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Anders Helander - One of the best experts on this subject based on the ideXlab platform.
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Acute Intoxications Involving α-Pyrrolidinobutiophenone (α-PBP): Results from the Swedish STRIDA Project
Journal of Medical Toxicology, 2018Co-Authors: Lisa Franzén, Matilda Bäckberg, Olof Beck, Anders HelanderAbstract:Introduction Many new psychoactive substances (NPS) introduced as recreational drugs have been associated with severe Intoxication and death. Methods Blood and/or urine samples were collected from intoxicated patients treated at Swedish hospitals that participated in the STRIDA project, a nationawide effort to address the growing problem of NPS. In patients undergoing evaluation for drug overdose, α-PBP was identified using liquid chromatography-mass spectrometry. Demographic and clinical data were collected during Poisons Information Centre consultations and retrieved from medical records. Results From April 2013 to November 2015, 43 patients tested positive for α-PBP. However, α-PBP was never specifically mentioned during consultation but only confirmed analytically. The α-PBP concentrations ranged 2.0–13,200 ng/mL in urine and 2.0–440 ng/mL in serum. The patients were aged 19–57 (mean 34) years, 81% were men, and 73% were known drug addicts. All cases except 1 also involved other NPS and/or classical drugs. MDPV, α-PVP, and other pyrovalerone analogues were the most common other NPS (31 cases; 72%). CNS depressants were detected in 28 cases (65%), with benzodiazepines (16 cases) being most frequent. Main clinical characteristics were agitation/anxiety (59%), tachycardia (54%), and hypertension (37%), and 14 patients (33%) required monitoring in the intensive care unit of which 8 were graded as severe Intoxications. No fatalities were reported. Conclusion Patients with Intoxication from α-PBP resembled those by NPS cathinones MDPV and α-PVP. As patients never specifically declared α-PBP intake and poly-drug Intoxication was common, they may have been unaware of the actual substance taken.
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Intoxications involving the fentanyl analogs acetylfentanyl 4 methoxybutyrfentanyl and furanylfentanyl results from the swedish strida project
Clinical Toxicology, 2016Co-Authors: Anders Helander, Matilda Bäckberg, Olof BeckAbstract:AbstractBackground: Potent and potentially harmful new psychoactive substances (NPS) are continuously introduced on the recreational drugs market. This report from the Swedish STRIDA project describes analytically confirmed cases of Intoxication involving the fentanyl analogs acetylfentanyl, 4-methoxybutyrfentanyl, and furanylfentanyl. Methods: Patients with suspected NPS exposure presenting in emergency departments and intensive care units in Sweden and requiring hospital care are invited to the STRIDA project. Toxicological analysis of serum and urine samples was performed by multi-component liquid chromatographic–mass spectrometric methods. Data on clinical features were retrieved from telephone consultations with the Swedish Poisons Information Centre and from medical records. Results: Between April and November 2015, 14 analytically confirmed Intoxications involving acetylfentanyl (nine cases), 4-methoxybutyrfentanyl (3), furanylfentanyl (1), and 4-methoxybutyrfentanyl together with furanylfentanyl (...
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opioid Intoxications involving butyrfentanyl 4 fluorobutyrfentanyl and fentanyl from the swedish strida project
Clinical Toxicology, 2015Co-Authors: Matilda Bäckberg, Olof Beck, Karlhenrik Jonsson, Anders HelanderAbstract:AbstractBackground. The supply of unregulated “new psychoactive substances” (NPS) has shown a steady increase over the past six years. This report from the Swedish STRIDA project describes analytically confirmed non-fatal Intoxications involving butyrfentanyl (butyrylfentanyl) or 4-fluorobutyrfentanyl (para-fluorobutyrfentanyl), two fentanyl analogues recently introduced as NPS opioids. Study design. Observational case series of consecutive patients with suspected acute NPS exposure and requiring hospital care from all over Sweden. Patients and methods. From May 2014 to January 2015, blood and urine samples were obtained from four Intoxication cases involving butyrfentanyl and one case involving 4-fluorobutyrfentanyl (men, 19–30 years) presenting in emergency departments (ED) or intensive care units (ICU). Laboratory analysis of serum and/or urine samples was performed by multi-component liquid chromatography–mass spectrometry methods. Data on clinical features were collected during consultations with the...
Olof Beck - One of the best experts on this subject based on the ideXlab platform.
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Acute Intoxications Involving α-Pyrrolidinobutiophenone (α-PBP): Results from the Swedish STRIDA Project
Journal of Medical Toxicology, 2018Co-Authors: Lisa Franzén, Matilda Bäckberg, Olof Beck, Anders HelanderAbstract:Introduction Many new psychoactive substances (NPS) introduced as recreational drugs have been associated with severe Intoxication and death. Methods Blood and/or urine samples were collected from intoxicated patients treated at Swedish hospitals that participated in the STRIDA project, a nationawide effort to address the growing problem of NPS. In patients undergoing evaluation for drug overdose, α-PBP was identified using liquid chromatography-mass spectrometry. Demographic and clinical data were collected during Poisons Information Centre consultations and retrieved from medical records. Results From April 2013 to November 2015, 43 patients tested positive for α-PBP. However, α-PBP was never specifically mentioned during consultation but only confirmed analytically. The α-PBP concentrations ranged 2.0–13,200 ng/mL in urine and 2.0–440 ng/mL in serum. The patients were aged 19–57 (mean 34) years, 81% were men, and 73% were known drug addicts. All cases except 1 also involved other NPS and/or classical drugs. MDPV, α-PVP, and other pyrovalerone analogues were the most common other NPS (31 cases; 72%). CNS depressants were detected in 28 cases (65%), with benzodiazepines (16 cases) being most frequent. Main clinical characteristics were agitation/anxiety (59%), tachycardia (54%), and hypertension (37%), and 14 patients (33%) required monitoring in the intensive care unit of which 8 were graded as severe Intoxications. No fatalities were reported. Conclusion Patients with Intoxication from α-PBP resembled those by NPS cathinones MDPV and α-PVP. As patients never specifically declared α-PBP intake and poly-drug Intoxication was common, they may have been unaware of the actual substance taken.
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Intoxications involving the fentanyl analogs acetylfentanyl 4 methoxybutyrfentanyl and furanylfentanyl results from the swedish strida project
Clinical Toxicology, 2016Co-Authors: Anders Helander, Matilda Bäckberg, Olof BeckAbstract:AbstractBackground: Potent and potentially harmful new psychoactive substances (NPS) are continuously introduced on the recreational drugs market. This report from the Swedish STRIDA project describes analytically confirmed cases of Intoxication involving the fentanyl analogs acetylfentanyl, 4-methoxybutyrfentanyl, and furanylfentanyl. Methods: Patients with suspected NPS exposure presenting in emergency departments and intensive care units in Sweden and requiring hospital care are invited to the STRIDA project. Toxicological analysis of serum and urine samples was performed by multi-component liquid chromatographic–mass spectrometric methods. Data on clinical features were retrieved from telephone consultations with the Swedish Poisons Information Centre and from medical records. Results: Between April and November 2015, 14 analytically confirmed Intoxications involving acetylfentanyl (nine cases), 4-methoxybutyrfentanyl (3), furanylfentanyl (1), and 4-methoxybutyrfentanyl together with furanylfentanyl (...
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opioid Intoxications involving butyrfentanyl 4 fluorobutyrfentanyl and fentanyl from the swedish strida project
Clinical Toxicology, 2015Co-Authors: Matilda Bäckberg, Olof Beck, Karlhenrik Jonsson, Anders HelanderAbstract:AbstractBackground. The supply of unregulated “new psychoactive substances” (NPS) has shown a steady increase over the past six years. This report from the Swedish STRIDA project describes analytically confirmed non-fatal Intoxications involving butyrfentanyl (butyrylfentanyl) or 4-fluorobutyrfentanyl (para-fluorobutyrfentanyl), two fentanyl analogues recently introduced as NPS opioids. Study design. Observational case series of consecutive patients with suspected acute NPS exposure and requiring hospital care from all over Sweden. Patients and methods. From May 2014 to January 2015, blood and urine samples were obtained from four Intoxication cases involving butyrfentanyl and one case involving 4-fluorobutyrfentanyl (men, 19–30 years) presenting in emergency departments (ED) or intensive care units (ICU). Laboratory analysis of serum and/or urine samples was performed by multi-component liquid chromatography–mass spectrometry methods. Data on clinical features were collected during consultations with the...
Matilda Bäckberg - One of the best experts on this subject based on the ideXlab platform.
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Acute Intoxications Involving α-Pyrrolidinobutiophenone (α-PBP): Results from the Swedish STRIDA Project
Journal of Medical Toxicology, 2018Co-Authors: Lisa Franzén, Matilda Bäckberg, Olof Beck, Anders HelanderAbstract:Introduction Many new psychoactive substances (NPS) introduced as recreational drugs have been associated with severe Intoxication and death. Methods Blood and/or urine samples were collected from intoxicated patients treated at Swedish hospitals that participated in the STRIDA project, a nationawide effort to address the growing problem of NPS. In patients undergoing evaluation for drug overdose, α-PBP was identified using liquid chromatography-mass spectrometry. Demographic and clinical data were collected during Poisons Information Centre consultations and retrieved from medical records. Results From April 2013 to November 2015, 43 patients tested positive for α-PBP. However, α-PBP was never specifically mentioned during consultation but only confirmed analytically. The α-PBP concentrations ranged 2.0–13,200 ng/mL in urine and 2.0–440 ng/mL in serum. The patients were aged 19–57 (mean 34) years, 81% were men, and 73% were known drug addicts. All cases except 1 also involved other NPS and/or classical drugs. MDPV, α-PVP, and other pyrovalerone analogues were the most common other NPS (31 cases; 72%). CNS depressants were detected in 28 cases (65%), with benzodiazepines (16 cases) being most frequent. Main clinical characteristics were agitation/anxiety (59%), tachycardia (54%), and hypertension (37%), and 14 patients (33%) required monitoring in the intensive care unit of which 8 were graded as severe Intoxications. No fatalities were reported. Conclusion Patients with Intoxication from α-PBP resembled those by NPS cathinones MDPV and α-PVP. As patients never specifically declared α-PBP intake and poly-drug Intoxication was common, they may have been unaware of the actual substance taken.
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Intoxications involving the fentanyl analogs acetylfentanyl 4 methoxybutyrfentanyl and furanylfentanyl results from the swedish strida project
Clinical Toxicology, 2016Co-Authors: Anders Helander, Matilda Bäckberg, Olof BeckAbstract:AbstractBackground: Potent and potentially harmful new psychoactive substances (NPS) are continuously introduced on the recreational drugs market. This report from the Swedish STRIDA project describes analytically confirmed cases of Intoxication involving the fentanyl analogs acetylfentanyl, 4-methoxybutyrfentanyl, and furanylfentanyl. Methods: Patients with suspected NPS exposure presenting in emergency departments and intensive care units in Sweden and requiring hospital care are invited to the STRIDA project. Toxicological analysis of serum and urine samples was performed by multi-component liquid chromatographic–mass spectrometric methods. Data on clinical features were retrieved from telephone consultations with the Swedish Poisons Information Centre and from medical records. Results: Between April and November 2015, 14 analytically confirmed Intoxications involving acetylfentanyl (nine cases), 4-methoxybutyrfentanyl (3), furanylfentanyl (1), and 4-methoxybutyrfentanyl together with furanylfentanyl (...
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opioid Intoxications involving butyrfentanyl 4 fluorobutyrfentanyl and fentanyl from the swedish strida project
Clinical Toxicology, 2015Co-Authors: Matilda Bäckberg, Olof Beck, Karlhenrik Jonsson, Anders HelanderAbstract:AbstractBackground. The supply of unregulated “new psychoactive substances” (NPS) has shown a steady increase over the past six years. This report from the Swedish STRIDA project describes analytically confirmed non-fatal Intoxications involving butyrfentanyl (butyrylfentanyl) or 4-fluorobutyrfentanyl (para-fluorobutyrfentanyl), two fentanyl analogues recently introduced as NPS opioids. Study design. Observational case series of consecutive patients with suspected acute NPS exposure and requiring hospital care from all over Sweden. Patients and methods. From May 2014 to January 2015, blood and urine samples were obtained from four Intoxication cases involving butyrfentanyl and one case involving 4-fluorobutyrfentanyl (men, 19–30 years) presenting in emergency departments (ED) or intensive care units (ICU). Laboratory analysis of serum and/or urine samples was performed by multi-component liquid chromatography–mass spectrometry methods. Data on clinical features were collected during consultations with the...
Tony Wl Mak - One of the best experts on this subject based on the ideXlab platform.
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two cases of severe Intoxication associated with analytically confirmed use of the novel psychoactive substances 25b nbome and 25c nbome
Clinical Toxicology, 2014Co-Authors: Magdalene Hy Tang, C K Ching, Matthew Sik Hon Tsui, F K C Chu, Tony Wl MakAbstract:AbstractContext. A new group of novel psychoactive substance, the N-methoxybenzyl (NBOMe) derivatives of substituted phenethylamine, has recently emerged on the drug market, among which 25I-NBOMe and 25B-NBOMe have previously been implicated in clinical Intoxications and fatalities. We report two cases of acute Intoxication associated with these substances. Case details. Two male patients (17 and 31 years of age) had ingested drugs labelled as ‘NBOMe’ or ‘Holland film’ and developed confusion, agitation, hypertension, tachycardia, hyperthermia, sweating and dilated pupils. Other features included convulsion, rhabdomyolysis and deranged liver function. The patients required benzodiazepines and other drugs for the control of symptoms. Urine samples from both patients were analysed using liquid-chromatography tandem mass spectrometry (LC-MS/MS) following glucuronidase digestion and solid-phase extraction. Identification was based upon comparison of the retention time and enhanced product ion scan with refere...
Lisa Franzén - One of the best experts on this subject based on the ideXlab platform.
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Acute Intoxications Involving α-Pyrrolidinobutiophenone (α-PBP): Results from the Swedish STRIDA Project
Journal of Medical Toxicology, 2018Co-Authors: Lisa Franzén, Matilda Bäckberg, Olof Beck, Anders HelanderAbstract:Introduction Many new psychoactive substances (NPS) introduced as recreational drugs have been associated with severe Intoxication and death. Methods Blood and/or urine samples were collected from intoxicated patients treated at Swedish hospitals that participated in the STRIDA project, a nationawide effort to address the growing problem of NPS. In patients undergoing evaluation for drug overdose, α-PBP was identified using liquid chromatography-mass spectrometry. Demographic and clinical data were collected during Poisons Information Centre consultations and retrieved from medical records. Results From April 2013 to November 2015, 43 patients tested positive for α-PBP. However, α-PBP was never specifically mentioned during consultation but only confirmed analytically. The α-PBP concentrations ranged 2.0–13,200 ng/mL in urine and 2.0–440 ng/mL in serum. The patients were aged 19–57 (mean 34) years, 81% were men, and 73% were known drug addicts. All cases except 1 also involved other NPS and/or classical drugs. MDPV, α-PVP, and other pyrovalerone analogues were the most common other NPS (31 cases; 72%). CNS depressants were detected in 28 cases (65%), with benzodiazepines (16 cases) being most frequent. Main clinical characteristics were agitation/anxiety (59%), tachycardia (54%), and hypertension (37%), and 14 patients (33%) required monitoring in the intensive care unit of which 8 were graded as severe Intoxications. No fatalities were reported. Conclusion Patients with Intoxication from α-PBP resembled those by NPS cathinones MDPV and α-PVP. As patients never specifically declared α-PBP intake and poly-drug Intoxication was common, they may have been unaware of the actual substance taken.
