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Eric A. Stone - One of the best experts on this subject based on the ideXlab platform.

  • Further evidence for an immediate antidepressant action of Intracerebral Drug Administration in a model of chronic depression
    The international journal of neuropsychopharmacology, 2010
    Co-Authors: Yan Lin, Raymond F. Suckow, Yasmeen Sarfraz, Eric A. Stone
    Abstract:

    This study was designed to replicate an earlier finding of a rapid acute therapeutic action of Intracerebrally administered antidepressant in chronically depressed rodents. The effects of acute fourth ventricular (ivt.) injections were compared to those of acute peripheral (i.p.) injections of desipramine (DMI) in mice subjected to repeated open-space forced swim. In confirmation, it was found that a single ivt. injection of a low (3 nmol) but not high (30 nmol) dose immediately reversed the immobility and inactivity of the model whereas acute i.p. Administration was without effect up to 30 mg/kg. The repeated forced swim stress was also found to significantly reduce the net accumulation of DMI in the brain but not liver after a single i.p. injection of a moderate dose (10 mg/kg). The results suggest that stress-induced alterations of regional Drug uptake or metabolism in the CNS may contribute to the therapeutic lag for antidepressants and other compounds in disorders with high distress.

Yan Lin - One of the best experts on this subject based on the ideXlab platform.

  • Further evidence for an immediate antidepressant action of Intracerebral Drug Administration in a model of chronic depression
    The international journal of neuropsychopharmacology, 2010
    Co-Authors: Yan Lin, Raymond F. Suckow, Yasmeen Sarfraz, Eric A. Stone
    Abstract:

    This study was designed to replicate an earlier finding of a rapid acute therapeutic action of Intracerebrally administered antidepressant in chronically depressed rodents. The effects of acute fourth ventricular (ivt.) injections were compared to those of acute peripheral (i.p.) injections of desipramine (DMI) in mice subjected to repeated open-space forced swim. In confirmation, it was found that a single ivt. injection of a low (3 nmol) but not high (30 nmol) dose immediately reversed the immobility and inactivity of the model whereas acute i.p. Administration was without effect up to 30 mg/kg. The repeated forced swim stress was also found to significantly reduce the net accumulation of DMI in the brain but not liver after a single i.p. injection of a moderate dose (10 mg/kg). The results suggest that stress-induced alterations of regional Drug uptake or metabolism in the CNS may contribute to the therapeutic lag for antidepressants and other compounds in disorders with high distress.

Simone H. Pinheiro - One of the best experts on this subject based on the ideXlab platform.

  • Elevated mazes as animal models of anxiety: effects of serotonergic agents
    Anais da Academia Brasileira de Ciencias, 2007
    Co-Authors: Simone H. Pinheiro, Hélio Zangrossi, Cristina Marta Del-ben, Frederico Guilherme Graeff
    Abstract:

    This article reviews reported results about the effects of Drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, Intracerebral Drug Administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of Drugs on the inhibitory avoidance task performed in the elevated T-maze and on the spatio temporal indexes of anxiety measured in the X and plus mazes correlate with their effect in patients diagnosed with generalized anxiety disorder. In contrast, the Drug effects on the one-way escape task in the elevated T-maze predict the Drug response of panic disorder patients. Overall, the Drug effects assessed with the avoidance task in the T-maze are more consistent than those measured through the anxiety indexes of the X and plus mazes. Therefore, the elevated T-maze is a promising animal model of generalized anxiety and panic disorder.

  • Elevated mazes as animal models of anxiety: effects of serotonergic agents
    Academia Brasileira de Ciências, 2007
    Co-Authors: Simone H. Pinheiro, Cristina Marta Del-ben, Hélio Zangrossi-jr, Frederico Guilherme Graeff
    Abstract:

    This article reviews reported results about the effects of Drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, Intracerebral Drug Administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of Drugs on the inhibitory avoidance task performed in the elevated T-maze and on the spatio temporal indexes of anxiety measured in the X and plus mazes correlate with their effect in patients diagnosed with generalized anxiety disorder. In contrast, the Drug effects on the one-way escape task in the elevated T-maze predict the Drug response of panic disorder patients. Overall, the Drug effects assessed with the avoidance task in the T-maze are more consistent than those measured through the anxiety indexes of the X and plus mazes. Therefore, the elevated T-maze is a promising animal model of generalized anxiety and panic disorder.No presente artigo, revisamos resultados publicados relatando efeitos de drogas que atuam na neurotransmissão serotonérgica medidos em três labirintos elevados, que são modelos animais de ansiedade. Realizamos uma busca bibliográfica no MEDLINE, usando diferentes combinações das palavras-chave: X-maze, plus-maze, T-maze, serotonin e 5-HT, presentes no título ou no resumo, sem limite de tempo. Dos resumos obtidos, vários foram excluídos com base nos seguintes critérios: artigos de revisão que não continham resultados originais, espécies diferentes do rato, apenas injeções intracerebrais, ratos geneticamente manipulados, animais com algum tipo de patologia experimental. Os resultados relatados indicam que o efeito de drogas na tarefa de esquiva inibitória desempenhada no labirinto em T elevado, bem como nos índices espaciais de ansiedade nos labirintos em X ou em forma de cruz se correlacionam com os efeitos em pacientes diagnosticados com o transtorno de ansiedade generalizada. Por outro lado, os efeitos de drogas na tarefa de fuga unidirecional do labirinto em T predizem a resposta a drogas dos pacientes com o transtorno de pânico. De modo geral, os efeitos de drogas sobre a tarefa de esquiva no labirinto em T são mais consistentes que os medidos pelos índices de ansiedade calculados nos labirintos em X e em forma de cruz. Portanto, o labirinto em T-elevado é um modelo promissor dos transtornos de ansiedade generalizada e de pânico

  • www.scielo.br/aabc Elevated mazes as animal models of anxiety: effects of serotonergic agents
    2006
    Co-Authors: Simone H. Pinheiro, Cristina Marta Del-ben, Hélio Zangrossi-jr, Psiquiatria Psicologia E Médica, Hospital Das Clínicas
    Abstract:

    contributed by FREDERICO G. GRAEFF* This article reviews reported results about the effects of Drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MED-LINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, Intracerebral Drug Administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of Drugs on the inhibitory avoidance task performed in the elevated T-maze and on the spatio temporal indexes of anxiety measured in the X and plus mazes correlate with their effect in patients diagnosed with generalized anxiety disorder. In contrast, the Drug effects on the one-way escape task in the elevated T-maze predict the Drug response of panic disorder patients. Overall, the Drug effects assessed with the avoidance task in the T-maze are more consistent than those measured through the anxiety indexes of the X and plus mazes. Therefore, the elevated T-maze is a promising animal model of generalized anxiety and panic disorder. Key words: animal model, elevated maze, anxiety, panic, serotonin

Frederico Guilherme Graeff - One of the best experts on this subject based on the ideXlab platform.

  • Elevated mazes as animal models of anxiety: effects of serotonergic agents
    Anais da Academia Brasileira de Ciencias, 2007
    Co-Authors: Simone H. Pinheiro, Hélio Zangrossi, Cristina Marta Del-ben, Frederico Guilherme Graeff
    Abstract:

    This article reviews reported results about the effects of Drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, Intracerebral Drug Administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of Drugs on the inhibitory avoidance task performed in the elevated T-maze and on the spatio temporal indexes of anxiety measured in the X and plus mazes correlate with their effect in patients diagnosed with generalized anxiety disorder. In contrast, the Drug effects on the one-way escape task in the elevated T-maze predict the Drug response of panic disorder patients. Overall, the Drug effects assessed with the avoidance task in the T-maze are more consistent than those measured through the anxiety indexes of the X and plus mazes. Therefore, the elevated T-maze is a promising animal model of generalized anxiety and panic disorder.

  • Elevated mazes as animal models of anxiety: effects of serotonergic agents
    Academia Brasileira de Ciências, 2007
    Co-Authors: Simone H. Pinheiro, Cristina Marta Del-ben, Hélio Zangrossi-jr, Frederico Guilherme Graeff
    Abstract:

    This article reviews reported results about the effects of Drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, Intracerebral Drug Administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of Drugs on the inhibitory avoidance task performed in the elevated T-maze and on the spatio temporal indexes of anxiety measured in the X and plus mazes correlate with their effect in patients diagnosed with generalized anxiety disorder. In contrast, the Drug effects on the one-way escape task in the elevated T-maze predict the Drug response of panic disorder patients. Overall, the Drug effects assessed with the avoidance task in the T-maze are more consistent than those measured through the anxiety indexes of the X and plus mazes. Therefore, the elevated T-maze is a promising animal model of generalized anxiety and panic disorder.No presente artigo, revisamos resultados publicados relatando efeitos de drogas que atuam na neurotransmissão serotonérgica medidos em três labirintos elevados, que são modelos animais de ansiedade. Realizamos uma busca bibliográfica no MEDLINE, usando diferentes combinações das palavras-chave: X-maze, plus-maze, T-maze, serotonin e 5-HT, presentes no título ou no resumo, sem limite de tempo. Dos resumos obtidos, vários foram excluídos com base nos seguintes critérios: artigos de revisão que não continham resultados originais, espécies diferentes do rato, apenas injeções intracerebrais, ratos geneticamente manipulados, animais com algum tipo de patologia experimental. Os resultados relatados indicam que o efeito de drogas na tarefa de esquiva inibitória desempenhada no labirinto em T elevado, bem como nos índices espaciais de ansiedade nos labirintos em X ou em forma de cruz se correlacionam com os efeitos em pacientes diagnosticados com o transtorno de ansiedade generalizada. Por outro lado, os efeitos de drogas na tarefa de fuga unidirecional do labirinto em T predizem a resposta a drogas dos pacientes com o transtorno de pânico. De modo geral, os efeitos de drogas sobre a tarefa de esquiva no labirinto em T são mais consistentes que os medidos pelos índices de ansiedade calculados nos labirintos em X e em forma de cruz. Portanto, o labirinto em T-elevado é um modelo promissor dos transtornos de ansiedade generalizada e de pânico

B. Jardon - One of the best experts on this subject based on the ideXlab platform.

  • Effects on the chicken monocular OKN of unilateral microinjections of GABA_A antagonist into the mesencephalic structures responsible for OKN
    Experimental Brain Research, 1992
    Co-Authors: N. Bonaventure, M. S. Kim, B. Jardon
    Abstract:

    The SR 95531, a GABA_A antagonist was microinjected into either the pretectum nuclei, (nucleus Superficialis Synencephali nSS) or the nBOR (nucleus Ectomammillaris nEM) of chickens. Monocular optokinetic nystamus (OKN) of each eye was recorded by the search coil technique before and after unilateral Intracerebral Drug Administration. Before injection, monocular horizontal OKN in chickens, as in other lower vertebrates, displays a directional asymmetry: the stimulation in the Temporo-Nasal (T-N) direction is more efficient in evoking OKN than is stimulation in the Naso-Temporal (N-T) direction. Unilateral microinjections of SR 95531 into either the nSS or nEM induce a reversible increase of gain in OKN directed by the contralateral eye for both directions of stimulation. However Administration into the nSS increased directional asymmetry by increasing the T-N component slow phase velocity more strongly than the N-T component slow phase velocity. On the other hand, the unilateral Administration of the Drug into the nEM suppressed the directional OKN asymmetry by increasing the N-T component slow phase velocity more strongly than the T-N component slow phase velocity. These results indicate that the Drug suppresses GABAergic inhibition at the mesencephalic level. Moreover the nSS seems especially involved in monocular OKN in response to a T-N stimulation, while the nEM seems more involved in the OKN response to N-T stimulation. The increase in gain of OKN directed by the ipsilateral eye to microinjected nuclei could account for the strong interactions existing between these mesencephalic structures responsible for horizontal OKN.