The Experts below are selected from a list of 1338 Experts worldwide ranked by ideXlab platform

Nobuyuki Itoh - One of the best experts on this subject based on the ideXlab platform.

  • identification of a novel fibroblast growth factor fgf 22 preferentially expressed in the Inner Root Sheath of the hair follicle
    2001
    Co-Authors: Yuhki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh
    Abstract:

    Abstract We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (∼46% and ∼40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the Inner Root Sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.

  • identification of a novel fibroblast growth factor fgf 22 preferentially expressed in the Inner Root Sheath of the hair follicle
    2001
    Co-Authors: Yuhki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh
    Abstract:

    We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (approximately 46% and approximately 40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the Inner Root Sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.

Yuhki Nakatake - One of the best experts on this subject based on the ideXlab platform.

  • identification of a novel fibroblast growth factor fgf 22 preferentially expressed in the Inner Root Sheath of the hair follicle
    2001
    Co-Authors: Yuhki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh
    Abstract:

    Abstract We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (∼46% and ∼40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the Inner Root Sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.

  • identification of a novel fibroblast growth factor fgf 22 preferentially expressed in the Inner Root Sheath of the hair follicle
    2001
    Co-Authors: Yuhki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh
    Abstract:

    We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (approximately 46% and approximately 40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the Inner Root Sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.

Sanjeev K. Waghmare - One of the best experts on this subject based on the ideXlab platform.

  • Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response.
    2017
    Co-Authors: Gopal L. Chovatiya, Rahul M. Sarate, Raghava R. Sunkara, Nilesh P. Gawas, Vineet Kala, Sanjeev K. Waghmare
    Abstract:

    Secretory phospholipase A2 Group-IIA (sPLA2-IIA) is involved in lipid catabolism and growth promoting activity. sPLA2-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA2-IIA in the development of cyclic alopecia and wound healing response in relation to complete loss of hair follicle stem cells (HFSCs). Our data showed that overexpression of sPLA2-IIA in homozygous mice results in hyperproliferation and terminal epidermal differentiation followed by hair follicle cycle being halted at anagen like stage. In addition, sPLA2-IIA induced hyperproliferation leads to compl pathological conditions including various cancers. Here ete exhaustion of hair follicle stem cell pool at PD28 (Postnatal day). Importantly, sPLA2-IIA overexpression affects the hair shaft differentiation leading to development of cyclic alopecia. Molecular investigation study showed aberrant expression of Sox21, Msx2 and signalling modulators necessary for proper differentiation of Inner Root Sheath (IRS) and hair shaft formation. Further, full-thickness skin wounding on dorsal skin of K14-sPLA2-IIA homozygous mice displayed impaired initial healing response. Our results showed the involvement of sPLA2-IIA in regulation of matrix cells differentiation, hair shaft formation and complete loss of HFSCs mediated impaired wound healing response. These novel functions of sPLA2-IIA may have clinical implications in alopecia, cancer development and ageing.

  • secretory phospholipase a 2 iia overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response
    2017
    Co-Authors: Gopal L. Chovatiya, Rahul M. Sarate, Raghava R. Sunkara, Nilesh P. Gawas, Vineet Kala, Sanjeev K. Waghmare
    Abstract:

    Secretory phospholipase A2 Group-IIA (sPLA2-IIA) is involved in lipid catabolism and growth promoting activity. sPLA2-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA2-IIA in the development of cyclic alopecia and wound healing response in relation to complete loss of hair follicle stem cells (HFSCs). Our data showed that overexpression of sPLA2-IIA in homozygous mice results in hyperproliferation and terminal epidermal differentiation followed by hair follicle cycle being halted at anagen like stage. In addition, sPLA2-IIA induced hyperproliferation leads to compl pathological conditions including various cancers. Here ete exhaustion of hair follicle stem cell pool at PD28 (Postnatal day). Importantly, sPLA2-IIA overexpression affects the hair shaft differentiation leading to development of cyclic alopecia. Molecular investigation study showed aberrant expression of Sox21, Msx2 and signalling modulators necessary for proper differentiation of Inner Root Sheath (IRS) and hair shaft formation. Further, full-thickness skin wounding on dorsal skin of K14-sPLA2-IIA homozygous mice displayed impaired initial healing response. Our results showed the involvement of sPLA2-IIA in regulation of matrix cells differentiation, hair shaft formation and complete loss of HFSCs mediated impaired wound healing response. These novel functions of sPLA2-IIA may have clinical implications in alopecia, cancer development and ageing.

Yoshiaki Kassai - One of the best experts on this subject based on the ideXlab platform.

  • identification of a novel fibroblast growth factor fgf 22 preferentially expressed in the Inner Root Sheath of the hair follicle
    2001
    Co-Authors: Yuhki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh
    Abstract:

    Abstract We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (∼46% and ∼40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the Inner Root Sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.

  • identification of a novel fibroblast growth factor fgf 22 preferentially expressed in the Inner Root Sheath of the hair follicle
    2001
    Co-Authors: Yuhki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh
    Abstract:

    We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (approximately 46% and approximately 40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the Inner Root Sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.

Toshiyuki Asaki - One of the best experts on this subject based on the ideXlab platform.

  • identification of a novel fibroblast growth factor fgf 22 preferentially expressed in the Inner Root Sheath of the hair follicle
    2001
    Co-Authors: Yuhki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh
    Abstract:

    Abstract We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (∼46% and ∼40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the Inner Root Sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.

  • identification of a novel fibroblast growth factor fgf 22 preferentially expressed in the Inner Root Sheath of the hair follicle
    2001
    Co-Authors: Yuhki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh
    Abstract:

    We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (approximately 46% and approximately 40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the Inner Root Sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.