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Tjalling W. De Vries - One of the best experts on this subject based on the ideXlab platform.
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The Quality of Instructional YouTube Videos for the Administration of Intranasal Spray : Observational Study
JMIR medical education, 2020Co-Authors: Marije M Peters-geven, Corine Rollema, Esther Metting, Eric N. Van Roon, Tjalling W. De VriesAbstract:BACKGROUND: Allergic rhinitis is a common disorder affecting both children and adults. Recommended treatment consists of Intranasal corticosteroid spray Administration, but only few patients administer the nasal spray in the correct technical manner. A wrong Administration technique may result in side effects and affect the efficacy and adherence, thus making accurate Administration instructions indispensable. Unfortunately, information about Intranasal Drug Administration is generally not explained accurately, thereby leading to confusion among patients and inaccuracy in the self-Administration of Drugs. OBJECTIVE: In this study, we analyzed instructional videos available on YouTube for the Administration of nasal sprays for allergic rhinitis. Our aim was to determine if the videos provided instructions in accordance with the standardized nationwide patient protocol in the Netherlands for Intranasal spray Administration. METHODS: Instructional videos for the Administration of aqueous formulations of nasal spray for allergic rhinitis were found on YouTube. All videos were reviewed by 2 researchers and scored using the instructions from the Dutch standardized protocol. Correct instructions were given a score of 1, while incorrect or missing instructions were given a score of 0. The interrater reliability using Cohen ĸ was used to determine the differences in the scores between the researchers. RESULTS: We identified 33 YouTube videos made by different health care professionals and pharmaceutical companies around the world. None of the videos displayed all the steps correctly, while 5 of the 33 (15%) videos displayed over 75% of the steps correctly. The median score of the correctly displayed steps was 11 out of 19 (range 2-17, IQR 6). The interrater reliability using Cohen ĸ was statistically significant (range 0.872-1.00, P
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The Quality of Instructional YouTube Videos for the Administration of Intranasal Spray: Observational Study (Preprint)
2020Co-Authors: Marije M Peters-geven, Corine Rollema, Esther Metting, Eric N. Van Roon, Tjalling W. De VriesAbstract:BACKGROUND Allergic rhinitis is a common disorder affecting both children and adults. Recommended treatment consists of Intranasal corticosteroid spray Administration, but only few patients administer the nasal spray in the correct technical manner. A wrong Administration technique may result in side effects and affect the efficacy and adherence, thus making accurate Administration instructions indispensable. Unfortunately, information about Intranasal Drug Administration is generally not explained accurately, thereby leading to confusion among patients and inaccuracy in the self-Administration of Drugs. OBJECTIVE In this study, we analyzed instructional videos available on YouTube for the Administration of nasal sprays for allergic rhinitis. Our aim was to determine if the videos provided instructions in accordance with the standardized nationwide patient protocol in the Netherlands for Intranasal spray Administration. METHODS Instructional videos for the Administration of aqueous formulations of nasal spray for allergic rhinitis were found on YouTube. All videos were reviewed by 2 researchers and scored using the instructions from the Dutch standardized protocol. Correct instructions were given a score of 1, while incorrect or missing instructions were given a score of 0. The interrater reliability using Cohen ĸ was used to determine the differences in the scores between the researchers. RESULTS We identified 33 YouTube videos made by different health care professionals and pharmaceutical companies around the world. None of the videos displayed all the steps correctly, while 5 of the 33 (15%) videos displayed over 75% of the steps correctly. The median score of the correctly displayed steps was 11 out of 19 (range 2-17, IQR 6). The interrater reliability using Cohen ĸ was statistically significant (range 0.872-1.00, <i>P</i><.001)<i>.</i> The steps “neutral position of the head,” “breathing out through the mouth,” and “periodically cleaning with water” scored the lowest and were incorrectly displayed in 28 (85%), 28 (85%), and 30 (91%) of the 33 videos, respectively. CONCLUSIONS The findings of our study revealed that only few instructional videos on YouTube provided correct instructions for the Administration of nasal sprays to patients. The inaccuracy of the instructions for nasal spray Administration in the majority of the videos may lead to confusion in patients and incorrect use of nasal sprays. In the future, it is important to make evidence-based instructional videos that show patients the correct technique of nasal spray Administration. CLINICALTRIAL Not applicable
Andis Graudins - One of the best experts on this subject based on the ideXlab platform.
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The pharmacokinetics of Intranasal droperidol in volunteers characterised via population modelling.
SAGE open medicine, 2018Co-Authors: Isabelle Cooper, Cornelia B Landersdorfer, Ashley Gordon St John, Andis GraudinsAbstract:Background:Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol. Intranasal Drug Administration re...
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The pharmacokinetics of Intranasal droperidol in volunteers characterised via population modelling
SAGE Publishing, 2018Co-Authors: Isabelle Cooper, Cornelia B Landersdorfer, Ashley Gordon St John, Andis GraudinsAbstract:Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol. Intranasal Drug Administration reduces need for intravenous line placement and risk of needle-stick. Objective: To model population pharmacokinetics of Intranasal droperidol. Method: Single doses of Intranasal and intravenous droperidol (0.02 mg/kg) were studied in an open-label crossover-trial in seven volunteers with a 1-week washout period. Blood samples collected over 10-h were analysed by liquid chromatography tandem mass spectrometer. Droperidol plasma concentrations following intravenous and Intranasal Administration were subjected to non-compartmental analysis and population pharmacokinetic modelling using S-ADAPT. Monte Carlo simulations were conducted for various potential Intranasal dosage regimens. Results: The droperidol concentration-time profiles following intravenous and Intranasal Administration were best described by a model with two equilibrating disposition compartments and linear elimination. The apparent elimination clearance for Intranasal dosing was 87.9 L/h and apparent central volume of distribution 18.2 L. Monte Carlo simulations of 5 mg droperidol (corresponding to the maximum volume that can be practically administered Intranasal at a time) given Intranasally at 0 and 5 min or 0 and 10 min indicated peak concentrations would reach those seen at 25 min after single intravenous Administration of 1.5 mg. No adverse clinical effects or QT interval prolongation were observed. Conclusion: Given the reduced bioavailability of Intranasal droperidol, Monte Carlo simulations suggested that it could potentially be used at a higher dose (2.5–5 mg) than currently used intravenously in clinical trials assessing the effectiveness in treatment of nausea, vomiting and migraine
Marije M Peters-geven - One of the best experts on this subject based on the ideXlab platform.
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The Quality of Instructional YouTube Videos for the Administration of Intranasal Spray : Observational Study
JMIR medical education, 2020Co-Authors: Marije M Peters-geven, Corine Rollema, Esther Metting, Eric N. Van Roon, Tjalling W. De VriesAbstract:BACKGROUND: Allergic rhinitis is a common disorder affecting both children and adults. Recommended treatment consists of Intranasal corticosteroid spray Administration, but only few patients administer the nasal spray in the correct technical manner. A wrong Administration technique may result in side effects and affect the efficacy and adherence, thus making accurate Administration instructions indispensable. Unfortunately, information about Intranasal Drug Administration is generally not explained accurately, thereby leading to confusion among patients and inaccuracy in the self-Administration of Drugs. OBJECTIVE: In this study, we analyzed instructional videos available on YouTube for the Administration of nasal sprays for allergic rhinitis. Our aim was to determine if the videos provided instructions in accordance with the standardized nationwide patient protocol in the Netherlands for Intranasal spray Administration. METHODS: Instructional videos for the Administration of aqueous formulations of nasal spray for allergic rhinitis were found on YouTube. All videos were reviewed by 2 researchers and scored using the instructions from the Dutch standardized protocol. Correct instructions were given a score of 1, while incorrect or missing instructions were given a score of 0. The interrater reliability using Cohen ĸ was used to determine the differences in the scores between the researchers. RESULTS: We identified 33 YouTube videos made by different health care professionals and pharmaceutical companies around the world. None of the videos displayed all the steps correctly, while 5 of the 33 (15%) videos displayed over 75% of the steps correctly. The median score of the correctly displayed steps was 11 out of 19 (range 2-17, IQR 6). The interrater reliability using Cohen ĸ was statistically significant (range 0.872-1.00, P
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The Quality of Instructional YouTube Videos for the Administration of Intranasal Spray: Observational Study (Preprint)
2020Co-Authors: Marije M Peters-geven, Corine Rollema, Esther Metting, Eric N. Van Roon, Tjalling W. De VriesAbstract:BACKGROUND Allergic rhinitis is a common disorder affecting both children and adults. Recommended treatment consists of Intranasal corticosteroid spray Administration, but only few patients administer the nasal spray in the correct technical manner. A wrong Administration technique may result in side effects and affect the efficacy and adherence, thus making accurate Administration instructions indispensable. Unfortunately, information about Intranasal Drug Administration is generally not explained accurately, thereby leading to confusion among patients and inaccuracy in the self-Administration of Drugs. OBJECTIVE In this study, we analyzed instructional videos available on YouTube for the Administration of nasal sprays for allergic rhinitis. Our aim was to determine if the videos provided instructions in accordance with the standardized nationwide patient protocol in the Netherlands for Intranasal spray Administration. METHODS Instructional videos for the Administration of aqueous formulations of nasal spray for allergic rhinitis were found on YouTube. All videos were reviewed by 2 researchers and scored using the instructions from the Dutch standardized protocol. Correct instructions were given a score of 1, while incorrect or missing instructions were given a score of 0. The interrater reliability using Cohen ĸ was used to determine the differences in the scores between the researchers. RESULTS We identified 33 YouTube videos made by different health care professionals and pharmaceutical companies around the world. None of the videos displayed all the steps correctly, while 5 of the 33 (15%) videos displayed over 75% of the steps correctly. The median score of the correctly displayed steps was 11 out of 19 (range 2-17, IQR 6). The interrater reliability using Cohen ĸ was statistically significant (range 0.872-1.00, <i>P</i><.001)<i>.</i> The steps “neutral position of the head,” “breathing out through the mouth,” and “periodically cleaning with water” scored the lowest and were incorrectly displayed in 28 (85%), 28 (85%), and 30 (91%) of the 33 videos, respectively. CONCLUSIONS The findings of our study revealed that only few instructional videos on YouTube provided correct instructions for the Administration of nasal sprays to patients. The inaccuracy of the instructions for nasal spray Administration in the majority of the videos may lead to confusion in patients and incorrect use of nasal sprays. In the future, it is important to make evidence-based instructional videos that show patients the correct technique of nasal spray Administration. CLINICALTRIAL Not applicable
Isabelle Cooper - One of the best experts on this subject based on the ideXlab platform.
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The pharmacokinetics of Intranasal droperidol in volunteers characterised via population modelling.
SAGE open medicine, 2018Co-Authors: Isabelle Cooper, Cornelia B Landersdorfer, Ashley Gordon St John, Andis GraudinsAbstract:Background:Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol. Intranasal Drug Administration re...
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The pharmacokinetics of Intranasal droperidol in volunteers characterised via population modelling
SAGE Publishing, 2018Co-Authors: Isabelle Cooper, Cornelia B Landersdorfer, Ashley Gordon St John, Andis GraudinsAbstract:Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol. Intranasal Drug Administration reduces need for intravenous line placement and risk of needle-stick. Objective: To model population pharmacokinetics of Intranasal droperidol. Method: Single doses of Intranasal and intravenous droperidol (0.02 mg/kg) were studied in an open-label crossover-trial in seven volunteers with a 1-week washout period. Blood samples collected over 10-h were analysed by liquid chromatography tandem mass spectrometer. Droperidol plasma concentrations following intravenous and Intranasal Administration were subjected to non-compartmental analysis and population pharmacokinetic modelling using S-ADAPT. Monte Carlo simulations were conducted for various potential Intranasal dosage regimens. Results: The droperidol concentration-time profiles following intravenous and Intranasal Administration were best described by a model with two equilibrating disposition compartments and linear elimination. The apparent elimination clearance for Intranasal dosing was 87.9 L/h and apparent central volume of distribution 18.2 L. Monte Carlo simulations of 5 mg droperidol (corresponding to the maximum volume that can be practically administered Intranasal at a time) given Intranasally at 0 and 5 min or 0 and 10 min indicated peak concentrations would reach those seen at 25 min after single intravenous Administration of 1.5 mg. No adverse clinical effects or QT interval prolongation were observed. Conclusion: Given the reduced bioavailability of Intranasal droperidol, Monte Carlo simulations suggested that it could potentially be used at a higher dose (2.5–5 mg) than currently used intravenously in clinical trials assessing the effectiveness in treatment of nausea, vomiting and migraine
Sveinbjörn Gizurarson - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of Intranasal delivery route of Drug Administration for brain targeting
Brain Research Bulletin, 2018Co-Authors: Franciska Erdő, Luca Bors, Daniel Farkas, Ágnes Bajza, Sveinbjörn GizurarsonAbstract:Abstract The acute or chronic Drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral Drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society. The reason of low brain penetration of the compounds is that they have to overcome the blood-brain barrier which protects the brain against xenobiotics. Intranasal Drug Administration is one of the promising options to bypass blood-brain barrier, to reduce the systemic adverse effects of the Drugs and to lower the doses to be administered. Furthermore, the Drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral Drugs. In this review the focus is on giving an overview on the anatomical and cellular structure of nasal cavity and absorption surface. It presents some possibilities to enhance the Drug penetration through the nasal barrier and summarizes some in vitro, ex vivo and in vivo technologies to test the Drug delivery across the nasal epithelium into the brain. Finally, the authors give a critical evaluation of the nasal route of Administration showing its main advantages and limitations of this delivery route for CNS Drug targeting.
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Pharmacokinetics of Intranasal Drug Administration: the influence of some biological factors.
Journal of pharmaceutical sciences, 1991Co-Authors: Sveinbjörn Gizurarson, Soren N. Rasmussen, Frank LarsenAbstract:Abstract The pharmacokinetics of Intranasal Drug Administration have previously been described in detail by Colaizzi et al. 1 In the meantime, some important biological data are now available and should be incorporated into the description. These describe factors such as disappearance from the absorption site by the mucociliary clearance and enzymatic degradation (for peptides only). The purpose of this communication is to include these factors in a model describing the pharmacokinetics of Drugs (such as insulin) after Intranasal Administration.