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Akira Ono - One of the best experts on this subject based on the ideXlab platform.
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design synthesis and cellular uptake of oligonucleotides bearing glutathione labile protecting groups
Organic Letters, 2019Co-Authors: Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, Takeo Saneyoshi, Akira OnoAbstract:Glutathione-labile protecting groups for phosphodiester moieties in oligonucleotides were designed, synthesized, and incorporated into oligonucleotides. The protecting groups on the phosphodiester moieties were cleaved in a buffer containing 10 mM glutathione, which was used as a model of Intracellular Fluid. Cellular uptake of oligonucleotides bearing glutathione-labile protecting groups was strongly affected by the location and number of the protecting groups.
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Design, Synthesis, and Cellular Uptake of Oligonucleotides Bearing Glutathione-Labile Protecting Groups
2019Co-Authors: Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, Takeo Saneyoshi, Akira OnoAbstract:Glutathione-labile protecting groups for phosphodiester moieties in oligonucleotides were designed, synthesized, and incorporated into oligonucleotides. The protecting groups on the phosphodiester moieties were cleaved in a buffer containing 10 mM glutathione, which was used as a model of Intracellular Fluid. Cellular uptake of oligonucleotides bearing glutathione-labile protecting groups was strongly affected by the location and number of the protecting groups
Hisao Saneyoshi - One of the best experts on this subject based on the ideXlab platform.
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design synthesis and cellular uptake of oligonucleotides bearing glutathione labile protecting groups
Organic Letters, 2019Co-Authors: Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, Takeo Saneyoshi, Akira OnoAbstract:Glutathione-labile protecting groups for phosphodiester moieties in oligonucleotides were designed, synthesized, and incorporated into oligonucleotides. The protecting groups on the phosphodiester moieties were cleaved in a buffer containing 10 mM glutathione, which was used as a model of Intracellular Fluid. Cellular uptake of oligonucleotides bearing glutathione-labile protecting groups was strongly affected by the location and number of the protecting groups.
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Design, Synthesis, and Cellular Uptake of Oligonucleotides Bearing Glutathione-Labile Protecting Groups
2019Co-Authors: Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, Takeo Saneyoshi, Akira OnoAbstract:Glutathione-labile protecting groups for phosphodiester moieties in oligonucleotides were designed, synthesized, and incorporated into oligonucleotides. The protecting groups on the phosphodiester moieties were cleaved in a buffer containing 10 mM glutathione, which was used as a model of Intracellular Fluid. Cellular uptake of oligonucleotides bearing glutathione-labile protecting groups was strongly affected by the location and number of the protecting groups
Nancy Shanklin - One of the best experts on this subject based on the ideXlab platform.
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effect of bicarbonate administration on plasma potassium in dialysis patients interactions with insulin and albuterol
American Journal of Kidney Diseases, 1996Co-Authors: Michael Allon, Nancy ShanklinAbstract:Acute treatment of hyperkalemia in patients with end-stage renal disease requires temporizing measures to shift potassium rapidly from the extracellular to the Intracellular Fluid compartments until hemodialysis can be initiated. Whereas insulin and albuterol are effective in lowering plasma potassium acutely, bicarbonate by itself is not. Bicarbonate administration may, however, potentiate the effects of insulin and albuterol on plasma potassium. Using a prospective cross-over design, we investigated the acute effects of (1) isotonic bicarbonate, (2) isotonic saline, (3) insulin + bicarbonate, (4) insulin + saline, (5) albuterol + bicarbonate, and (6) albuterol + saline on plasma potassium as well as blood bicarbonate and pH in nondiabetic hemodialysis patients. After obtaining a baseline blood sample, the subjects received one of the six treatment protocols, with plasma potassium measured every 15 minutes over 1 hour. Neither isotonic bicarbonate nor isotonic saline decreased plasma potassium significantly (-0.03 +/- 0.06 mmol/L v -0.01 +/- 0.10 mmol/L at 60 minutes; P = 0.60). Intravenous insulin decreased plasma potassium by a similar degree when given in conjunction with bicarbonate or saline (-0.81 +/- 0.05 mmol/L v -0.85 +/- 0.06 mmol/L at 60 minutes; P = 0.65). Likewise, nebulized albuterol decreased plasma potassium by a similar degree when given with bicarbonate or saline (-0.71 +/- 0.16 mmol/L v -0.53 +/- 0.15 mmol/L at 60 minutes; P = 0.18). The three protocols that included bicarbonate administration resulted in significant increases in blood bicarbonate (P < 0.005) and pH (P < 0.01), whereas the three protocols that included saline did not affect blood bicarbonate or pH. These observations suggest that bicarbonate administration does not potentiate the potassium-lowering effects of insulin or albuterol in hemodialysis patients.
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effect of bicarbonate administration on plasma potassium in dialysis patients interactions with insulin and albuterol
American Journal of Kidney Diseases, 1996Co-Authors: Michael Allon, Nancy ShanklinAbstract:Abstract Acute treatment of hyperkalemia in patients with end-stage renal disease requires temporizing measures to shift potassium rapidly from the extracellular to the Intracellular Fluid compartments until hemodialysis can be initiated. Whereas insulin and albuterol are effective in lowering plasma potassium acutely, bicarbonate by itself is not. Bicarbonate administration may, however, potentiate the effects of insulin and albuterol on plasma potassium. Using a prospective cross-over design, we investigated the acute effects of (1) isotonic bicarbonate, (2) isotonic saline, (3) insulin + bicarbonate, (4) insulin + saline, (5) albuterol + bicarbonate, and (6) albuterol + saline on plasma potassium as well as blood bicarbonate and pH in nondiabetic hemodialysis patients. After obtaining a baseline blood sample, the subjects received one of the six treatment protocols, with plasma potassium measured every 15 minutes over 1 hour. Neither isotonic bicarbonate nor isotonic saline decreased plasma potassium significantly (−0.03 ± 0.06 mmol/L v −0.01 ± 0.10 mmol/L at 60 minutes; P = 0.60). Intravenous insulin decreased plasma potassium by a similar degree when given in conjunction with bicarbonate or saline (−0.81 ± 0.05 mmol/ L v −0.85 ± 0.06 mmol/L at 60 minutes; P = 0.65). Likewise, nebulized albuterol decreased plasma potassium by a similar degree when given with bicarbonate or saline (−0.71 ± 0.16 mmol/L v −0.53 ± 0.15 mmol/L at 60 minutes; P = 0.18). The three protocols that included bicarbonate administration resulted in significant increases in blood bicarbonate ( P P
Rifai Akhmad - One of the best experts on this subject based on the ideXlab platform.
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HIPERVOLEMIA PADA PASIEN CONGESTIVE HEART FAILURE (CHF)
Interest : Jurnal Ilmu Kesehatan, 2018Co-Authors: Astuti, Yeni Eka, Setyorini Yuyun, Rifai AkhmadAbstract:Background: Congestive Heart Failure (CHF) is a condition in which the heart is unable to pump blood normally, causing disturbed venous return pressure to cause edema. The problem that arises is hypervolemia or Intracellular Fluid resuscitation to the interstitial that causes edema so that can be arranged nursing intervention one of them is giving diuretic and monitor Fluid balance. Describes nursing care performed in Congestive Heart Failure (CHF) patients with hypervolemia. Method: This study uses data analysis method that is conducting the nursing process of two patients Congestive Heart Failure (CHF) who suffered from Hypervolemia disorder and then compared with case study journal as well as other sources. Result: After nursing action in both patients the Hipervolemia problem is equally partially resolved by Fluid restriction nursing interventions, and the administration of diuretics. Conclusion: In providing nursing care to patients with Congestive Heart Failure (CHF) should pay attention to Fluid restriction and appropriate diuretic administration to reduce edema. Keyword: Congestive Heart Failure (CHF), Hipervolemia, Nursing Care LINK OJS 3 ARTIKEL "HIPERVOLEMIA PADA PASIEN CONGESTIVE HEART FAILURE (CHF)
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Hipervolemia Pada Pasien Congestive Heart Failure (CHF)
'Poltekkes Kemenkes Surakarta', 2018Co-Authors: Astuti, Yeni Eka, Setyorini Yuyun, Rifai AkhmadAbstract:Background: Congestive Heart Failure (CHF) is a condition in which the heart is unable to pump blood normally, causing disturbed venous return pressure to cause edema. The problem that arises is hypervolemia or Intracellular Fluid resuscitation to the interstitial that causes edema so that can be arranged nursing intervention one of them is giving diuretic and monitor Fluid balance. Describes nursing care performed in Congestive Heart Failure (CHF) patients with hypervolemia. Method: This study uses data analysis method that is conducting the nursing process of two patients Congestive Heart Failure (CHF) who suffered from Hypervolemia disorder and then compared with case study journal as well as other sources. Result: After nursing action in both patients the Hipervolemia problem is equally partially resolved by Fluid restriction nursing interventions, and the administration of diuretics. Conclusion: In providing nursing care to patients with Congestive Heart Failure (CHF) should pay attention to Fluid restriction and appropriate diuretic administration to reduce edema
James T Kuznicki - One of the best experts on this subject based on the ideXlab platform.
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bioimpedance spectroscopy technique intra extracellular and total body water
Medicine and Science in Sports and Exercise, 1997Co-Authors: Lawrence E Armstrong, Robert W Kenefick, John W Castellani, Deborah Riebe, Stavros A Kavouras, James T KuznickiAbstract:The purpose of this study was to test the validity of a multiple frequency bioimpedance spectroscopy (BIS) technique that estimates extracellular Fluid volume (ECV), Intracellular Fluid volume (ICV), and total body water (TBW). Thirteen healthy males (mean +/- SD: age, 23 +/- 3 yr; body mass, 80.6 +/- 14.7 kg) had their TBW and ECV measured by ingesting dilution tracers (7.27 g deuterium oxide, 1.70 g sodium bromide; blood samples at 0 and 4 h). ICV was calculated as TBW minus ECV. Impedance was measured (50-500 kHz) at rest, on a nonconducting surface, with a BIS analyzer. Electrode placement, posture, exercise, food/Fluid intake, and ambient temperature were controlled. Dilution measures (TBW, 51.00 +/- 9.30; ECV, 19.88 +/- 3.14; ICV, 31.12 +/- 6.80 L) and BIS volumes (TBW, 50.03 +/- 7.67; ECV, 20.95 +/- 3.33; ICV, 29.04 +/- 4.51 L) were significantly different for ECV (P < 0.01) and ICV (P < 0.05); some individual differences were large. The correlation coefficients of dilution versus BIS volumes (r = 0.93 to 0.96) were significant at P < 0.0001; SEEs were: TBW, 2.23 L; ECV, 1.26 L; and ICV, 1.71 L. We concluded that BIS is valid for between-subject comparisons of body Fluid compartments, is appropriate in clinical settings where change in ECV/ICV ratio is important, and should be used by comparing the required level of accuracy to the inherent technique error/variance.
