The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform
Alan G Marshall - One of the best experts on this subject based on the ideXlab platform.
-
CollisIon Cross SectIon Measurements for Biomolecules within a High-ResolutIon Fourier Transform Ion Cyclotron Resonance Cell
Analytical Chemistry, 2015Co-Authors: Yu Chen, Alan G Marshall, Li Zheng, Nathan K. Kaiser, Wei XuAbstract:To understand the role and functIon of a biomolecule in a biosystem, it is important to know both its compositIon and structure. Here, a mass spectrometric based approach has been proposed and applied to demonstrate that collisIon cross sectIons and high-resolutIon mass spectra of biomolecule Ions may be obtained simultaneously by Fourier transform Ion Cyclotron Resonance mass spectrometry. With this method, the unfolding phenomena for ubiquitin Ions that possess different number of charges have been investigated, and results agree well with Ion mobility measurements. In the present approach, we extend Ion collisIon cross-sectIon measurements to lower pressures than in prior Ion Cyclotron Resonance (ICR)-based experiments, thereby maintaining the potentially high resolutIon of Fourier transform Ion Cyclotron Resonance mass spectrometry (FTICR MS), and enabling collisIon cross sectIon (CCS) measurements for high-mass biomolecules.
-
Fourier transform Ion Cyclotron Resonance: state of the art
European Journal of Mass Spectrometry, 2007Co-Authors: Alan G Marshall, Gregory T. Blakney, Christopher L Hendrickson, Mark R. Emmett, Ryan P Rodgers, Carol L. NilssonAbstract:This short review summarizes recent and projected advances in Fourier transform Ion Cyclotron Resonance mass spectrometry instrumentatIon and applicatIons, ranging from petroleomics to proteomics. More details are available from the cited primary literature and topical reviews.
-
Fourier transform Ion Cyclotron Resonance spectroscopy
Journal of Mass Spectrometry, 2007Co-Authors: Melvin B. Comisarow, Alan G MarshallAbstract:An Ion Cyclotron Resonance (ICR) absorptIon spectrum has been obtained by exciting an ICR spectral segment with a fixed-frequency electric field pulse, followed by broad-band detectIon, digitizatIon of the (time-domain) transient response, and digital Fourier transformatIon to produce the (frequency-domain) absorptIon spectrum. For a given signal-to-noise ratio and resolutIon, the FT-ICR method generates a spectrum in a time which is two orders of magnitude shorter than that required in conventIonal slow-sweep ICR detectIon. In the present example, a signal-to-noise ratio of 8 :1 and a mass resolutIon of about 0.005 amu for CH 4 + (from CH 4 at a pressure of 8 X 10 -7 torr) have been achieved, using a single data acquisitIon period of 25.6 msec.
-
Frequency‐sweep fourier tranform Ion Cyclotron Resonance spectroscopy
Journal of Mass Spectrometry, 2007Co-Authors: Melvin B. Comisarow, Alan G MarshallAbstract:A single Ion Cyclotron Resonance (ICR) absorptIon spectrum showing both CH 3 + and CH 4 + signals has been obtained by exciting both Ion Cyclotron Resonances with a frequency-swept rf irradiatIon, followed by broad-band detectIon, digitizatIon of the (time-domain) response, and finally discrete Fourier transformatIon to produce the (frequency-domain) spectrum. Pulsed-excitatIon Fourier transform ICR has demonstrated the use of broad-band detectIon in rapid generatIon of ICR spectra by Fourier transform methods ; this paper demonstrates that frequency-sweep excitatIon can provide the broad-band irradiatIon required to excite Ion Cyclotron Resonances throughout any desired mass range. It will thus be possible to obtain an ICR absorptIon spectrum of given mass range, signal-to-noise ratio, and resolutIon in an observatIon period which is two orders of magnitude shorter than that needed to obtain the same spectrum by conventIonal slow-sweep detectIon.
-
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Encyclopedia of Analytical Chemistry, 2006Co-Authors: Alan G Marshall, Christopher L Hendrickson, George S. JacksonAbstract:This review offers an introductIon to the principles and generic applicatIons of Fourier transform Ion Cyclotron Resonance/mass spectrometry (FTICR/MS), directed to readers with no prior experience with the technique. The fundamental Fourier transform Ion Cyclotron Resonance (FTICR) phenomenon is explained from a simplified theoretical treatment of Ion behavior in idealized magnetic and electric fields. The effects of trapping voltage, trap size and shape, and other nonidealities are then manifested mainly as perturbatIons that preserve the idealized Ion behavior modified by appropriate numerical correctIon factors. Topics include: effect of Ion mass, charge, magnetic field, and trapping voltage on Ion Cyclotron frequency; excitatIon and detectIon of Ion Cyclotron Resonance (ICR) signals; mass calibratIon; mass resolving power and mass accuracy; upper mass limit(s); dynamic range; detectIon limit, strategies for mass and energy selectIon for multiple mass spectroscopy (MSn); Ion axializatIon, cooling, and remeasurement; and means for guiding externally formed Ions into the Ion trap. The relatIonship of FTICR/MS to other types of Fourier transform (FT) spectroscopy and to the Paul (quadrupole) Ion trap is described. The article concludes with selected applicatIons, an appendix listing accurate fundamental constants needed for ultrahigh-precisIon analysis, and an annotated list of selected reviews and primary source publicatIons describing various FTICR/MS techniques and applicatIons in fuller detail.
Christopher L Hendrickson - One of the best experts on this subject based on the ideXlab platform.
-
Fourier transform Ion Cyclotron Resonance: state of the art
European Journal of Mass Spectrometry, 2007Co-Authors: Alan G Marshall, Gregory T. Blakney, Christopher L Hendrickson, Mark R. Emmett, Ryan P Rodgers, Carol L. NilssonAbstract:This short review summarizes recent and projected advances in Fourier transform Ion Cyclotron Resonance mass spectrometry instrumentatIon and applicatIons, ranging from petroleomics to proteomics. More details are available from the cited primary literature and topical reviews.
-
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Encyclopedia of Analytical Chemistry, 2006Co-Authors: Alan G Marshall, Christopher L Hendrickson, George S. JacksonAbstract:This review offers an introductIon to the principles and generic applicatIons of Fourier transform Ion Cyclotron Resonance/mass spectrometry (FTICR/MS), directed to readers with no prior experience with the technique. The fundamental Fourier transform Ion Cyclotron Resonance (FTICR) phenomenon is explained from a simplified theoretical treatment of Ion behavior in idealized magnetic and electric fields. The effects of trapping voltage, trap size and shape, and other nonidealities are then manifested mainly as perturbatIons that preserve the idealized Ion behavior modified by appropriate numerical correctIon factors. Topics include: effect of Ion mass, charge, magnetic field, and trapping voltage on Ion Cyclotron frequency; excitatIon and detectIon of Ion Cyclotron Resonance (ICR) signals; mass calibratIon; mass resolving power and mass accuracy; upper mass limit(s); dynamic range; detectIon limit, strategies for mass and energy selectIon for multiple mass spectroscopy (MSn); Ion axializatIon, cooling, and remeasurement; and means for guiding externally formed Ions into the Ion trap. The relatIonship of FTICR/MS to other types of Fourier transform (FT) spectroscopy and to the Paul (quadrupole) Ion trap is described. The article concludes with selected applicatIons, an appendix listing accurate fundamental constants needed for ultrahigh-precisIon analysis, and an annotated list of selected reviews and primary source publicatIons describing various FTICR/MS techniques and applicatIons in fuller detail.
-
fourier transform Ion Cyclotron Resonance detectIon principles and experimental configuratIons
International Journal of Mass Spectrometry, 2002Co-Authors: Alan G Marshall, Christopher L HendricksonAbstract:Fourier transform Ion Cyclotron Resonance mass spectrometry is based on image current detectIon of coherently excited Ion Cyclotron motIon. The detected signal magnitude and peak shape may be understood from idealized behavior: single Ion, zero-pressure, spatially uniform magnetic field, three-dimensIonal axial quadrupolar electrostatic trapping potential, and spatially uniform resonant alternating electric field. In practice, deviatIon from any of the above conditIons will shift, distort, split, and/or coalesce FT-ICR mass spectral peaks. Fortunately, such peak distortIons may typically be avoided by appropriate experimental design and/or greatly minimized by internal frequency-to-m/z calibratIon. Various aspects of modern FT-ICR detectIon (hardware and software) are discussed.
-
ELECTROSPRAY IonIZATIon FOURIER TRANSFORM Ion Cyclotron Resonance MASS SPECTROMETRY
Annual Review of Physical Chemistry, 1999Co-Authors: Christopher L Hendrickson, Mark R. EmmettAbstract:▪ Abstract The basic principles and recent advances in electrospray IonizatIon Fourier transform Ion Cyclotron Resonance mass spectrometry are reviewed. A brief history of electrospray IonizatIon i...
Per Håkansson - One of the best experts on this subject based on the ideXlab platform.
-
Reproducibility of tryptic digestIon investigated by quantitative fourier transform Ion Cyclotron Resonance mass spectrometry.
Journal of Proteome Research, 2005Co-Authors: Charlotte Hagman, Margareta Ramström, Maria Jansson, Peter James, Per Håkansson, Jonas BergquistAbstract:In this study, the reproducibility of tryptic digestIon of complex solutIons was investigated using liquid chromatography Fourier transform Ion Cyclotron Resonance (LC FT-ICR) mass spectrometry. Tr ...
-
combined infrared multiphoton dissociatIon and electron capture dissociatIon with a hollow electron beam in fourier transform Ion Cyclotron Resonance mass spectrometry
Rapid Communications in Mass Spectrometry, 2003Co-Authors: Yu O. Tsybin, Frank Kjeldsen, Matthias Witt, Goekhan Baykut, Per HåkanssonAbstract:Combined Infrared Multiphoton DissociatIon and Electron Capture DissociatIon with a Hollow Electron Beam in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
-
improved low energy electron injectIon systems for high rate electron capture dissociatIon in fourier transform Ion Cyclotron Resonance mass spectrometry
Rapid Communications in Mass Spectrometry, 2001Co-Authors: Yu O. Tsybin, Michael V. Gorshkov, Per Håkansson, Bogdan A Budnik, Kim F Haselmann, Frank Kjeldsen, Roman A ZubarevAbstract:Improved Low-Energy Electron InjectIon Systems for High Rate Electron Capture DissociatIon in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Yu O. Tsybin - One of the best experts on this subject based on the ideXlab platform.
-
Injector of low-energy electrons in an Ion Cyclotron Resonance mass spectrometer
2020Co-Authors: N. P. Sargaeva, Yu O. Tsybin, O. Yu Tsybin, Per HaekanssonAbstract:The design features of the injectIon system are analyzed and exptl. measurements are performed to define its parameters and energy characteristics of low-energy electron beams obtained for the electron capture dissocn. in Fourier transform Ion Cyclotron Resonance mass spectrometry. Different low-energy electron injectIon systems are compared. [on SciFinder (R)]
-
combined infrared multiphoton dissociatIon and electron capture dissociatIon with a hollow electron beam in fourier transform Ion Cyclotron Resonance mass spectrometry
Rapid Communications in Mass Spectrometry, 2003Co-Authors: Yu O. Tsybin, Frank Kjeldsen, Matthias Witt, Goekhan Baykut, Per HåkanssonAbstract:Combined Infrared Multiphoton DissociatIon and Electron Capture DissociatIon with a Hollow Electron Beam in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
-
improved low energy electron injectIon systems for high rate electron capture dissociatIon in fourier transform Ion Cyclotron Resonance mass spectrometry
Rapid Communications in Mass Spectrometry, 2001Co-Authors: Yu O. Tsybin, Michael V. Gorshkov, Per Håkansson, Bogdan A Budnik, Kim F Haselmann, Frank Kjeldsen, Roman A ZubarevAbstract:Improved Low-Energy Electron InjectIon Systems for High Rate Electron Capture DissociatIon in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Michael V. Gorshkov - One of the best experts on this subject based on the ideXlab platform.
-
improved low energy electron injectIon systems for high rate electron capture dissociatIon in fourier transform Ion Cyclotron Resonance mass spectrometry
Rapid Communications in Mass Spectrometry, 2001Co-Authors: Yu O. Tsybin, Michael V. Gorshkov, Per Håkansson, Bogdan A Budnik, Kim F Haselmann, Frank Kjeldsen, Roman A ZubarevAbstract:Improved Low-Energy Electron InjectIon Systems for High Rate Electron Capture DissociatIon in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
-
A high performance low magnetic field internal electrospray IonizatIon-fourier transform Ion Cyclotron Resonance mass spectrometer
Journal of the American Society for Mass Spectrometry, 1996Co-Authors: Qinyuan Wu, Michael V. Gorshkov, Gordon A. Anderson, Harold R. Udseth, Michael G. Sherman, Steven Orden, Ruidan Chen, Steven A. Hofstadler, Dale W. Mitchell, Alan L. RockwoodAbstract:A new in-magnetic field electrospray IonizatIon (ESI) and Fourier transform Ion Cyclotron Resonance mass spectrometer has been constructed and evaluated. This system is characterized by the use of multiple concentric cryopanels to achieve ultrahigh vacuum in the Ion Cyclotron Resonance cell regIon, a probe-mounted internal ESI source, and a novel in-field shutter. Initial experiments demonstrate high resolutIon mass measurement capability at a field strength of 1 T. Mass resolutIon of 700,000 has been obtained for the 3+ charge state of Met-Lys-bradykinin (at m/z 440) generated by electrospray IonizatIon. When electron impact IonizatIon was employed, resolutIon in excess of 9,200,000 was achieved for nitrogen molecular Ions (N _2 ^+ ). Isotopic resolutIon for molecular Ions of bovine ubiquitin (MW=8565 µ ) also was achieved by using small Ion populatIons.
-
Ion Cyclotron Resonance signal‐detectIon at multiples of the Cyclotron frequency
Rapid Communications in Mass Spectrometry, 1990Co-Authors: Eugene N. Nikolaev, Michael V. Gorshkov, A. V. Mordehai, V. L. TalroseAbstract:A Fourier-transform mass spectrometric technique for detecting Ion Cyclotron Resonance signals at multiple Cyclotron frequencies is proposed and initial experimental results are presented. The technique is readily adapted to existing instruments.
