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Ralph W Moss - One of the best experts on this subject based on the ideXlab platform.

  • patient responses to cytoluminescent therapy for cancer an Investigative Report of early experiences and adverse effects of an unconventional form of photodynamic therapy
    Integrative Cancer Therapies, 2003
    Co-Authors: Ralph W Moss
    Abstract:

    Cytoluminescent Therapy (CLT) is an unconventional form of photodynamic therapy (PDT), utilizing a second-generation chlorophyll-derived photosensitizing agent and whole-body illumination. Starting in late 2002, CLT was administered in Ireland to 48 patients. Illumination with lasers and light-emitting diodes followed the administration of an initial bolus i.v. After returning home, patients continued self-administered treatment using oral agent activated by infrared lamps. CLT proponents claimed that these procedures were beneficial to patients with advanced cancer. An organization devoted to making information on alternative therapies available to the public was engaged to contact these CLT patients and assess the outcome. In informal contacts, patients Reported that initial side effects were generally mild and transient. However, especially after commencing self-treatment, many Reported unanticipated effects, including fatigue and general weakness, increased pain, cough, dyspnea, diminished appetite and weight loss, tissue necrosis, and other major symptoms. At a minimum of 6 months after initial CLT, no patient has Reported an objective response, and some have complained of deterioration on the home treatment. There have been 17 deaths among the 48, with a mean survival after initial treatment among decedents of 4.2 months. CLT, in this group, was a qualified failure, with a high incidence of aftereffects. The mode of action of these aftereffects has yet to be explored. In the future, CLT should be administered to patients only in carefully managed medical facilities, by fully trained and licensed professionals, under the supervision of relevant regulatory agencies, and with meticulous follow-up care.

  • for cancer an Investigative Report of early experiences and adverse effects of an unconventional form of photodynamic therapy
    2003
    Co-Authors: Ralph W Moss
    Abstract:

    ® (CLT) is an unconventional form of photodynamic therapy (PDT), utilizing a second- generation chlorophyll-derived photosensitizing agent and whole-body illumination. Starting in late 2002, CLT was administered in Ireland to 48 patients. Illumination with lasers and light-emitting diodes followed the administration of an initial bolus IV. After returning home, patients contin- ued self-administered treatment using oral agent activated by infrared lamps. CLT proponents claimed that these pro- cedures were beneficial to patients with advanced cancer. An organization devoted to making information on alterna- tive therapies available to the public was engaged to contact these CLT patients and assess the outcome. In informal con- tacts, patients Reported that initial side effects were gen- erally mild and transient. However, especially after com- mencing self-treatment, many Reported unanticipated effects, including fatigue and general weakness, increased pain, cough, dyspnea, diminished appetite and weight loss, tissue necrosis, and other major symptoms. At a minimum of 6 months after initial CLT, no patient has Reported an objec- tive response, and some have complained of deterioration on the home treatment. There have been 17 deaths among the 48, with a mean survival after initial treatment among decedents of 4.2 months. CLT, in this group, was a qualified failure, with a high incidence of aftereffects. The mode of action of these aftereffects has yet to be explored. In the future, CLT should be administered to patients only in care- fully managed medical facilities, by fully trained and licensed professionals, under the supervision of relevant regulatory agencies, and with meticulous follow-up care.

Michael Deshields - One of the best experts on this subject based on the ideXlab platform.

Mike Deshields - One of the best experts on this subject based on the ideXlab platform.

Lan Daju - One of the best experts on this subject based on the ideXlab platform.

Elizabeth N Miles - One of the best experts on this subject based on the ideXlab platform.

  • Improvement in the incident Reporting and investigation procedures using process excellence (DMAI2C) methodology.
    Journal of hazardous materials, 2005
    Co-Authors: Elizabeth N Miles
    Abstract:

    In 1996, Health & Safety introduced an incident investigation process called Learning to Look to Johnson & Johnson. This process provides a systematic way of analyzing work-related injuries and illness, uncovers root cause that leads to system defects, and points to viable solutions. The process analyzed involves three steps: investigation and Reporting of the incident, determination of root cause, and development and implementation of a corrective action plan. The process requires the investigators to provide an initial communication for work-related serious injuries and illness as well as lost workday cases to Corporate Headquarters within 72 h of the incident with a full Investigative Report to follow within 10 days. A full investigation requires a written Report, a cause-result logic diagram (CRLD), a corrective action plan (CAP) and a Report of incident costs (SafeCost) all due to be filed electronically. It is incumbent on the principal investigator and his or her Investigative teams to assemble the various parts of the investigation and to follow up with the relevant parties to ensure corrective actions are implemented, and a full Report submitted to Corporate executives. Initial review of the system revealed that the process was not working as designed. A number of Reports were late, not signed by the business leaders, and in some instances, all cause were not identified. Process excellence was the process used to study the issue. The team used six sigma DMAI2C methodologies to identify and implement system improvements. The project examined the breakdown of the critical aspects of the Reporting and investigation process that lead to system errors. This Report will discuss the study findings, recommended improvements, and methods used to monitor the new improved process.

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