The Experts below are selected from a list of 270 Experts worldwide ranked by ideXlab platform
Deborah Cohan - One of the best experts on this subject based on the ideXlab platform.
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Interferon Gamma release assay compared with the tuberculin skin test for latent tuberculosis detection in pregnancy
Obstetrics & Gynecology, 2011Co-Authors: Ayaba Worjoloh, Rachel Freyre, Natali Aziz, Midori Katomaeda, Dennis Osmond, Deborah CohanAbstract:OBJECTIVE: To estimate agreement and correlation between the tuberculin skin test and an Interferon Gamma release assay for detecting latent tuberculosis (TB) infection in pregnant women. METHODS: We conducted a cross-sectional study of pregnant women initiating prenatal care at a university-affiliated public hospital between January 5, 2009, and March 15, 2010. Eligible women received a questionnaire about TB history and risk factors as well as the tuberculin skin test and phlebotomy for the Interferon Gamma release assay. Agreement and correlation between tests were estimated, and different cutoffs for Interferon Gamma release assay positivity were used to assess effect on agreement. Furthermore, predictors of test positivity and test discordance were evaluated using multivariable analysis. RESULTS: Of the 220 enrolled women, 199 (90.5%) returned for tuberculin skin test evaluation. Over 70% were Hispanic and 65% were born in a country with high TB prevalence. Agreement between the tuberculin skin test and Interferon Gamma release assay was 77.39 (κ=0.26). This agreement was not significantly changed using different cutoffs for the assay. Birth bacille Calmette-Guerin vaccination was associated with tuberculin skin test positivity (odds ratio [OR] 4.33, 95% confidence interval [CI] 1.4–13.48, P=.01), but not Interferon Gamma release assay positivity. There were no statistically significant predictors of the tuberculin skin test and Interferon Gamma release assay result discordance; however, birth in a high-prevalence country was marginally associated with tuberculin skin test-positive and Interferon Gamma release assay-negative results (OR 2.94, 95% CI 0.86–9.97 P=.08). CONCLUSION: Comparing the tuberculin skin test and Interferon Gamma release assay results in pregnancy, concordance and agreement were poor. Given that much is still unknown about the performance of Interferon Gamma release assays in pregnancy, further research is necessary before the tuberculin skin test is abandoned for screening of latent TB infection in pregnancy. LEVEL OF EVIDENCE: III
Alamelu Raja - One of the best experts on this subject based on the ideXlab platform.
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role of quantiferon tb gold Interferon Gamma inducible protein 10 and tuberculin skin test in active tuberculosis diagnosis
PLOS ONE, 2010Co-Authors: Basirudeen Syed Ahamed Kabeer, Balambal Raman, Venkatesan Perumal, A. Thomas, Alamelu RajaAbstract:Background The measurement of Interferon Gamma or Interferon Gamma inducible protein (IP)-10 in antigen stimulated blood samples is suggested as an alternative method for latent tuberculosis (TB) diagnosis. Nonetheless, their role in active TB diagnosis, particularly in TB endemic settings is yet to be defined. In this study, the sensitivities and specificities of Interferon Gamma release assay (IGRA), IP-10 assay and tuberculin skin test (TST) in detecting active TB cases were assessed in human immunodeficiency virus (HIV) sero-negative TB patients and healthy controls respectively.
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Comparison of Interferon Gamma and Interferon Gamma-inducible protein-10 secretion in HIV-tuberculosis patients.
AIDS, 2010Co-Authors: Basirudeen Syed Ahamed Kabeer, Rajasekaran Sikhamani, Alamelu RajaAbstract:Interferon Gamma (IFNγ)-based in-vitro assays have suboptimal sensitivity, especially in immunocompromised individuals, which emphasizes the need for alternative markers for tuberculosis (TB) diagnosis. We compared TB antigens-specific IFNγ and IFNγ-inducible protein-10 levels in culture of whole bl
Ayaba Worjoloh - One of the best experts on this subject based on the ideXlab platform.
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Interferon Gamma release assay compared with the tuberculin skin test for latent tuberculosis detection in pregnancy
Obstetrics & Gynecology, 2011Co-Authors: Ayaba Worjoloh, Rachel Freyre, Natali Aziz, Midori Katomaeda, Dennis Osmond, Deborah CohanAbstract:OBJECTIVE: To estimate agreement and correlation between the tuberculin skin test and an Interferon Gamma release assay for detecting latent tuberculosis (TB) infection in pregnant women. METHODS: We conducted a cross-sectional study of pregnant women initiating prenatal care at a university-affiliated public hospital between January 5, 2009, and March 15, 2010. Eligible women received a questionnaire about TB history and risk factors as well as the tuberculin skin test and phlebotomy for the Interferon Gamma release assay. Agreement and correlation between tests were estimated, and different cutoffs for Interferon Gamma release assay positivity were used to assess effect on agreement. Furthermore, predictors of test positivity and test discordance were evaluated using multivariable analysis. RESULTS: Of the 220 enrolled women, 199 (90.5%) returned for tuberculin skin test evaluation. Over 70% were Hispanic and 65% were born in a country with high TB prevalence. Agreement between the tuberculin skin test and Interferon Gamma release assay was 77.39 (κ=0.26). This agreement was not significantly changed using different cutoffs for the assay. Birth bacille Calmette-Guerin vaccination was associated with tuberculin skin test positivity (odds ratio [OR] 4.33, 95% confidence interval [CI] 1.4–13.48, P=.01), but not Interferon Gamma release assay positivity. There were no statistically significant predictors of the tuberculin skin test and Interferon Gamma release assay result discordance; however, birth in a high-prevalence country was marginally associated with tuberculin skin test-positive and Interferon Gamma release assay-negative results (OR 2.94, 95% CI 0.86–9.97 P=.08). CONCLUSION: Comparing the tuberculin skin test and Interferon Gamma release assay results in pregnancy, concordance and agreement were poor. Given that much is still unknown about the performance of Interferon Gamma release assays in pregnancy, further research is necessary before the tuberculin skin test is abandoned for screening of latent TB infection in pregnancy. LEVEL OF EVIDENCE: III
Basirudeen Syed Ahamed Kabeer - One of the best experts on this subject based on the ideXlab platform.
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role of quantiferon tb gold Interferon Gamma inducible protein 10 and tuberculin skin test in active tuberculosis diagnosis
PLOS ONE, 2010Co-Authors: Basirudeen Syed Ahamed Kabeer, Balambal Raman, Venkatesan Perumal, A. Thomas, Alamelu RajaAbstract:Background The measurement of Interferon Gamma or Interferon Gamma inducible protein (IP)-10 in antigen stimulated blood samples is suggested as an alternative method for latent tuberculosis (TB) diagnosis. Nonetheless, their role in active TB diagnosis, particularly in TB endemic settings is yet to be defined. In this study, the sensitivities and specificities of Interferon Gamma release assay (IGRA), IP-10 assay and tuberculin skin test (TST) in detecting active TB cases were assessed in human immunodeficiency virus (HIV) sero-negative TB patients and healthy controls respectively.
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Comparison of Interferon Gamma and Interferon Gamma-inducible protein-10 secretion in HIV-tuberculosis patients.
AIDS, 2010Co-Authors: Basirudeen Syed Ahamed Kabeer, Rajasekaran Sikhamani, Alamelu RajaAbstract:Interferon Gamma (IFNγ)-based in-vitro assays have suboptimal sensitivity, especially in immunocompromised individuals, which emphasizes the need for alternative markers for tuberculosis (TB) diagnosis. We compared TB antigens-specific IFNγ and IFNγ-inducible protein-10 levels in culture of whole bl
Natali Aziz - One of the best experts on this subject based on the ideXlab platform.
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Interferon Gamma release assay compared with the tuberculin skin test for latent tuberculosis detection in pregnancy
Obstetrics & Gynecology, 2011Co-Authors: Ayaba Worjoloh, Rachel Freyre, Natali Aziz, Midori Katomaeda, Dennis Osmond, Deborah CohanAbstract:OBJECTIVE: To estimate agreement and correlation between the tuberculin skin test and an Interferon Gamma release assay for detecting latent tuberculosis (TB) infection in pregnant women. METHODS: We conducted a cross-sectional study of pregnant women initiating prenatal care at a university-affiliated public hospital between January 5, 2009, and March 15, 2010. Eligible women received a questionnaire about TB history and risk factors as well as the tuberculin skin test and phlebotomy for the Interferon Gamma release assay. Agreement and correlation between tests were estimated, and different cutoffs for Interferon Gamma release assay positivity were used to assess effect on agreement. Furthermore, predictors of test positivity and test discordance were evaluated using multivariable analysis. RESULTS: Of the 220 enrolled women, 199 (90.5%) returned for tuberculin skin test evaluation. Over 70% were Hispanic and 65% were born in a country with high TB prevalence. Agreement between the tuberculin skin test and Interferon Gamma release assay was 77.39 (κ=0.26). This agreement was not significantly changed using different cutoffs for the assay. Birth bacille Calmette-Guerin vaccination was associated with tuberculin skin test positivity (odds ratio [OR] 4.33, 95% confidence interval [CI] 1.4–13.48, P=.01), but not Interferon Gamma release assay positivity. There were no statistically significant predictors of the tuberculin skin test and Interferon Gamma release assay result discordance; however, birth in a high-prevalence country was marginally associated with tuberculin skin test-positive and Interferon Gamma release assay-negative results (OR 2.94, 95% CI 0.86–9.97 P=.08). CONCLUSION: Comparing the tuberculin skin test and Interferon Gamma release assay results in pregnancy, concordance and agreement were poor. Given that much is still unknown about the performance of Interferon Gamma release assays in pregnancy, further research is necessary before the tuberculin skin test is abandoned for screening of latent TB infection in pregnancy. LEVEL OF EVIDENCE: III