Fumio ShiragaAbstract:We assessed the efficacy of vitrectomy and Inner Limiting Membrane (ILM) peeling, followed by anti-vascular endothelial growth factor (VEGF) therapy, anti-VEGF-resistant age-related macular degeneration (AMD) due to vitreomacular traction (VMT) or epiretinal Membrane (ERM). We identified six patients with anti-VEGF-resistant AMD due to VMT or ERM amongst a total of 588 patients with AMD (821 eyes) referred to Okayama University Hospital between February 2012 and May 2014. These patients underwent vitrectomy to release the VMT (4 cases) or remove the ERM (2 cases), along with ILM peeling. The regimen used for intravitreal injections of anti-VEGF reagents after surgery was based on the severity of exudative changes in each patient. Preoperative and postoperative best-corrected visual acuity (BCVA) and central retinal thickness (CRT) measurements were compared. After vitrectomy and ILM peeling, all six patients responded to anti-VEGF therapy, which was then able to maintain dry retinas. Mean BCVA did not improve significantly (0.49 ± 0.28 before vs. 0.43 ± 0.38 after surgery, P = 0.538). However, mean CR was significantly decreased after surgery, from 423 ± 83.5 μm to 257 ± 75.8 μm (P = 0.0078). Vitrectomy and ILM peeling followed by anti-VEGF therapy may be a useful therapeutic option for anti-VEGF-resistant AMD with VMT or ERM.
Ling Zuo - One of the best experts on this subject based on the ideXlab platform.
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macular hole with Inner Limiting Membrane peeling off spontaneously in terson syndrome a case report
Medicine, 2021Co-Authors: Hongtao Yan, Yan Cheng, Ling ZuoAbstract:Introduction Terson's syndrome with Inner Limiting Membrane (ILM) peeled off spontaneously is rarely seen, and the mechanism of it is not clear. Here we report a case of Terson Syndrome with a rare finding: the ILM peeled off spontaneously associated with macular hole (MH). Patient concerns A 36-year-old female patient was admitted to our hospital with decreased visual acuity in the right eye lasting for 1 month. She just had surgery for subarachnoid hemorrhage that occurred 1 month before due to the rupture of the intracranial aneurysm. Diagnosis Terson syndrome was diagnosed according to her medical history and examination. A partial posterior vitreous detachment (PVD) and dense vitreous hemorrhage (VH) was confirmed in the right eye by performing ophthalmic B-scan ultrasonography examination. Head computed tomography showed the subarachnoid hemorrhage after aneurysmal rupture. Interventions The patient underwent pars plana vitrectomy in her right eye to remove the VH. After removal of the VH, a full-thickness macular hole was noted with the ILM peeled off spontaneously. So we conducted gas tamponade, and face-down positioning after pas plana vitrectomy. Outcomes At two weeks follow-up, her best corrected visual acuity was 0.15 in the right eye. Spectral domain optical coherence tomography showed that the MH was closed completely, while the thickness of the nasal retina of the foveal was thicker than that on the temporal side. Lessons ILM peeled off spontaneously associated with MH is a rarely seen complication of Terson Syndrome. Due to the large-scale of the ILM peeling off, final visual acuity may be poor in patients, even though successful macular hole closure after the operation.
Muneyuki Takao - One of the best experts on this subject based on the ideXlab platform.
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a surgical simulator for peeling the Inner Limiting Membrane during wet conditions
PLOS ONE, 2018Co-Authors: Seiji Omata, Yusei Someya, Taisuke Masuda, Kanako Harada, Mamoru Mitsuishi, Fumiyuki Araki, Shynya Adachi, Takeshi Hayakawa, Kiyohito Totsuka, Muneyuki TakaoAbstract:The present study was performed to establish a novel ocular surgery simulator for training in peeling of the Inner limited Membrane (ILM). This simulator included a next-generation artificial ILM with mechanical properties similar to the natural ILM that could be peeled underwater in the same manner as in actual surgery. An artificial eye consisting of a fundus and eyeball parts was fabricated. The artificial eye was installed in the eye surgery simulator. The fundus part was mounted in the eyeball, which consisted of an artificial sclera, retina, and ILM. To measure the thickness of the fabricated ILM on the artificial retina, we calculated the distance of the step height as the thickness of the artificial ILM. Two experienced ophthalmologists then assessed the fabricated ILM by sensory evaluation. The minimum thickness of the artificial ILM was 1.9 ± 0.3 μm (n = 3). We were able to perform the peeling task with the ILM in water. Based on the sensory evaluation, an ILM with a minimum thickness and 1000 degrees of polymerization was suitable for training. We installed the eye model on an ocular surgery simulator, which allowed for the performance of a sequence of operations similar to ILM peeling. In conclusion, we developed a novel ocular surgery simulator for ILM peeling. The artificial ILM was peeled underwater in the same manner as in an actual operation.
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Eye surgery simulator for training intracular operation of Inner Limiting Membrane
2017 IEEE International Conference on Cyborg and Bionic Systems (CBS), 2017Co-Authors: Seiji Omata, Fumihito Arai, Yusei Someya, Shun'ya Adachi, Taisuke Masuda, Kanako Harada, Mamoru Mitsuishi, Kiyoto Totsuka, Fumiyuki Araki, Muneyuki TakaoAbstract:We established a brand-new eye surgery simulator for training of peeling the Inner limited Membrane (ILM) which is superficial layer of retina. This simulator included a novel artificial ILM with mechanical properties similar to natural ILM. We could peel the artificial ILM under water like as actual surgery. An artificial eye consisting of a fundus and eye ball parts was fabricated. The artificial eye could be installed in the simulator. The fundus part was mounted in the eyeball, which consisted of an artificial sclera, retina, and ILM. The artificial ILM was fabricated by chemically crosslinked PVA hydrogel. Thickness measurement and sensory evaluation of the fabricated ILM were done. The minimum thickness of the artificial ILM was 1.9 ± 0.3 μm (n = 3). We could perform the peeling task with the ILM in water. Based on the sensory evaluation, an ILM with a minimum thickness and 1000 degrees of polymerization was suitable for training to novice doctors. We installed the eye model on an ocular surgery simulator, which could perform a sequence of operations like ILM peeling. Then, we succeeded in developing a novel ocular surgery simulator for peeling task of ILM and peeling under water like as the actual surgery.
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A novel eye surgery simulator for exercising operation task of Inner Limiting Membrane peeling
2017 International Symposium on Micro-NanoMechatronics and Human Science (MHS), 2017Co-Authors: Seiji Omata, Yusei Someya, Kanako Harada, Mamoru Mitsuishi, Kiyoto Totsuka, Fumiyuki Araki, Muneyuki Takao, Shyun'ya Adachi, Makoto Aihara, Fumihito AraiAbstract:We established a brand-new eye surgery simulator for training of peeling the Inner limited Membrane (ILM) which is superficial layer of retina. The artificial ILM could be peeled under water like as actual surgery. An artificial eye consisting of a fundus and eye ball parts was fabricated. The artificial eye could be installed in the simulator. The fundus part was mounted in the eyeball, which consisted of an artificial sclera, retina, and ILM. The artificial ILM was fabricated by chemically crosslinked PVA hydrogel. Thickness measurement and sensory evaluation of the fabricated ILM were done. We installed the eye model on an ocular surgery simulator, which could perform a sequence of operations like ILM peeling. Then, we succeeded in developing a novel ocular surgery simulator for peeling task of ILM and peeling under water like as the actual surgery.
Atsushi Fujiwara - One of the best experts on this subject based on the ideXlab platform.
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efficacy of vitrectomy and Inner Limiting Membrane peeling in age related macular degeneration resistant to anti vascular endothelial growth factor therapy with vitreomacular traction or epiretinal Membrane
Graefes Archive for Clinical and Experimental Ophthalmology, 2016Co-Authors: Shuhei Kimura, Yuki Morizane, Shinji Toshima, Mika Hosogi, Fumiaki Kumase, Mio Hosokawa, Yusuke Shiode, Atsushi Fujiwara, Fumio ShiragaAbstract:Purpose We assessed the efficacy of vitrectomy and Inner Limiting Membrane (ILM) peeling, followed by anti-vascular endothelial growth factor (VEGF) therapy, anti-VEGF-resistant age-related macular degeneration (AMD) due to vitreomacular traction (VMT) or epiretinal Membrane (ERM).
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efficacy of vitrectomy and Inner Limiting Membrane peeling in age related macular degeneration resistant to anti vascular endothelial growth factor therapy with vitreomacular traction or epiretinal Membrane
Graefes Archive for Clinical and Experimental Ophthalmology, 2016Co-Authors: Shuhei Kimura, Yuki Morizane, Shinji Toshima, Mika Hosogi, Fumiaki Kumase, Mio Hosokawa, Yusuke Shiode, Atsushi Fujiwara, Fumio ShiragaAbstract:We assessed the efficacy of vitrectomy and Inner Limiting Membrane (ILM) peeling, followed by anti-vascular endothelial growth factor (VEGF) therapy, anti-VEGF-resistant age-related macular degeneration (AMD) due to vitreomacular traction (VMT) or epiretinal Membrane (ERM). We identified six patients with anti-VEGF-resistant AMD due to VMT or ERM amongst a total of 588 patients with AMD (821 eyes) referred to Okayama University Hospital between February 2012 and May 2014. These patients underwent vitrectomy to release the VMT (4 cases) or remove the ERM (2 cases), along with ILM peeling. The regimen used for intravitreal injections of anti-VEGF reagents after surgery was based on the severity of exudative changes in each patient. Preoperative and postoperative best-corrected visual acuity (BCVA) and central retinal thickness (CRT) measurements were compared. After vitrectomy and ILM peeling, all six patients responded to anti-VEGF therapy, which was then able to maintain dry retinas. Mean BCVA did not improve significantly (0.49 ± 0.28 before vs. 0.43 ± 0.38 after surgery, P = 0.538). However, mean CR was significantly decreased after surgery, from 423 ± 83.5 μm to 257 ± 75.8 μm (P = 0.0078). Vitrectomy and ILM peeling followed by anti-VEGF therapy may be a useful therapeutic option for anti-VEGF-resistant AMD with VMT or ERM.