The Experts below are selected from a list of 282 Experts worldwide ranked by ideXlab platform
A J Smout - One of the best experts on this subject based on the ideXlab platform.
-
24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance
Scandinavian Journal of Gastroenterology, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:BACKGROUND: Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. METHODS: Literature review. RESULTS: Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H+ activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an increased gastric acidity is found and in patients with gastric ulcer gastric acidity is decreased. In GERD, no relation between reflux oesophagitis and gastric acidity is found. Helicobacter pylori affects Intragastric pH most pronounced during acid inhibitory therapy, both in DU patients and in healthy subjects. In the absence of H. pylori the effect of proton-pump inhibitors on Intragastric pH is much less than in the presence of the microorganism, whereas the effect of ranitidine on Intragastric pH is barely affected by the H. pylori status. CONCLUSIONS: Despite some limitations, Intragastric pH monitoring provides important information about gastric acidit
-
24-h recording of Intragastric pH: technical aspects and clinical relevance.
Scandinavian journal of gastroenterology. Supplement, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. Literature review. Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H+ activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an increased gastric acidity is found and in patients with gastric ulcer gastric acidity is decreased. In GERD, no relation between reflux oesophagitis and gastric acidity is found. Helicobacter pylori affects Intragastric pH most pronounced during acid inhibitory therapy, both in DU patients and in healthy subjects. In the absence of H. pylori the effect of proton-pump inhibitors on Intragastric pH is much less than in the presence of the microorganism, whereas the effect of ranitidine on Intragastric pH is barely affected by the H. pylori status. Despite some limitations, Intragastric pH monitoring provides important information about gastric acidity.
-
24-h recording of Intragastric pH: technical aspects and clinical relevance.
Scandinavian Journal of Gastroenterology, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:Background : Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. Methods : Literature review. Results : Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H + activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an i...
M A Van Herwaarden - One of the best experts on this subject based on the ideXlab platform.
-
24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance
Scandinavian Journal of Gastroenterology, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:BACKGROUND: Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. METHODS: Literature review. RESULTS: Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H+ activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an increased gastric acidity is found and in patients with gastric ulcer gastric acidity is decreased. In GERD, no relation between reflux oesophagitis and gastric acidity is found. Helicobacter pylori affects Intragastric pH most pronounced during acid inhibitory therapy, both in DU patients and in healthy subjects. In the absence of H. pylori the effect of proton-pump inhibitors on Intragastric pH is much less than in the presence of the microorganism, whereas the effect of ranitidine on Intragastric pH is barely affected by the H. pylori status. CONCLUSIONS: Despite some limitations, Intragastric pH monitoring provides important information about gastric acidit
-
24-h recording of Intragastric pH: technical aspects and clinical relevance.
Scandinavian journal of gastroenterology. Supplement, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. Literature review. Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H+ activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an increased gastric acidity is found and in patients with gastric ulcer gastric acidity is decreased. In GERD, no relation between reflux oesophagitis and gastric acidity is found. Helicobacter pylori affects Intragastric pH most pronounced during acid inhibitory therapy, both in DU patients and in healthy subjects. In the absence of H. pylori the effect of proton-pump inhibitors on Intragastric pH is much less than in the presence of the microorganism, whereas the effect of ranitidine on Intragastric pH is barely affected by the H. pylori status. Despite some limitations, Intragastric pH monitoring provides important information about gastric acidity.
-
24-h recording of Intragastric pH: technical aspects and clinical relevance.
Scandinavian Journal of Gastroenterology, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:Background : Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. Methods : Literature review. Results : Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H + activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an i...
Philip O Katz - One of the best experts on this subject based on the ideXlab platform.
-
relationship between Intragastric acid control and healing status in the treatment of moderate to severe erosive oesophagitis
Alimentary Pharmacology & Therapeutics, 2006Co-Authors: Philip O Katz, Gregory G Ginsberg, P E Hoyle, Mark Sostek, John T Monyak, D G SilbergAbstract:Summary Aim To assess the relationship between the percentage of time Intragastric pH >4.0 and healing of erosive oesophagitis. Methods In this proof-of-concept study, adults with endoscopically verified Los Angeles grade C or grade D erosive oesophagitis were randomly assigned to oral esomeprazole 10 or 40 mg once daily for 4 weeks. On day 5, patients underwent 24-h pH monitoring. At 4 weeks, erosive oesophagitis healing status was endoscopically assessed. Investigators scored gastro-oesophageal reflux disease symptoms on a 4-point scale [none to severe (0–3)] before and 4 weeks after treatment. The percentage of time Intragastric pH was >4.0 and healing status were correlated and tested for significance using a Spearman rank correlation (r). Results 103 patients had evaluable data (mean age, 48.7 years; 65% men). Mean percentages of time with Intragastric pH >4.0 on day 5 in patients with healed and unhealed erosive oesophagitis were 61% and 42%, respectively (P = 0.0002), indicating that erosive oesophagitis healing rates were positively related to the percentage of time Intragastric pH was >4.0. Greater Intragastric acid control correlated with lower final daytime and night-time heartburn and acid regurgitation symptom scores (r = −0.029, −0.029 and −0.021; P = 0.003, 0.003 and 0.032, respectively). Conclusion A positive relationship between Intragastric acid control and erosive oesophagitis healing was demonstrated.
-
Use of Intragastric pH monitoring in gastroesophageal reflux disease.
Gastrointestinal endoscopy clinics of North America, 2005Co-Authors: Philip O KatzAbstract:Prolonged Intragastric pH monitoring is a valuable technique for evaluating head-to-head comparisons of the antisecretory effects of different pharmacologic agents, for studying the effects of higher doses of proton pump inhibitors (PPIs) on daytime and nighttime pH control, for evaluating the effects of dose timing in relation to a meal on the Intragastric pH response to these antisecretory agents, and for examining interindividual variability in individual pH response to PPIs taken orally. Measuring Intragastric pH has helped immeasurably in understanding the efficacy of PPIs and is especially useful in the clinical arena to guide the management of patients across the spectrum of gastroesophageal reflux disease.
M Samsom - One of the best experts on this subject based on the ideXlab platform.
-
24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance
Scandinavian Journal of Gastroenterology, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:BACKGROUND: Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. METHODS: Literature review. RESULTS: Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H+ activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an increased gastric acidity is found and in patients with gastric ulcer gastric acidity is decreased. In GERD, no relation between reflux oesophagitis and gastric acidity is found. Helicobacter pylori affects Intragastric pH most pronounced during acid inhibitory therapy, both in DU patients and in healthy subjects. In the absence of H. pylori the effect of proton-pump inhibitors on Intragastric pH is much less than in the presence of the microorganism, whereas the effect of ranitidine on Intragastric pH is barely affected by the H. pylori status. CONCLUSIONS: Despite some limitations, Intragastric pH monitoring provides important information about gastric acidit
-
24-h recording of Intragastric pH: technical aspects and clinical relevance.
Scandinavian journal of gastroenterology. Supplement, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. Literature review. Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H+ activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an increased gastric acidity is found and in patients with gastric ulcer gastric acidity is decreased. In GERD, no relation between reflux oesophagitis and gastric acidity is found. Helicobacter pylori affects Intragastric pH most pronounced during acid inhibitory therapy, both in DU patients and in healthy subjects. In the absence of H. pylori the effect of proton-pump inhibitors on Intragastric pH is much less than in the presence of the microorganism, whereas the effect of ranitidine on Intragastric pH is barely affected by the H. pylori status. Despite some limitations, Intragastric pH monitoring provides important information about gastric acidity.
-
24-h recording of Intragastric pH: technical aspects and clinical relevance.
Scandinavian Journal of Gastroenterology, 1999Co-Authors: M A Van Herwaarden, M Samsom, A J SmoutAbstract:Background : Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous Intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of Intragastric pH monitoring in research and clinical practice. Methods : Literature review. Results : Most studies on Intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h Intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of Intragastric pH monitoring are expressed either as median H + activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an i...
Kyo Young Song - One of the best experts on this subject based on the ideXlab platform.
-
Intragastric approach for submucosal tumors located near the z line a hybrid laparoscopic and endoscopic technique
Journal of Surgical Oncology, 2011Co-Authors: Jung Ho Shim, Han Hong Lee, Han Mo Yoo, Hae Myung Jeon, Cho Hyun Park, Jun Gi Kim, Kyo Young SongAbstract:Background The present study was designed to evaluate the feasibility and impact of the “Intragastric” approach to laparoscopic wedge resection as a surgical option for the treatment of suspected small sized gastric submucosal tumors (SMTs) located at the level of Z-line. Methods We reviewed six patients who underwent laparoscopic Intragastric resection of a suspected gastric SMT. In all cases, tumor mass was located just below the Z-line. The patients' clinicopathologic characteristics and surgical outcomes were prospectively recorded and reviewed. Results All six patients were underwent successfully laparoscopic wedge resection by the Intragastric approach using a balloon-type trocar. No case was required open conversion. The mean operation time was 128 min, and the mean hospital stay was 4 days. Five cases were proven to have leiomyoma, and one case was found to have gastrointestinal stromal tumor with low risk. The mean tumor size was 2.7 cm. Conclusion Laparoscopic resection through the “Intragastric” approach is a safe and feasible option for gastric SMTs located at the level of Z-line. J. Surg. Oncol. 2011; 104:312–315. © 2011 Wiley-Liss, Inc.
