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Heloisa Beraldo - One of the best experts on this subject based on the ideXlab platform.

  • vanadium complexes with 2 pyridineformamide thiosemicarbazones in vitro studies of Insulin Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Abstract Reaction of VOCl 2 with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N (4)-methyl (H2Am4Me), N (4)-ethyl (H2Am4Et) and N (4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH)Cl 2 ] ( 1 ), [VO(H2Am4Me)Cl 2 ] · 1/2HCl ( 2 ), [VO(H2Am4Et)Cl 2 ] · HCl ( 3 ) and [VO(2Am4Ph)Cl] ( 4 ). Upon the dissolution of 1 – 4 in water, oxidation immediately occurs with the formation of [VO 2 (2Am4DH)] ( 5 ), [VO 2 (2Am4Me)] ( 6 ), [VO 2 (2Am4Et)] ( 7 ) and [VO 2 (2Am4Ph)] ( 8 ). The crystal and molecular structures of 5 and 6 were determined. Complexes 5 – 8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes.

  • Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of Insulin-Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Reaction of VOCl(2) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH) Cl(2)] (1), [VO(H2Am4Me) Cl(2)] center dot 1/2HCl (2), [VO(H2Am4Et) Cl(2)] center dot HCl (3) and [VO(2Am4Ph) Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of [VO(2)(2Am4DH)] (5), [VO(2)(2Am4Me)] (6), [VO(2)(2Am4Et)] (7) and [VO(2)(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. (C) 2008 Elsevier B.V. All rights reserved.CNPqConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e MedicamentosInstituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e Medicamentos[CNPq 420015/05-1

  • oxovanadium iv and v complexes of acetylpyridine derived semicarbazones exhibit Insulin Like Activity
    Polyhedron, 2008
    Co-Authors: Ana Mena Barreto Bastos, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Jeferson G Da Silva, Pedro I S Maia, Victor M Deflon, Alzir A Batista, Elke Niquet, Heloisa Beraldo
    Abstract:

    Abstract Reaction of 2-acetylpyridine semicarbazone (H2APS), 3-acetylpyridine semicarbazone (H3APS) and 4-acetylpyridine semicarbazone (H4APS) with [VO(acac)2] (acac = acetylacetonate) gave [VO(H2APS)(acac)2] (1), [VO(H3APS)(acac)2] (2) and [VO(4APS)(acac)(H2O)] · 1/2H2O (3). Oxidation of complex 1 in acetonitrile gave [VO2(2APS)] (4). The crystal structures of complexes 1 and 4 have been determined. Complexes 1–3 were able to enhance glucose uptake and to inhibit glycerol release from adipocytes, which indicate their potential to act as Insulin-mimics.

Isolda C. Mendes - One of the best experts on this subject based on the ideXlab platform.

  • vanadium complexes with 2 pyridineformamide thiosemicarbazones in vitro studies of Insulin Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Abstract Reaction of VOCl 2 with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N (4)-methyl (H2Am4Me), N (4)-ethyl (H2Am4Et) and N (4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH)Cl 2 ] ( 1 ), [VO(H2Am4Me)Cl 2 ] · 1/2HCl ( 2 ), [VO(H2Am4Et)Cl 2 ] · HCl ( 3 ) and [VO(2Am4Ph)Cl] ( 4 ). Upon the dissolution of 1 – 4 in water, oxidation immediately occurs with the formation of [VO 2 (2Am4DH)] ( 5 ), [VO 2 (2Am4Me)] ( 6 ), [VO 2 (2Am4Et)] ( 7 ) and [VO 2 (2Am4Ph)] ( 8 ). The crystal and molecular structures of 5 and 6 were determined. Complexes 5 – 8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes.

  • Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of Insulin-Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Reaction of VOCl(2) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH) Cl(2)] (1), [VO(H2Am4Me) Cl(2)] center dot 1/2HCl (2), [VO(H2Am4Et) Cl(2)] center dot HCl (3) and [VO(2Am4Ph) Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of [VO(2)(2Am4DH)] (5), [VO(2)(2Am4Me)] (6), [VO(2)(2Am4Et)] (7) and [VO(2)(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. (C) 2008 Elsevier B.V. All rights reserved.CNPqConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e MedicamentosInstituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e Medicamentos[CNPq 420015/05-1

Adaliene Versiani Matos Ferreira - One of the best experts on this subject based on the ideXlab platform.

  • vanadium complexes with 2 pyridineformamide thiosemicarbazones in vitro studies of Insulin Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Abstract Reaction of VOCl 2 with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N (4)-methyl (H2Am4Me), N (4)-ethyl (H2Am4Et) and N (4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH)Cl 2 ] ( 1 ), [VO(H2Am4Me)Cl 2 ] · 1/2HCl ( 2 ), [VO(H2Am4Et)Cl 2 ] · HCl ( 3 ) and [VO(2Am4Ph)Cl] ( 4 ). Upon the dissolution of 1 – 4 in water, oxidation immediately occurs with the formation of [VO 2 (2Am4DH)] ( 5 ), [VO 2 (2Am4Me)] ( 6 ), [VO 2 (2Am4Et)] ( 7 ) and [VO 2 (2Am4Ph)] ( 8 ). The crystal and molecular structures of 5 and 6 were determined. Complexes 5 – 8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes.

  • Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of Insulin-Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Reaction of VOCl(2) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH) Cl(2)] (1), [VO(H2Am4Me) Cl(2)] center dot 1/2HCl (2), [VO(H2Am4Et) Cl(2)] center dot HCl (3) and [VO(2Am4Ph) Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of [VO(2)(2Am4DH)] (5), [VO(2)(2Am4Me)] (6), [VO(2)(2Am4Et)] (7) and [VO(2)(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. (C) 2008 Elsevier B.V. All rights reserved.CNPqConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e MedicamentosInstituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e Medicamentos[CNPq 420015/05-1

  • oxovanadium iv and v complexes of acetylpyridine derived semicarbazones exhibit Insulin Like Activity
    Polyhedron, 2008
    Co-Authors: Ana Mena Barreto Bastos, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Jeferson G Da Silva, Pedro I S Maia, Victor M Deflon, Alzir A Batista, Elke Niquet, Heloisa Beraldo
    Abstract:

    Abstract Reaction of 2-acetylpyridine semicarbazone (H2APS), 3-acetylpyridine semicarbazone (H3APS) and 4-acetylpyridine semicarbazone (H4APS) with [VO(acac)2] (acac = acetylacetonate) gave [VO(H2APS)(acac)2] (1), [VO(H3APS)(acac)2] (2) and [VO(4APS)(acac)(H2O)] · 1/2H2O (3). Oxidation of complex 1 in acetonitrile gave [VO2(2APS)] (4). The crystal structures of complexes 1 and 4 have been determined. Complexes 1–3 were able to enhance glucose uptake and to inhibit glycerol release from adipocytes, which indicate their potential to act as Insulin-mimics.

Leida Maria Botion - One of the best experts on this subject based on the ideXlab platform.

  • vanadium complexes with 2 pyridineformamide thiosemicarbazones in vitro studies of Insulin Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Abstract Reaction of VOCl 2 with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N (4)-methyl (H2Am4Me), N (4)-ethyl (H2Am4Et) and N (4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH)Cl 2 ] ( 1 ), [VO(H2Am4Me)Cl 2 ] · 1/2HCl ( 2 ), [VO(H2Am4Et)Cl 2 ] · HCl ( 3 ) and [VO(2Am4Ph)Cl] ( 4 ). Upon the dissolution of 1 – 4 in water, oxidation immediately occurs with the formation of [VO 2 (2Am4DH)] ( 5 ), [VO 2 (2Am4Me)] ( 6 ), [VO 2 (2Am4Et)] ( 7 ) and [VO 2 (2Am4Ph)] ( 8 ). The crystal and molecular structures of 5 and 6 were determined. Complexes 5 – 8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes.

  • Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of Insulin-Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Reaction of VOCl(2) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH) Cl(2)] (1), [VO(H2Am4Me) Cl(2)] center dot 1/2HCl (2), [VO(H2Am4Et) Cl(2)] center dot HCl (3) and [VO(2Am4Ph) Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of [VO(2)(2Am4DH)] (5), [VO(2)(2Am4Me)] (6), [VO(2)(2Am4Et)] (7) and [VO(2)(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. (C) 2008 Elsevier B.V. All rights reserved.CNPqConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e MedicamentosInstituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e Medicamentos[CNPq 420015/05-1

  • oxovanadium iv and v complexes of acetylpyridine derived semicarbazones exhibit Insulin Like Activity
    Polyhedron, 2008
    Co-Authors: Ana Mena Barreto Bastos, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Jeferson G Da Silva, Pedro I S Maia, Victor M Deflon, Alzir A Batista, Elke Niquet, Heloisa Beraldo
    Abstract:

    Abstract Reaction of 2-acetylpyridine semicarbazone (H2APS), 3-acetylpyridine semicarbazone (H3APS) and 4-acetylpyridine semicarbazone (H4APS) with [VO(acac)2] (acac = acetylacetonate) gave [VO(H2APS)(acac)2] (1), [VO(H3APS)(acac)2] (2) and [VO(4APS)(acac)(H2O)] · 1/2H2O (3). Oxidation of complex 1 in acetonitrile gave [VO2(2APS)] (4). The crystal structures of complexes 1 and 4 have been determined. Complexes 1–3 were able to enhance glucose uptake and to inhibit glycerol release from adipocytes, which indicate their potential to act as Insulin-mimics.

Eduardo E. Castellano - One of the best experts on this subject based on the ideXlab platform.

  • vanadium complexes with 2 pyridineformamide thiosemicarbazones in vitro studies of Insulin Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Abstract Reaction of VOCl 2 with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N (4)-methyl (H2Am4Me), N (4)-ethyl (H2Am4Et) and N (4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH)Cl 2 ] ( 1 ), [VO(H2Am4Me)Cl 2 ] · 1/2HCl ( 2 ), [VO(H2Am4Et)Cl 2 ] · HCl ( 3 ) and [VO(2Am4Ph)Cl] ( 4 ). Upon the dissolution of 1 – 4 in water, oxidation immediately occurs with the formation of [VO 2 (2Am4DH)] ( 5 ), [VO 2 (2Am4Me)] ( 6 ), [VO 2 (2Am4Et)] ( 7 ) and [VO 2 (2Am4Ph)] ( 8 ). The crystal and molecular structures of 5 and 6 were determined. Complexes 5 – 8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes.

  • Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of Insulin-Like Activity
    Inorganica Chimica Acta, 2009
    Co-Authors: Isolda C. Mendes, Leida Maria Botion, Adaliene Versiani Matos Ferreira, Eduardo E. Castellano, Heloisa Beraldo
    Abstract:

    Reaction of VOCl(2) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH) Cl(2)] (1), [VO(H2Am4Me) Cl(2)] center dot 1/2HCl (2), [VO(H2Am4Et) Cl(2)] center dot HCl (3) and [VO(2Am4Ph) Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of [VO(2)(2Am4DH)] (5), [VO(2)(2Am4Me)] (6), [VO(2)(2Am4Et)] (7) and [VO(2)(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with Insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. (C) 2008 Elsevier B.V. All rights reserved.CNPqConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e MedicamentosInstituto do Milenio-Inovacao e Desenvolvimento de Novos Farmacos e Medicamentos[CNPq 420015/05-1