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Mitsunori Yamakawa - One of the best experts on this subject based on the ideXlab platform.

  • Interdigitating Dendritic Cell Sarcoma and Follicular Dendritic Cell Sarcoma : Histopathological Findings for Differential Diagnosis
    Journal of clinical and experimental hematopathology : JCEH, 2013
    Co-Authors: Hiroya Ohtake, Mitsunori Yamakawa
    Abstract:

    Both Interdigitating Cell sarcoma (IDCS) and follicular dendritic Cell sarcoma (FDCS) are rare neoplasms derived from dendritic Cells in lymphoid organs. IDCS is defined as a neoplastic proliferation of spindle-shaped to ovoid Cells with phenotypic features similar to those of IDCs. FDCS is a malignant neoplasm derived from FDCs that possess and present antigens to B Cells in the follicular (germinal) centers of lymphoid organs. They often occur in lymph nodes, although they can also arise at extranodal sites. In this review, we have highlighted the morphological and immunohistochemical properties of these neoplasms, which could help in unequivocal and accurate diagnosis.

  • Interdigitating Cell sarcoma: a morphologic and immunologic study of lymph node lesions in four cases
    Pathology international, 2008
    Co-Authors: Shigeo Nakamura, Mitsunori Yamakawa, Yutaka Imai, Takashi Koshikawa, Kuniyoshi Kitoh, Atsuo Nakayama, K Ishii, M Fujita, Taizan Suchi
    Abstract:

    Interdigitating Cell sarcoma is an extremely rare tumor. Its presentation and histologic appearance has varied among the reported cases. In this study, the authors investigated four cases of the hematolymphoid malignancy arising within lymph nodes, which were considered to be of Interdigitating Cell origin. All patients presented in the 6th to 8th decade of life with peripheral lymphadenopathy, and had a relatively indolent clinical course, without bone marrow or skin involvement. Carcinomas were observed as a second neoplasm in two of four patients. Distinctive morphologic features are proliferation of histiocyte-like Cells with nuclear pleomorphism and occasionally multinucleated, paracortical distribution sparing of B-Cell regions, fibrosis, sinus infiltration, and a prominent eosinophil/plasma Cell infiltrates. The combination of light microscopic, fine structural, and immunohistochemical features suggested that these tumors derive from Interdigitating Cells; these tumor Cells expressed CD68 (KP1), S-100 protein and HLA-DR, but lack CD21 (1F8), desmosomes and Birbeck granules. The diagnosis of Interdigitating Cell sarcoma should be considered on any pleomorphic tumor with the features described in this report.

  • Interdigitating Cell sarcoma
    Journal of Clinical and Experimental Hematopathology, 2005
    Co-Authors: Kunihiko Maeda, Tomoko Takahashi, Chihiro Saitoh, Keiko Watarai, Kiriko Wada, Katsushi Tajima, Yuko Harada, Yuki Hiroshima, Mitsunori Yamakawa
    Abstract:

    A 58-year-old Japanese man developed discomfort of his left neck, gradually increasing left chest pain, and weight loss (15 kg over six months). His primary physician noted generalized lymphadenopathy, and a neck lymph node was excised for diagnosis. When he was admitted to our hospital, he had severely decreased appetite accompanied by a large intra-abdominal mass. The lymphadenopathy was temporarily reduced by CHOP (cyclophosphamide, hydroxydoxorubicin/adriamycin, vincristine/oncovin, prednisone) chemotherapy, but pancytopenia and hepatomegaly persisted. After 3 courses of therapy, tumor Cell regrowth was evident in peripheral blood and bone marrow and his course rapidly declined, with complications from hemophagocytic syndrome. He expired after a total course of 6 months. A postmortem examination was performed 2 hours after death. A final diagnosis of Interdigitating Cell sarcoma was made based on histological and immunohistochemical analyses of the biopsied lymph nodes and autopsy materials. His clinical course was extremely aggressive, and chemotherapy was not effective. Discussion of this case provides important insight into the clinicopathological features and treatment of this neoplasm.

  • Lymph node Interdigitating Cell sarcoma. A case report.
    American journal of clinical pathology, 1992
    Co-Authors: Mitsunori Yamakawa, Mikio Matsuda, Yutaka Imai, Shigeru Arai, Kohji Harada, Takayuki Sato
    Abstract:

    A 54-year-old man was admitted because of right supraclavicular lymphadenopathy of some weeks duration. Computed axial tomography revealed a large multinodular lesion in a supraclavicular lymph node. The patient then had a supraclavicular lymph node biopsy. Light microscopy showed a tumor whose structure was suggestive of an Interdigitating Cell sarcoma. Enzyme and immunohistochemical analysis showed that the tumor Cells possessed membranous adenosine triphosphatase activity, intracytoplasmic S100 protein, surface CD1a and CD4 antigens, and HLA-DR antigen. Ultrastructural examination showed that the Cells exhibited many Interdigitating cytoplasmic extensions, but no Birbeck granules. DNA content analysis of the tumor Cells proved that the Cells were malignant. These data are consistent with derivation from a lymph node Interdigitating Cell.

Siamon Gordon - One of the best experts on this subject based on the ideXlab platform.

  • THE MONONUCLEAR PHAGOCYTE SYSTEM OF THE MOUSE DEFINED BY IMMUNOHISTOCHEMICAL LOCALIZATION OF ANTIGEN F4/80 Relationship Between Macrophages, Langerhans Cells, Reticular Cells,
    2013
    Co-Authors: Dendritic Cells In Lymphoid, Anne P Robinson, Gordon G Macpherson, Hematopoietic Organs, A. Hume, Siamon Gordon
    Abstract:

    The immune response genes of the major histocompatibility gene complex code for surface antigens (Ia) now believed to be involved in the interaction between T Cells and accessory or "antigen-presenting " Cells (1, 2). Whilst some groups suggest that Ia antigens present on subpopulations of mononuclear phagocytes are involved in T Cell activation (1-4), others have presented evidence for the involvement of a separate Ia + Cell population (5-8) now generally referred to as dendritic Cells. The in vivo correlate of the isolated antigen-presenting dendritic Cell is not yet clear. The availability of a specific monoclonal antibody against mouse dendritic Cells (9) will be helpful in clarifying this question. One obvious candidate is the Ia + "Interdigitating Cell " that has been described in thymus and in T Cell-dependent areas of lymphoid organs (10-15). However, whilst the isolated splenic dendritic Cell has virtually none of the functional characteristics of a mononuclear phagocyte (6), it has been suggested that Interdigitating Cells are members of the mononuclear phagocyte system and are related to epidermal Langerhans Cells and similar Cells.found in afferent lymphatic

Takayuki Sato - One of the best experts on this subject based on the ideXlab platform.

  • Lymph node Interdigitating Cell sarcoma. A case report.
    American journal of clinical pathology, 1992
    Co-Authors: Mitsunori Yamakawa, Mikio Matsuda, Yutaka Imai, Shigeru Arai, Kohji Harada, Takayuki Sato
    Abstract:

    A 54-year-old man was admitted because of right supraclavicular lymphadenopathy of some weeks duration. Computed axial tomography revealed a large multinodular lesion in a supraclavicular lymph node. The patient then had a supraclavicular lymph node biopsy. Light microscopy showed a tumor whose structure was suggestive of an Interdigitating Cell sarcoma. Enzyme and immunohistochemical analysis showed that the tumor Cells possessed membranous adenosine triphosphatase activity, intracytoplasmic S100 protein, surface CD1a and CD4 antigens, and HLA-DR antigen. Ultrastructural examination showed that the Cells exhibited many Interdigitating cytoplasmic extensions, but no Birbeck granules. DNA content analysis of the tumor Cells proved that the Cells were malignant. These data are consistent with derivation from a lymph node Interdigitating Cell.

Russell K. Brynes - One of the best experts on this subject based on the ideXlab platform.

  • Dendritic Cell Tumors Associated With Low-Grade B-Cell Malignancies: Report of Three Cases
    American journal of clinical pathology, 1995
    Co-Authors: Mohammad A. Vasef, Ghazi Zaatari, C. Chan, Nora C. J. Sun, Lawrence M. Weiss, Russell K. Brynes
    Abstract:

    Indeterminate and Interdigitating Cell tumors are rare proliferations of immunoregulatory Cells that demonstrate morphologic, immunologic, and ultrastructural features similar to their Cells of origin. Although an association of lymphoproliferative disease with Langerhans' Cell histiocytosis is well described, only sporadic cases of non-Langerhans' dendritic Cell proliferations have been published. The authors describe three patients with low grade B-Cell lymphoproliferative disease who developed subsequent indeterminate Cell or Interdigitating Cell tumors. When the two cases of indeterminate Cell tumor are added to those previously described in the literature, it appears that 4 of 13 cases (31%) are associated with a history of low grade B-Cell malignancy. Possible explanations for the relationship between these two disorders are discussed.

Ivo Lambrichts - One of the best experts on this subject based on the ideXlab platform.

  • Ultrastructure of the human spinal arachnoid mater and dura mater.
    Journal of anatomy, 1996
    Co-Authors: F Vandenabeele, J. Creemers, Ivo Lambrichts
    Abstract:

    Human spinal dura and arachnoid, obtained during neurosurgical operations, were studied by transmission electron microscopy. The ultrastructure of spinal meninges largely conformed to the morphology of the cranial meninges, but some minor differences were detected. The dura was composed of an outermost loosely arranged fibroelastic layer, a middle basically fibrous portion and an innermost Cellular layer (dural border Cell layer). The dural border Cell layer was characterised by multiple Interdigitating Cell processes, no extraCellular collagen, significant extraCellular spaces and few Cell junctions. Paravascular vesiculated nerve profiles were encountered within the fibroadipose epidural tissue. The arachnoid was composed of an outermost portion (arachnoid barrier Cell layer), presenting tightly packed Cells, numerous tight junctions and no extraCellular collagen. In view of its numerous tight junctions, the arachnoid barrier Cell layer is considered to represent an effective morphological and physiological meningeal barrier between the cerebrospinal fluid in the subarachnoid space and the blood circulation in the dura. The arachnoid barrier layer was always characterised by a distinct continuous basal lamina on its inner surface towards the innermost collagenous portion of the arachnoid (arachnoid reticular Cell layer). The interweaving arachnoid trabecular Cells within this layer possessed numerous mitochondria and were anchored to the inner surface of the arachnoid barrier Cell layer by desmosomes. An additional layer of flattened branching Cells was demonstrated along the inner surface of the arachnoid reticular Cell layer and assumed to be an "arachnoid border Cell layer'. Morphological data suggest that the dura and arachnoid closely adhere at spinal levels in man without any naturally occurring "subdural space'. However, structurally, the dural border Cell layer forms a weak Cell layer at the dura-arachnoid continuum that is easily disrupted. The creation of an artifactual subdural space at spinal levels is discussed.