The Experts below are selected from a list of 5619 Experts worldwide ranked by ideXlab platform
Johannes T Heverhagen - One of the best experts on this subject based on the ideXlab platform.
-
intravenous Iodinated Contrast agents amplify dna radiation damage at ct
Radiology, 2015Co-Authors: Eike Immo Piechowiak, Janfriedrich W Peter, Beate Kleb, Klaus J Klose, Johannes T HeverhagenAbstract:Our study showed that the application of Iodinated Contrast agents during chest CT clearly increased the amount of DNA radiation damage.
-
the presence of Iodinated Contrast agents amplifies dna radiation damage in computed tomography
Contrast Media & Molecular Imaging, 2011Co-Authors: Caroline Pathe, Beate Kleb, Klaus J Klose, Katharina Eble, Daniel Schmitzbeuting, Boris Keil, Bjoern Kaestner, Maximilian Voelker, Johannes T HeverhagenAbstract:The purpose of this study was to determine the influence of Iodinated Contrast agents on the formation of DNA double-strand breaks in vitro in lymphocytes and to verify these results in patients undergoing diagnostic computed tomography examinations. Blood samples were irradiated in vitro in the presence of Iodinated X-ray Contrast agent. Controls were irradiated without Contrast agent. Fourteen patients were investigated using Contrast-enhanced computed tomography (CT), and 14 other patients with unenhanced CT. Blood samples were taken prior to and 5 min and 1, 2 and 24 h after the CT examination. In these blood samples the average number of γH2Ax-foci per lymphocyte was enumerated by fluorescence microscopy. Statistical differences between foci numbers developed in the presence and absence of Contrast agent were tested using an independent sample t-test. In vitro foci numbers after irradiation were significantly higher when Contrast agent was present during irradiation. In vivo, γH2Ax-foci levels were 58% higher in patients undergoing Contrast-enhanced CT compared with those undergoing unenhanced CT. In the presence of Iodinated Contrast agents DNA, damage is increased and the radiation dose is not the only factor affecting the amount of DNA damage. Individual patient characteristics and biological dosimetry applications, e.g. the analysis of γH2Ax-foci, have to be considered.
Beate Kleb - One of the best experts on this subject based on the ideXlab platform.
-
intravenous Iodinated Contrast agents amplify dna radiation damage at ct
Radiology, 2015Co-Authors: Eike Immo Piechowiak, Janfriedrich W Peter, Beate Kleb, Klaus J Klose, Johannes T HeverhagenAbstract:Our study showed that the application of Iodinated Contrast agents during chest CT clearly increased the amount of DNA radiation damage.
-
the presence of Iodinated Contrast agents amplifies dna radiation damage in computed tomography
Contrast Media & Molecular Imaging, 2011Co-Authors: Caroline Pathe, Beate Kleb, Klaus J Klose, Katharina Eble, Daniel Schmitzbeuting, Boris Keil, Bjoern Kaestner, Maximilian Voelker, Johannes T HeverhagenAbstract:The purpose of this study was to determine the influence of Iodinated Contrast agents on the formation of DNA double-strand breaks in vitro in lymphocytes and to verify these results in patients undergoing diagnostic computed tomography examinations. Blood samples were irradiated in vitro in the presence of Iodinated X-ray Contrast agent. Controls were irradiated without Contrast agent. Fourteen patients were investigated using Contrast-enhanced computed tomography (CT), and 14 other patients with unenhanced CT. Blood samples were taken prior to and 5 min and 1, 2 and 24 h after the CT examination. In these blood samples the average number of γH2Ax-foci per lymphocyte was enumerated by fluorescence microscopy. Statistical differences between foci numbers developed in the presence and absence of Contrast agent were tested using an independent sample t-test. In vitro foci numbers after irradiation were significantly higher when Contrast agent was present during irradiation. In vivo, γH2Ax-foci levels were 58% higher in patients undergoing Contrast-enhanced CT compared with those undergoing unenhanced CT. In the presence of Iodinated Contrast agents DNA, damage is increased and the radiation dose is not the only factor affecting the amount of DNA damage. Individual patient characteristics and biological dosimetry applications, e.g. the analysis of γH2Ax-foci, have to be considered.
Klaus J Klose - One of the best experts on this subject based on the ideXlab platform.
-
intravenous Iodinated Contrast agents amplify dna radiation damage at ct
Radiology, 2015Co-Authors: Eike Immo Piechowiak, Janfriedrich W Peter, Beate Kleb, Klaus J Klose, Johannes T HeverhagenAbstract:Our study showed that the application of Iodinated Contrast agents during chest CT clearly increased the amount of DNA radiation damage.
-
the presence of Iodinated Contrast agents amplifies dna radiation damage in computed tomography
Contrast Media & Molecular Imaging, 2011Co-Authors: Caroline Pathe, Beate Kleb, Klaus J Klose, Katharina Eble, Daniel Schmitzbeuting, Boris Keil, Bjoern Kaestner, Maximilian Voelker, Johannes T HeverhagenAbstract:The purpose of this study was to determine the influence of Iodinated Contrast agents on the formation of DNA double-strand breaks in vitro in lymphocytes and to verify these results in patients undergoing diagnostic computed tomography examinations. Blood samples were irradiated in vitro in the presence of Iodinated X-ray Contrast agent. Controls were irradiated without Contrast agent. Fourteen patients were investigated using Contrast-enhanced computed tomography (CT), and 14 other patients with unenhanced CT. Blood samples were taken prior to and 5 min and 1, 2 and 24 h after the CT examination. In these blood samples the average number of γH2Ax-foci per lymphocyte was enumerated by fluorescence microscopy. Statistical differences between foci numbers developed in the presence and absence of Contrast agent were tested using an independent sample t-test. In vitro foci numbers after irradiation were significantly higher when Contrast agent was present during irradiation. In vivo, γH2Ax-foci levels were 58% higher in patients undergoing Contrast-enhanced CT compared with those undergoing unenhanced CT. In the presence of Iodinated Contrast agents DNA, damage is increased and the radiation dose is not the only factor affecting the amount of DNA damage. Individual patient characteristics and biological dosimetry applications, e.g. the analysis of γH2Ax-foci, have to be considered.
Angela M Leung - One of the best experts on this subject based on the ideXlab platform.
-
thyroid dysfunction in children exposed to Iodinated Contrast media
The Journal of Clinical Endocrinology and Metabolism, 2016Co-Authors: Meaghan L Barr, Connie M Rhee, Angela M Leung, Harvey K Chiu, Michael W Yeh, Jacqueline Casillas, Paul IskanderAbstract:Context: Iodinated Contrast media (ICM) is routinely used in imaging studies and contains several 100-fold the recommended daily allowance of iodine. Objective: To determine whether children exposed to ICM have a higher risk of iodine-induced thyroid dysfunction. Design: This was a single-institution case-control study, examining patients with incident thyroid dysfunction aged less than 18 years from 2001 to 2015. Cases were matched 1:1 to euthyroid controls by age, sex, and race. Setting: This was a single-institution case-control study occurring at tertiary care center. Participants: Cases were defined as those with thyroid dysfunction (by International Classification of Diseases, Ninth Revision diagnosis codes and/or 2 consecutive abnormal serum TSH values <6 mo apart). We analyzed 870 cases matched to 870 controls (64% female, 51% White). Main Outcomes Measures: Using conditional logistic regression, the association between ICM exposure and the primary outcome, thyroid dysfunction, occurring within 2 ...
-
a review radiographic Iodinated Contrast media induced thyroid dysfunction
The Journal of Clinical Endocrinology and Metabolism, 2015Co-Authors: Sun Y Lee, Connie M Rhee, Angela M Leung, Lewis E Braverman, Gregory A Brent, Elizabeth N PearceAbstract:Context: Thyroid hormone production is dependent on adequate iodine intake. Excess iodine is generally well-tolerated, but thyroid dysfunction can occur in susceptible individuals after excess iodine exposure. Radiological Iodinated Contrast media represent an increasingly common source of excess iodine. Objective: This review will discuss the thyroidal response after acute exposure to excess iodine; Contrast iodine-induced thyroid dysfunction; risks of iodine-induced thyroid dysfunction in vulnerable populations, such as the fetus, neonate, and patients with impaired renal function; and recommendations for the assessment and treatment of Contrast iodine-induced thyroid dysfunction. Methods: Data for this review were identified by searching PubMed, Google Scholar, and references from relevant articles from 1948 to 2014. Conclusions: With the increase in the use of computed tomography scans in the United States, there is increasing risk of Contrast-induced thyroid dysfunction. Patients at risk of developin...
James H. Ellis - One of the best experts on this subject based on the ideXlab platform.
-
Contrast material induced nephrotoxicity and intravenous low osmolality Iodinated Contrast material
Radiology, 2013Co-Authors: Matthew S Davenport, Richard H. Cohan, Elaine M Caoili, Shokoufeh Khalatbari, Jonathan R Dillman, James H. EllisAbstract:Intravenous Iodinated Contrast material is an independent risk factor for post-CT acute kidney injury, but not in patients with a stable serum creatinine level less than 1.5 mg/dL.
-
frequency outcome and appropriateness of treatment of nonionic Iodinated Contrast media reactions
American Journal of Roentgenology, 2008Co-Authors: Carolyn L. Wang, Richard H. Cohan, James H. Ellis, Elaine M Caoili, George H K Wang, Isaac R FrancisAbstract:OBJECTIVE. The objective of our study was to evaluate the frequency, outcome, and appropriateness of treatment of adults with acute allergiclike reactions related to IV-administered nonionic Iodinated Contrast media.MATERIALS AND METHODS. For IV injections of nonionic Iodinated Contrast media between January 1, 1999, and December 31, 2005, Contrast reaction reports and medical records of patients in whom Contrast reactions occurred were reviewed. Data collected included patient sex and age, symptoms, reaction manifestations, treatment, and long-term sequelae. The appropriateness and efficacy of patient management were assessed.RESULTS. Allergic-type reactions occurred in 545 (0.6%) of patients injected with nonionic Iodinated Contrast media: 418 (77%) reactions were mild, 116 (21%) were moderate, and 11 (2%) were severe. Two hundred twenty-one patients (41%) received treatment. The most commonly administered medication was diphenhydramine (145 patients or 27%). Corticosteroids were administered to 17 pati...
-
incidence and severity of acute allergic like reactions to iv nonionic Iodinated Contrast material in children
American Journal of Roentgenology, 2007Co-Authors: Jonathan R Dillman, Richard H. Cohan, James H. Ellis, Peter J Strouse, Sophia JanAbstract:OBJECTIVE. The purpose of this study was to evaluate the incidence and severity of acute allergic-like reactions related to IV administration of low-osmolality nonionic Iodinated Contrast material in children.MATERIALS AND METHODS. Department of radiology Contrast material reaction forms involving pediatric (younger than 19 years) imaging examinations performed from January 1, 1999, through June 30, 2006, were retrospectively evaluated for type of acute allergic-like reaction, severity of reaction, and patient outcome. The electronic medical record was reviewed for pertinent medical history related to each acute reaction, including previous Contrast material reaction, premedication before administration of IV Iodinated Contrast material, previous allergic-like reaction to substances other than Contrast material, and history of asthma.RESULTS. In our department during the time period specified, 11,306 pediatric IV administrations of low-osmolality nonionic Iodinated Contrast material were performed. Acute ...
-
Frequency, Management, and Outcome of Extravasation of Nonionic Iodinated Contrast Medium in 69 657 Intravenous Injections
Radiology, 2007Co-Authors: Carolyn L. Wang, Richard H. Cohan, James H. Ellis, Saroja Adusumilli, N. Reed DunnickAbstract:Purpose: To determine retrospectively the frequency, management, and outcomes of extravasations of intravenously injected nonionic Iodinated Contrast medium. Materials and Methods: Institutional review board approval was obtained, and the requirement for informed consent was waived. The study was HIPAA compliant. For 69 657 intravenous injections of nonionic Iodinated Contrast medium for computed tomographic examinations between January 1, 2000, and March 31, 2005, the incident reports, radiology reports, and medical records of patients in whom Contrast medium extravasations occurred were reviewed. Data collected included patient age, catheter gauge, injection site, volume extravasated, patient symptoms, severity of injury, treatment, whether or not the plastic surgery service was consulted and any additional treatment that service instituted, and patient outcome. Results: Extravasations occurred in 475 (0.7%) of 69 657 patients, and follow-up information was available for 442 adults (280 women, 162 men; ...
