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Catharina J M Klijn - One of the best experts on this subject based on the ideXlab platform.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral Hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Robert J Van Oostenbrugge, Walter H Backes, Frans R J Verhey, Catharina J M Klijn
    Abstract:

    Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral Hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral Hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral Hemorrhage or cerebral microbleeds. Results: Of 26 eligible studies, 10 were animal studies and 16 were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral Hemorrhage (n = 32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n = 47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n = 117) and seven out of nine studies examining Intracerebral Hemorrhage with mixed or unspecified underlying etiology (n = 489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral Hemorrhage (n = 82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in 20 out of 26 studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral Hemorrhage.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral Hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Walter H Backes, Frans R J Verhey, Robert J Van Oostenbrugge, Catharina J M Klijn
    Abstract:

    Background and purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral Hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral Hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral Hemorrhage or cerebral microbleeds. Results: Of twenty-six eligible studies, ten were animal studies and sixteen were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral Hemorrhage (n=32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n=47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n=117) and seven out of nine studies examining Intracerebral Hemorrhage with mixed or unspecified underlying etiology (n=489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral Hemorrhage (n=82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in twenty out of twenty-six studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral Hemorrhage.

Christopher P. Kellner - One of the best experts on this subject based on the ideXlab platform.

  • Minimally Invasive Surgery for Intracerebral Hemorrhage.
    Current neurology and neuroscience reports, 2018
    Co-Authors: Eliza H. Hersh, Yakov Gologorsky, Alex G Chartrain, J Mocco, Christopher P. Kellner
    Abstract:

    Recent success in preliminary clinical studies evaluating various forms of minimally invasive surgery for spontaneous Intracerebral Hemorrhage (ICH) has renewed interest in the surgical treatment of this disease process. In December of 2016, phase 2 of the Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation (MISTIE) study demonstrated that this form of stereotactic thrombolysis safely reduces clot burden and may improve functional outcome 6 months after injury. A smaller arm of this study, the Intraoperative Stereotactic Computer Tomography-Guided Endoscopic Surgery (ICES) study, also demonstrated feasibility and good functional outcome for endoscopic minimally invasive evacuation. Early-phase clinical studies evaluating various forms of minimally invasive surgery for Intracerebral Hemorrhage evacuation have shown safety and feasibility with a preliminary signal towards improved functional long-term outcome. Results from phase 3 studies addressing various minimally invasive techniques are imminent and will shape how Intracerebral Hemorrhage is treated.

  • Minimally Invasive Surgery for Intracerebral Hemorrhage
    Current Neurology and Neuroscience Reports, 2018
    Co-Authors: Eliza H. Hersh, Yakov Gologorsky, Alex G Chartrain, J Mocco, Christopher P. Kellner
    Abstract:

    Purpose of Review Recent success in preliminary clinical studies evaluating various forms of minimally invasive surgery for spontaneous Intracerebral Hemorrhage (ICH) has renewed interest in the surgical treatment of this disease process. Recent Findings In December of 2016, phase 2 of the Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation (MISTIE) study demonstrated that this form of stereotactic thrombolysis safely reduces clot burden and may improve functional outcome 6 months after injury. A smaller arm of this study, the Intraoperative Stereotactic Computer Tomography-Guided Endoscopic Surgery (ICES) study, also demonstrated feasibility and good functional outcome for endoscopic minimally invasive evacuation. Summary Early-phase clinical studies evaluating various forms of minimally invasive surgery for Intracerebral Hemorrhage evacuation have shown safety and feasibility with a preliminary signal towards improved functional long-term outcome. Results from phase 3 studies addressing various minimally invasive techniques are imminent and will shape how Intracerebral Hemorrhage is treated.

Heidi I L Jacobs - One of the best experts on this subject based on the ideXlab platform.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral Hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Robert J Van Oostenbrugge, Walter H Backes, Frans R J Verhey, Catharina J M Klijn
    Abstract:

    Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral Hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral Hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral Hemorrhage or cerebral microbleeds. Results: Of 26 eligible studies, 10 were animal studies and 16 were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral Hemorrhage (n = 32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n = 47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n = 117) and seven out of nine studies examining Intracerebral Hemorrhage with mixed or unspecified underlying etiology (n = 489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral Hemorrhage (n = 82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in 20 out of 26 studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral Hemorrhage.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral Hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Walter H Backes, Frans R J Verhey, Robert J Van Oostenbrugge, Catharina J M Klijn
    Abstract:

    Background and purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral Hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral Hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral Hemorrhage or cerebral microbleeds. Results: Of twenty-six eligible studies, ten were animal studies and sixteen were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral Hemorrhage (n=32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n=47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n=117) and seven out of nine studies examining Intracerebral Hemorrhage with mixed or unspecified underlying etiology (n=489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral Hemorrhage (n=82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in twenty out of twenty-six studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral Hemorrhage.

Whitney M Freeze - One of the best experts on this subject based on the ideXlab platform.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral Hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Robert J Van Oostenbrugge, Walter H Backes, Frans R J Verhey, Catharina J M Klijn
    Abstract:

    Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral Hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral Hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral Hemorrhage or cerebral microbleeds. Results: Of 26 eligible studies, 10 were animal studies and 16 were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral Hemorrhage (n = 32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n = 47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n = 117) and seven out of nine studies examining Intracerebral Hemorrhage with mixed or unspecified underlying etiology (n = 489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral Hemorrhage (n = 82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in 20 out of 26 studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral Hemorrhage.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral Hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Walter H Backes, Frans R J Verhey, Robert J Van Oostenbrugge, Catharina J M Klijn
    Abstract:

    Background and purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral Hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral Hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral Hemorrhage or cerebral microbleeds. Results: Of twenty-six eligible studies, ten were animal studies and sixteen were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral Hemorrhage (n=32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n=47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral Hemorrhage (n=117) and seven out of nine studies examining Intracerebral Hemorrhage with mixed or unspecified underlying etiology (n=489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral Hemorrhage (n=82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in twenty out of twenty-six studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral Hemorrhage.

Eliza H. Hersh - One of the best experts on this subject based on the ideXlab platform.

  • Minimally Invasive Surgery for Intracerebral Hemorrhage.
    Current neurology and neuroscience reports, 2018
    Co-Authors: Eliza H. Hersh, Yakov Gologorsky, Alex G Chartrain, J Mocco, Christopher P. Kellner
    Abstract:

    Recent success in preliminary clinical studies evaluating various forms of minimally invasive surgery for spontaneous Intracerebral Hemorrhage (ICH) has renewed interest in the surgical treatment of this disease process. In December of 2016, phase 2 of the Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation (MISTIE) study demonstrated that this form of stereotactic thrombolysis safely reduces clot burden and may improve functional outcome 6 months after injury. A smaller arm of this study, the Intraoperative Stereotactic Computer Tomography-Guided Endoscopic Surgery (ICES) study, also demonstrated feasibility and good functional outcome for endoscopic minimally invasive evacuation. Early-phase clinical studies evaluating various forms of minimally invasive surgery for Intracerebral Hemorrhage evacuation have shown safety and feasibility with a preliminary signal towards improved functional long-term outcome. Results from phase 3 studies addressing various minimally invasive techniques are imminent and will shape how Intracerebral Hemorrhage is treated.

  • Minimally Invasive Surgery for Intracerebral Hemorrhage
    Current Neurology and Neuroscience Reports, 2018
    Co-Authors: Eliza H. Hersh, Yakov Gologorsky, Alex G Chartrain, J Mocco, Christopher P. Kellner
    Abstract:

    Purpose of Review Recent success in preliminary clinical studies evaluating various forms of minimally invasive surgery for spontaneous Intracerebral Hemorrhage (ICH) has renewed interest in the surgical treatment of this disease process. Recent Findings In December of 2016, phase 2 of the Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation (MISTIE) study demonstrated that this form of stereotactic thrombolysis safely reduces clot burden and may improve functional outcome 6 months after injury. A smaller arm of this study, the Intraoperative Stereotactic Computer Tomography-Guided Endoscopic Surgery (ICES) study, also demonstrated feasibility and good functional outcome for endoscopic minimally invasive evacuation. Summary Early-phase clinical studies evaluating various forms of minimally invasive surgery for Intracerebral Hemorrhage evacuation have shown safety and feasibility with a preliminary signal towards improved functional long-term outcome. Results from phase 3 studies addressing various minimally invasive techniques are imminent and will shape how Intracerebral Hemorrhage is treated.