The Experts below are selected from a list of 7074 Experts worldwide ranked by ideXlab platform
Kenichi Yano - One of the best experts on this subject based on the ideXlab platform.
-
Involuntary Movement suppression filter for electric wheelchair with athetosis type cerebral palsy
Joint IEEE International Conference on Development and Learning and Epigenetic Robotics, 2020Co-Authors: Motoyu Katsumura, Kenichi Yano, Tomoyuki Nakao, Atsushi Hamada, Katsuhiko ToriiAbstract:Individuals with cerebral palsy use electric wheelchairs due to their abnormal gait caused by paralysis and other symptoms. However, it is difficult for them to operate the wheelchair joystick because of their suddenly occurring uncontrollable, Involuntary Movements and the difficulty they have maintaining their posture. In this study, we developed a control system, which suppresses the effects of Involuntary Movement. This system is capable of controlling electric wheelchairs as intended by individuals with tension-athetosis-type cerebral palsy. We demonstrated the experiments to compare the stability of operation by normal system and the proposed system. Finally, we showed the effectiveness of the proposed system in the straight running experiment.
-
joystick grip for electric wheelchair for tension athetosis type cerebral palsy
International Conference of the IEEE Engineering in Medicine and Biology Society, 2019Co-Authors: Yuto Ogata, Motoyu Katsumura, Kenichi Yano, Tomoyuki Nakao, Atsushi Hamada, Katsuhiko ToriiAbstract:In Japan, the number of people who have difficulty walking has been increasing with the rise in the aging population and that of people with physical disabilities. Individuals with athetosis-type cerebral palsy may use electric wheelchairs due to abnormal walking. However, since they have problems with fine motor control, including the occurrence of Involuntary Movements and difficulty maintaining posture, they have difficulty intentionally controlling their hand Movements. Therefore, they cannot operate a joystick, even if they desire to use electric wheelchairs, and there are risks of accidents. In this study, by considering the arch structure of hand, we developed a new joystick grip that enables the suppression of Involuntary Movement. We evaluated our proposed grip by comparing running stability with a conventional grip, and demonstrated the effectiveness of proposed method.
-
development of drawing assist system for patients with cerebral palsy of the tension athetosis type
International Conference on Robotics and Automation, 2011Co-Authors: Hiroaki Aoyama, Tomoyuki Nakao, Naruto Miyagawa, Naoki Kubota, Satoshi Horihata, Kenichi YanoAbstract:Creative activities, such as painting and music, are one source of satisfaction and fulfillment for people with disabilities. However, some individuals with a disability cannot satisfactorily enjoy such activities because of Involuntary Movement or spasms. In this study, we developed a drawing assist system for patients with cerebral palsy of the tension athetosis type, who experience spasticity that makes it difficult for the assist system to distinguish Involuntary Movement from voluntary Movement. We designed a variable filter to attenuate Involuntary Movement on the basis of the behavioral characteristics of the velocity component with respect to Involuntary Movement. Our system enabled drawing based on the participant's own senses and motor control, even when experiencing Involuntary Movement.
-
development of drawing assist system for one patient with tension athetosis type cerebral palsy
Transactions of the Japan Society of Mechanical Engineers. C, 2011Co-Authors: Tomoyuki Nakao, Kenichi Yano, Hiroaki Aoyama, Naruto Miyagawa, Naoki Kubota, Satoshi HorihataAbstract:Creative activities, such as painting and music, are one source of satisfaction and fulfillment for people with disabilities. However, some individuals with disabilities cannot satisfactorily enjoy such activities due to Involuntary Movement. In this study, we developed a drawing assist system for patients with cerebral palsy of the tension athetosis type, who experience Involuntary Movement. It has been difficult for the assist system to distinguish Involuntary Movement from voluntary Movement. We designed a variable filter to attenuate Involuntary Movement on the basis of characteristics of synthesized velocity with respect to Involuntary Movement. Our system enabled drawing based on the participant's own senses and motor control, even when experiencing Involuntary Movement.
Arun K Tiwari - One of the best experts on this subject based on the ideXlab platform.
-
liver enzyme cyp2d6 gene and tardive dyskinesia
Pharmacogenomics, 2020Co-Authors: Arun K Tiwari, Natalie Freeman, Gwyneth Zai, Vincenzo De Luca, Daniel J Muller, Maria TampakerasAbstract:Background: Tardive dyskinesia (TD) is an iatrogenic Involuntary Movement disorder occurring after extended antipsychotic use with an unclear pathogenesis. CYP2D6 is a liver enzyme involved in antipsychotic metabolism and a well-studied gene candidate for TD. Materials & methods: We tested predicted CYP2D6 metabolizer phenotype with TD occurrence and severity in our two samples of European chronic schizophrenia patients (total n = 198, of which 82 had TD). Results: TD occurrence were associated with extreme metabolizer phenotype, controlling for age and sex (p = 0.012). In other words, individuals with either increased and no CYP2D6 activity were at higher risk of having TD. Conclusion: Unlike most previous findings, TD occurrence may be associated with both extremes of CYP2D6 metabolic activity rather than solely for poor metabolizers.
-
genetic study of neuregulin 1 and receptor tyrosine protein kinase erbb 4 in tardive dyskinesia
World Journal of Biological Psychiatry, 2019Co-Authors: Clement C Zai, Arun K Tiwari, Vincenzo De Luca, Daniel J Muller, Nabilah I Chowdhury, Zeynep Yilmaz, Steven G Potkin, Jeffrey A Lieberman, Herbert Y Meltzer, Aristotle N VoineskosAbstract:AbstractObjectives: Tardive dyskinesia (TD) is a Movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed.Methods: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD.Results: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P = .003).Conclusions: This study supports a role for the neuregulin signalling pathway in TD, although independent replications are warranted.
-
association study of disrupted in schizophrenia 1 gene variants and tardive dyskinesia
Neuroscience Letters, 2018Co-Authors: Arun K Tiwari, Gwyneth Zai, Daniel J Muller, Sajid A Shaikh, Aristotle N Voineskos, Anjali RastogiAbstract:Abstract Tardive dyskinesia (TD) is an Involuntary Movement disorder that occurs in ∼20% of patients after extended antipsychotic use. Its pathophysiology is unclear; however, familial patterns and gene association studies indicate an inherited component to risk. The disrupted in schizophrenia 1 (DISC1) gene was selected for analysis because it interacts with and regulates two important proteins involved in antipsychotic medication action: the dopamine D2 receptor and the cAMP phosphodiesterase type IVB (PDE4B). The D2 receptor is the obligate target of all existing antipsychotic medications, and PDE4B hydrolyzes cAMP, a core signaling molecule activated by agonist binding to the D2 receptor. Notably, PDE4B inhibitors such as rolipram have been shown to reduce TD-like behaviours in animal models. Nine single-nucleotide polymorphisms (SNPs) in the DISC1 gene were investigated in a sample of 193 chronic schizophrenia patients for association with the presence and severity of TD, with age and sex as additional variables. TD severity was measured using the Abnormal Involuntary Movement Scale (AIMS). Two DISC1 SNPs were associated with TD severity (uncorrected p
-
association study of the vesicular monoamine transporter gene slc18a2 with tardive dyskinesia
Journal of Psychiatric Research, 2013Co-Authors: Clement C Zai, Arun K Tiwari, Vincenzo De Luca, Daniel J Muller, Falk W Lohoff, Marina Mazzoco, Sajid A Shaikh, Natalie FreemanAbstract:Tardive dyskinesia (TD) is an Involuntary Movement disorder that can occur in up to 25% of patients receiving long-term first-generation antipsychotic treatment. Its etiology is unclear, but family studies suggest that genetic factors play an important role in contributing to risk for TD. The vesicular monoamine transporter 2 (VMAT2) is an interesting candidate for genetic studies of TD because it regulates the release of neurotransmitters implicated in TD, including dopamine, serotonin, and GABA. VMAT2 is also a target of tetrabenazine, a drug used in the treatment of hyperkinetic Movement disorders, including TD. We examined nine single-nucleotide polymorphisms (SNPs) in the SLC18A2 gene that encodes VMAT2 for association with TD in our sample of chronic schizophrenia patients (n = 217). We found a number of SNPs to be nominally associated with TD occurrence and the Abnormal Involuntary Movement Scale (AIMS), including the rs2015586 marker which was previously found associated with TD in the CATIE sample (Tsai et al., 2010), as well as the rs363224 marker, with the low-expression AA genotype appearing to be protective against TD (p = 0.005). We further found the rs363224 marker to interact with the putative functional D2 receptor rs6277 (C957T) polymorphism (p = 0.001), supporting the dopamine hypothesis of TD. Pending further replication, VMAT2 may be considered a therapeutic target for the treatment and/or prevention of TD.
Ib R Odderson - One of the best experts on this subject based on the ideXlab platform.
-
Involuntary masturbation as a manifestation of stroke related alien hand syndrome
American Journal of Physical Medicine & Rehabilitation, 2000Co-Authors: Ib R OddersonAbstract:ABSTRACT Alien hand syndrome is a perplexing and uncommon clinical diagnosis. We report an unusual manifestation of alien hand syndrome in a 73-yr-old man with a right anterior cerebral artery infarct affecting the right medial frontal cortex and the anterior portion of the corpus callosum. We conclude that alien hand syndrome should be considered in patients who present with a feeling of alienation of one or both upper limbs accompanied by complex purposeful Involuntary Movement.
Daniel J Muller - One of the best experts on this subject based on the ideXlab platform.
-
liver enzyme cyp2d6 gene and tardive dyskinesia
Pharmacogenomics, 2020Co-Authors: Arun K Tiwari, Natalie Freeman, Gwyneth Zai, Vincenzo De Luca, Daniel J Muller, Maria TampakerasAbstract:Background: Tardive dyskinesia (TD) is an iatrogenic Involuntary Movement disorder occurring after extended antipsychotic use with an unclear pathogenesis. CYP2D6 is a liver enzyme involved in antipsychotic metabolism and a well-studied gene candidate for TD. Materials & methods: We tested predicted CYP2D6 metabolizer phenotype with TD occurrence and severity in our two samples of European chronic schizophrenia patients (total n = 198, of which 82 had TD). Results: TD occurrence were associated with extreme metabolizer phenotype, controlling for age and sex (p = 0.012). In other words, individuals with either increased and no CYP2D6 activity were at higher risk of having TD. Conclusion: Unlike most previous findings, TD occurrence may be associated with both extremes of CYP2D6 metabolic activity rather than solely for poor metabolizers.
-
genetic study of neuregulin 1 and receptor tyrosine protein kinase erbb 4 in tardive dyskinesia
World Journal of Biological Psychiatry, 2019Co-Authors: Clement C Zai, Arun K Tiwari, Vincenzo De Luca, Daniel J Muller, Nabilah I Chowdhury, Zeynep Yilmaz, Steven G Potkin, Jeffrey A Lieberman, Herbert Y Meltzer, Aristotle N VoineskosAbstract:AbstractObjectives: Tardive dyskinesia (TD) is a Movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed.Methods: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD.Results: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P = .003).Conclusions: This study supports a role for the neuregulin signalling pathway in TD, although independent replications are warranted.
-
association study of disrupted in schizophrenia 1 gene variants and tardive dyskinesia
Neuroscience Letters, 2018Co-Authors: Arun K Tiwari, Gwyneth Zai, Daniel J Muller, Sajid A Shaikh, Aristotle N Voineskos, Anjali RastogiAbstract:Abstract Tardive dyskinesia (TD) is an Involuntary Movement disorder that occurs in ∼20% of patients after extended antipsychotic use. Its pathophysiology is unclear; however, familial patterns and gene association studies indicate an inherited component to risk. The disrupted in schizophrenia 1 (DISC1) gene was selected for analysis because it interacts with and regulates two important proteins involved in antipsychotic medication action: the dopamine D2 receptor and the cAMP phosphodiesterase type IVB (PDE4B). The D2 receptor is the obligate target of all existing antipsychotic medications, and PDE4B hydrolyzes cAMP, a core signaling molecule activated by agonist binding to the D2 receptor. Notably, PDE4B inhibitors such as rolipram have been shown to reduce TD-like behaviours in animal models. Nine single-nucleotide polymorphisms (SNPs) in the DISC1 gene were investigated in a sample of 193 chronic schizophrenia patients for association with the presence and severity of TD, with age and sex as additional variables. TD severity was measured using the Abnormal Involuntary Movement Scale (AIMS). Two DISC1 SNPs were associated with TD severity (uncorrected p
-
association study of the vesicular monoamine transporter gene slc18a2 with tardive dyskinesia
Journal of Psychiatric Research, 2013Co-Authors: Clement C Zai, Arun K Tiwari, Vincenzo De Luca, Daniel J Muller, Falk W Lohoff, Marina Mazzoco, Sajid A Shaikh, Natalie FreemanAbstract:Tardive dyskinesia (TD) is an Involuntary Movement disorder that can occur in up to 25% of patients receiving long-term first-generation antipsychotic treatment. Its etiology is unclear, but family studies suggest that genetic factors play an important role in contributing to risk for TD. The vesicular monoamine transporter 2 (VMAT2) is an interesting candidate for genetic studies of TD because it regulates the release of neurotransmitters implicated in TD, including dopamine, serotonin, and GABA. VMAT2 is also a target of tetrabenazine, a drug used in the treatment of hyperkinetic Movement disorders, including TD. We examined nine single-nucleotide polymorphisms (SNPs) in the SLC18A2 gene that encodes VMAT2 for association with TD in our sample of chronic schizophrenia patients (n = 217). We found a number of SNPs to be nominally associated with TD occurrence and the Abnormal Involuntary Movement Scale (AIMS), including the rs2015586 marker which was previously found associated with TD in the CATIE sample (Tsai et al., 2010), as well as the rs363224 marker, with the low-expression AA genotype appearing to be protective against TD (p = 0.005). We further found the rs363224 marker to interact with the putative functional D2 receptor rs6277 (C957T) polymorphism (p = 0.001), supporting the dopamine hypothesis of TD. Pending further replication, VMAT2 may be considered a therapeutic target for the treatment and/or prevention of TD.
Mariagiovanna Spinella - One of the best experts on this subject based on the ideXlab platform.
-
subjective experience Involuntary Movement and posterior alien hand syndrome
Journal of Neurology Neurosurgery and Psychiatry, 2000Co-Authors: T Bundick, Mariagiovanna SpinellaAbstract:The alien hand syndrome, as originally defined, was used to describe cases involving anterior corpus callosal lesions producing Involuntary Movement and a concomitant inability to distinguish the affected hand from an examiner's hand when these were placed in the patient's unaffected hand. In recent years, acceptable usage of the term has broadened considerably, and has been defined as Involuntary Movement occurring in the context of feelings of estrangement from or personification of the affected limb or its Movements. Three varieties of alien hand syndrome have been reported, involving lesions of the corpus callosum alone, the corpus callosum plus dominant medial frontal cortex, and posterior cortical/subcortical areas. A patient with posterior alien hand syndrome of vascular aetiology is reported and the findings are discussed in the light of a conceptualisation of posterior alien hand syndrome as a disorder which may be less associated with specific focal neuropathology than are its callosal and callosal-frontal counterparts.
