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Shigeaki Ohno - One of the best experts on this subject based on the ideXlab platform.

  • Retinal neovascularization during treatment with IGF-1 for insulin resistance syndrome
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2005
    Co-Authors: Hirokuni Kitamei, Masahiko Yokoi, Manabu Kase, Shigeaki Ohno
    Abstract:

    Background Leprechaunism is a rare congenital syndrome and the most severe form of insulin resistance syndrome, with mutations in the insulin receptor gene. Recombinant human Insulin-Like growth factor-1 (rhIGF-1) is currently applicable to the treatment for insulin resistance syndrome by its Insulin-Like Effect. Although IGF-1 is thought to promote tissue proliferation and neovascularization, it is uncertain how it acts on the development of diabetic retinopathy. Methods Interventional case report. Results A 12-year-old girl with leprechaunism has been treated with IGF-1 since she was 6 months old. She presented with neovascular glaucoma in the left eye, but with no serious changes in the right fundus except for tortuosity and dilatation of retinal veins. Thereafter, retinal neovascularization in the right eye developed in 6 months to form a loop-shaped vascular network in the vitreous cavity despite panretinal photocoagulation. Conclusions Characteristics of retinal neovascularization and clinical course suggest that IGF-1 treatment was closely associated with the development of diabetic retinopathy in this case.

  • Retinal neovascularization during treatment with IGF-1 for insulin resistance syndrome.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005
    Co-Authors: Hirokuni Kitamei, Masahiko Yokoi, Manabu Kase, Shigeaki Ohno
    Abstract:

    Background Leprechaunism is a rare congenital syndrome and the most severe form of insulin resistance syndrome, with mutations in the insulin receptor gene. Recombinant human Insulin-Like growth factor-1 (rhIGF-1) is currently applicable to the treatment for insulin resistance syndrome by its Insulin-Like Effect. Although IGF-1 is thought to promote tissue proliferation and neovascularization, it is uncertain how it acts on the development of diabetic retinopathy.

Jankan Chen - One of the best experts on this subject based on the ideXlab platform.

  • resveratrol a red wine antioxidant possesses an insulin like Effect in streptozotocin induced diabetic rats
    American Journal of Physiology-endocrinology and Metabolism, 2006
    Co-Authors: Huichen Su, Liman Hung, Jankan Chen
    Abstract:

    Aberrant energy metabolism is one characteristic of diabetes mellitus (DM). Two types of DM have been identified, type 1 and type 2. Most of type 2 DM patients eventually become insulin dependent because insulin secretion by the islets of Langerhans becomes exhausted. In the present study, we show that resveratrol (3,5,4′-trihydroxylstilbene) possesses hypoglycemic and hypolipidemic Effects in streptozotocin-induced DM (STZ-DM) rats. In resveratrol-treated STZ-DM rats, the plasma glucose concentration on day 14 was reduced by 25.3 ± 4.2%, and the triglyceride concentration was reduced by 50.2 ± 3.2% compared with the vehicle-treated rats. In STZ-nicotinamide DM rats, the plasma glucose concentration on day 14 was reduced by 20.3 ± 4.2%, and the triglyceride concentration was reduced by 33.3 ± 2.2% compared with the vehicle-treated rats. Resveratrol administration ameliorates common DM symptoms, such as body weight loss, polyphagia, and polydipsia. In STZ-nicotinamide DM rats, resveratrol administration si...

  • Resveratrol, a red wine antioxidant, possesses an Insulin-Like Effect in streptozotocin-induced diabetic rats
    American journal of physiology. Endocrinology and metabolism, 2006
    Co-Authors: Liman Hung, Jankan Chen
    Abstract:

    Aberrant energy metabolism is one characteristic of diabetes mellitus (DM). Two types of DM have been identified, type 1 and type 2. Most of type 2 DM patients eventually become insulin dependent b...

Hirokuni Kitamei - One of the best experts on this subject based on the ideXlab platform.

  • Retinal neovascularization during treatment with IGF-1 for insulin resistance syndrome
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2005
    Co-Authors: Hirokuni Kitamei, Masahiko Yokoi, Manabu Kase, Shigeaki Ohno
    Abstract:

    Background Leprechaunism is a rare congenital syndrome and the most severe form of insulin resistance syndrome, with mutations in the insulin receptor gene. Recombinant human Insulin-Like growth factor-1 (rhIGF-1) is currently applicable to the treatment for insulin resistance syndrome by its Insulin-Like Effect. Although IGF-1 is thought to promote tissue proliferation and neovascularization, it is uncertain how it acts on the development of diabetic retinopathy. Methods Interventional case report. Results A 12-year-old girl with leprechaunism has been treated with IGF-1 since she was 6 months old. She presented with neovascular glaucoma in the left eye, but with no serious changes in the right fundus except for tortuosity and dilatation of retinal veins. Thereafter, retinal neovascularization in the right eye developed in 6 months to form a loop-shaped vascular network in the vitreous cavity despite panretinal photocoagulation. Conclusions Characteristics of retinal neovascularization and clinical course suggest that IGF-1 treatment was closely associated with the development of diabetic retinopathy in this case.

  • Retinal neovascularization during treatment with IGF-1 for insulin resistance syndrome.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005
    Co-Authors: Hirokuni Kitamei, Masahiko Yokoi, Manabu Kase, Shigeaki Ohno
    Abstract:

    Background Leprechaunism is a rare congenital syndrome and the most severe form of insulin resistance syndrome, with mutations in the insulin receptor gene. Recombinant human Insulin-Like growth factor-1 (rhIGF-1) is currently applicable to the treatment for insulin resistance syndrome by its Insulin-Like Effect. Although IGF-1 is thought to promote tissue proliferation and neovascularization, it is uncertain how it acts on the development of diabetic retinopathy.

Liman Hung - One of the best experts on this subject based on the ideXlab platform.

  • resveratrol a red wine antioxidant possesses an insulin like Effect in streptozotocin induced diabetic rats
    American Journal of Physiology-endocrinology and Metabolism, 2006
    Co-Authors: Huichen Su, Liman Hung, Jankan Chen
    Abstract:

    Aberrant energy metabolism is one characteristic of diabetes mellitus (DM). Two types of DM have been identified, type 1 and type 2. Most of type 2 DM patients eventually become insulin dependent because insulin secretion by the islets of Langerhans becomes exhausted. In the present study, we show that resveratrol (3,5,4′-trihydroxylstilbene) possesses hypoglycemic and hypolipidemic Effects in streptozotocin-induced DM (STZ-DM) rats. In resveratrol-treated STZ-DM rats, the plasma glucose concentration on day 14 was reduced by 25.3 ± 4.2%, and the triglyceride concentration was reduced by 50.2 ± 3.2% compared with the vehicle-treated rats. In STZ-nicotinamide DM rats, the plasma glucose concentration on day 14 was reduced by 20.3 ± 4.2%, and the triglyceride concentration was reduced by 33.3 ± 2.2% compared with the vehicle-treated rats. Resveratrol administration ameliorates common DM symptoms, such as body weight loss, polyphagia, and polydipsia. In STZ-nicotinamide DM rats, resveratrol administration si...

  • Resveratrol, a red wine antioxidant, possesses an Insulin-Like Effect in streptozotocin-induced diabetic rats
    American journal of physiology. Endocrinology and metabolism, 2006
    Co-Authors: Liman Hung, Jankan Chen
    Abstract:

    Aberrant energy metabolism is one characteristic of diabetes mellitus (DM). Two types of DM have been identified, type 1 and type 2. Most of type 2 DM patients eventually become insulin dependent b...

Masahiko Yokoi - One of the best experts on this subject based on the ideXlab platform.

  • Retinal neovascularization during treatment with IGF-1 for insulin resistance syndrome
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2005
    Co-Authors: Hirokuni Kitamei, Masahiko Yokoi, Manabu Kase, Shigeaki Ohno
    Abstract:

    Background Leprechaunism is a rare congenital syndrome and the most severe form of insulin resistance syndrome, with mutations in the insulin receptor gene. Recombinant human Insulin-Like growth factor-1 (rhIGF-1) is currently applicable to the treatment for insulin resistance syndrome by its Insulin-Like Effect. Although IGF-1 is thought to promote tissue proliferation and neovascularization, it is uncertain how it acts on the development of diabetic retinopathy. Methods Interventional case report. Results A 12-year-old girl with leprechaunism has been treated with IGF-1 since she was 6 months old. She presented with neovascular glaucoma in the left eye, but with no serious changes in the right fundus except for tortuosity and dilatation of retinal veins. Thereafter, retinal neovascularization in the right eye developed in 6 months to form a loop-shaped vascular network in the vitreous cavity despite panretinal photocoagulation. Conclusions Characteristics of retinal neovascularization and clinical course suggest that IGF-1 treatment was closely associated with the development of diabetic retinopathy in this case.

  • Retinal neovascularization during treatment with IGF-1 for insulin resistance syndrome.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005
    Co-Authors: Hirokuni Kitamei, Masahiko Yokoi, Manabu Kase, Shigeaki Ohno
    Abstract:

    Background Leprechaunism is a rare congenital syndrome and the most severe form of insulin resistance syndrome, with mutations in the insulin receptor gene. Recombinant human Insulin-Like growth factor-1 (rhIGF-1) is currently applicable to the treatment for insulin resistance syndrome by its Insulin-Like Effect. Although IGF-1 is thought to promote tissue proliferation and neovascularization, it is uncertain how it acts on the development of diabetic retinopathy.