The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Tetsuhito Murata - One of the best experts on this subject based on the ideXlab platform.
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Neuronal damage in the Interval Form of CO poisoning determined by serial diffusion weighted magnetic resonance imaging plus ^1H-magnetic resonance spectroscopy
Journal of neurology neurosurgery and psychiatry, 2001Co-Authors: Tetsuhito Murata, Masao Omori, H Kimura, Hirotsugu Kado, J Onizuka, T Takahashi, Harumi Itoh, Y WadaAbstract:In a patient with the Interval Form of carbon monoxide (CO) poisoning diffusion weighted MRI and proton magnetic resonance spectroscopy ( 1 H-MRS) were serially perFormed immediately after the appearance of delayed sequelae (the 23rd day after exposure). During the period in which few clear findings were evident on MRI T2 weighted images, a high signal area in the cerebral white matter and relative decrease in the apparent diffusion coefficient (ADCav) were already apparent on diffusion weighted images, with these findings thought to sensitively reflect the tissue injury associated with the onset of sequelae. The decrease in relative ADCav persisted until the 38th day after exposure. Subsequently, ADCav gradually increased, and in the cerebral white matter showed higher values in the 118th day after exposure than immediately after the onset of sequelae. During this period, on 1 H-MRS choline containing compounds showed persistently high values throughout the course, with N-acetylaspartate depletion and the appearance of a lactate peak later in the course. These findings, with regional specificity in the cerebral white matter, reflect the developmental process of the white matter lesions in the Interval Form of CO poisoning in which demyelination progresses leading to neuronal necrosis. Serial diffusion weighted imaging plus 1 H-MRS measurements are useful in determining the tissue damage and long term outcome of delayed sequelae associated with the Interval Form of CO poisoning.
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Clinical studies on three cases of the Interval Form of carbon monoxide poisoning : serial proton magnetic resonance spectroscopy as a prognostic predictor
Psychiatry research, 1998Co-Authors: K. Sakamoto, Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, Y Ishii, Hirohiko Kimura, Masashi Nishio, Kiminori IsakiAbstract:Three patients with the Interval Form of carbon monoxide (CO) poisoning were studied for associations between their clinical courses and serial changes on: (1) MRI; (2) EEG; (3) single photon emission computed tomography with N-isopropyl-p-[123I]iodoamphetamine ([123I]IMP SPECT); and (4) proton magnetic resonance spectroscopy ([1HIMRS) to evaluate their usefulness as prognostic predictors. A hyperintense area on MRI T2-weighted images and a hypointense area on T1-weighted images, appearing in the deep white matter, persisted for a prolonged period even after improvement of the clinical symptoms, and did not become an accurate indicator of clinical evaluation or prognosis. [1H]MRS studies with the volume of interest set in the frontal lobe white matter revealed increases in choline-containing compounds, and reductions of N-acetylaspartate in all cases. These findings normalized in one subclinical case over time. Distinctive findings in the severe cases included increased lactate in two cases showing akinetic mutism, with a difference in prognosis noted according to the degree and period of persistence of this increase. EEG findings were relatively well correlated with clinical symptoms in the early period, with a good correlation no longer consistent after a certain period was exceeded. [123I]IMP SPECT findings did not always reflectclinical symptomatology either. These results indicate that [1H]MRS is the most useful indicator in the clinical evaluation of patients with the Interval Form of CO poisoning.
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Serial proton magnetic resonance spectroscopy in a patient with the Interval Form of carbon monoxide poisoning.
Journal of neurology neurosurgery and psychiatry, 1995Co-Authors: Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, K. Sakamoto, Kiminori Isaki, H Kimura, Y IshiiAbstract:Serial proton magnetic resonance spectroscopy (1H-MRS) studies were perFormed from immediately after the appearance of sequelae in a patient with the Interval Form of carbon monoxide (CO) poisoning. The volume of interest was set over the frontal lobe white matter. In the early period a persistent increase in choline was found, which was thought to reflect the course of progressive demyelination. The appearance of lactate and decrease in N-acetylaspartate reflected the point at which neuron injury became irreversible. These were followed later by the finding of irreversible changes on MRI and single photon emission computed tomography. The findings suggest that 1H-MRS may be a useful modality to determine neuron viability and prognosis early in the course of the Interval Form of CO poisoning.
Y Ishii - One of the best experts on this subject based on the ideXlab platform.
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Clinical studies on three cases of the Interval Form of carbon monoxide poisoning : serial proton magnetic resonance spectroscopy as a prognostic predictor
Psychiatry research, 1998Co-Authors: K. Sakamoto, Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, Y Ishii, Hirohiko Kimura, Masashi Nishio, Kiminori IsakiAbstract:Three patients with the Interval Form of carbon monoxide (CO) poisoning were studied for associations between their clinical courses and serial changes on: (1) MRI; (2) EEG; (3) single photon emission computed tomography with N-isopropyl-p-[123I]iodoamphetamine ([123I]IMP SPECT); and (4) proton magnetic resonance spectroscopy ([1HIMRS) to evaluate their usefulness as prognostic predictors. A hyperintense area on MRI T2-weighted images and a hypointense area on T1-weighted images, appearing in the deep white matter, persisted for a prolonged period even after improvement of the clinical symptoms, and did not become an accurate indicator of clinical evaluation or prognosis. [1H]MRS studies with the volume of interest set in the frontal lobe white matter revealed increases in choline-containing compounds, and reductions of N-acetylaspartate in all cases. These findings normalized in one subclinical case over time. Distinctive findings in the severe cases included increased lactate in two cases showing akinetic mutism, with a difference in prognosis noted according to the degree and period of persistence of this increase. EEG findings were relatively well correlated with clinical symptoms in the early period, with a good correlation no longer consistent after a certain period was exceeded. [123I]IMP SPECT findings did not always reflectclinical symptomatology either. These results indicate that [1H]MRS is the most useful indicator in the clinical evaluation of patients with the Interval Form of CO poisoning.
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Serial proton magnetic resonance spectroscopy in a patient with the Interval Form of carbon monoxide poisoning.
Journal of neurology neurosurgery and psychiatry, 1995Co-Authors: Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, K. Sakamoto, Kiminori Isaki, H Kimura, Y IshiiAbstract:Serial proton magnetic resonance spectroscopy (1H-MRS) studies were perFormed from immediately after the appearance of sequelae in a patient with the Interval Form of carbon monoxide (CO) poisoning. The volume of interest was set over the frontal lobe white matter. In the early period a persistent increase in choline was found, which was thought to reflect the course of progressive demyelination. The appearance of lactate and decrease in N-acetylaspartate reflected the point at which neuron injury became irreversible. These were followed later by the finding of irreversible changes on MRI and single photon emission computed tomography. The findings suggest that 1H-MRS may be a useful modality to determine neuron viability and prognosis early in the course of the Interval Form of CO poisoning.
Masao Omori - One of the best experts on this subject based on the ideXlab platform.
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Neuronal damage in the Interval Form of CO poisoning determined by serial diffusion weighted magnetic resonance imaging plus ^1H-magnetic resonance spectroscopy
Journal of neurology neurosurgery and psychiatry, 2001Co-Authors: Tetsuhito Murata, Masao Omori, H Kimura, Hirotsugu Kado, J Onizuka, T Takahashi, Harumi Itoh, Y WadaAbstract:In a patient with the Interval Form of carbon monoxide (CO) poisoning diffusion weighted MRI and proton magnetic resonance spectroscopy ( 1 H-MRS) were serially perFormed immediately after the appearance of delayed sequelae (the 23rd day after exposure). During the period in which few clear findings were evident on MRI T2 weighted images, a high signal area in the cerebral white matter and relative decrease in the apparent diffusion coefficient (ADCav) were already apparent on diffusion weighted images, with these findings thought to sensitively reflect the tissue injury associated with the onset of sequelae. The decrease in relative ADCav persisted until the 38th day after exposure. Subsequently, ADCav gradually increased, and in the cerebral white matter showed higher values in the 118th day after exposure than immediately after the onset of sequelae. During this period, on 1 H-MRS choline containing compounds showed persistently high values throughout the course, with N-acetylaspartate depletion and the appearance of a lactate peak later in the course. These findings, with regional specificity in the cerebral white matter, reflect the developmental process of the white matter lesions in the Interval Form of CO poisoning in which demyelination progresses leading to neuronal necrosis. Serial diffusion weighted imaging plus 1 H-MRS measurements are useful in determining the tissue damage and long term outcome of delayed sequelae associated with the Interval Form of CO poisoning.
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Clinical studies on three cases of the Interval Form of carbon monoxide poisoning : serial proton magnetic resonance spectroscopy as a prognostic predictor
Psychiatry research, 1998Co-Authors: K. Sakamoto, Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, Y Ishii, Hirohiko Kimura, Masashi Nishio, Kiminori IsakiAbstract:Three patients with the Interval Form of carbon monoxide (CO) poisoning were studied for associations between their clinical courses and serial changes on: (1) MRI; (2) EEG; (3) single photon emission computed tomography with N-isopropyl-p-[123I]iodoamphetamine ([123I]IMP SPECT); and (4) proton magnetic resonance spectroscopy ([1HIMRS) to evaluate their usefulness as prognostic predictors. A hyperintense area on MRI T2-weighted images and a hypointense area on T1-weighted images, appearing in the deep white matter, persisted for a prolonged period even after improvement of the clinical symptoms, and did not become an accurate indicator of clinical evaluation or prognosis. [1H]MRS studies with the volume of interest set in the frontal lobe white matter revealed increases in choline-containing compounds, and reductions of N-acetylaspartate in all cases. These findings normalized in one subclinical case over time. Distinctive findings in the severe cases included increased lactate in two cases showing akinetic mutism, with a difference in prognosis noted according to the degree and period of persistence of this increase. EEG findings were relatively well correlated with clinical symptoms in the early period, with a good correlation no longer consistent after a certain period was exceeded. [123I]IMP SPECT findings did not always reflectclinical symptomatology either. These results indicate that [1H]MRS is the most useful indicator in the clinical evaluation of patients with the Interval Form of CO poisoning.
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Serial proton magnetic resonance spectroscopy in a patient with the Interval Form of carbon monoxide poisoning.
Journal of neurology neurosurgery and psychiatry, 1995Co-Authors: Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, K. Sakamoto, Kiminori Isaki, H Kimura, Y IshiiAbstract:Serial proton magnetic resonance spectroscopy (1H-MRS) studies were perFormed from immediately after the appearance of sequelae in a patient with the Interval Form of carbon monoxide (CO) poisoning. The volume of interest was set over the frontal lobe white matter. In the early period a persistent increase in choline was found, which was thought to reflect the course of progressive demyelination. The appearance of lactate and decrease in N-acetylaspartate reflected the point at which neuron injury became irreversible. These were followed later by the finding of irreversible changes on MRI and single photon emission computed tomography. The findings suggest that 1H-MRS may be a useful modality to determine neuron viability and prognosis early in the course of the Interval Form of CO poisoning.
Kiminori Isaki - One of the best experts on this subject based on the ideXlab platform.
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Clinical studies on three cases of the Interval Form of carbon monoxide poisoning : serial proton magnetic resonance spectroscopy as a prognostic predictor
Psychiatry research, 1998Co-Authors: K. Sakamoto, Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, Y Ishii, Hirohiko Kimura, Masashi Nishio, Kiminori IsakiAbstract:Three patients with the Interval Form of carbon monoxide (CO) poisoning were studied for associations between their clinical courses and serial changes on: (1) MRI; (2) EEG; (3) single photon emission computed tomography with N-isopropyl-p-[123I]iodoamphetamine ([123I]IMP SPECT); and (4) proton magnetic resonance spectroscopy ([1HIMRS) to evaluate their usefulness as prognostic predictors. A hyperintense area on MRI T2-weighted images and a hypointense area on T1-weighted images, appearing in the deep white matter, persisted for a prolonged period even after improvement of the clinical symptoms, and did not become an accurate indicator of clinical evaluation or prognosis. [1H]MRS studies with the volume of interest set in the frontal lobe white matter revealed increases in choline-containing compounds, and reductions of N-acetylaspartate in all cases. These findings normalized in one subclinical case over time. Distinctive findings in the severe cases included increased lactate in two cases showing akinetic mutism, with a difference in prognosis noted according to the degree and period of persistence of this increase. EEG findings were relatively well correlated with clinical symptoms in the early period, with a good correlation no longer consistent after a certain period was exceeded. [123I]IMP SPECT findings did not always reflectclinical symptomatology either. These results indicate that [1H]MRS is the most useful indicator in the clinical evaluation of patients with the Interval Form of CO poisoning.
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Serial proton magnetic resonance spectroscopy in a patient with the Interval Form of carbon monoxide poisoning.
Journal of neurology neurosurgery and psychiatry, 1995Co-Authors: Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, K. Sakamoto, Kiminori Isaki, H Kimura, Y IshiiAbstract:Serial proton magnetic resonance spectroscopy (1H-MRS) studies were perFormed from immediately after the appearance of sequelae in a patient with the Interval Form of carbon monoxide (CO) poisoning. The volume of interest was set over the frontal lobe white matter. In the early period a persistent increase in choline was found, which was thought to reflect the course of progressive demyelination. The appearance of lactate and decrease in N-acetylaspartate reflected the point at which neuron injury became irreversible. These were followed later by the finding of irreversible changes on MRI and single photon emission computed tomography. The findings suggest that 1H-MRS may be a useful modality to determine neuron viability and prognosis early in the course of the Interval Form of CO poisoning.
K. Sakamoto - One of the best experts on this subject based on the ideXlab platform.
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Clinical studies on three cases of the Interval Form of carbon monoxide poisoning : serial proton magnetic resonance spectroscopy as a prognostic predictor
Psychiatry research, 1998Co-Authors: K. Sakamoto, Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, Y Ishii, Hirohiko Kimura, Masashi Nishio, Kiminori IsakiAbstract:Three patients with the Interval Form of carbon monoxide (CO) poisoning were studied for associations between their clinical courses and serial changes on: (1) MRI; (2) EEG; (3) single photon emission computed tomography with N-isopropyl-p-[123I]iodoamphetamine ([123I]IMP SPECT); and (4) proton magnetic resonance spectroscopy ([1HIMRS) to evaluate their usefulness as prognostic predictors. A hyperintense area on MRI T2-weighted images and a hypointense area on T1-weighted images, appearing in the deep white matter, persisted for a prolonged period even after improvement of the clinical symptoms, and did not become an accurate indicator of clinical evaluation or prognosis. [1H]MRS studies with the volume of interest set in the frontal lobe white matter revealed increases in choline-containing compounds, and reductions of N-acetylaspartate in all cases. These findings normalized in one subclinical case over time. Distinctive findings in the severe cases included increased lactate in two cases showing akinetic mutism, with a difference in prognosis noted according to the degree and period of persistence of this increase. EEG findings were relatively well correlated with clinical symptoms in the early period, with a good correlation no longer consistent after a certain period was exceeded. [123I]IMP SPECT findings did not always reflectclinical symptomatology either. These results indicate that [1H]MRS is the most useful indicator in the clinical evaluation of patients with the Interval Form of CO poisoning.
-
Serial proton magnetic resonance spectroscopy in a patient with the Interval Form of carbon monoxide poisoning.
Journal of neurology neurosurgery and psychiatry, 1995Co-Authors: Tetsuhito Murata, S Itoh, Y. Koshino, Masao Omori, I Murata, K. Sakamoto, Kiminori Isaki, H Kimura, Y IshiiAbstract:Serial proton magnetic resonance spectroscopy (1H-MRS) studies were perFormed from immediately after the appearance of sequelae in a patient with the Interval Form of carbon monoxide (CO) poisoning. The volume of interest was set over the frontal lobe white matter. In the early period a persistent increase in choline was found, which was thought to reflect the course of progressive demyelination. The appearance of lactate and decrease in N-acetylaspartate reflected the point at which neuron injury became irreversible. These were followed later by the finding of irreversible changes on MRI and single photon emission computed tomography. The findings suggest that 1H-MRS may be a useful modality to determine neuron viability and prognosis early in the course of the Interval Form of CO poisoning.
