The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform
Shital N. Parikh - One of the best experts on this subject based on the ideXlab platform.
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Spectrum of operative childhood Intra-Articular shoulder pathology
Journal of Children's Orthopaedics, 2014Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Purpose With increased sports participation and medical community awareness, there appears to be an increase in pediatric musculoskeletal injuries. Our purpose was to identify the Intra-Articular Injury pattern seen within the pediatric shoulder. Methods A retrospective review was performed at two tertiary-care children’s hospitals between 2008 and 2011 on all patients who underwent magnetic resonance imaging (MRI) and subsequent shoulder arthroscopy. Exclusion criteria included: girls >14 years old and boys >16 years old. Demographics, MRI and arthroscopic findings were recorded. Labral pathology was grouped: Zone I (Bankart lesions, 3–6 o’clock for right shoulder), Zone II (posterior labral lesions, 6–11 o’clock), Zone III (SLAP lesions, 11–1 o’clock), and Zone IV (anatomic variants, 1–3 o’clock). Results One hundred and fifteen children met criteria, mean age 14.4 years (range 8–16). There were 24 girls and 91 boys, with 70 right shoulders. Of 108 children, labral pathology involved: 72 Zone I (16 isolated anterior), 56 Zone II (15 isolated posterior), 38 Zone III (four isolated superior), and three had an isolated Buford complex. Seventy had more than one labral zone injured, and 31 (30 %) had more than two zones injured. Non-labral pathology included partial rotator cuff tears and humeral avulsions of the glenohumeral ligament. Conclusion With 94 % of Intra-Articular pathology being labral tears, the distribution of proportion in children differs from adults; moreover, 23 % involved only the posterior or posterosuperior labrum. Treating surgeons should be prepared to find anterior tears extending beyond the zone of a classic Bankart lesion and an association with C rotator cuff tears.
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Spectrum of operative childhood Intra-Articular shoulder pathology
Journal of Children's Orthopaedics, 2014Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Purpose With increased sports participation and medical community awareness, there appears to be an increase in pediatric musculoskeletal injuries. Our purpose was to identify the Intra-Articular Injury pattern seen within the pediatric shoulder.
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Spectrum of Childhood Intra-Articular Shoulder Pathology
Orthopaedic Journal of Sports Medicine, 2013Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Objectives: With increased sports participation and awareness on behalf of the medical community, there appears to be an increase in childhood musculoskeletal injuries. The spectrum of Intra-Articular shoulder pathology in this skeletally immature population has not been well described. The purpose of this study was to identify the Intra-Articular Injury pattern seen within the childhood shoulder.
Dana L Nettles - One of the best experts on this subject based on the ideXlab platform.
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Synovial fluid cytokines, matrix metalloproteinases, and cartilage breakdown products correlate with time from Intra-Articular ankle fracture but not severity
Journal of Orthopaedic Research, 2017Co-Authors: S B Adams, R M Reilly, Janet L Huebner, Virginia B Kraus, Dana L NettlesAbstract:INTRODUCTION: Post-traumatic osteoarthritis (PTOA) is a frequent cause of disability and is estimated to be the primary etiology of ankle arthritis (80%). The most common predisposing factor for ankle PTOA is Intra-Articular ankle fracture. It has been hypothesized that an early inflammatory response after Intra-Articular Injury could lead to irreversible cartilage damage. The most commonly studied post-traumatic scenario is the anterior cruciate ligament (ACL) injured knee. It is known that after ACL Injury, cytokines and matrix metalloproteinases (MMPs) are released and initiate an inflammatory response that persists for weeks. However, the post-fracture situation has rarely been studied and likely differs from ACL Injury due to the exposure of the synovium and cartilage to bone marrow elements. Previously, our group demonstrated significantly elevated inflammatory cytokines and MMPs in the synovial fluid (SF) of Intra-Articular ankle fractures. However, the composition of these inflammatory mediators in the synovial fluid with regard to time after ankle fracture and fracture severity is still unknown. Understanding the temporal relationship of inflammatory mediators after ankle fracture is important for the development of appropriate anti-inflammatory therapeutics. The purpose of this study was to define the SF composition of inflammatory mediators and cartilage breakdown products with relation to time after and severity of Intra-Articular ankle fracture. METHODS: Undiluted synovial fluid was obtained from 54 Intra-Articular ankle fractures at the time of surgery (either external fixation or definitive fixation) under IRB approval. The synovial fluid was immediately aliquoted and stored at -80degreeC for batch analysis. After all samples were collected, the SF was analyzed for GM-CSF, IFN-gamma, TNF-alpha, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, CTXII, sGAG, and bilirubin/biliverdin (markers of hemarthrosis) with either multiplex assay or ELISA using commercially available kits. In addition, the number of intraarticular fracture lines was recorded based on radiographs and fractures were grouped accordingly (1, 2, 3, or 4 fracture lines). Values for concentrations of measured cytokines and soluble factors that fell below the manufacturer's lower limit of detection (LLOD) were replaced by 1/2 LLOD for statistical analyses. Distributions for all measured variables were found to be non-parametric (Shapiro-Wilk W test); thus, Spearman's correlation coefficient (rho) was tested against the null hypothesis that rho = 0 (alpha
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Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-Articular Ankle Fracture.
Foot & Ankle International, 2015Co-Authors: Samuel B. Adams, Janet L Huebner, Virginia B Kraus, Lori A. Setton, Richard D. Bell, Mark E. Easley, Thomas Stabler, Elizabeth M. Leimer, Steven A. Olson, Dana L NettlesAbstract:Background:Posttraumatic osteoarthritis (PTOA) can occur after Intra-Articular fracture despite anatomic fracture reduction. It has been hypothesized that an early inflammatory response after Intra-Articular Injury could lead to irreversible cartilage damage that progresses to PTOA. Therefore, in addition to meticulous fracture reduction, it would be ideal to prevent this initial inflammatory response but little is known about the composition of the synovial environment after Intra-Articular fracture. The purpose of this work was to characterize the inflammatory cytokine and matrix metalloproteinase (MMP) composition in the synovial fluid (SF) of patients with acute Intra-Articular ankle fractures.Methods:Twenty-one patients with an Intra-Articular ankle fracture were included in this study. All patients had a contralateral ankle joint that was pain free, had no radiographic evidence of arthritis, and no history of trauma. The uninjured ankle served as a matched control. SF was obtained from bilateral ank...
Eric W. Edmonds - One of the best experts on this subject based on the ideXlab platform.
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Spectrum of operative childhood Intra-Articular shoulder pathology
Journal of Children's Orthopaedics, 2014Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Purpose With increased sports participation and medical community awareness, there appears to be an increase in pediatric musculoskeletal injuries. Our purpose was to identify the Intra-Articular Injury pattern seen within the pediatric shoulder. Methods A retrospective review was performed at two tertiary-care children’s hospitals between 2008 and 2011 on all patients who underwent magnetic resonance imaging (MRI) and subsequent shoulder arthroscopy. Exclusion criteria included: girls >14 years old and boys >16 years old. Demographics, MRI and arthroscopic findings were recorded. Labral pathology was grouped: Zone I (Bankart lesions, 3–6 o’clock for right shoulder), Zone II (posterior labral lesions, 6–11 o’clock), Zone III (SLAP lesions, 11–1 o’clock), and Zone IV (anatomic variants, 1–3 o’clock). Results One hundred and fifteen children met criteria, mean age 14.4 years (range 8–16). There were 24 girls and 91 boys, with 70 right shoulders. Of 108 children, labral pathology involved: 72 Zone I (16 isolated anterior), 56 Zone II (15 isolated posterior), 38 Zone III (four isolated superior), and three had an isolated Buford complex. Seventy had more than one labral zone injured, and 31 (30 %) had more than two zones injured. Non-labral pathology included partial rotator cuff tears and humeral avulsions of the glenohumeral ligament. Conclusion With 94 % of Intra-Articular pathology being labral tears, the distribution of proportion in children differs from adults; moreover, 23 % involved only the posterior or posterosuperior labrum. Treating surgeons should be prepared to find anterior tears extending beyond the zone of a classic Bankart lesion and an association with C rotator cuff tears.
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Spectrum of operative childhood Intra-Articular shoulder pathology
Journal of Children's Orthopaedics, 2014Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Purpose With increased sports participation and medical community awareness, there appears to be an increase in pediatric musculoskeletal injuries. Our purpose was to identify the Intra-Articular Injury pattern seen within the pediatric shoulder.
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Spectrum of Childhood Intra-Articular Shoulder Pathology
Orthopaedic Journal of Sports Medicine, 2013Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Objectives: With increased sports participation and awareness on behalf of the medical community, there appears to be an increase in childhood musculoskeletal injuries. The spectrum of Intra-Articular shoulder pathology in this skeletally immature population has not been well described. The purpose of this study was to identify the Intra-Articular Injury pattern seen within the childhood shoulder.
S B Adams - One of the best experts on this subject based on the ideXlab platform.
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Synovial fluid cytokines, matrix metalloproteinases, and cartilage breakdown products correlate with time from Intra-Articular ankle fracture but not severity
Journal of Orthopaedic Research, 2017Co-Authors: S B Adams, R M Reilly, Janet L Huebner, Virginia B Kraus, Dana L NettlesAbstract:INTRODUCTION: Post-traumatic osteoarthritis (PTOA) is a frequent cause of disability and is estimated to be the primary etiology of ankle arthritis (80%). The most common predisposing factor for ankle PTOA is Intra-Articular ankle fracture. It has been hypothesized that an early inflammatory response after Intra-Articular Injury could lead to irreversible cartilage damage. The most commonly studied post-traumatic scenario is the anterior cruciate ligament (ACL) injured knee. It is known that after ACL Injury, cytokines and matrix metalloproteinases (MMPs) are released and initiate an inflammatory response that persists for weeks. However, the post-fracture situation has rarely been studied and likely differs from ACL Injury due to the exposure of the synovium and cartilage to bone marrow elements. Previously, our group demonstrated significantly elevated inflammatory cytokines and MMPs in the synovial fluid (SF) of Intra-Articular ankle fractures. However, the composition of these inflammatory mediators in the synovial fluid with regard to time after ankle fracture and fracture severity is still unknown. Understanding the temporal relationship of inflammatory mediators after ankle fracture is important for the development of appropriate anti-inflammatory therapeutics. The purpose of this study was to define the SF composition of inflammatory mediators and cartilage breakdown products with relation to time after and severity of Intra-Articular ankle fracture. METHODS: Undiluted synovial fluid was obtained from 54 Intra-Articular ankle fractures at the time of surgery (either external fixation or definitive fixation) under IRB approval. The synovial fluid was immediately aliquoted and stored at -80degreeC for batch analysis. After all samples were collected, the SF was analyzed for GM-CSF, IFN-gamma, TNF-alpha, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, CTXII, sGAG, and bilirubin/biliverdin (markers of hemarthrosis) with either multiplex assay or ELISA using commercially available kits. In addition, the number of intraarticular fracture lines was recorded based on radiographs and fractures were grouped accordingly (1, 2, 3, or 4 fracture lines). Values for concentrations of measured cytokines and soluble factors that fell below the manufacturer's lower limit of detection (LLOD) were replaced by 1/2 LLOD for statistical analyses. Distributions for all measured variables were found to be non-parametric (Shapiro-Wilk W test); thus, Spearman's correlation coefficient (rho) was tested against the null hypothesis that rho = 0 (alpha
Joanna H. Roocroft - One of the best experts on this subject based on the ideXlab platform.
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Spectrum of operative childhood Intra-Articular shoulder pathology
Journal of Children's Orthopaedics, 2014Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Purpose With increased sports participation and medical community awareness, there appears to be an increase in pediatric musculoskeletal injuries. Our purpose was to identify the Intra-Articular Injury pattern seen within the pediatric shoulder. Methods A retrospective review was performed at two tertiary-care children’s hospitals between 2008 and 2011 on all patients who underwent magnetic resonance imaging (MRI) and subsequent shoulder arthroscopy. Exclusion criteria included: girls >14 years old and boys >16 years old. Demographics, MRI and arthroscopic findings were recorded. Labral pathology was grouped: Zone I (Bankart lesions, 3–6 o’clock for right shoulder), Zone II (posterior labral lesions, 6–11 o’clock), Zone III (SLAP lesions, 11–1 o’clock), and Zone IV (anatomic variants, 1–3 o’clock). Results One hundred and fifteen children met criteria, mean age 14.4 years (range 8–16). There were 24 girls and 91 boys, with 70 right shoulders. Of 108 children, labral pathology involved: 72 Zone I (16 isolated anterior), 56 Zone II (15 isolated posterior), 38 Zone III (four isolated superior), and three had an isolated Buford complex. Seventy had more than one labral zone injured, and 31 (30 %) had more than two zones injured. Non-labral pathology included partial rotator cuff tears and humeral avulsions of the glenohumeral ligament. Conclusion With 94 % of Intra-Articular pathology being labral tears, the distribution of proportion in children differs from adults; moreover, 23 % involved only the posterior or posterosuperior labrum. Treating surgeons should be prepared to find anterior tears extending beyond the zone of a classic Bankart lesion and an association with C rotator cuff tears.
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Spectrum of operative childhood Intra-Articular shoulder pathology
Journal of Children's Orthopaedics, 2014Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Purpose With increased sports participation and medical community awareness, there appears to be an increase in pediatric musculoskeletal injuries. Our purpose was to identify the Intra-Articular Injury pattern seen within the pediatric shoulder.
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Spectrum of Childhood Intra-Articular Shoulder Pathology
Orthopaedic Journal of Sports Medicine, 2013Co-Authors: Eric W. Edmonds, Joanna H. Roocroft, Shital N. ParikhAbstract:Objectives: With increased sports participation and awareness on behalf of the medical community, there appears to be an increase in childhood musculoskeletal injuries. The spectrum of Intra-Articular shoulder pathology in this skeletally immature population has not been well described. The purpose of this study was to identify the Intra-Articular Injury pattern seen within the childhood shoulder.
