The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
E. Saboori - One of the best experts on this subject based on the ideXlab platform.
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Effect of Vitamin E on diabetes-induced changes in small Intestine and plasma antioxidant capacity in rat
Journal of Physiology and Biochemistry, 2006Co-Authors: Alireza Shirpoor, Behrouz Ilkhanizadeh, R Saadatian, B. S. Darvari, F. Behtaj, Mojtaba Karimipour, Firouz Ghaderi-pakdel, E. SabooriAbstract:The present study was designed to evaluate the effect of Vitamin E (Vit. E) on diabetes-induced changes in small Intestine, lipid peroxidation and plasma antioxidant capacity in rats. Twenty-four rats were divided into three groups (n=8), namely control, non-treated diabetic (NTD) and Vit. E-treated diabetic (VETD) groups. The VETD group received 300 mg of Vit. E daily in drinking water. After 6 weeks, the length and weight of small Intestine, Villus height, crypt depth and muscular layer thickness showed a significant increase in the NTD group compared to the control group. In the VETD group, these parameters did not show any significant difference compared to the control group. The level of malondialdehyde (MDA) in the red blood cells showed a signficant increase in the NTD group, but not in the VETD group, compared to the control group. The plasma antioxidant capacity showed a significant increase in VETD compared to the NTD group. These findings indicate that Vit. E significantly improved small intestinal changes in diabetic rats and that these effects could be mediated at least in part by enhanced plasma antioxidant capacity and reduced lipid peroxidation. Se estudia en el presente trabajo el efecto de la vitamina E sobre los cambios debidos a la diabetes en la estructura intestinal, peroxidación lipídica y capacidad antioxidante del plasma en la rata. Se utilizaron 24 animales, divididos en tres grupos (n=8): control, diabéticos no tratados (NTD) y diabéticos tratados con Vit. E (VETD). El grupo VETD recibió 300 mg de Vit. E diariamente en el agua de bebida. Tras 6 semanas, se observó aumento significativo en el grupo NTD de la longitud y peso del intestino delgado, espesor de la capa muscular, altura de las vellosidades y profundidad de las criptas respecto del grupo control. En cambio, en el grupo VETD, esos parámetros no se modificaron significativamente respecto de los controles. De modo similar, el nivel de malondialdehido (MDA) en los eritrocitos aumentó significativamente respecto del control en el grupo NTD y no en el VETD. La capacidad antioxidante del plasma mostró un significativo incremento en el grupo VETD respecto del control y NTD. Estos hechos indican que la vitamina E mejora las alteraciones intestinales debidas a la diabetes y que los efectos podrían estar parcialmente mediados por la disminución de la peroxidación lipídica y el aumento de la capacidad antioxidante del plasma.
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Effect of vitamin E on diabetes-induced changes in small Intestine and plasma antioxidant capacity in rat.
Journal of physiology and biochemistry, 2006Co-Authors: Alireza Shirpoor, Behrouz Ilkhanizadeh, R Saadatian, B. S. Darvari, F. Behtaj, Mojtaba Karimipour, Firouz Ghaderi-pakdel, E. SabooriAbstract:The present study was designed to evaluate the effect of Vitamin E (Vit. E) on diabetes-induced changes in small Intestine, lipid peroxidation and plasma antioxidant capacity in rats. Twenty-four rats were divided into three groups (n=8), namely control, non-treated diabetic (NTD) and Vit. E-treated diabetic (VETD) groups. The VETD group received 300 mg of Vit. E daily in drinking water. After 6 weeks, the length and weight of small Intestine, Villus height, crypt depth and muscular layer thickness showed a significant increase in the NTD group compared to the control group. In the VETD group, these parameters did not show any significant difference compared to the control group. The level of malondialdehyde (MDA) in the red blood cells showed a signficant increase in the NTD group, but not in the VETD group, compared to the control group. The plasma antioxidant capacity showed a significant increase in VETD compared to the NTD group. These findings indicate that Vit. E significantly improved small intestinal changes in diabetic rats and that these effects could be mediated at least in part by enhanced plasma antioxidant capacity and reduced lipid peroxidation.
Leonard R Forte - One of the best experts on this subject based on the ideXlab platform.
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distribution of heat stable enterotoxin guanylin receptors in the intestinal tract of man and other mammals
Journal of Anatomy, 1994Co-Authors: William J Krause, G L Cullingford, R H Freeman, Sammy L Eber, K C Richardson, K F Fok, M G Currie, Leonard R ForteAbstract:The human intestinal tract, as well as that of several eutherian and metatherian mammals, was examined for the distribution of heat-stable enterotoxin (ST)/guanylin receptors. These receptors were confined to the intestinal epithelium lining the lumen and forming the intestinal glands throughout the length of both the small Intestine and colon of all species examined. In man and most other mammalian species, there appeared to be a decrease in receptor density distally along the longitudinal axis of the small Intestine. ST/guanylin receptors were not observed in other strata forming the gut wall. Along the vertical axis of the human small Intestine (Villus/crypt unit), as well as that of most other mammals, receptor density was greatest in enterocytes located near the base of villi and in those forming the proximal portion of the intestinal glands. ST/guanylin receptors were for the most part confined to the region of the plasmalemma forming the microVillus border. In the colon of man and the other species examined, receptor density was greatest in enterocytes forming the proximal region of the intestinal glands. Receptors were present in the intestinal epithelium lining the lumen of the colon, but generally were fewer in number. The distribution of cellular cGMP accumulation responses to E. coli ST and guanylin in the opossum (Didelphis virginiana) and raccoon (Procyon lotor) revealed that proximal small Intestine had greater magnitudes of cGMP responses than did the distal small Intestine. Proximal colon had greater cGMP responses than distal colon, which had no significant cGMP responses to either ST or guanylin.
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Distribution of heat-stable enterotoxin/guanylin receptors in the intestinal tract of man and other mammals.
Journal of Anatomy, 1994Co-Authors: William J Krause, G L Cullingford, R H Freeman, Sammy L Eber, K C Richardson, K F Fok, M G Currie, Leonard R ForteAbstract:The human intestinal tract, as well as that of several eutherian and metatherian mammals, was examined for the distribution of heat-stable enterotoxin (ST)/guanylin receptors. These receptors were confined to the intestinal epithelium lining the lumen and forming the intestinal glands throughout the length of both the small Intestine and colon of all species examined. In man and most other mammalian species, there appeared to be a decrease in receptor density distally along the longitudinal axis of the small Intestine. ST/guanylin receptors were not observed in other strata forming the gut wall. Along the vertical axis of the human small Intestine (Villus/crypt unit), as well as that of most other mammals, receptor density was greatest in enterocytes located near the base of villi and in those forming the proximal portion of the intestinal glands. ST/guanylin receptors were for the most part confined to the region of the plasmalemma forming the microVillus border. In the colon of man and the other species examined, receptor density was greatest in enterocytes forming the proximal region of the intestinal glands. Receptors were present in the intestinal epithelium lining the lumen of the colon, but generally were fewer in number. The distribution of cellular cGMP accumulation responses to E. coli ST and guanylin in the opossum (Didelphis virginiana) and raccoon (Procyon lotor) revealed that proximal small Intestine had greater magnitudes of cGMP responses than did the distal small Intestine. Proximal colon had greater cGMP responses than distal colon, which had no significant cGMP responses to either ST or guanylin.
Alireza Shirpoor - One of the best experts on this subject based on the ideXlab platform.
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Effect of Vitamin E on diabetes-induced changes in small Intestine and plasma antioxidant capacity in rat
Journal of Physiology and Biochemistry, 2006Co-Authors: Alireza Shirpoor, Behrouz Ilkhanizadeh, R Saadatian, B. S. Darvari, F. Behtaj, Mojtaba Karimipour, Firouz Ghaderi-pakdel, E. SabooriAbstract:The present study was designed to evaluate the effect of Vitamin E (Vit. E) on diabetes-induced changes in small Intestine, lipid peroxidation and plasma antioxidant capacity in rats. Twenty-four rats were divided into three groups (n=8), namely control, non-treated diabetic (NTD) and Vit. E-treated diabetic (VETD) groups. The VETD group received 300 mg of Vit. E daily in drinking water. After 6 weeks, the length and weight of small Intestine, Villus height, crypt depth and muscular layer thickness showed a significant increase in the NTD group compared to the control group. In the VETD group, these parameters did not show any significant difference compared to the control group. The level of malondialdehyde (MDA) in the red blood cells showed a signficant increase in the NTD group, but not in the VETD group, compared to the control group. The plasma antioxidant capacity showed a significant increase in VETD compared to the NTD group. These findings indicate that Vit. E significantly improved small intestinal changes in diabetic rats and that these effects could be mediated at least in part by enhanced plasma antioxidant capacity and reduced lipid peroxidation. Se estudia en el presente trabajo el efecto de la vitamina E sobre los cambios debidos a la diabetes en la estructura intestinal, peroxidación lipídica y capacidad antioxidante del plasma en la rata. Se utilizaron 24 animales, divididos en tres grupos (n=8): control, diabéticos no tratados (NTD) y diabéticos tratados con Vit. E (VETD). El grupo VETD recibió 300 mg de Vit. E diariamente en el agua de bebida. Tras 6 semanas, se observó aumento significativo en el grupo NTD de la longitud y peso del intestino delgado, espesor de la capa muscular, altura de las vellosidades y profundidad de las criptas respecto del grupo control. En cambio, en el grupo VETD, esos parámetros no se modificaron significativamente respecto de los controles. De modo similar, el nivel de malondialdehido (MDA) en los eritrocitos aumentó significativamente respecto del control en el grupo NTD y no en el VETD. La capacidad antioxidante del plasma mostró un significativo incremento en el grupo VETD respecto del control y NTD. Estos hechos indican que la vitamina E mejora las alteraciones intestinales debidas a la diabetes y que los efectos podrían estar parcialmente mediados por la disminución de la peroxidación lipídica y el aumento de la capacidad antioxidante del plasma.
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Effect of vitamin E on diabetes-induced changes in small Intestine and plasma antioxidant capacity in rat.
Journal of physiology and biochemistry, 2006Co-Authors: Alireza Shirpoor, Behrouz Ilkhanizadeh, R Saadatian, B. S. Darvari, F. Behtaj, Mojtaba Karimipour, Firouz Ghaderi-pakdel, E. SabooriAbstract:The present study was designed to evaluate the effect of Vitamin E (Vit. E) on diabetes-induced changes in small Intestine, lipid peroxidation and plasma antioxidant capacity in rats. Twenty-four rats were divided into three groups (n=8), namely control, non-treated diabetic (NTD) and Vit. E-treated diabetic (VETD) groups. The VETD group received 300 mg of Vit. E daily in drinking water. After 6 weeks, the length and weight of small Intestine, Villus height, crypt depth and muscular layer thickness showed a significant increase in the NTD group compared to the control group. In the VETD group, these parameters did not show any significant difference compared to the control group. The level of malondialdehyde (MDA) in the red blood cells showed a signficant increase in the NTD group, but not in the VETD group, compared to the control group. The plasma antioxidant capacity showed a significant increase in VETD compared to the NTD group. These findings indicate that Vit. E significantly improved small intestinal changes in diabetic rats and that these effects could be mediated at least in part by enhanced plasma antioxidant capacity and reduced lipid peroxidation.
L. Favennec - One of the best experts on this subject based on the ideXlab platform.
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Cryptosporidium parvum Isolate-Dependent Postinfectious Jejunal Hypersensitivity and Mast Cell Accumulation in an Immunocompetent Rat Model{triangledown}
Infection and Immunity, 2009Co-Authors: S. Khaldi, G. Gargala, L. Le Goff, S. Parey, A. Francois, J. Fioramonti, J.j. Ballet, Jean-paul Dupont, P. Ducrotté, L. FavennecAbstract:Cryptosporidium spp. are a cause of self-limited diarrhea in immunocompetent hosts. In immunocompetent rats, Cryptosporidium parvum infection induced digestive hypersensitivity, a key pathophysiological factor in functional digestive disorders such as irritable bowel syndrome (IBS). In such a rat model, we sought to document whether jejunal hypersensitivity depends on C. parvum isolate and is associated with a mast cell accumulation. Five-day-old rats were orally administered 105 oocysts of either Nouzilly (NoI) or Iowa (IoI) C. parvum isolate. NoI-infected rats exhibited the lowest food intake on days 7 and 14 postinfection (p.i.). On day 7 p.i., small Intestine Villus atrophy, crypt hyperplasia, and inflammatory cell infiltration were prominent in NoI-infected rats, with higher numbers of Cryptosporidium forms than in IoI-infected rats. Compared to uninfected control rats, jejunal intraepithelial lymphocytes (IELs) were increased only in NoI-infected rats on day 14 p.i. On day 50 p.i., jejunal hypersensitivity to distension was found only in NoI-infected rats; this hypersensitivity is associated with activated mast cell accumulation. The number of mast cells in the jejunal lamina propria was increased from day 36 p.i. in NoI-infected rats and only at day 120 p.i. in IoI-infected rats. Our data suggest that both the severity of infection (weight loss, reduced food intake, Villus atrophy, and IEL accumulation) and the onset of a jejunal hypersensitivity after infection in association with an activated mast cell accumulation are isolate dependent and related to NoI infection. This cryptosporidiosis rat model is a relevant model for the study of underlying mechanisms of postinfectious IBS-like symptoms.
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Cryptosporidium parvum isolate-dependent postinfectious jejunal hypersensitivity and mast cell accumulation in an immunocompetent rat model.
Infection and immunity, 2009Co-Authors: S. Khaldi, G. Gargala, L. Le Goff, S. Parey, A. Francois, J. Fioramonti, J.j. Ballet, Jean-paul Dupont, P. Ducrotté, L. FavennecAbstract:Cryptosporidium spp. are a cause of self-limited diarrhea in immunocompetent hosts. In immunocompetent rats, Cryptosporidium parvum infection induced digestive hypersensitivity, a key pathophysiological factor in functional digestive disorders such as irritable bowel syndrome (IBS). In such a rat model, we sought to document whether jejunal hypersensitivity depends on C. parvum isolate and is associated with a mast cell accumulation. Five-day-old rats were orally administered 105 oocysts of either Nouzilly (NoI) or Iowa (IoI) C. parvum isolate. NoI-infected rats exhibited the lowest food intake on days 7 and 14 postinfection (p.i.). On day 7 p.i., small Intestine Villus atrophy, crypt hyperplasia, and inflammatory cell infiltration were prominent in NoI-infected rats, with higher numbers of Cryptosporidium forms than in IoI-infected rats. Compared to uninfected control rats, jejunal intraepithelial lymphocytes (IELs) were increased only in NoI-infected rats on day 14 p.i. On day 50 p.i., jejunal hypersensitivity to distension was found only in NoI-infected rats; this hypersensitivity is associated with activated mast cell accumulation. The number of mast cells in the jejunal lamina propria was increased from day 36 p.i. in NoI-infected rats and only at day 120 p.i. in IoI-infected rats. Our data suggest that both the severity of infection (weight loss, reduced food intake, Villus atrophy, and IEL accumulation) and the onset of a jejunal hypersensitivity after infection in association with an activated mast cell accumulation are isolate dependent and related to NoI infection. This cryptosporidiosis rat model is a relevant model for the study of underlying mechanisms of postinfectious IBS-like symptoms.
William J Krause - One of the best experts on this subject based on the ideXlab platform.
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distribution of heat stable enterotoxin guanylin receptors in the intestinal tract of man and other mammals
Journal of Anatomy, 1994Co-Authors: William J Krause, G L Cullingford, R H Freeman, Sammy L Eber, K C Richardson, K F Fok, M G Currie, Leonard R ForteAbstract:The human intestinal tract, as well as that of several eutherian and metatherian mammals, was examined for the distribution of heat-stable enterotoxin (ST)/guanylin receptors. These receptors were confined to the intestinal epithelium lining the lumen and forming the intestinal glands throughout the length of both the small Intestine and colon of all species examined. In man and most other mammalian species, there appeared to be a decrease in receptor density distally along the longitudinal axis of the small Intestine. ST/guanylin receptors were not observed in other strata forming the gut wall. Along the vertical axis of the human small Intestine (Villus/crypt unit), as well as that of most other mammals, receptor density was greatest in enterocytes located near the base of villi and in those forming the proximal portion of the intestinal glands. ST/guanylin receptors were for the most part confined to the region of the plasmalemma forming the microVillus border. In the colon of man and the other species examined, receptor density was greatest in enterocytes forming the proximal region of the intestinal glands. Receptors were present in the intestinal epithelium lining the lumen of the colon, but generally were fewer in number. The distribution of cellular cGMP accumulation responses to E. coli ST and guanylin in the opossum (Didelphis virginiana) and raccoon (Procyon lotor) revealed that proximal small Intestine had greater magnitudes of cGMP responses than did the distal small Intestine. Proximal colon had greater cGMP responses than distal colon, which had no significant cGMP responses to either ST or guanylin.
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Distribution of heat-stable enterotoxin/guanylin receptors in the intestinal tract of man and other mammals.
Journal of Anatomy, 1994Co-Authors: William J Krause, G L Cullingford, R H Freeman, Sammy L Eber, K C Richardson, K F Fok, M G Currie, Leonard R ForteAbstract:The human intestinal tract, as well as that of several eutherian and metatherian mammals, was examined for the distribution of heat-stable enterotoxin (ST)/guanylin receptors. These receptors were confined to the intestinal epithelium lining the lumen and forming the intestinal glands throughout the length of both the small Intestine and colon of all species examined. In man and most other mammalian species, there appeared to be a decrease in receptor density distally along the longitudinal axis of the small Intestine. ST/guanylin receptors were not observed in other strata forming the gut wall. Along the vertical axis of the human small Intestine (Villus/crypt unit), as well as that of most other mammals, receptor density was greatest in enterocytes located near the base of villi and in those forming the proximal portion of the intestinal glands. ST/guanylin receptors were for the most part confined to the region of the plasmalemma forming the microVillus border. In the colon of man and the other species examined, receptor density was greatest in enterocytes forming the proximal region of the intestinal glands. Receptors were present in the intestinal epithelium lining the lumen of the colon, but generally were fewer in number. The distribution of cellular cGMP accumulation responses to E. coli ST and guanylin in the opossum (Didelphis virginiana) and raccoon (Procyon lotor) revealed that proximal small Intestine had greater magnitudes of cGMP responses than did the distal small Intestine. Proximal colon had greater cGMP responses than distal colon, which had no significant cGMP responses to either ST or guanylin.
