The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Julian I Schroeder - One of the best experts on this subject based on the ideXlab platform.
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plant Ion Channels gene families physiology and functIonal genomics analyses
Annual Review of Physiology, 2009Co-Authors: John M Ward, Pascal Maser, Julian I SchroederAbstract:Distinct potassium, anIon, and calcium Channels in the plasma membrane and vacuolar membrane of plant cells have been identified and characterized by patch clamping. Primarily owing to advances in Arabidopsis genetics and genomics, and yeast functIonal complementatIon, many of the corresponding genes have been identified. Recent advances in our understanding of Ion channel genes that mediate signal transductIon and Ion transport are discussed here. Some plant Ion Channels, for example, ALMT and SLAC anIon channel subunits, are unique. The majority of plant Ion channel families exhibit homology to animal genes; such families include both hyperpolarizatIon- and depolarizatIon-activated Shaker-type potassium Channels, CLC chloride transporters/Channels, cyclic nucleotide–gated Channels, and Ionotropic glutamate receptor homologs. These plant Ion Channels offer unique opportunities to analyze the structural mechanisms and functIons of Ion Channels. Here we review gene families of selected plant Ion channel cl...
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plant Ion Channels gene families physiology and functIonal genomics analyses
Annual Review of Physiology, 2009Co-Authors: John M Ward, Pascal Maser, Julian I SchroederAbstract:Distinct potassium, anIon, and calcium Channels in the plasma membrane and vacuolar membrane of plant cells have been identified and characterized by patch clamping. Primarily owing to advances in Arabidopsis genetics and genomics, and yeast functIonal complementatIon, many of the corresponding genes have been identified. Recent advances in our understanding of Ion channel genes that mediate signal transductIon and Ion transport are discussed here. Some plant Ion Channels, for example, ALMT and SLAC anIon channel subunits, are unique. The majority of plant Ion channel families exhibit homology to animal genes; such families include both hyperpolarizatIon- and depolarizatIon-activated Shaker-type potassium Channels, CLC chloride transporters/Channels, cyclic nucleotide-gated Channels, and Ionotropic glutamate receptor homologs. These plant Ion Channels offer unique opportunities to analyze the structural mechanisms and functIons of Ion Channels. Here we review gene families of selected plant Ion channel classes and discuss unique structure-functIon aspects and their physiological roles in plant cell signaling and transport.
Christopher Southan - One of the best experts on this subject based on the ideXlab platform.
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the concise guide to pharmacology 2017 18 ligand gated Ion Channels
British Journal of Pharmacology, 2017Co-Authors: Stephen P H Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher Southan, Simon D Harding, Jamie A DaviesAbstract:The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to informatIon and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this sectIon can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13879/full. Ligand-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, voltage-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunctIon with the Nomenclature Committee of the UnIon of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate.
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the concise guide to pharmacology 2017 18 voltage gated Ion Channels
British Journal of Pharmacology, 2017Co-Authors: Stephen P H Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Jorg Striessnig, Simon D Harding, Christopher SouthanAbstract:The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to informatIon and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this sectIon can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13884/full. Voltage-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunctIon with the Nomenclature Committee of the UnIon of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate.
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the concise guide to pharmacology 2015 16 voltage gated Ion Channels
British Journal of Pharmacology, 2015Co-Authors: Stephen P H Alexander, William A. Catterall, Eamonn Kelly, Neil V Marrion, John A Peters, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher SouthanAbstract:The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13350/full. Voltage-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed versIon of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunctIon with NC-IUPHAR and provides the official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate. It consolidates informatIon previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.
Stephen P H Alexander - One of the best experts on this subject based on the ideXlab platform.
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the concise guide to pharmacology 2017 18 ligand gated Ion Channels
British Journal of Pharmacology, 2017Co-Authors: Stephen P H Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher Southan, Simon D Harding, Jamie A DaviesAbstract:The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to informatIon and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this sectIon can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13879/full. Ligand-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, voltage-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunctIon with the Nomenclature Committee of the UnIon of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate.
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the concise guide to pharmacology 2017 18 voltage gated Ion Channels
British Journal of Pharmacology, 2017Co-Authors: Stephen P H Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Jorg Striessnig, Simon D Harding, Christopher SouthanAbstract:The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to informatIon and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this sectIon can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13884/full. Voltage-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunctIon with the Nomenclature Committee of the UnIon of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate.
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the concise guide to pharmacology 2015 16 voltage gated Ion Channels
British Journal of Pharmacology, 2015Co-Authors: Stephen P H Alexander, William A. Catterall, Eamonn Kelly, Neil V Marrion, John A Peters, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher SouthanAbstract:The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13350/full. Voltage-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed versIon of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunctIon with NC-IUPHAR and provides the official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate. It consolidates informatIon previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.
John M Ward - One of the best experts on this subject based on the ideXlab platform.
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plant Ion Channels gene families physiology and functIonal genomics analyses
Annual Review of Physiology, 2009Co-Authors: John M Ward, Pascal Maser, Julian I SchroederAbstract:Distinct potassium, anIon, and calcium Channels in the plasma membrane and vacuolar membrane of plant cells have been identified and characterized by patch clamping. Primarily owing to advances in Arabidopsis genetics and genomics, and yeast functIonal complementatIon, many of the corresponding genes have been identified. Recent advances in our understanding of Ion channel genes that mediate signal transductIon and Ion transport are discussed here. Some plant Ion Channels, for example, ALMT and SLAC anIon channel subunits, are unique. The majority of plant Ion channel families exhibit homology to animal genes; such families include both hyperpolarizatIon- and depolarizatIon-activated Shaker-type potassium Channels, CLC chloride transporters/Channels, cyclic nucleotide–gated Channels, and Ionotropic glutamate receptor homologs. These plant Ion Channels offer unique opportunities to analyze the structural mechanisms and functIons of Ion Channels. Here we review gene families of selected plant Ion channel cl...
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plant Ion Channels gene families physiology and functIonal genomics analyses
Annual Review of Physiology, 2009Co-Authors: John M Ward, Pascal Maser, Julian I SchroederAbstract:Distinct potassium, anIon, and calcium Channels in the plasma membrane and vacuolar membrane of plant cells have been identified and characterized by patch clamping. Primarily owing to advances in Arabidopsis genetics and genomics, and yeast functIonal complementatIon, many of the corresponding genes have been identified. Recent advances in our understanding of Ion channel genes that mediate signal transductIon and Ion transport are discussed here. Some plant Ion Channels, for example, ALMT and SLAC anIon channel subunits, are unique. The majority of plant Ion channel families exhibit homology to animal genes; such families include both hyperpolarizatIon- and depolarizatIon-activated Shaker-type potassium Channels, CLC chloride transporters/Channels, cyclic nucleotide-gated Channels, and Ionotropic glutamate receptor homologs. These plant Ion Channels offer unique opportunities to analyze the structural mechanisms and functIons of Ion Channels. Here we review gene families of selected plant Ion channel classes and discuss unique structure-functIon aspects and their physiological roles in plant cell signaling and transport.
Elena Faccenda - One of the best experts on this subject based on the ideXlab platform.
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the concise guide to pharmacology 2017 18 ligand gated Ion Channels
British Journal of Pharmacology, 2017Co-Authors: Stephen P H Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher Southan, Simon D Harding, Jamie A DaviesAbstract:The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to informatIon and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this sectIon can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13879/full. Ligand-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, voltage-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunctIon with the Nomenclature Committee of the UnIon of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate.
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the concise guide to pharmacology 2017 18 voltage gated Ion Channels
British Journal of Pharmacology, 2017Co-Authors: Stephen P H Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Jorg Striessnig, Simon D Harding, Christopher SouthanAbstract:The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to informatIon and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this sectIon can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13884/full. Voltage-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunctIon with the Nomenclature Committee of the UnIon of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate.
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the concise guide to pharmacology 2015 16 voltage gated Ion Channels
British Journal of Pharmacology, 2015Co-Authors: Stephen P H Alexander, William A. Catterall, Eamonn Kelly, Neil V Marrion, John A Peters, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher SouthanAbstract:The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13350/full. Voltage-gated Ion Channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated Ion Channels, other Ion Channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary informatIon on the best available pharmacological tools, alongside key references and suggestIons for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed versIon of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunctIon with NC-IUPHAR and provides the official IUPHAR classificatIon and nomenclature for human drug targets, where appropriate. It consolidates informatIon previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.
