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Catharina J M Klijn - One of the best experts on this subject based on the ideXlab platform.

  • location specific risk factors for Intracerebral hemorrhage systematic review and meta analysis
    Neurology, 2020
    Co-Authors: Wilmar M T Jolink, Catharina J M Klijn, Kim Wiegertjes, Gabriel J E Rinkel, Ale Algra, Frankerik De Leeuw
    Abstract:

    Objective To conduct a systematic review and meta-analysis of studies reporting on risk factors according to location of the Intracerebral hemorrhage. Methods We searched PubMed and Embase for cohort and case-control studies reporting ≥100 patients with spontaneous Intracerebral hemorrhage that specified the location of the hematoma and reported associations with risk factors published until June 27, 2019. Two authors independently extracted data on risk factors. Estimates were pooled with the generic variance-based random-effects method. Results After screening 10,013 articles, we included 42 studies totaling 26,174 patients with Intracerebral hemorrhage (9,141 lobar and 17,033 nonlobar). Risk factors for nonlobar Intracerebral hemorrhage were hypertension (risk ratio [RR] 4.25, 95% confidence interval [CI] 3.05–5.91, I2 = 92%), diabetes mellitus (RR 1.35, 95% CI 1.11–1.64, I2 = 37%), male sex (RR 1.63, 95% CI 1.25–2.14, I2 = 61%), alcohol overuse (RR 1.48, 95% CI 1.21–1.81, I2 = 19%), underweight (RR 2.12, 95% CI 1.12–4.01, I2 = 31%), and being a Black (RR 2.83, 95% CI 1.02-7.84, I2 = 96%) or Hispanic (RR 2.95, 95% CI 1.69-5.14, I2 = 71%) participant compared with being a White participant. Hypertension, but not any of the other risk factors, was also a risk factor for lobar Intracerebral hemorrhage (RR 1.83, 95% CI 1.39–2.42, I2 = 76%). Smoking, hypercholesterolemia, and obesity were associated with neither nonlobar nor lobar Intracerebral hemorrhage. Conclusions Hypertension is a risk factor for both nonlobar and lobar Intracerebral hemorrhage, although with double the effect for nonlobar Intracerebral hemorrhage. Diabetes mellitus, male sex, alcohol overuse, underweight, and being a Black or Hispanic person are risk factors for nonlobar Intracerebral hemorrhage only. Hence, the term hypertensive Intracerebral hemorrhage for nonlobar Intracerebral hemorrhage is not appropriate.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Robert J Van Oostenbrugge, Walter H Backes, Frans R J Verhey, Catharina J M Klijn
    Abstract:

    Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral hemorrhage or cerebral microbleeds. Results: Of 26 eligible studies, 10 were animal studies and 16 were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral hemorrhage (n = 32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral hemorrhage (n = 47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral hemorrhage (n = 117) and seven out of nine studies examining Intracerebral hemorrhage with mixed or unspecified underlying etiology (n = 489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral hemorrhage (n = 82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in 20 out of 26 studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral hemorrhage.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Walter H Backes, Frans R J Verhey, Robert J Van Oostenbrugge, Catharina J M Klijn
    Abstract:

    Background and purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral hemorrhage or cerebral microbleeds. Results: Of twenty-six eligible studies, ten were animal studies and sixteen were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral hemorrhage (n=32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral hemorrhage (n=47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral hemorrhage (n=117) and seven out of nine studies examining Intracerebral hemorrhage with mixed or unspecified underlying etiology (n=489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral hemorrhage (n=82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in twenty out of twenty-six studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral hemorrhage.

  • Image_1_Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage.TIFF
    2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Robert J Van Oostenbrugge, Walter H Backes, Frans R J Verhey, Catharina J M Klijn
    Abstract:

    Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral hemorrhage due to cerebral small vessel disease.Methods: We searched Medline (1946–2018) and Embase (1974–2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral hemorrhage or cerebral microbleeds.Results: Of 26 eligible studies, 10 were animal studies and 16 were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral hemorrhage (n = 32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral hemorrhage (n = 47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral hemorrhage (n = 117) and seven out of nine studies examining Intracerebral hemorrhage with mixed or unspecified underlying etiology (n = 489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral hemorrhage (n = 82) found no evidence for blood-brain barrier abnormalities.Conclusions: Signs of blood-brain barrier dysfunction were found in 20 out of 26 studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral hemorrhage.

  • apixaban versus antiplatelet drugs or no antithrombotic drugs after anticoagulation associated Intracerebral haemorrhage in patients with atrial fibrillation apache af study protocol for a randomised controlled trial
    Trials, 2015
    Co-Authors: Koen M Van Nieuwenhuizen, Catharina J M Klijn, Gabriel J E Rinkel, Ale Algra, Bart H Van Der Worp, Jaap L Kappelle, Isabelle C Van Gelder, Roger E G Schutgens
    Abstract:

    Background There is a marked lack of evidence on the optimal prevention of ischaemic stroke and other thromboembolic events in patients with non-valvular atrial fibrillation and a recent Intracerebral haemorrhage during treatment with oral anticoagulation. These patients are currently treated with oral anticoagulants, antiplatelet drugs, or no antithrombotic treatment, depending on personal and institutional preferences. Compared with warfarin, the direct oral anticoagulant apixaban reduces the risk of stroke or systemic embolism, intracranial haemorrhage, and case fatality in patients with atrial fibrillation. Compared with aspirin, apixaban reduces the risk of stroke or systemic embolism in patients with atrial fibrillation, and has a similar risk of Intracerebral haemorrhage. Novel oral anticoagulants have not been evaluated in patients with atrial fibrillation and a recent Intracerebral haemorrhage. To inform a phase III trial, the phase II Apixaban versus Antiplatelet drugs or no antithrombotic drugs after anticoagulation-associated Intracerebral HaEmorrhage in patients with Atrial Fibrillation (APACHE-AF) trial aims to obtain estimates of the rates of vascular death or non-fatal stroke in patients with atrial fibrillation and a recent anticoagulation-associated Intracerebral haemorrhage treated with apixaban and in those in whom oral anticoagulation is avoided.

Joseph P Broderick - One of the best experts on this subject based on the ideXlab platform.

  • guidelines for the management of spontaneous Intracerebral hemorrhage in adults 2007 update a guideline from the american heart association american stroke association stroke council high blood pressure research council and the quality of care and outcomes in research interdisciplinary working group
    Circulation, 2007
    Co-Authors: Joseph P Broderick, Daniel F Hanley, Sander Connolly, Edward Feldmann, Carlos S Kase, Derk Krieger, Marc R Mayberg, Lewis B Morgenstern, Christopher S Ogilvy, Paul M Vespa
    Abstract:

    Purpose— The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous Intracerebral hemorrhage. Methods— A formal literature search of Medline was performed through the end date of August 2006. The results of this search were complemented by additional articles on related issues known to the writing committee. Data were synthesized with the use of evidence tables. The American Heart Association Stroke Council’s Levels of Evidence grading algorithm was used to grade each recommendation. Prerelease review of the draft guideline was performed by 5 expert peer reviewers and by the members of the Stroke Council Leadership Committee. It is intended that this guideline be fully updated in 3 years’ time. Results— Evidence-based guidelines are presented for the diagnosis of Intracerebral hemorrhage, the management of increased arterial blood pressure and intracranial pressure, the treatment of medical complications of Intracerebral hemorrhage, and the prevention of recurrent Intracerebral hemorrhage. Recent trials of recombinant factor VII to slow initial bleeding are discussed. Recommendations for various surgical approaches for treatment of spontaneous Intracerebral hemorrhage are presented. Finally, withdrawal-of-care and end-of-life issues in patients with Intracerebral hemorrhage are examined.

  • guidelines for the management of spontaneous Intracerebral hemorrhage in adults 2007 update a guideline from the american heart association american stroke association stroke council high blood pressure research council and the quality of care and outcomes in research interdisciplinary working group the american academy of neurology affirms the value of this guideline as an educational tool for neurologists
    Stroke, 2007
    Co-Authors: Joseph P Broderick, Daniel F Hanley, Sander Connolly, Edward Feldmann, Carlos S Kase, Derk Krieger, Marc R Mayberg, Lewis B Morgenstern, Christopher S Ogilvy, Paul M Vespa
    Abstract:

    Purpose— The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous Intracerebral hemorrhage. Methods— A formal literature search of Medline was performed through the end date of August 2006. The results of this search were complemented by additional articles on related issues known to the writing committee. Data were synthesized with the use of evidence tables. The American Heart Association Stroke Council’s Levels of Evidence grading algorithm was used to grade each recommendation. Prerelease review of the draft guideline was performed by 5 expert peer reviewers and by the members of the Stroke Council Leadership Committee. It is intended that this guideline be fully updated in 3 years’ time. Results— Evidence-based guidelines are presented for the diagnosis of Intracerebral hemorrhage, the management of increased arterial blood pressure and intracranial pressure, the treatment of medical complications of Intracerebral hemorrhage, and the prevention of recurrent Intracerebral hemorrhage. Recent trials of recombinant factor VII to slow initial bleeding are discussed. Recommendations for various surgical approaches for treatment of spontaneous Intracerebral hemorrhage are presented. Finally, withdrawal-of-care and end-of-life issues in patients with Intracerebral hemorrhage are examined. (Stroke. 2007;38:2001-2023.)

  • Spontaneous Intracerebral hemorrhage.
    The New England journal of medicine, 2001
    Co-Authors: Adnan I Qureshi, Joseph P Broderick, Stanley Tuhrim, H. Hunt Batjer, Hideki Hondo, Daniel F Hanley
    Abstract:

    Nontraumatic Intracerebral hemorrhage is bleeding into the parenchyma of the brain that may extend into the ventricles and, in rare cases, the subarachnoid space. Each year, approximately 37,000 to 52,400 people in the United States have an Intracerebral hemorrhage.1,2 This rate is expected to double during the next 50 years as a result of the increasing age of the population and changes in racial demographics. Intracerebral hemorrhage accounts for 10 to 15 percent of all cases of stroke and is associated with the highest mortality rate, with only 38 percent of affected patients surviving the first year.3 Depending on . . .

  • volume of Intracerebral hemorrhage a powerful and easy to use predictor of 30 day mortality
    Stroke, 1993
    Co-Authors: Joseph P Broderick, Thomas G Brott, Thomas A Tomsick, John Duldner, Gertrude Huster
    Abstract:

    The aim of this study was to determine the 30-day mortality and morbidity of Intracerebral hemorrhage in a large metropolitan population and to determine the most important predictors of 30-day outcome.We reviewed the medical records and computed tomographic films for all cases of spontaneous Intracerebral hemorrhage in Greater Cincinnati during 1988. Independent predictors of 30-day mortality were determined using univariate and multivariate statistical analyses.The 30-day mortality for the 188 cases of Intracerebral hemorrhage was 44%, with half of deaths occurring within the first 2 days of onset. Volume of Intracerebral hemorrhage was the strongest predictor of 30-day mortality for all locations of Intracerebral hemorrhage. Using three categories of parenchymal hemorrhage volume (0 to 29 cm3, 30 to 60 cm3, and 61 cm3 or more), calculated by a quick and easy-to-use ellipsoid method, and two categories of the Glasgow Coma Scale (9 or more and 8 or less), 30-day mortality was predicted correctly with a s...

  • the risk of subarachnoid and Intracerebral hemorrhages in blacks as compared with whites
    The New England Journal of Medicine, 1992
    Co-Authors: Joseph P Broderick, Thomas G Brott, Thomas A Tomsick, Gertrude Huster, Rosemary Miller
    Abstract:

    Abstract Background Stroke is an important cause of death among blacks, and Intracerebral and subarachnoid hemorrhages account for nearly half of all early deaths from stroke. The present study investigates whether blacks and whites differ in their risk of having either Intracerebral or subarachnoid hemorrhage. Methods We reviewed the medical records, autopsy reports, and CT scans of all patients suspected of having had an Intracerebral or subarachnoid hemorrhage during 1988 among the nearly 1.3 million people in the Greater Cincinnati metropolitan area. There were 221 cases of first spontaneous intracranial hemorrhage among 1,086,462 whites (159 Intracerebral and 62 subarachnoid hemorrhages), and 45 cases among 171,718 blacks (27 Intracerebral and 18 subarachnoid hemorrhages). Blacks had 2.1 times the risk of subarachnoid hemorrhage of whites (95 percent confidence interval, 1.3 to 3.6) and 1.4 times the risk of Intracerebral hemorrhage (95 percent confidence interval, 0.9 to 2.1). In those under the age...

Paul M Vespa - One of the best experts on this subject based on the ideXlab platform.

  • guidelines for the management of spontaneous Intracerebral hemorrhage in adults 2007 update a guideline from the american heart association american stroke association stroke council high blood pressure research council and the quality of care and outcomes in research interdisciplinary working group
    Circulation, 2007
    Co-Authors: Joseph P Broderick, Daniel F Hanley, Sander Connolly, Edward Feldmann, Carlos S Kase, Derk Krieger, Marc R Mayberg, Lewis B Morgenstern, Christopher S Ogilvy, Paul M Vespa
    Abstract:

    Purpose— The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous Intracerebral hemorrhage. Methods— A formal literature search of Medline was performed through the end date of August 2006. The results of this search were complemented by additional articles on related issues known to the writing committee. Data were synthesized with the use of evidence tables. The American Heart Association Stroke Council’s Levels of Evidence grading algorithm was used to grade each recommendation. Prerelease review of the draft guideline was performed by 5 expert peer reviewers and by the members of the Stroke Council Leadership Committee. It is intended that this guideline be fully updated in 3 years’ time. Results— Evidence-based guidelines are presented for the diagnosis of Intracerebral hemorrhage, the management of increased arterial blood pressure and intracranial pressure, the treatment of medical complications of Intracerebral hemorrhage, and the prevention of recurrent Intracerebral hemorrhage. Recent trials of recombinant factor VII to slow initial bleeding are discussed. Recommendations for various surgical approaches for treatment of spontaneous Intracerebral hemorrhage are presented. Finally, withdrawal-of-care and end-of-life issues in patients with Intracerebral hemorrhage are examined.

  • guidelines for the management of spontaneous Intracerebral hemorrhage in adults 2007 update a guideline from the american heart association american stroke association stroke council high blood pressure research council and the quality of care and outcomes in research interdisciplinary working group the american academy of neurology affirms the value of this guideline as an educational tool for neurologists
    Stroke, 2007
    Co-Authors: Joseph P Broderick, Daniel F Hanley, Sander Connolly, Edward Feldmann, Carlos S Kase, Derk Krieger, Marc R Mayberg, Lewis B Morgenstern, Christopher S Ogilvy, Paul M Vespa
    Abstract:

    Purpose— The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous Intracerebral hemorrhage. Methods— A formal literature search of Medline was performed through the end date of August 2006. The results of this search were complemented by additional articles on related issues known to the writing committee. Data were synthesized with the use of evidence tables. The American Heart Association Stroke Council’s Levels of Evidence grading algorithm was used to grade each recommendation. Prerelease review of the draft guideline was performed by 5 expert peer reviewers and by the members of the Stroke Council Leadership Committee. It is intended that this guideline be fully updated in 3 years’ time. Results— Evidence-based guidelines are presented for the diagnosis of Intracerebral hemorrhage, the management of increased arterial blood pressure and intracranial pressure, the treatment of medical complications of Intracerebral hemorrhage, and the prevention of recurrent Intracerebral hemorrhage. Recent trials of recombinant factor VII to slow initial bleeding are discussed. Recommendations for various surgical approaches for treatment of spontaneous Intracerebral hemorrhage are presented. Finally, withdrawal-of-care and end-of-life issues in patients with Intracerebral hemorrhage are examined. (Stroke. 2007;38:2001-2023.)

Heidi I L Jacobs - One of the best experts on this subject based on the ideXlab platform.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Robert J Van Oostenbrugge, Walter H Backes, Frans R J Verhey, Catharina J M Klijn
    Abstract:

    Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral hemorrhage or cerebral microbleeds. Results: Of 26 eligible studies, 10 were animal studies and 16 were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral hemorrhage (n = 32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral hemorrhage (n = 47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral hemorrhage (n = 117) and seven out of nine studies examining Intracerebral hemorrhage with mixed or unspecified underlying etiology (n = 489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral hemorrhage (n = 82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in 20 out of 26 studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral hemorrhage.

  • blood brain barrier dysfunction in small vessel disease related Intracerebral hemorrhage
    Frontiers in Neurology, 2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Walter H Backes, Frans R J Verhey, Robert J Van Oostenbrugge, Catharina J M Klijn
    Abstract:

    Background and purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946-2018) and Embase (1974-2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral hemorrhage or cerebral microbleeds. Results: Of twenty-six eligible studies, ten were animal studies and sixteen were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral hemorrhage (n=32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral hemorrhage (n=47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral hemorrhage (n=117) and seven out of nine studies examining Intracerebral hemorrhage with mixed or unspecified underlying etiology (n=489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral hemorrhage (n=82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in twenty out of twenty-six studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral hemorrhage.

  • Image_1_Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage.TIFF
    2018
    Co-Authors: Whitney M Freeze, Heidi I L Jacobs, Floris H B M Schreuder, Robert J Van Oostenbrugge, Walter H Backes, Frans R J Verhey, Catharina J M Klijn
    Abstract:

    Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary Intracerebral hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous Intracerebral hemorrhage due to cerebral small vessel disease.Methods: We searched Medline (1946–2018) and Embase (1974–2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with Intracerebral hemorrhage or cerebral microbleeds.Results: Of 26 eligible studies, 10 were animal studies and 16 were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related Intracerebral hemorrhage (n = 32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related Intracerebral hemorrhage (n = 47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related Intracerebral hemorrhage (n = 117) and seven out of nine studies examining Intracerebral hemorrhage with mixed or unspecified underlying etiology (n = 489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related Intracerebral hemorrhage (n = 82) found no evidence for blood-brain barrier abnormalities.Conclusions: Signs of blood-brain barrier dysfunction were found in 20 out of 26 studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous Intracerebral hemorrhage.

Minshu Li - One of the best experts on this subject based on the ideXlab platform.

  • colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after Intracerebral hemorrhage
    Journal of Cerebral Blood Flow and Metabolism, 2017
    Co-Authors: Minshu Li, Kristofer Wood, Zhiguo Li, Kevin N Sheth
    Abstract:

    Microglia are the first responders to Intracerebral hemorrhage, but their precise role in Intracerebral hemorrhage remains to be defined. Microglia are the only type of brain cells expressing the colony-stimulating factor 1 receptor, a key regulator for myeloid lineage cells. Here, we determined the effects of a colony-stimulating factor 1 receptor inhibitor (PLX3397) on microglia and the outcome in the context of experimental mouse Intracerebral hemorrhage. We show that PLX3397 effectively depleted microglia, and the depletion of microglia was sustained after Intracerebral hemorrhage. Importantly, colony-stimulating factor 1 receptor inhibition attenuated neurodeficits and brain edema in two experimental models of Intracerebral hemorrhage induced by injection of collagenase or autologous blood. The benefit of colony-stimulating factor 1 receptor inhibition was associated with reduced leukocyte infiltration in the brain and improved blood–brain barrier integrity after Intracerebral hemorrhage, and each ob...