The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Cheng Guo - One of the best experts on this subject based on the ideXlab platform.
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A Comparative Study between Computer-controlled Enema Taxis Instrument and Simple Air Enema Taxis Instrument for Intussusception in Children
West China Medical Journal, 2012Co-Authors: Cheng GuoAbstract:Objective To compare the taxis effect between simple air enema taxis instrument and computercontrolled enema taxis instrument for intussusception in children,and explore more effective and safer air enema taxis.Methods Between November 2002 and November 2011,a total of 425 children with confirmed intussusception accepted air enema taxis,including 198 treated with simple air enema taxis instrument,and 227 treated with computer-controlled enema taxis instrument.Different onset time,intussusception position and the efficacy of the two methods of taxis were retrospectively analyzed.Results The success rates of reposition with simple air enema taxis instrument and computercontrolled enema taxis instrument were respectively 71.2% and 83.3%,with a significant difference(P 0.05).The success rate was higher for patients whose disease course was within 24 hours of the onset,and whose intussusception position was the ascending colon or transverse colon(P 0.05).Conclusions Computer-controlled enema taxis instrument is safer and more effective than simple air enema taxis instrument.Pulse air enema can relieve Intestinal Spasm and edema of intussusception and increase the success rate of reposition.
Marco A Martins - One of the best experts on this subject based on the ideXlab platform.
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antianaphylactic properties of 7 epiclusianone a tetraprenylated benzophenone isolated from garcinia brasiliensis
Planta Medica, 2007Co-Authors: Josiane S Neves, Luciana P Coelho, Renato S B Cordeiro, Marcia Paranho Veloso, Patricia M R E Silva, Marcelo Henrique Dos Santos, Marco A MartinsAbstract:Prior studies have emphasized the anti-inflammatory and antioxidant properties of polyisoprenylated benzophenone derivatives, but their putative effect on allergic conditions has not yet been addressed. In the current study, the naturally occurring 7-epiclusianone, isolated from Garcinia brasiliensis, was investigated to check its effectiveness on allergen-evoked Intestinal Spasm. The standard antiallergic azelastine was used for comparison. We found that 7-epiclusianone and azelastine inhibited antigen-induced contractions of guinea pig ileum with similar IC (50) values (2.3 +/- 1.1 microM and 3.3 +/- 1.2 microM, respectively). A similar blockade of anaphylactic histamine release from the ileum was also noted. In contrast, azelastine was more potent than 7-epiclusianone to prevent Spasms induced by histamine (IC (50) = 6.3 +/- 0.2 nM and 3.7 +/- 0.1 microM, respectively). These findings reveal that 7-epiclusianone is clearly active against the anaphylactic response and should be considered as a molecular template in drug discovery for allergic syndromes.
Josiane S Neves - One of the best experts on this subject based on the ideXlab platform.
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antianaphylactic properties of 7 epiclusianone a tetraprenylated benzophenone isolated from garcinia brasiliensis
Planta Medica, 2007Co-Authors: Josiane S Neves, Luciana P Coelho, Renato S B Cordeiro, Marcia Paranho Veloso, Patricia M R E Silva, Marcelo Henrique Dos Santos, Marco A MartinsAbstract:Prior studies have emphasized the anti-inflammatory and antioxidant properties of polyisoprenylated benzophenone derivatives, but their putative effect on allergic conditions has not yet been addressed. In the current study, the naturally occurring 7-epiclusianone, isolated from Garcinia brasiliensis, was investigated to check its effectiveness on allergen-evoked Intestinal Spasm. The standard antiallergic azelastine was used for comparison. We found that 7-epiclusianone and azelastine inhibited antigen-induced contractions of guinea pig ileum with similar IC (50) values (2.3 +/- 1.1 microM and 3.3 +/- 1.2 microM, respectively). A similar blockade of anaphylactic histamine release from the ileum was also noted. In contrast, azelastine was more potent than 7-epiclusianone to prevent Spasms induced by histamine (IC (50) = 6.3 +/- 0.2 nM and 3.7 +/- 0.1 microM, respectively). These findings reveal that 7-epiclusianone is clearly active against the anaphylactic response and should be considered as a molecular template in drug discovery for allergic syndromes.
Luciana P Coelho - One of the best experts on this subject based on the ideXlab platform.
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antianaphylactic properties of 7 epiclusianone a tetraprenylated benzophenone isolated from garcinia brasiliensis
Planta Medica, 2007Co-Authors: Josiane S Neves, Luciana P Coelho, Renato S B Cordeiro, Marcia Paranho Veloso, Patricia M R E Silva, Marcelo Henrique Dos Santos, Marco A MartinsAbstract:Prior studies have emphasized the anti-inflammatory and antioxidant properties of polyisoprenylated benzophenone derivatives, but their putative effect on allergic conditions has not yet been addressed. In the current study, the naturally occurring 7-epiclusianone, isolated from Garcinia brasiliensis, was investigated to check its effectiveness on allergen-evoked Intestinal Spasm. The standard antiallergic azelastine was used for comparison. We found that 7-epiclusianone and azelastine inhibited antigen-induced contractions of guinea pig ileum with similar IC (50) values (2.3 +/- 1.1 microM and 3.3 +/- 1.2 microM, respectively). A similar blockade of anaphylactic histamine release from the ileum was also noted. In contrast, azelastine was more potent than 7-epiclusianone to prevent Spasms induced by histamine (IC (50) = 6.3 +/- 0.2 nM and 3.7 +/- 0.1 microM, respectively). These findings reveal that 7-epiclusianone is clearly active against the anaphylactic response and should be considered as a molecular template in drug discovery for allergic syndromes.
Renato S B Cordeiro - One of the best experts on this subject based on the ideXlab platform.
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antianaphylactic properties of 7 epiclusianone a tetraprenylated benzophenone isolated from garcinia brasiliensis
Planta Medica, 2007Co-Authors: Josiane S Neves, Luciana P Coelho, Renato S B Cordeiro, Marcia Paranho Veloso, Patricia M R E Silva, Marcelo Henrique Dos Santos, Marco A MartinsAbstract:Prior studies have emphasized the anti-inflammatory and antioxidant properties of polyisoprenylated benzophenone derivatives, but their putative effect on allergic conditions has not yet been addressed. In the current study, the naturally occurring 7-epiclusianone, isolated from Garcinia brasiliensis, was investigated to check its effectiveness on allergen-evoked Intestinal Spasm. The standard antiallergic azelastine was used for comparison. We found that 7-epiclusianone and azelastine inhibited antigen-induced contractions of guinea pig ileum with similar IC (50) values (2.3 +/- 1.1 microM and 3.3 +/- 1.2 microM, respectively). A similar blockade of anaphylactic histamine release from the ileum was also noted. In contrast, azelastine was more potent than 7-epiclusianone to prevent Spasms induced by histamine (IC (50) = 6.3 +/- 0.2 nM and 3.7 +/- 0.1 microM, respectively). These findings reveal that 7-epiclusianone is clearly active against the anaphylactic response and should be considered as a molecular template in drug discovery for allergic syndromes.
