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Mingjong Bair - One of the best experts on this subject based on the ideXlab platform.
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A Rare Case of Chronic Diarrhea in an Elderly Male
International Journal of Gerontology, 2009Co-Authors: Mingjong Bair, Huan-lin Chen, Wen-hsiung Chang, Shou-chuan ShihAbstract:SUMMARY Chronic diarrhea is a common condition in older age groups, and many patients do not seek medical attention unless their diarrhea is associated with other symptoms, such as weight loss, gastroIntestinal bleeding or abdominal pain. It is a critical condition in the elderly, especially with systemic disease. We report the case of an elderly patient with chronic diarrhea secondary to Intestinal Capillariasis. Human Intestinal Capillariasis is a rare parasitosis of the gastroIntestinal tract, which may be a fatal disease if early treatment is not given. The clinical hallmarks of Capillariasis include chronic diarrhea, abdominal pain, borborygmi, marked weight loss, protein and electrolyte loss, and cachexia. Most patients die from electrolyte loss resulting in heart failure and/or septicemia. Taiwan, particularly in Taitung County, is a Capillaria-prevalent area. Thus, parasitosis must be considered in the differential diagnosis of patients with debilitating chronic diarrhea, especially in the elderly aboriginal population of Taitung County. A careful dietary and travel history is important in any such case; but even in the absence of clear-cut exposure, a parasitic infection should be considered and carefully investigated. (International Journal of Gerontology 2009; 3(2): 122-125)
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human Intestinal Capillariasis capillaria philippinensis in taiwan
American Journal of Tropical Medicine and Hygiene, 2006Co-Authors: Li Hua Lu, Wai Mau Choi, Kaopin Hwang, Mingjong Bair, Tsang En Wang, W C ChungAbstract:Capillaria philippinensis was first reported in 1963 in the Philippines. Major outbreaks have occurred in the Philippines and Thailand. This article reviews the known 30 Intestinal Capillariasis cases in Taiwan from January 1983 to December 2003. The infected cases were diagnosed each year with the exception of 1984 and 2002, making Taiwan a capillaria-prevalent area. Two Taiwanese aboriginal tribes, the Ami and Paiwan, presented a high prevalence. The males and elderly also had a high infection rate. Nine cases were diagnosed by histopathological biopsied specimens. About half of the 30 cases denied having consumed raw or undercooked fish. All cases recovered to health after receiving medication, with no deaths or recurrences.
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clinical features of human Intestinal Capillariasis in taiwan
World Journal of Gastroenterology, 2004Co-Authors: Mingjong Bair, Kaopin Hwang, Tsang En Wang, Taoyeuan Wang, Taicherng Liou, Kwokkuen PangAbstract:Human Intestinal Capillariasis is a rare parasitosis that was first recognized in the Philippines in the 1960 s. Parasitosis is a life threatening disease and has been reported from Thailand, Japan, South of Taiwan (Kaoh-Siung), Korea, Iran, Egypt, Italy and Spain. Its clinical symptoms are characterized by chronic diarrhea, abdominal pain, borborygmus, marked weight loss, protein and electrolyte loss and cachexia. Capillariasis may be fatal if early treatment is not given. We reported 14 cases living in rural areas of Taiwan. Three cases had histories of travelling to Thailand. They might have been infected in Thailand while stayed there. Two cases had the diet of raw freshwater fish before. Three cases received emergency laparotomy due to peritonitis and two cases were found of enteritis cystica profunda. According to the route of transmission, freshwater and brackish-water fish may act as the intermediate host of the parasite. The most simple and convenient method of diagnosing Capillariasis is stool examination. Two cases were diagnosed by histology. Mebendazole or albendezole 200 mg orally twice a day for 20-30 d is the treatment of choice. All the patients were cured, and relapses were not observed within 12 mo.
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human Intestinal Capillariasis with enteritis cystica profunda report of two cases
臺灣消化醫學雜誌, 2003Co-Authors: Mingjong Bair, Tsang En Wang, Taoyeuan WangAbstract:Human Intestinal Capillariasis is a rare parasitosis first recognized in the Philippines in the 1960s. It is a potentially life-threatening disease that has also been reported in Thailand, Japan, southern Taiwan (Kaohsiung), Korea, Iran, Egypt, Italy and Spain. Symptoms include chronic diarrhea, abdominal pain, borborygmi, marked weight loss, protein and electrolyte loss, and cachexia. We report two patients with Capillariasis living in rural Taiwan. They had no history of travelling abroad or eating raw freshwater fish. Both underwent emergency laparotomy for peritonitis and were found to have enteritis cystica profunda. They both had good responses to mebendazole.
Nimit Morakote - One of the best experts on this subject based on the ideXlab platform.
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AN ENZYME-LINKED IMMUNOSORBENT ASSAY AS SCREENING TOOL FOR HUMAN Intestinal Capillariasis
Southeast Asian Journal of Tropical Medicine and Public Health, 2010Co-Authors: Pewpan M Intapan, Wattana Sukeepaisarnjaroen, Wanchai Maleewong, Nimit MorakoteAbstract:Human Intestinal Capillariasis caused by Capillaria philippinensis is char- acterized by chronic diarrhea which may lead to death if left untreated. The mor- tality is highest among patients who are negative by conventional stool examina- tion. Therefore this study explored the application of an enzyme-linked immunosorbent assay (ELISA) as a screening test for human Intestinal capillari- asis. The ELISA was developed using Trichinella spiralis soluble antigen for the detection of antibodies against C. philippinensis. A cut-off level at the upper 99% limit of the absorbance values of the healthy controls was established for positiv- ity. All Intestinal Capillariasis sera showed positive ELISA, demonstrating 100% sensitivity, while all healthy control sera gave absorbance values below the cut-off level, resulting in 100% specificity. The ELISA was also positive with 75% of trichinellosis, 13.9% of strongyloidiasis, 9.1% of trichuriasis, and 4.2% of opisthor- chiasis sera. The ELISA and immunoblot were in agreement in 91.1% of the sera tested. It was suggested that the here-presented ELISA is capable to detect intesti- nal Capillariasis cases in endemic areas whose coproscopy is negative for worm eggs, larvae or adults.
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Potential use of Trichinella spiralis antigen for serodiagnosis of human Capillariasis philippinensis by immunoblot analysis
Parasitology Research, 2006Co-Authors: Pewpan M Intapan, Wattana Sukeepaisarnjaroen, Wanchai Maleewong, Nimit MorakoteAbstract:Intestinal Capillariasis is an emerging helminthic zoonosis caused by Capillaria philippinensis and is frequently fatal if not diagnosed correctly. The present study demonstrates cross-reactivity between Trichinella spiralis larval antigens and C. philippinensis -infected human sera by immunoblotting. Sera from 16 proven Intestinal Capillariasis patients and 16 proven trichinosis patients were tested. The antigenic patterns recognized by Intestinal Capillariasis sera varied with the molecular masses, ranging from less than 20.1 to more than 94 kDa. The immunoblotting profiles of the trichinosis sera were similar to those of the Intestinal Capillariasis sera. The antigenic bands with 100% reactivity were located at 36.5, 40.5, and 54 kDa, respectively. Sera from patients with trichuriasis, strongyloidiasis, opisthorchiasis, and healthy controls differed clearly from the previous two and produced very faint patterns of reactivity and attenuated bands. This assay is potentially useful for large-scale screenings of persons at risk for C. philippinensis infection. Parasitological stool examinations of the positive cases are necessary as second-tier laboratory tests for confirming the diagnosis.
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The value of enzyme-linked immunosorbent assay (ELISA) for diagnosis of human trichinosis
Tropical medicine and parasitology, 1991Co-Authors: Nimit Morakote, Chirasak Khamboonruang, V. Siriprasert, S. Suphawitayanukul, S. Marcanantachoti, W. ThamasonthiAbstract:Sera were collected from proven cases of trichinosis and other helminthic infections and examined for IgG and IgM antibodies by an enzyme-linked immunosorbent assay (ELISA). IgG-ELISA was positive in 68.75, 100, and 100% of cases on 23rd, 50th, 57th day of infection while IgM-ELISA was positive in 12.50, 85.71, 93.33% respectively. In the group with parasitic infections other than trichinosis 20.93% were positive by IgG-ELISA and strong cross-reactivity was prominent with Intestinal Capillariasis. With IgM-ELISA, positivity in the group with other parasitic infections was 9.30%. It was suggested that sera should be examined not before 1 month after infection to achieve maximum sensitivity for serodiagnosis of human trichinosis.
Pewpan M Intapan - One of the best experts on this subject based on the ideXlab platform.
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A Hospital-Based Study of Intestinal Capillariasis in Thailand: Clinical Features, Potential Clues for Diagnosis, and Epidemiological Characteristics of 85 Patients
American Journal of Tropical Medicine and Hygiene, 2018Co-Authors: Lakkhana Sadaow, Wattana Sukeepaisarnjaroen, Thidarat K. Prasongdee, Pewpan M Intapan, Oranuch Sanpool, Wanchai MaleewongAbstract:Abstract. Intestinal Capillariasis caused by Capillaria philippinensis, a fish-borne nematode, is an important, emerging zoonotic helminthiasis. Cases may be fatal if suitable treatment is not administered in time. We reported a hospital-based study of 85 cases in Thailand, most of which were in the northeast. All patients had a history of eating raw or insufficiently cooked fresh water fish or prawns. The clinical manifestations are characterized by chronic diarrhea, borborygmi, abdominal pain, marked weight loss, muscle weakness, fatigue, dizziness, anorexia, and edema, as well as protein and electrolyte loss. Fecal examination revealed C. philippinensis in all patients. Although 16 of the total of 85 (18.8%) cases were initially found to be negative for C. philippinensis using fecal examination, further examination using an immunoblotting technique found them to be positive for the IgG antibody against Trichinella spiralis larval antigen. One day after administration of 400 mg of albendazole, eggs and/or larvae and/or adult C. philippinensis were found in 16 fecal samples. After treatment with mebendazole (200 mg twice a day for 30 days) or albendazole (200 mg twice a day for 10 days), all 85 patients recovered. The potential clues for diagnosis are clinical manifestations, history of eating raw contaminated food, and positive serological test, and fecal examinations under professional. Administration of anthelminthic drugs stimulates the excretion of larvae, eggs, and/or adult worms and can be used as a supportive method for the diagnosis of Intestinal Capillariasis in areas where serological test is not available.
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Development and evaluation of a rapid diagnostic immunochromatographic device to detect antibodies in sera from Intestinal Capillariasis cases
Parasitology Research, 2017Co-Authors: Pewpan M Intapan, Lakkhana Sadaow, Oranuch Sanpool, Rutchanee Rodpai, Tongjit Thanchomnang, Issarapong Phosuk, Wanchai MaleewongAbstract:Intestinal Capillariasis, a fish-borne nematodiasis, is an important emerging zoonotic disease. Patients present clinical symptoms of borborygmus chronic diarrhea, intermittent abdominal pain, weight loss, and several degrees of painless lower-leg edema. Death may occur in cases of misdiagnosis and improper treatment. Diagnosis is difficult because of the atypical clinical symptoms and diagnostic confusion with diarrhea caused by gastroIntestinal cancer, opportunistic infections in human immunodeficiency virus patients, and hyperthyroidism. In addition, parasite eggs are not always found in stool examination. Serology can provide a supportive diagnostic tool. We have produced a rapid and simple immunochromatographic test (ICT) kit for diagnosis of Intestinal Capillariasis by detection of diagnostic antibodies in human sera. Serum samples from healthy volunteers and patients with proven Intestinal Capillariasis and other parasitic diseases were evaluated with the Trichinella spiralis larval extract antigen absorbed ICT strips. The diagnostic sensitivity, specificity, and positive and negative predictive values were 100, 96.6, 90.2, and 100%, respectively. The ICT kit is simple and rapid to use and can supplement stool examination in clinical diagnosis of Intestinal Capillariasis. The test can be completed in 15 min without a need for any sophisticated instruments or reagents.
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AN ENZYME-LINKED IMMUNOSORBENT ASSAY AS SCREENING TOOL FOR HUMAN Intestinal Capillariasis
Southeast Asian Journal of Tropical Medicine and Public Health, 2010Co-Authors: Pewpan M Intapan, Wattana Sukeepaisarnjaroen, Wanchai Maleewong, Nimit MorakoteAbstract:Human Intestinal Capillariasis caused by Capillaria philippinensis is char- acterized by chronic diarrhea which may lead to death if left untreated. The mor- tality is highest among patients who are negative by conventional stool examina- tion. Therefore this study explored the application of an enzyme-linked immunosorbent assay (ELISA) as a screening test for human Intestinal capillari- asis. The ELISA was developed using Trichinella spiralis soluble antigen for the detection of antibodies against C. philippinensis. A cut-off level at the upper 99% limit of the absorbance values of the healthy controls was established for positiv- ity. All Intestinal Capillariasis sera showed positive ELISA, demonstrating 100% sensitivity, while all healthy control sera gave absorbance values below the cut-off level, resulting in 100% specificity. The ELISA was also positive with 75% of trichinellosis, 13.9% of strongyloidiasis, 9.1% of trichuriasis, and 4.2% of opisthor- chiasis sera. The ELISA and immunoblot were in agreement in 91.1% of the sera tested. It was suggested that the here-presented ELISA is capable to detect intesti- nal Capillariasis cases in endemic areas whose coproscopy is negative for worm eggs, larvae or adults.
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Potential use of Trichinella spiralis antigen for serodiagnosis of human Capillariasis philippinensis by immunoblot analysis
Parasitology Research, 2006Co-Authors: Pewpan M Intapan, Wattana Sukeepaisarnjaroen, Wanchai Maleewong, Nimit MorakoteAbstract:Intestinal Capillariasis is an emerging helminthic zoonosis caused by Capillaria philippinensis and is frequently fatal if not diagnosed correctly. The present study demonstrates cross-reactivity between Trichinella spiralis larval antigens and C. philippinensis -infected human sera by immunoblotting. Sera from 16 proven Intestinal Capillariasis patients and 16 proven trichinosis patients were tested. The antigenic patterns recognized by Intestinal Capillariasis sera varied with the molecular masses, ranging from less than 20.1 to more than 94 kDa. The immunoblotting profiles of the trichinosis sera were similar to those of the Intestinal Capillariasis sera. The antigenic bands with 100% reactivity were located at 36.5, 40.5, and 54 kDa, respectively. Sera from patients with trichuriasis, strongyloidiasis, opisthorchiasis, and healthy controls differed clearly from the previous two and produced very faint patterns of reactivity and attenuated bands. This assay is potentially useful for large-scale screenings of persons at risk for C. philippinensis infection. Parasitological stool examinations of the positive cases are necessary as second-tier laboratory tests for confirming the diagnosis.
Kaopin Hwang - One of the best experts on this subject based on the ideXlab platform.
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human Intestinal Capillariasis capillaria philippinensis in taiwan
American Journal of Tropical Medicine and Hygiene, 2006Co-Authors: Li Hua Lu, Wai Mau Choi, Kaopin Hwang, Mingjong Bair, Tsang En Wang, W C ChungAbstract:Capillaria philippinensis was first reported in 1963 in the Philippines. Major outbreaks have occurred in the Philippines and Thailand. This article reviews the known 30 Intestinal Capillariasis cases in Taiwan from January 1983 to December 2003. The infected cases were diagnosed each year with the exception of 1984 and 2002, making Taiwan a capillaria-prevalent area. Two Taiwanese aboriginal tribes, the Ami and Paiwan, presented a high prevalence. The males and elderly also had a high infection rate. Nine cases were diagnosed by histopathological biopsied specimens. About half of the 30 cases denied having consumed raw or undercooked fish. All cases recovered to health after receiving medication, with no deaths or recurrences.
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clinical features of human Intestinal Capillariasis in taiwan
World Journal of Gastroenterology, 2004Co-Authors: Mingjong Bair, Kaopin Hwang, Tsang En Wang, Taoyeuan Wang, Taicherng Liou, Kwokkuen PangAbstract:Human Intestinal Capillariasis is a rare parasitosis that was first recognized in the Philippines in the 1960 s. Parasitosis is a life threatening disease and has been reported from Thailand, Japan, South of Taiwan (Kaoh-Siung), Korea, Iran, Egypt, Italy and Spain. Its clinical symptoms are characterized by chronic diarrhea, abdominal pain, borborygmus, marked weight loss, protein and electrolyte loss and cachexia. Capillariasis may be fatal if early treatment is not given. We reported 14 cases living in rural areas of Taiwan. Three cases had histories of travelling to Thailand. They might have been infected in Thailand while stayed there. Two cases had the diet of raw freshwater fish before. Three cases received emergency laparotomy due to peritonitis and two cases were found of enteritis cystica profunda. According to the route of transmission, freshwater and brackish-water fish may act as the intermediate host of the parasite. The most simple and convenient method of diagnosing Capillariasis is stool examination. Two cases were diagnosed by histology. Mebendazole or albendezole 200 mg orally twice a day for 20-30 d is the treatment of choice. All the patients were cured, and relapses were not observed within 12 mo.
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human Intestinal Capillariasis capillaria philippinensis in taiwan
Acta paediatrica sinica, 1998Co-Authors: Kaopin HwangAbstract:A human case of Intestinal Capillariasis was first recognized in the Philippines in the mid-1960s. The parasitosis is a life threatening disease and has been reported from Thailand, Japan, Taiwan, Korea, Iran, and Egypt. Clinical symptoms include diarrhea, abdominal pain, borborygmi, marked weight loss, protein and electrolyte loss, and cachexia. Capillariasis may be fatal if treatment is not given early. We observed 7 cases living in the more rural areas of Taiwan. Two cases had histories of travelling to Thailand. These two cases might have been infected in Thailand while stayed there. The other 5 cases didn't have histories of going abroad. According to the route of transmission, freshwater and brackish-water fish may act as the intermediate host of the parasite. People who like to eat raw fish, and have had long term diarrhea with abdominal pain and borborygmi, Capillariasis philippinensis should be highly suspected. The most simple and convenient method of diagnosing Capillariasis is stool examination. Treatment with mebendazole or albendazole for 20-30days is known to be effective. All 7 cases we observed were cured through adequate treatment with anthelmintics and general management. A case, found in Kaohsiung Medical College Hospital in 1983, may be the first case in Taiwan.
Wanchai Maleewong - One of the best experts on this subject based on the ideXlab platform.
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A Hospital-Based Study of Intestinal Capillariasis in Thailand: Clinical Features, Potential Clues for Diagnosis, and Epidemiological Characteristics of 85 Patients
American Journal of Tropical Medicine and Hygiene, 2018Co-Authors: Lakkhana Sadaow, Wattana Sukeepaisarnjaroen, Thidarat K. Prasongdee, Pewpan M Intapan, Oranuch Sanpool, Wanchai MaleewongAbstract:Abstract. Intestinal Capillariasis caused by Capillaria philippinensis, a fish-borne nematode, is an important, emerging zoonotic helminthiasis. Cases may be fatal if suitable treatment is not administered in time. We reported a hospital-based study of 85 cases in Thailand, most of which were in the northeast. All patients had a history of eating raw or insufficiently cooked fresh water fish or prawns. The clinical manifestations are characterized by chronic diarrhea, borborygmi, abdominal pain, marked weight loss, muscle weakness, fatigue, dizziness, anorexia, and edema, as well as protein and electrolyte loss. Fecal examination revealed C. philippinensis in all patients. Although 16 of the total of 85 (18.8%) cases were initially found to be negative for C. philippinensis using fecal examination, further examination using an immunoblotting technique found them to be positive for the IgG antibody against Trichinella spiralis larval antigen. One day after administration of 400 mg of albendazole, eggs and/or larvae and/or adult C. philippinensis were found in 16 fecal samples. After treatment with mebendazole (200 mg twice a day for 30 days) or albendazole (200 mg twice a day for 10 days), all 85 patients recovered. The potential clues for diagnosis are clinical manifestations, history of eating raw contaminated food, and positive serological test, and fecal examinations under professional. Administration of anthelminthic drugs stimulates the excretion of larvae, eggs, and/or adult worms and can be used as a supportive method for the diagnosis of Intestinal Capillariasis in areas where serological test is not available.
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Development and evaluation of a rapid diagnostic immunochromatographic device to detect antibodies in sera from Intestinal Capillariasis cases
Parasitology Research, 2017Co-Authors: Pewpan M Intapan, Lakkhana Sadaow, Oranuch Sanpool, Rutchanee Rodpai, Tongjit Thanchomnang, Issarapong Phosuk, Wanchai MaleewongAbstract:Intestinal Capillariasis, a fish-borne nematodiasis, is an important emerging zoonotic disease. Patients present clinical symptoms of borborygmus chronic diarrhea, intermittent abdominal pain, weight loss, and several degrees of painless lower-leg edema. Death may occur in cases of misdiagnosis and improper treatment. Diagnosis is difficult because of the atypical clinical symptoms and diagnostic confusion with diarrhea caused by gastroIntestinal cancer, opportunistic infections in human immunodeficiency virus patients, and hyperthyroidism. In addition, parasite eggs are not always found in stool examination. Serology can provide a supportive diagnostic tool. We have produced a rapid and simple immunochromatographic test (ICT) kit for diagnosis of Intestinal Capillariasis by detection of diagnostic antibodies in human sera. Serum samples from healthy volunteers and patients with proven Intestinal Capillariasis and other parasitic diseases were evaluated with the Trichinella spiralis larval extract antigen absorbed ICT strips. The diagnostic sensitivity, specificity, and positive and negative predictive values were 100, 96.6, 90.2, and 100%, respectively. The ICT kit is simple and rapid to use and can supplement stool examination in clinical diagnosis of Intestinal Capillariasis. The test can be completed in 15 min without a need for any sophisticated instruments or reagents.
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AN ENZYME-LINKED IMMUNOSORBENT ASSAY AS SCREENING TOOL FOR HUMAN Intestinal Capillariasis
Southeast Asian Journal of Tropical Medicine and Public Health, 2010Co-Authors: Pewpan M Intapan, Wattana Sukeepaisarnjaroen, Wanchai Maleewong, Nimit MorakoteAbstract:Human Intestinal Capillariasis caused by Capillaria philippinensis is char- acterized by chronic diarrhea which may lead to death if left untreated. The mor- tality is highest among patients who are negative by conventional stool examina- tion. Therefore this study explored the application of an enzyme-linked immunosorbent assay (ELISA) as a screening test for human Intestinal capillari- asis. The ELISA was developed using Trichinella spiralis soluble antigen for the detection of antibodies against C. philippinensis. A cut-off level at the upper 99% limit of the absorbance values of the healthy controls was established for positiv- ity. All Intestinal Capillariasis sera showed positive ELISA, demonstrating 100% sensitivity, while all healthy control sera gave absorbance values below the cut-off level, resulting in 100% specificity. The ELISA was also positive with 75% of trichinellosis, 13.9% of strongyloidiasis, 9.1% of trichuriasis, and 4.2% of opisthor- chiasis sera. The ELISA and immunoblot were in agreement in 91.1% of the sera tested. It was suggested that the here-presented ELISA is capable to detect intesti- nal Capillariasis cases in endemic areas whose coproscopy is negative for worm eggs, larvae or adults.
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Potential use of Trichinella spiralis antigen for serodiagnosis of human Capillariasis philippinensis by immunoblot analysis
Parasitology Research, 2006Co-Authors: Pewpan M Intapan, Wattana Sukeepaisarnjaroen, Wanchai Maleewong, Nimit MorakoteAbstract:Intestinal Capillariasis is an emerging helminthic zoonosis caused by Capillaria philippinensis and is frequently fatal if not diagnosed correctly. The present study demonstrates cross-reactivity between Trichinella spiralis larval antigens and C. philippinensis -infected human sera by immunoblotting. Sera from 16 proven Intestinal Capillariasis patients and 16 proven trichinosis patients were tested. The antigenic patterns recognized by Intestinal Capillariasis sera varied with the molecular masses, ranging from less than 20.1 to more than 94 kDa. The immunoblotting profiles of the trichinosis sera were similar to those of the Intestinal Capillariasis sera. The antigenic bands with 100% reactivity were located at 36.5, 40.5, and 54 kDa, respectively. Sera from patients with trichuriasis, strongyloidiasis, opisthorchiasis, and healthy controls differed clearly from the previous two and produced very faint patterns of reactivity and attenuated bands. This assay is potentially useful for large-scale screenings of persons at risk for C. philippinensis infection. Parasitological stool examinations of the positive cases are necessary as second-tier laboratory tests for confirming the diagnosis.
