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Hideki Moriyama - One of the best experts on this subject based on the ideXlab platform.
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Low body mass index negatively affects muscle mass and Intramuscular Fat of chronic stroke survivors.
PloS one, 2019Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Objective Relationship between secondary changes in skeletal muscle and body weight in chronic stroke survivors has not yet been carefully examined. The objective of this study was to clarify the relationships between muscle mass, Intramuscular Fat, and body weight in chronic stroke survivors. Methods Seventy-two chronic stroke survivors participated in this study. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Quadriceps muscle mass and Intramuscular Fat were assessed based on muscle thickness and echo intensity, respectively. We used a stepwise multiple regression analysis to identify the factors that were independently associated with the body mass index. We entered quadriceps thickness and echo intensity of the paretic and non-paretic sides into another stepwise multiple regression model to avoid multicollinearity. Age, sex, type of stroke, time since stroke, thigh length, number of medications, and an updated Charlson comorbidity index were included as the independent variables. Results The quadriceps thickness and echo intensity of the paretic and non-paretic sides were significantly independently associated with the body mass index: quadriceps thickness of the paretic side, β = 0.52; quadriceps thickness of the non-paretic side, β = 0.55; quadriceps echo intensity of the paretic side, β = −0.35; quadriceps echo intensity of the non-paretic side, β = −0.27). Conclusions Our results suggest that low body mass index is associated with loss of muscle mass and increased Intramuscular Fat on both the paretic and non-paretic sides of chronic stroke survivors. Further studies examining whether appropriate weight management, along with targeted rehabilitation programs aimed at increasing muscle mass and decreasing Intramuscular Fat, achieves good outcomes in chronic stroke survivors are warranted.
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Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors: A cross-sectional study.
PloS one, 2018Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Improving muscle mass and Intramuscular Fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors. There is a remarkable decrease in muscle mass and muscle strength and an increase in Intramuscular Fat in the quadriceps of both limbs of non-ambulatory compared with ambulatory survivors. Therefore, given that paretic lower extremity function does not recover sufficiently in the chronic phase, it may be helpful to improve muscle mass and Intramuscular Fat to increase muscle strength in the quadriceps of non-ambulatory chronic stroke survivors. However, these relationships remain unclear. The purpose of this study was to clarify the relationships between muscle strength, muscle mass, and Intramuscular Fat of the quadriceps in non-ambulatory chronic stroke survivors. Study design: A cross-sectional study. Participants: Fifty non-ambulatory chronic stroke survivors. Main outcome measures: Quadriceps muscle strength was measured using a handheld dynamometer. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Muscle mass and Intramuscular Fat of the quadriceps were assessed based on muscle thickness and echo intensity, respectively. Data analysis: Stepwise multiple regression analyses were used to identify the factors independently associated with the quadriceps muscle strength of the paretic and non-paretic limbs. To avoid multicollinearity, muscle thickness and echo intensity were entered into separate multiple regression models. Muscle thickness or echo intensity of the paretic or non-paretic limbs and other confounding factors were set as the independent variables. Muscle thickness was positively related and echo intensity was negatively related to the quadriceps muscle strength of the paretic and non-paretic limbs. Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors. Increasing muscle mass and decreasing Intramuscular Fat of the quadriceps of both limbs may improve muscle strength.
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muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non ambulatory chronic stroke survivors a cross sectional study
PLOS ONE, 2018Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Objective Improving muscle mass and Intramuscular Fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors. There is a remarkable decrease in muscle mass and muscle strength and an increase in Intramuscular Fat in the quadriceps of both limbs of non-ambulatory compared with ambulatory survivors. Therefore, given that paretic lower extremity function does not recover sufficiently in the chronic phase, it may be helpful to improve muscle mass and Intramuscular Fat to increase muscle strength in the quadriceps of non-ambulatory chronic stroke survivors. However, these relationships remain unclear. The purpose of this study was to clarify the relationships between muscle strength, muscle mass, and Intramuscular Fat of the quadriceps in non-ambulatory chronic stroke survivors. Methods Study design: A cross-sectional study. Participants: Fifty non-ambulatory chronic stroke survivors. Main outcome measures: Quadriceps muscle strength was measured using a handheld dynamometer. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Muscle mass and Intramuscular Fat of the quadriceps were assessed based on muscle thickness and echo intensity, respectively. Data analysis: Stepwise multiple regression analyses were used to identify the factors independently associated with the quadriceps muscle strength of the paretic and non-paretic limbs. To avoid multicollinearity, muscle thickness and echo intensity were entered into separate multiple regression models. Muscle thickness or echo intensity of the paretic or non-paretic limbs and other confounding factors were set as the independent variables. Results Muscle thickness was positively related and echo intensity was negatively related to the quadriceps muscle strength of the paretic and non-paretic limbs. Conclusions Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors. Increasing muscle mass and decreasing Intramuscular Fat of the quadriceps of both limbs may improve muscle strength.
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Relationships between Intramuscular Fat, muscle strength and gait independence in older women: A cross-sectional study.
Geriatrics & gerontology international, 2016Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Hideki MoriyamaAbstract:The objectives of the present study were to examine the relationships between Intramuscular Fat, muscle strength and gait independence, as well as to clarify the Intramuscular Fat characteristics of dependent older women. A total of 25 older women who were unable to walk with or without assistance (dependent group), 22 frail older women (frail group) and 22 healthy older women (healthy group) participated in the present study. The frail participants could walk independently, but showed three or more of the following characteristics: slowness, weakness, weight loss, exhaustion and low physical activity. Outcome measures were quadriceps Intramuscular Fat determined by ultrasound echo intensity, and quadriceps muscle strength of the dependent, frail and healthy groups. In addition, the degree of gait independence (functional independence measures gait score) was assessed in the dependent and frail groups. Echo intensity in the dependent group was significantly negatively correlated with muscle strength and the functional independence measure gait score (correlation coefficients -0.635 and -0.344, respectively). Furthermore, echo intensity in the dependent group was significantly higher than in the healthy group. There was no significant difference in echo intensity between the dependent and frail groups. The present results suggest negative relationships between Intramuscular Fat and muscle strength, and Intramuscular Fat and degree of gait independence in dependent older women. In addition, dependent older women have more Intramuscular Fat than healthy older women. Geriatr Gerontol Int 2017; 17: 1683-1688. © 2016 Japan Geriatrics Society.
Naoki Akazawa - One of the best experts on this subject based on the ideXlab platform.
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Longitudinal Relationship Between Intramuscular Fat in the Quadriceps and Gait Independence in Convalescent Stroke Patients.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020Co-Authors: Taisei Ishimoto, Yusuke Taniguchi, Naoki AkazawaAbstract:Abstract Background and Aim In a cross-sectional study, Intramuscular Fat in the quadriceps of stroke patients has been associated with gait independence. However, the longitudinal relationship between Intramuscular Fat and gait independence remain unclear. If these relationships are clarified, it can be demonstrated that improvement in gait independence eventually contributes to improved Intramuscular Fat in the quadriceps of stroke patients. The aim of this study was to investigate the longitudinal relationship between Intramuscular Fat in the quadriceps and gait independence in convalescent stroke patients. Methods Eleven stroke patients participated in this study. Gait independence was assessed using the Functional Independence Measure (FIM) gait score. The Intramuscular Fat in the quadriceps was assessed using ultrasound echo intensity, whereas higher echo intensity indicated greater Intramuscular Fat. The baseline and discharge assessment values for the echo intensity of the quadriceps were compared using a paired t-test. Correlation analysis of the FIM gait score gain and echo intensity changes in the quadriceps on the paretic and non-paretic sides was performed using Kendall's rank correlation coefficient. Results For quadriceps on the paretic side, echo intensity values at discharge were significantly lower than those at admission. However there was no significant difference for quadriceps on the non-paretic side (paretic side: 19.9% decrease; non-paretic side: 8.0% decrease). We observed that the change in the echo intensity of quadriceps on the non-paretic side was negatively corelated with FIM gait score gain. Conclusions Our results revealed a strong correlation between longitudinal change in Intramuscular Fat in the quadriceps and gait independence, implying that improved gait independence in convalescent stroke patients might have a positive effect on improvements in Intramuscular Fat.
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Low body mass index negatively affects muscle mass and Intramuscular Fat of chronic stroke survivors.
PloS one, 2019Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Objective Relationship between secondary changes in skeletal muscle and body weight in chronic stroke survivors has not yet been carefully examined. The objective of this study was to clarify the relationships between muscle mass, Intramuscular Fat, and body weight in chronic stroke survivors. Methods Seventy-two chronic stroke survivors participated in this study. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Quadriceps muscle mass and Intramuscular Fat were assessed based on muscle thickness and echo intensity, respectively. We used a stepwise multiple regression analysis to identify the factors that were independently associated with the body mass index. We entered quadriceps thickness and echo intensity of the paretic and non-paretic sides into another stepwise multiple regression model to avoid multicollinearity. Age, sex, type of stroke, time since stroke, thigh length, number of medications, and an updated Charlson comorbidity index were included as the independent variables. Results The quadriceps thickness and echo intensity of the paretic and non-paretic sides were significantly independently associated with the body mass index: quadriceps thickness of the paretic side, β = 0.52; quadriceps thickness of the non-paretic side, β = 0.55; quadriceps echo intensity of the paretic side, β = −0.35; quadriceps echo intensity of the non-paretic side, β = −0.27). Conclusions Our results suggest that low body mass index is associated with loss of muscle mass and increased Intramuscular Fat on both the paretic and non-paretic sides of chronic stroke survivors. Further studies examining whether appropriate weight management, along with targeted rehabilitation programs aimed at increasing muscle mass and decreasing Intramuscular Fat, achieves good outcomes in chronic stroke survivors are warranted.
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Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors: A cross-sectional study.
PloS one, 2018Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Improving muscle mass and Intramuscular Fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors. There is a remarkable decrease in muscle mass and muscle strength and an increase in Intramuscular Fat in the quadriceps of both limbs of non-ambulatory compared with ambulatory survivors. Therefore, given that paretic lower extremity function does not recover sufficiently in the chronic phase, it may be helpful to improve muscle mass and Intramuscular Fat to increase muscle strength in the quadriceps of non-ambulatory chronic stroke survivors. However, these relationships remain unclear. The purpose of this study was to clarify the relationships between muscle strength, muscle mass, and Intramuscular Fat of the quadriceps in non-ambulatory chronic stroke survivors. Study design: A cross-sectional study. Participants: Fifty non-ambulatory chronic stroke survivors. Main outcome measures: Quadriceps muscle strength was measured using a handheld dynamometer. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Muscle mass and Intramuscular Fat of the quadriceps were assessed based on muscle thickness and echo intensity, respectively. Data analysis: Stepwise multiple regression analyses were used to identify the factors independently associated with the quadriceps muscle strength of the paretic and non-paretic limbs. To avoid multicollinearity, muscle thickness and echo intensity were entered into separate multiple regression models. Muscle thickness or echo intensity of the paretic or non-paretic limbs and other confounding factors were set as the independent variables. Muscle thickness was positively related and echo intensity was negatively related to the quadriceps muscle strength of the paretic and non-paretic limbs. Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors. Increasing muscle mass and decreasing Intramuscular Fat of the quadriceps of both limbs may improve muscle strength.
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muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non ambulatory chronic stroke survivors a cross sectional study
PLOS ONE, 2018Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Objective Improving muscle mass and Intramuscular Fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors. There is a remarkable decrease in muscle mass and muscle strength and an increase in Intramuscular Fat in the quadriceps of both limbs of non-ambulatory compared with ambulatory survivors. Therefore, given that paretic lower extremity function does not recover sufficiently in the chronic phase, it may be helpful to improve muscle mass and Intramuscular Fat to increase muscle strength in the quadriceps of non-ambulatory chronic stroke survivors. However, these relationships remain unclear. The purpose of this study was to clarify the relationships between muscle strength, muscle mass, and Intramuscular Fat of the quadriceps in non-ambulatory chronic stroke survivors. Methods Study design: A cross-sectional study. Participants: Fifty non-ambulatory chronic stroke survivors. Main outcome measures: Quadriceps muscle strength was measured using a handheld dynamometer. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Muscle mass and Intramuscular Fat of the quadriceps were assessed based on muscle thickness and echo intensity, respectively. Data analysis: Stepwise multiple regression analyses were used to identify the factors independently associated with the quadriceps muscle strength of the paretic and non-paretic limbs. To avoid multicollinearity, muscle thickness and echo intensity were entered into separate multiple regression models. Muscle thickness or echo intensity of the paretic or non-paretic limbs and other confounding factors were set as the independent variables. Results Muscle thickness was positively related and echo intensity was negatively related to the quadriceps muscle strength of the paretic and non-paretic limbs. Conclusions Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors. Increasing muscle mass and decreasing Intramuscular Fat of the quadriceps of both limbs may improve muscle strength.
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Relationships between Intramuscular Fat, muscle strength and gait independence in older women: A cross-sectional study.
Geriatrics & gerontology international, 2016Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Hideki MoriyamaAbstract:The objectives of the present study were to examine the relationships between Intramuscular Fat, muscle strength and gait independence, as well as to clarify the Intramuscular Fat characteristics of dependent older women. A total of 25 older women who were unable to walk with or without assistance (dependent group), 22 frail older women (frail group) and 22 healthy older women (healthy group) participated in the present study. The frail participants could walk independently, but showed three or more of the following characteristics: slowness, weakness, weight loss, exhaustion and low physical activity. Outcome measures were quadriceps Intramuscular Fat determined by ultrasound echo intensity, and quadriceps muscle strength of the dependent, frail and healthy groups. In addition, the degree of gait independence (functional independence measures gait score) was assessed in the dependent and frail groups. Echo intensity in the dependent group was significantly negatively correlated with muscle strength and the functional independence measure gait score (correlation coefficients -0.635 and -0.344, respectively). Furthermore, echo intensity in the dependent group was significantly higher than in the healthy group. There was no significant difference in echo intensity between the dependent and frail groups. The present results suggest negative relationships between Intramuscular Fat and muscle strength, and Intramuscular Fat and degree of gait independence in dependent older women. In addition, dependent older women have more Intramuscular Fat than healthy older women. Geriatr Gerontol Int 2017; 17: 1683-1688. © 2016 Japan Geriatrics Society.
Kimiyuki Tamura - One of the best experts on this subject based on the ideXlab platform.
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Low body mass index negatively affects muscle mass and Intramuscular Fat of chronic stroke survivors.
PloS one, 2019Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Objective Relationship between secondary changes in skeletal muscle and body weight in chronic stroke survivors has not yet been carefully examined. The objective of this study was to clarify the relationships between muscle mass, Intramuscular Fat, and body weight in chronic stroke survivors. Methods Seventy-two chronic stroke survivors participated in this study. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Quadriceps muscle mass and Intramuscular Fat were assessed based on muscle thickness and echo intensity, respectively. We used a stepwise multiple regression analysis to identify the factors that were independently associated with the body mass index. We entered quadriceps thickness and echo intensity of the paretic and non-paretic sides into another stepwise multiple regression model to avoid multicollinearity. Age, sex, type of stroke, time since stroke, thigh length, number of medications, and an updated Charlson comorbidity index were included as the independent variables. Results The quadriceps thickness and echo intensity of the paretic and non-paretic sides were significantly independently associated with the body mass index: quadriceps thickness of the paretic side, β = 0.52; quadriceps thickness of the non-paretic side, β = 0.55; quadriceps echo intensity of the paretic side, β = −0.35; quadriceps echo intensity of the non-paretic side, β = −0.27). Conclusions Our results suggest that low body mass index is associated with loss of muscle mass and increased Intramuscular Fat on both the paretic and non-paretic sides of chronic stroke survivors. Further studies examining whether appropriate weight management, along with targeted rehabilitation programs aimed at increasing muscle mass and decreasing Intramuscular Fat, achieves good outcomes in chronic stroke survivors are warranted.
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Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors: A cross-sectional study.
PloS one, 2018Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Improving muscle mass and Intramuscular Fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors. There is a remarkable decrease in muscle mass and muscle strength and an increase in Intramuscular Fat in the quadriceps of both limbs of non-ambulatory compared with ambulatory survivors. Therefore, given that paretic lower extremity function does not recover sufficiently in the chronic phase, it may be helpful to improve muscle mass and Intramuscular Fat to increase muscle strength in the quadriceps of non-ambulatory chronic stroke survivors. However, these relationships remain unclear. The purpose of this study was to clarify the relationships between muscle strength, muscle mass, and Intramuscular Fat of the quadriceps in non-ambulatory chronic stroke survivors. Study design: A cross-sectional study. Participants: Fifty non-ambulatory chronic stroke survivors. Main outcome measures: Quadriceps muscle strength was measured using a handheld dynamometer. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Muscle mass and Intramuscular Fat of the quadriceps were assessed based on muscle thickness and echo intensity, respectively. Data analysis: Stepwise multiple regression analyses were used to identify the factors independently associated with the quadriceps muscle strength of the paretic and non-paretic limbs. To avoid multicollinearity, muscle thickness and echo intensity were entered into separate multiple regression models. Muscle thickness or echo intensity of the paretic or non-paretic limbs and other confounding factors were set as the independent variables. Muscle thickness was positively related and echo intensity was negatively related to the quadriceps muscle strength of the paretic and non-paretic limbs. Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors. Increasing muscle mass and decreasing Intramuscular Fat of the quadriceps of both limbs may improve muscle strength.
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muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non ambulatory chronic stroke survivors a cross sectional study
PLOS ONE, 2018Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Objective Improving muscle mass and Intramuscular Fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors. There is a remarkable decrease in muscle mass and muscle strength and an increase in Intramuscular Fat in the quadriceps of both limbs of non-ambulatory compared with ambulatory survivors. Therefore, given that paretic lower extremity function does not recover sufficiently in the chronic phase, it may be helpful to improve muscle mass and Intramuscular Fat to increase muscle strength in the quadriceps of non-ambulatory chronic stroke survivors. However, these relationships remain unclear. The purpose of this study was to clarify the relationships between muscle strength, muscle mass, and Intramuscular Fat of the quadriceps in non-ambulatory chronic stroke survivors. Methods Study design: A cross-sectional study. Participants: Fifty non-ambulatory chronic stroke survivors. Main outcome measures: Quadriceps muscle strength was measured using a handheld dynamometer. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Muscle mass and Intramuscular Fat of the quadriceps were assessed based on muscle thickness and echo intensity, respectively. Data analysis: Stepwise multiple regression analyses were used to identify the factors independently associated with the quadriceps muscle strength of the paretic and non-paretic limbs. To avoid multicollinearity, muscle thickness and echo intensity were entered into separate multiple regression models. Muscle thickness or echo intensity of the paretic or non-paretic limbs and other confounding factors were set as the independent variables. Results Muscle thickness was positively related and echo intensity was negatively related to the quadriceps muscle strength of the paretic and non-paretic limbs. Conclusions Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors. Increasing muscle mass and decreasing Intramuscular Fat of the quadriceps of both limbs may improve muscle strength.
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Relationships between Intramuscular Fat, muscle strength and gait independence in older women: A cross-sectional study.
Geriatrics & gerontology international, 2016Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Hideki MoriyamaAbstract:The objectives of the present study were to examine the relationships between Intramuscular Fat, muscle strength and gait independence, as well as to clarify the Intramuscular Fat characteristics of dependent older women. A total of 25 older women who were unable to walk with or without assistance (dependent group), 22 frail older women (frail group) and 22 healthy older women (healthy group) participated in the present study. The frail participants could walk independently, but showed three or more of the following characteristics: slowness, weakness, weight loss, exhaustion and low physical activity. Outcome measures were quadriceps Intramuscular Fat determined by ultrasound echo intensity, and quadriceps muscle strength of the dependent, frail and healthy groups. In addition, the degree of gait independence (functional independence measures gait score) was assessed in the dependent and frail groups. Echo intensity in the dependent group was significantly negatively correlated with muscle strength and the functional independence measure gait score (correlation coefficients -0.635 and -0.344, respectively). Furthermore, echo intensity in the dependent group was significantly higher than in the healthy group. There was no significant difference in echo intensity between the dependent and frail groups. The present results suggest negative relationships between Intramuscular Fat and muscle strength, and Intramuscular Fat and degree of gait independence in dependent older women. In addition, dependent older women have more Intramuscular Fat than healthy older women. Geriatr Gerontol Int 2017; 17: 1683-1688. © 2016 Japan Geriatrics Society.
Naomi Okawa - One of the best experts on this subject based on the ideXlab platform.
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Low body mass index negatively affects muscle mass and Intramuscular Fat of chronic stroke survivors.
PloS one, 2019Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Objective Relationship between secondary changes in skeletal muscle and body weight in chronic stroke survivors has not yet been carefully examined. The objective of this study was to clarify the relationships between muscle mass, Intramuscular Fat, and body weight in chronic stroke survivors. Methods Seventy-two chronic stroke survivors participated in this study. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Quadriceps muscle mass and Intramuscular Fat were assessed based on muscle thickness and echo intensity, respectively. We used a stepwise multiple regression analysis to identify the factors that were independently associated with the body mass index. We entered quadriceps thickness and echo intensity of the paretic and non-paretic sides into another stepwise multiple regression model to avoid multicollinearity. Age, sex, type of stroke, time since stroke, thigh length, number of medications, and an updated Charlson comorbidity index were included as the independent variables. Results The quadriceps thickness and echo intensity of the paretic and non-paretic sides were significantly independently associated with the body mass index: quadriceps thickness of the paretic side, β = 0.52; quadriceps thickness of the non-paretic side, β = 0.55; quadriceps echo intensity of the paretic side, β = −0.35; quadriceps echo intensity of the non-paretic side, β = −0.27). Conclusions Our results suggest that low body mass index is associated with loss of muscle mass and increased Intramuscular Fat on both the paretic and non-paretic sides of chronic stroke survivors. Further studies examining whether appropriate weight management, along with targeted rehabilitation programs aimed at increasing muscle mass and decreasing Intramuscular Fat, achieves good outcomes in chronic stroke survivors are warranted.
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Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors: A cross-sectional study.
PloS one, 2018Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Improving muscle mass and Intramuscular Fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors. There is a remarkable decrease in muscle mass and muscle strength and an increase in Intramuscular Fat in the quadriceps of both limbs of non-ambulatory compared with ambulatory survivors. Therefore, given that paretic lower extremity function does not recover sufficiently in the chronic phase, it may be helpful to improve muscle mass and Intramuscular Fat to increase muscle strength in the quadriceps of non-ambulatory chronic stroke survivors. However, these relationships remain unclear. The purpose of this study was to clarify the relationships between muscle strength, muscle mass, and Intramuscular Fat of the quadriceps in non-ambulatory chronic stroke survivors. Study design: A cross-sectional study. Participants: Fifty non-ambulatory chronic stroke survivors. Main outcome measures: Quadriceps muscle strength was measured using a handheld dynamometer. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Muscle mass and Intramuscular Fat of the quadriceps were assessed based on muscle thickness and echo intensity, respectively. Data analysis: Stepwise multiple regression analyses were used to identify the factors independently associated with the quadriceps muscle strength of the paretic and non-paretic limbs. To avoid multicollinearity, muscle thickness and echo intensity were entered into separate multiple regression models. Muscle thickness or echo intensity of the paretic or non-paretic limbs and other confounding factors were set as the independent variables. Muscle thickness was positively related and echo intensity was negatively related to the quadriceps muscle strength of the paretic and non-paretic limbs. Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors. Increasing muscle mass and decreasing Intramuscular Fat of the quadriceps of both limbs may improve muscle strength.
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muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non ambulatory chronic stroke survivors a cross sectional study
PLOS ONE, 2018Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Kazuhiro Harada, Hideki MoriyamaAbstract:Objective Improving muscle mass and Intramuscular Fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors. There is a remarkable decrease in muscle mass and muscle strength and an increase in Intramuscular Fat in the quadriceps of both limbs of non-ambulatory compared with ambulatory survivors. Therefore, given that paretic lower extremity function does not recover sufficiently in the chronic phase, it may be helpful to improve muscle mass and Intramuscular Fat to increase muscle strength in the quadriceps of non-ambulatory chronic stroke survivors. However, these relationships remain unclear. The purpose of this study was to clarify the relationships between muscle strength, muscle mass, and Intramuscular Fat of the quadriceps in non-ambulatory chronic stroke survivors. Methods Study design: A cross-sectional study. Participants: Fifty non-ambulatory chronic stroke survivors. Main outcome measures: Quadriceps muscle strength was measured using a handheld dynamometer. Transverse ultrasound images were acquired using B-mode ultrasound imaging. Muscle mass and Intramuscular Fat of the quadriceps were assessed based on muscle thickness and echo intensity, respectively. Data analysis: Stepwise multiple regression analyses were used to identify the factors independently associated with the quadriceps muscle strength of the paretic and non-paretic limbs. To avoid multicollinearity, muscle thickness and echo intensity were entered into separate multiple regression models. Muscle thickness or echo intensity of the paretic or non-paretic limbs and other confounding factors were set as the independent variables. Results Muscle thickness was positively related and echo intensity was negatively related to the quadriceps muscle strength of the paretic and non-paretic limbs. Conclusions Muscle mass and Intramuscular Fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors. Increasing muscle mass and decreasing Intramuscular Fat of the quadriceps of both limbs may improve muscle strength.
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Relationships between Intramuscular Fat, muscle strength and gait independence in older women: A cross-sectional study.
Geriatrics & gerontology international, 2016Co-Authors: Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Hideki MoriyamaAbstract:The objectives of the present study were to examine the relationships between Intramuscular Fat, muscle strength and gait independence, as well as to clarify the Intramuscular Fat characteristics of dependent older women. A total of 25 older women who were unable to walk with or without assistance (dependent group), 22 frail older women (frail group) and 22 healthy older women (healthy group) participated in the present study. The frail participants could walk independently, but showed three or more of the following characteristics: slowness, weakness, weight loss, exhaustion and low physical activity. Outcome measures were quadriceps Intramuscular Fat determined by ultrasound echo intensity, and quadriceps muscle strength of the dependent, frail and healthy groups. In addition, the degree of gait independence (functional independence measures gait score) was assessed in the dependent and frail groups. Echo intensity in the dependent group was significantly negatively correlated with muscle strength and the functional independence measure gait score (correlation coefficients -0.635 and -0.344, respectively). Furthermore, echo intensity in the dependent group was significantly higher than in the healthy group. There was no significant difference in echo intensity between the dependent and frail groups. The present results suggest negative relationships between Intramuscular Fat and muscle strength, and Intramuscular Fat and degree of gait independence in dependent older women. In addition, dependent older women have more Intramuscular Fat than healthy older women. Geriatr Gerontol Int 2017; 17: 1683-1688. © 2016 Japan Geriatrics Society.
Yukio Taniguchi - One of the best experts on this subject based on the ideXlab platform.
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exploration of genes showing Intramuscular Fat deposition associated expression changes in musculus longissimus muscle
Animal Genetics, 2006Co-Authors: Yoshiyuki Sasaki, Takeshi Miyake, K. Nagai, Y. Nagata, K. Doronbekov, S. Nishimura, S. Yoshioka, Tatsuo Fujita, K. Shiga, Yukio TaniguchiAbstract:Marbling, as defined by the amount of Intramuscular Fat, is an economically important trait in beef cattle. Intramuscular Fat deposition is postulated to arise mainly from a series of adipogenic events in Intramuscular adipocyte-lineage cells and in the physiological or anatomical milieux surrounding them. This study was designed to investigate gene-expression patterns associated with Fat deposition in musculus longissimus muscle, including adipocyte-lineage cells and part of the milieux. Differential-display PCR (ddPCR) was used to examine expression differences between low-marbled and high-marbled steer groups at 8, 10, 12 and 14 months of age, encompassing the time that marbling starts to appear. Seventy-four of 2114 total bands on ddPCR gel-bands were significant (P < 0.05) for the group effect, the interaction effect between group and age, or both the group and the interaction effects. Sequence analysis of 72 of these bands revealed 77 genes, including 35 annotated genes and 42 novel sequences. Among the 35 annotated genes, 6 (BTG2, PDHB, SORBS1, TRDN, TTN and MGP) have been related to changes in Intramuscular Fat deposition, possibly by exerting effects on adipocyte-lineage cells or on the milieux surrounding them.
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Exploration of genes showing Intramuscular Fat deposition‐associated expression changes in musculus longissimus muscle
Animal genetics, 2006Co-Authors: Yoshiyuki Sasaki, Takeshi Miyake, K. Nagai, Y. Nagata, K. Doronbekov, S. Nishimura, S. Yoshioka, Tatsuo Fujita, K. Shiga, Yukio TaniguchiAbstract:Marbling, as defined by the amount of Intramuscular Fat, is an economically important trait in beef cattle. Intramuscular Fat deposition is postulated to arise mainly from a series of adipogenic events in Intramuscular adipocyte-lineage cells and in the physiological or anatomical milieux surrounding them. This study was designed to investigate gene-expression patterns associated with Fat deposition in musculus longissimus muscle, including adipocyte-lineage cells and part of the milieux. Differential-display PCR (ddPCR) was used to examine expression differences between low-marbled and high-marbled steer groups at 8, 10, 12 and 14 months of age, encompassing the time that marbling starts to appear. Seventy-four of 2114 total bands on ddPCR gel-bands were significant (P < 0.05) for the group effect, the interaction effect between group and age, or both the group and the interaction effects. Sequence analysis of 72 of these bands revealed 77 genes, including 35 annotated genes and 42 novel sequences. Among the 35 annotated genes, 6 (BTG2, PDHB, SORBS1, TRDN, TTN and MGP) have been related to changes in Intramuscular Fat deposition, possibly by exerting effects on adipocyte-lineage cells or on the milieux surrounding them.
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a congenic strain f344 oletf imfm displays the existence of Intramuscular Fat accumulation qtl on rat chromosome 1
Experimental Animals, 2003Co-Authors: Hideki Tanomura, Yukio Taniguchi, Youji Muramatsu, Takeshi Miyake, Hiroyuki Kose, Takahisa Yamada, Kozo Matsumoto, Yoshiyuki SasakiAbstract:A genomic region between D1Wox8 and D1Rat90 on rat chromosome 1 was previously shown to be linked to Intramuscular Fat accumulation by quantitative trait locus (QTL) analysis using a F2 population derived from the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, which exhibits an increase in the levels of Intramuscular Fat content in Musculus longissimus, and the F344 rat. There exist two regions showing major and minor lod peaks for linkage to Intramuscular Fat accumulation, in the chromosomal region. We constructed a congenic strain introgressing the OLETF allele on the minor but not the major lod peak region in the F344 rat strain. The congenic strain had higher levels of Intramuscular Fat content in Musculus longissimus than the inbred partner F344 rat, thereby proving the existence of a QTL, designated Imfm (for Intramuscular Fat-minor), responsible for the Intramuscular Fat accumulation in the congenic region of the minor lod peak region of about 10 cM. The F344.OLETF-Imfm congenic strain might provide a refined tool for the analysis of the gene causing Intramuscular Fat accumulation.
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Detection of a quantitative trait locus for Intramuscular Fat accumulation using the OLETF rat.
The Journal of veterinary medical science, 2002Co-Authors: Hideki Tanomura, Yukio Taniguchi, Takeshi Miyake, Hiroyuki Kose, Takahisa Yamada, Kozo Matsumoto, Noboru Manabe, Yoshiyuki SasakiAbstract:The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes. We showed that the OLETF rat exhibits higher levels of Intramuscular Fat content in Musculus longissimus as compared to the Fischer-344 (F344) rat. Our investigation was designed to identify quantitative trait loci (QTLs) contributing to the increased levels of Intramuscular Fat content by performing a whole-genome search using 108 F2 intercross obtained by mating the OLETF and the F344 rats. We identified one QTL responsible for Intramuscular Fat accumulation on rat chromosome 1 with a maximum lod score of 3.4, which accounts for 5% of the total variance. As expected, the OLETF allele corresponds to the increased levels of Intramuscular Fat content.