The Experts below are selected from a list of 111 Experts worldwide ranked by ideXlab platform
Sarah Heinze - One of the best experts on this subject based on the ideXlab platform.
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hippocampal characteristics and Invariant Sequence elements distribution of glra2 and glra3 c to u editing
Molecular Syndromology, 2017Co-Authors: Philipp Schaefermeier, Sarah HeinzeAbstract:Glycine receptor α2 and α3 subunit (GLRA2/GLRA3) high-affinity variants, of which the subjacent amino acid substitutions issue from C-to-U RNA editing, are thought to influence tonic inhibition and pathophysiology. In light of the detection of GLRA3 NM_006529:r.1157C>U and GLRA2 NM_002063:r.1416C>U exchanges in hippocampus explants of temporal lobe epilepsy patients, we now examine the healthy situation and relate it to the epileptic situation by ascertaining controls in a legitimate reanalysis. The GLRA2 and GLRA3 editing events that would ultimately result in a glycine receptor with increased affinity occur in the postmortem nonepileptic hippocampus. Most notably, their relative amounts do not significantly differ from those in increased damaged hippocampus explants, whereas curbed relative amounts in epileptic explants without cell loss come out statistically significant. Local Sequence alignment reveals Invariant Sequence stretches consistent in GLRA2/ GLRA3 and other edited transcripts that coincide with known APOB Sequence elements. Concerning the essential mooring element, GLRA2/GLRA3 comply strictly only with the motif's 5' part. While this lack of canonical mooring elements and uncertain action of the famous deaminase APOBEC1 suggest a specific regulation of GLRA2/GLRA3 editing, its reduction in the less-damaged epileptic hippocampus could be attributed to anomalous epileptic neurogenesis.
Michael Milford - One of the best experts on this subject based on the ideXlab platform.
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towards condition Invariant Sequence based route recognition
International Conference on Robotics and Automation, 2011Co-Authors: Michael MilfordAbstract:In this paper we present a novel algorithm for localization during navigation that performs matching over local image Sequences. Instead of calculating the single location most likely to correspond to a current visual scene, the approach finds candidate matching locations within every section (subroute) of all learned routes. Through this approach, we reduce the demands upon the image processing front-end, requiring it to only be able to correctly pick the best matching image from within a short local image Sequence, rather than globally. We applied this algorithm to a challenging downhill mountainbiking visual dataset where there was significant perceptual or environment change between repeated traverses of the environment, and compared performance to applying the feature-based algorithm FAB-MAP. The results demonstrate the potential for localization using visual Sequences, even when there are no visual features that can be reliably detected.
Andrew J Newman - One of the best experts on this subject based on the ideXlab platform.
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the Invariant u5 snrna loop 1 Sequence is dispensable for the first catalytic step of pre mrna splicing in yeast
Cell, 1996Co-Authors: Raymond T Okeefe, Christine M Norman, Andrew J NewmanAbstract:Abstract We have developed an in vitro reconstitution system to investigate the role of U5 snRNA in the two catalytic steps of pre-mRNA splicing. The Invariant U5 loop 1 is known to interact with exon Sequences at the 5′ splice site before the first catalytic step. Remarkably, analysis of U5 mutations in vitro reveals that the first transesterification occurs accurately in the absence of the U5 loop. Therefore this Sequence is not an essential component of the spliceosomal active site for the first catalytic step. The second catalytic step, although strongly dependent on the presence of a U5 loop to tether the exon 1 splicing intermediate, is surprisingly tolerant of mutations in the Invariant Sequence.
Daniel Pellegrino - One of the best experts on this subject based on the ideXlab platform.
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on the size of certain subsets of Invariant banach Sequence spaces
Linear Algebra and its Applications, 2015Co-Authors: Tony Nogueira, Daniel PellegrinoAbstract:Abstract The essence of the notion of lineability and spaceability is to find linear structures in somewhat chaotic environments. The existing methods, in general, use ad hoc arguments and few general techniques are known. Motivated by the search of general methods, in this paper we formally extend recent results of G. Botelho and V.V. Favaro on Invariant Sequence spaces to a more general setting. Our main results show that some subsets of Invariant Sequence spaces contain, up to the null vector, a closed infinite-dimensional subspace.
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on the size of certain subsets of Invariant banach Sequence spaces
arXiv: Functional Analysis, 2015Co-Authors: Tony Nogueira, Daniel PellegrinoAbstract:The essence of the notion of lineability and spaceability is to find linear structures in somewhat chaotic environments. The existing methods, in general, use \textit{ad hoc} arguments and few general techniques are known. Motivated by the search of general methods, in this paper we formally extend recent results of G.\ Botelho and V.V. F\'{a}varo on Invariant Sequence spaces to a more general setting. Our main results show that some subsets of Invariant Sequence spaces contain, up to the null vector, a closed infinite-dimensional subspace.
Michael D. Berzonsky - One of the best experts on this subject based on the ideXlab platform.
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The Structure of Identity: Commentary on Jane Kroger's View of Identity Status Transition
Identity, 2003Co-Authors: Michael D. BerzonskyAbstract:Kroger's (this issue) view that Marcia's (1966) identity statuses constitute an Invariant Sequence of "soft," structural developmental stages is evaluated. I argue that the reliable status differences found along a number of social, personality, and cognitive dimensions, do not reflect a common underlying identity structure. First, the amount of intrastatus variability found is incompatible with a structural hypothesis. Second, the amount of regression found in longitudinal studies (especially from an achieved to foreclosed status) is inconsistent with an Invariant, developmental-stage Sequence. An alternative perspective of identity structure is proposed. Identity is conceptualized as a self-theory that influences what information people attend to, how it is encoded, and how it is interpreted. Possible elements from which self-theories are constructed and analytic strategies that could be used to investigate their structural architecture are considered.
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Reevaluating the Identity Status Paradigm: Still Useful after 35 Years☆
Developmental Review, 1999Co-Authors: Michael D. Berzonsky, Gerald R. AdamsAbstract:Abstract In this article we respond to van Hoof's (1999) critique of the identity status paradigm. Our review and evaluation of the existing data on identity statuses lead us to be more optimistic than van Hoof about the convergent and discriminant validity of identity status measures, especially objective measures that provide continuous status scores as well as nominal status classifications. Our review of longitudinal studies revealed that among university students tested annually 3 or more times, change in status classifications is significantly more likely to be observed than stability. Moreover, virtually all longitudinal studies with university students indicate that status changes are more likely to be progressive rather than regressive in terms of the hypothesized identity status developmental Sequence. However, considerable status regression and fluctuation is observed and we agree with van Hoof that it may no longer be useful to postulate an Invariant Sequence of identity status stages. Nonetheless, the data do indicate reliable status differences in self-regulatory control processes including ego development, social-cognitive processing orientations, cognitive complexity, self-integration, moral development, and so on. Consequently, we conclude that a useful strategy, at least with university students, may be to focus on the social-cognitive processes that underpin identity statuses and to conceptualize these identity orientations as different styles of dealing with the demands, challenges, and opportunities afforded by institutionalized moratoria, such as a university context. Two lines of recent research inspired by this conceptualization are discussed.
