The Experts below are selected from a list of 12507 Experts worldwide ranked by ideXlab platform
Debabrata Chakrabarty - One of the best experts on this subject based on the ideXlab platform.
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characterization of nanocellulose reinforced semi Interpenetrating Polymer Network of poly vinyl alcohol polyacrylamide composite films
Carbohydrate Polymers, 2015Co-Authors: Arup Ratan Mandal, Debabrata ChakrabartyAbstract:Semi-Interpenetrating Polymer Network (semi-IPN) of poly(vinyl alcohol)/polyacrylamide was reinforced with various doses of nanocellulose. The different composite films thus prepared were characterized with respect to their mechanical, thermal, morphological and barrier properties. The composite film containing 5 wt.% of nanocellulose showed the highest tensile strength. The semi-Interpenetrating Polymer Network of poly(vinyl alcohol)/polyacrylamide; and its various composites with nanocellulose were almost identical in their thermal stability. Each of the composites however exhibited much superior stability with respect to the linear poly(vinyl alcohol) and crosslinked polyacrylamide. The scanning electron microscopy (SEM) and atomic force microscopy (AFM) studies exhibited phase separated morphology where agglomerates of nanocellulose were found to be dispersed in the matrix of the semi-IPN. The moisture vapor transmission rate (MVTR) was the lowest for the film containing 5 wt.% of nanocellulose.
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Characterization of nanocellulose reinforced semi-Interpenetrating Polymer Network of poly(vinyl alcohol) & polyacrylamide composite films
Carbohydrate Polymers, 2015Co-Authors: Arup Mandal, Debabrata ChakrabartyAbstract:Abstract Semi-Interpenetrating Polymer Network (semi-IPN) of poly(vinyl alcohol)/polyacrylamide was reinforced with various doses of nanocellulose. The different composite films thus prepared were characterized with respect to their mechanical, thermal, morphological and barrier properties. The composite film containing 5 wt.% of nanocellulose showed the highest tensile strength. The semi-Interpenetrating Polymer Network of poly(vinyl alcohol)/polyacrylamide; and its various composites with nanocellulose were almost identical in their thermal stability. Each of the composites however exhibited much superior stability with respect to the linear poly(vinyl alcohol) and crosslinked polyacrylamide. The scanning electron microscopy (SEM) and atomic force microscopy (AFM) studies exhibited phase separated morphology where agglomerates of nanocellulose were found to be dispersed in the matrix of the semi-IPN. The moisture vapor transmission rate (MVTR) was the lowest for the film containing 5 wt.% of nanocellulose.
Tejraj M Aminabhavi - One of the best experts on this subject based on the ideXlab platform.
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novel Interpenetrating Polymer Network hydrogel microspheres of chitosan and poly acrylamide grafted guar gum for controlled release of ciprofloxacin
Industrial & Engineering Chemistry Research, 2011Co-Authors: Praveen B Kajjari, Lata S Manjeshwar, Tejraj M AminabhaviAbstract:Acrylamide-grafted-guar gum (pAAm-g-GG) was prepared and blended with chitosan (CS) to form Interpenetrating Polymer Network (IPN) hydrogel microspheres by the emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. The microspheres encapsulated up to 74% of ciprofloxacin (CFX), an antibiotic drug, having a plasma half-life of 4 h and the release of CFX was extended up to 12 h. Scanning electron microscopy (SEM) confirmed their spherical structure with smooth surfaces; Fourier transform infrared spectroscopy (FTIR) confirmed the grafting reaction as well as chemical stability of CFX in the blend IPN hydrogel microspheres. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques confirmed the molecular level dispersion of CFX in the matrix. Swelling of microspheres performed in pH 7.4 buffer media was used to understand the drug release kinetics. In vitro release of CFX in pH 1.2 and 7.4 media showed a dependence on blend composition of the IPN, extent of cross-link...
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semi Interpenetrating Polymer Network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline
Industrial & Engineering Chemistry Research, 2011Co-Authors: Praveen B Kajjari, Lata S Manjeshwar, Tejraj M AminabhaviAbstract:Semi-Interpenetrating Polymer Network (semi-IPN) hydrogel blend microspheres of gelatin and hydroxyethyl cellulose were prepared by a water-in-oil (w/o) emulsion technique and used to investigate the controlled release (CR) of theophylline (THP), an antiasthamatic drug. About 74% encapsulation of THP was achieved, and the drug release profiles were analyzed in terms of gelatin and hydroxyethyl cellulose blend composition, amount of cross-linking agent, and percentage drug loading. Fourier transform infrared (FTIR) spectroscopy confirmed the formation of the IPN blend matrix, as well as chemical stability of the drug in the microsphere. The physical state of the drug in the IPN matrix as evaluated by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) remained undisturbed. The size of the microspheres varied from 98 to 144 μm as measured by laser light scattering. Scanning electron microscopy (SEM) indicated the smooth surface morphology of the microspheres. Equilibrium and dynamic swelling...
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stearic acid coated chitosan based Interpenetrating Polymer Network microspheres controlled release characteristics
Industrial & Engineering Chemistry Research, 2011Co-Authors: Sudha C Angadi, Lata S Manjeshwar, Tejraj M AminabhaviAbstract:Novel pH-sensitive stearic acid-coated Interpenetrating Polymer Network (IPN) blend microspheres of chitosan and gelatin were prepared by the emulsion cross-linking method using glutaraldehyde for ...
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Interpenetrating Polymer Network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid
International Journal of Biological Macromolecules, 2010Co-Authors: Sudha C Angadi, Lata S Manjeshwar, Tejraj M AminabhaviAbstract:Abstract Glutaraldehyde crosslinked Interpenetrating Polymer Network (IPN) blend microspheres of chitosan (CS) and hydroxyethyl cellulose (HEC) were prepared in the form of microspheres (66–82 μm dia) and investigated for the controlled release (CR) of isoniazid (INH), an antituberculosis drug. Microspheres were characterized by X-ray diffraction (XRD) to study the uniform distribution of drug in the matrices, differential scanning calorimetry (DSC) and thermogravimetry (TGA) to study thermal stabilities of IPN blends. Fourier transform infrared (FTIR) spectroscopy was used to understand chemical interactions and to assess the IPN structure. Scanning electron microscopy (SEM) was employed to investigate the morphology of microspheres. Drug-loaded microspheres were produced in spherical shapes with encapsulation efficiency ranging from 50 to 66%. Equilibrium swelling measured in pH 7.4 buffer solution as well as in vitro release of drug in pH 1.2 and 7.4 buffer solutions indicated the dependence of drug release on crosslinking as well as blend composition of the IPN matrix.
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novel Interpenetrating Polymer Network microspheres of chitosan and methylcellulose for controlled release of theophylline
Carbohydrate Polymers, 2007Co-Authors: Ajit P Rokhade, Namdev B Shelke, Sangamesh A Patil, Tejraj M AminabhaviAbstract:Interpenetrating Polymer Network (IPN) microspheres of chitosan (CS) and methylcellulose (MC) were prepared by emulsion-crosslinking in the presence of glutaraldehyde (GA) as a crosslinker. Theophylline (THP), an antiasthmatic drug was encapsulated into IPN microspheres under varying ratios of MC and CS, % drug loading and amount of GA added. IPNs have shown better mechanical properties than pure CS. Cross-link density of the matrices was significantly affected by the amount of GA and MC. Microspheres were characterized by Fourier transform infrared (FTIR) spectroscopy to assess the formation of IPN structure and to confirm the absence of chemical interactions between drug, Polymer and crosslinking agent. Particle size was measured by laser light scattering technique. Microspheres with the average particle sizes ranging from 119 to 318 μm were produced. Differential scanning calorimetry (DSC) and X-ray diffraction (X-RD) studies were performed to understand the crystalline nature of drug after encapsulation into IPN microspheres. Theophylline encapsulation of up to 82% was achieved as measured by UV spectrometer. Equilibrium swelling was performed in distilled water. In vitro release studies were performed in both 0.1 N HCl and pH 7.4 buffer solutions. These data indicated a dependence of drug release on the extent of crosslinking and amount of MC added during the preparation of microspheres. The release was extended up to 12 h and release rates were fitted to an empirical equation to compute the diffusional parameters, which indicated a slight deviation from the Fickian trend for the release of theophylline.
Lianyong Wang - One of the best experts on this subject based on the ideXlab platform.
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synthesis and characterization of photocrosslinkable gelatin and silk fibroin Interpenetrating Polymer Network hydrogels
Acta Biomaterialia, 2011Co-Authors: Wenqian Xiao, Jiankang He, Jason W Nichol, Lianyong Wang, Che B HutsonAbstract:Abstract To effectively repair or replace damaged tissues, it is necessary to design scaffolds with tunable structural and biomechanical properties that closely mimic the host tissue. In this paper, we describe a newly synthesized photocrosslinkable Interpenetrating Polymer Network (IPN) hydrogel based on gelatin methacrylate (GelMA) and silk fibroin (SF) formed by sequential Polymerization, which possesses tunable structural and biological properties. Experimental results revealed that IPNs, where both the GelMA and SF were independently crosslinked in Interpenetrating Networks, demonstrated a lower swelling ratio, higher compressive modulus and lower degradation rate as compared to the GelMA and semi-IPN hydrogels, where only GelMA was crosslinked. These differences were likely caused by a higher degree of overall crosslinking due to the presence of crystallized SF in the IPN hydrogels. NIH-3T3 fibroblasts readily attached to, spread and proliferated on the surface of IPN hydrogels, as demonstrated by F-actin staining and analysis of mitochondrial activity (MTT). In addition, photolithography combined with lyophilization techniques was used to fabricate three-dimensional micropatterned and porous microscaffolds from GelMA–SF IPN hydrogels, furthering their versatility for use in various microscale tissue engineering applications. Overall, this study introduces a class of photocrosslinkable, mechanically robust and tunable IPN hydrogels that could be useful for various tissue engineering and regenerative medicine applications.
Jiankang He - One of the best experts on this subject based on the ideXlab platform.
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synthesis and characterization of photocrosslinkable gelatin and silk fibroin Interpenetrating Polymer Network hydrogels
Acta Biomaterialia, 2011Co-Authors: Wenqian Xiao, Jiankang He, Jason W Nichol, Lianyong Wang, Che B HutsonAbstract:Abstract To effectively repair or replace damaged tissues, it is necessary to design scaffolds with tunable structural and biomechanical properties that closely mimic the host tissue. In this paper, we describe a newly synthesized photocrosslinkable Interpenetrating Polymer Network (IPN) hydrogel based on gelatin methacrylate (GelMA) and silk fibroin (SF) formed by sequential Polymerization, which possesses tunable structural and biological properties. Experimental results revealed that IPNs, where both the GelMA and SF were independently crosslinked in Interpenetrating Networks, demonstrated a lower swelling ratio, higher compressive modulus and lower degradation rate as compared to the GelMA and semi-IPN hydrogels, where only GelMA was crosslinked. These differences were likely caused by a higher degree of overall crosslinking due to the presence of crystallized SF in the IPN hydrogels. NIH-3T3 fibroblasts readily attached to, spread and proliferated on the surface of IPN hydrogels, as demonstrated by F-actin staining and analysis of mitochondrial activity (MTT). In addition, photolithography combined with lyophilization techniques was used to fabricate three-dimensional micropatterned and porous microscaffolds from GelMA–SF IPN hydrogels, furthering their versatility for use in various microscale tissue engineering applications. Overall, this study introduces a class of photocrosslinkable, mechanically robust and tunable IPN hydrogels that could be useful for various tissue engineering and regenerative medicine applications.
Ecaterina Stela Dragan - One of the best experts on this subject based on the ideXlab platform.
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Interpenetrating Polymer Network Composite Cryogels with Tailored Porous Morphology and Sorption Properties
Methods of Molecular Biology, 2020Co-Authors: Ecaterina Stela Dragan, Maria Valentina DinuAbstract:Cryogels, by their particular morphology and mechanical properties, proved to be invaluable materials in biomedicine and biotechnology as carriers for molecules and cells, chromatographic materials for cell separations and cell culture. Methods used in the characterization of porosity and sorption properties of cryogels are very needful tools, which assist the investigator in the decision on the performances of the gel. Herein, we describe the preparation of ionic Interpenetrating Polymer Network composite cryogels and the characterization methods of their porous morphology, and then the methods used for testing their sorption properties for ionic dyes used as models for drugs.
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sorption isotherms of heavy metal ions onto semi Interpenetrating Polymer Network cryogels based on polyacrylamide and anionically modified potato starch
Industrial & Engineering Chemistry Research, 2012Co-Authors: Diana Felicia Apopei, Maria Valentina Dinu, Andrzej W Trochimczuk, Ecaterina Stela DraganAbstract:Semi-Interpenetrating Polymer Network (semi-IPN) cryogels based on polyacrylamide (PAAm) and anionically modified potato starch (PA) were synthesized and tested as sorbents for heavy metal ions like: Cu2+, Cd2+, Ni2+, and Zn2+ from aqueous solutions by batch-mode under noncompetitive conditions. Experimental data obtained from batch equilibrium tests have been analyzed using four models: Langmuir, Freundlich, Temkin, and Sips isotherms. The equilibrium data obtained for the sorption of heavy metal ions onto the semi-IPN cryogels were well fitted in the Sips nonlinear regression model with a maximum theoretical sorption capacity of 40.72 mg Cu2+/g composite, 19.27 mg Cd2+/g composite, 9.31 mg Ni2+/g composite, and 7.48 mg Zn2+/g composite.
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synthesis and swelling behavior of ph sensitive semi Interpenetrating Polymer Network composite hydrogels based on native and modified potatoes starch as potential sorbent for cationic dyes
Chemical Engineering Journal, 2011Co-Authors: Ecaterina Stela Dragan, Diana Felicia ApopeiAbstract:Abstract Semi-Interpenetrating Polymer Network (semi-IPN) composite hydrogels based on polyacrylamide (PAAm) as a matrix and either native potatoes starch (PS) or the hydrolyzed PS- g -PAN coPolymer as entrapped Polymer have been prepared using N,N-methylenebisacrylamide (BAAm) as cross-linker, ammonium persulfate as radical initiator and N,N,N′,N′-tetramethylethylenediamine as accelerator of free-radical Polymerization. The composite hydrogels have been characterized by FT-IR and swelling behavior as a function of the cross-linker ratio. The kinetics of Methylene Blue (MB) adsorption on the semi-IPN composite hydrogels has been investigated as a function of the nature of the entrapped Polymer in PAAm matrix. Sorption of MB on the composite hydrogels has been well described by the pseudo-first order kinetic model, which support physisorption dominates the adsorption process. The dye adsorption tests up to four adsorption/desorption cycles support the reusability of the composite hydrogels as sorbents for cationic dyes.
