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Haoyu Chen - One of the best experts on this subject based on the ideXlab platform.

  • An Iris Tumor Secondary to Talaromyces Marneffei Infection in a Patient with AIDS and Syphilis.
    Ocular immunology and inflammation, 2021
    Co-Authors: Tingkun Shi, Jinnan Cai, Haoyu Chen
    Abstract:

    Purpose: To report a case of Iris Tumor secondary to Talaromyces marneffei infection in a patient with AIDS and syphilis.Case report: A 25-year-old man presented with gradual vision decrease in the right eye for 2 months. Ocular examination revealed best-corrected visual acuity (BCVA) of 0.12 and a vascularized and solid Tumor at inferotemporal Iris base in the right eye. There were some papulonecrotic skin lesions. Both serum treponema pallidum particle agglutination and human immunodeficiency virus antibody were positive. Non-target metagenome next-generation sequencing detected Talaromyces marneffei in the skin lesion and aqueous humor. After 8 weeks of oral voriconazole and fluconazole eyedrop treatment, the Iris Tumor completely subsided, and the BCVA improved to 1.0.Conclusion: Talaromyces marneffei infection may present as an Iris Tumor. Metagenome next-generation sequencing is helpful in diagnosis. Oral and topical anti-fungus therapy was sufficient to regress the disease without intraocular injection.

  • An Iris Tumor Secondary to Talaromyces Marneffei Infection in a Patient with AIDS and Syphilis.
    Ocular immunology and inflammation, 2021
    Co-Authors: Tingkun Shi, Jinnan Cai, Haoyu Chen
    Abstract:

    Purpose: To report a case of Iris Tumor secondary to Talaromyces marneffei infection in a patient with AIDS and syphilis.Case report: A 25-year-old man presented with gradual vision decrease in the...

Tingkun Shi - One of the best experts on this subject based on the ideXlab platform.

  • An Iris Tumor Secondary to Talaromyces Marneffei Infection in a Patient with AIDS and Syphilis.
    Ocular immunology and inflammation, 2021
    Co-Authors: Tingkun Shi, Jinnan Cai, Haoyu Chen
    Abstract:

    Purpose: To report a case of Iris Tumor secondary to Talaromyces marneffei infection in a patient with AIDS and syphilis.Case report: A 25-year-old man presented with gradual vision decrease in the right eye for 2 months. Ocular examination revealed best-corrected visual acuity (BCVA) of 0.12 and a vascularized and solid Tumor at inferotemporal Iris base in the right eye. There were some papulonecrotic skin lesions. Both serum treponema pallidum particle agglutination and human immunodeficiency virus antibody were positive. Non-target metagenome next-generation sequencing detected Talaromyces marneffei in the skin lesion and aqueous humor. After 8 weeks of oral voriconazole and fluconazole eyedrop treatment, the Iris Tumor completely subsided, and the BCVA improved to 1.0.Conclusion: Talaromyces marneffei infection may present as an Iris Tumor. Metagenome next-generation sequencing is helpful in diagnosis. Oral and topical anti-fungus therapy was sufficient to regress the disease without intraocular injection.

  • An Iris Tumor Secondary to Talaromyces Marneffei Infection in a Patient with AIDS and Syphilis.
    Ocular immunology and inflammation, 2021
    Co-Authors: Tingkun Shi, Jinnan Cai, Haoyu Chen
    Abstract:

    Purpose: To report a case of Iris Tumor secondary to Talaromyces marneffei infection in a patient with AIDS and syphilis.Case report: A 25-year-old man presented with gradual vision decrease in the...

Carol L. Shields - One of the best experts on this subject based on the ideXlab platform.

  • Iris Melanoma in a Child Simulating Juvenile Xanthogranuloma.
    Middle East African journal of ophthalmology, 2018
    Co-Authors: Jerry A. Shields, Carol L. Shields, Sara E. Lally, Tatyana Milman, Ralph C. Eagle
    Abstract:

    An 8-year-old girl was referred for an amelanotic Iris Tumor believed to have enlarged slightly over 3 months, suspicious for juvenile xanthogranuloma (JXG). The affected right eye had a lightly pigmented, vascular Iris mass measuring 6 mm in basal dimension and 2 mm in thickness. There were no feeder vessels, seeding, inflammatory cells, or cutaneous abnormalities. Diagnostic fine needle aspiration biopsy (FNAB) was performed, revealing spindle B melanoma cells that were immunoreactive for melanocytic markers HMB45 and Melan-A. Complete Tumor resection by basal sector iridectomy was performed. Histopathology confirmed spindle B melanoma. At 14-years follow up, there has been no recurrence or metastasis and visual acuity remains 20/25. Iris melanoma can develop in children and clinically resemble nodular JXG.

  • Diffuse Anterior Retinoblastoma with Globe Salvage and Visual Preservation in 3 Consecutive Cases.
    Ophthalmology, 2015
    Co-Authors: Carol L. Shields, Sara E. Lally, Fairooz P. Manjandavida, Ann Leahey, Jerry A. Shields
    Abstract:

    Purpose Diffuse anterior retinoblastoma is an exquisitely rare variant of retinoblastoma in which the Tumor resides in the anterior segment of the eye, without apparent retinal involvement. Previously published cases have been managed with enucleation. We describe globe salvage and visual preservation in 3 consecutive cases using chemotherapy and radiotherapy. Design Retrospective case series. Participants Three children with diffuse anterior retinoblastoma. Methods Plaque radiotherapy plus intravenous chemotherapy. Main Outcome Measures Globe and vision preservation. Results The mean patient age at presentation elsewhere was 5.7 years (median, 7; range, 3–7 years). There were 2 white female patients and 1 African American male patient. The initial observation by parents/caregiver was reduced vision (n = 1), red eye (n = 1), or cloudy eye (n = 1), and the initial finding by physician was Iris Tumor (n = 2) or hyphema (n = 1). Referring diagnosis was Iris melanoma (n = 1), infectious endotheliitis (n = 1), and possible Tumor (nonspecified) (n = 1). At our evaluation, visual acuity was 20/50 to 20/60 (n = 2) and fix no follow (n = 1). In all cases, the opposite eye was normal. Mean intraocular pressure was 20 mm Hg (median, 16; range, 15–30 mmHg). Our examination revealed solid Iris Tumor (n = 3), ciliary body involvement (n = 2), and anterior chamber seeding (n = 3). In no case was there choroidal or retinal Tumor, vitreous seed or subretinal seed, or extrascleral extension. Clear corneal fine-needle aspiration biopsy confirmed the diagnosis as retinoblastoma in each case. Treatment included plaque radiotherapy (n = 3) plus additional systemic chemotherapy (n = 2). At mean follow-up of 35 months (median, 34; range, 20–51 months), there has been no recurrence, extrascleral extension, enucleation, metastasis, or death. In all 3 cases, cataract surgery was necessary at a mean interval of 16 months after complete and stable regression of retinoblastoma. Conclusions The rare diffuse anterior form of retinoblastoma can be managed with globe-salvaging alternatives and with visual preservation in selected cases.

  • juvenile xanthogranuloma involving the eye and ocular adnexa Tumor control visual outcomes and globe salvage in 30 patients
    Ophthalmology, 2015
    Co-Authors: Wasim A Samara, Jerry A. Shields, Ralph C. Eagle, Chloe T L Khoo, Emil Anthony T Say, Jarin Saktanasate, Carol L. Shields
    Abstract:

    Purpose To report clinical features and treatment outcomes of ocular juvenile xanthogranuloma (JXG). Design Retrospective case series. Participants There were 32 Tumors in 31 eyes of 30 patients with ocular JXG. Methods Review of medical records. Main Outcome Measures Tumor control, intraocular pressure (IOP), and visual acuity. Results The mean patient age at presentation was 51 months (median, 15 months; range, 1–443 months). Eye redness (12/30, 40%) and hyphema (4/30, 13%) were the most common presenting symptoms. Cutaneous JXG was concurrently present in 3 patients (3/30, 10%), and spinal JXG was present in 1 patient (1/30, 3%). The ocular tissue affected by JXG included the Iris (21/31, 68%), conjunctiva (6/31, 19%), eyelid (2/31, 6%), choroid (2/31, 6%), and orbit (1/31, 3%). Those with Iris JXG presented at a median age of 13 months compared with 30 months for those with conjunctival JXG. In the Iris JXG group, mean IOP was 19 mmHg (median, 18 mmHg; range, 11–30 mmHg) and hyphema was noted in 8 eyes (8/21, 38%). The Iris Tumor was nodular (16/21, 76%) or diffuse (5/21, 24%). Fine-needle aspiration biopsy was used in 10 cases and confirmed JXG cytologically in all cases. The Iris lesion was treated with topical (18/21, 86%) and/or periocular (4/21, 19%) corticosteroids. The eyelid, conjunctiva, and orbital JXG were treated with excisional biopsy in 5 patients (5/9, 56%), topical corticosteroids in 2 patients (2/9, 22%), and observation in 2 patients (2/9, 22%). Of 28 patients with a mean follow-up of 15 months (median, 6 months; range, 1–68 months), Tumor regression was achieved in all cases, without recurrence. Two patients were lost to follow-up. Upon follow-up of the Iris JXG group, visual acuity was stable or improved (18/19 patients, 95%) and IOP was controlled long-term without medication (14/21 patients, 74%). No eyes were managed with enucleation. Conclusions Ocular JXG preferentially affects the Iris and is often isolated without cutaneous involvement. Iris JXG responds to topical or periocular corticosteroids, often with stabilization or improvement of vision and IOP.

  • Fluorescein angiography of Iris juvenile xanthogranuloma.
    Journal of pediatric ophthalmology and strabismus, 2008
    Co-Authors: Carl J Danzig, Carol L. Shields, Arman Mashayekhi, Hormoz Ehya, Maria E. Manquez, Jerry A. Shields
    Abstract:

    A 3-year-old boy was referred because of the presence of a non-pigmented, highly vascular mass with tapioca appearance involving the superior portion of the left Iris. Iris fluorescein angiography revealed early hyperfluorescence of the Iris Tumor with diffuse, intense late leakage of dye throughout the entire Iris, not just in the region of the Tumor. Cytopathologic examination revealed Touton giant cells and the presence of histiocytes, confirming the diagnosis of Iris juvenile xanthogranuloma. The patient was prescribed topical prednisolone acetate, and the lesion resolved during the next 3 months. Fluorescein angiography may be useful in differentiating Iris juvenile xanthogranuloma from malignant or non-inflammatory benign Iris lesions.

  • fine needle aspiration biopsy of Iris Tumors in 100 consecutive cases technique and complications
    Ophthalmology, 2006
    Co-Authors: Carol L. Shields, Carl J Danzig, Arman Mashayekhi, Hormoz Ehya, Maria E. Manquez, Jerry A. Shields
    Abstract:

    OBJECTIVE: To evaluate the technique and complications of fine-needle aspiration biopsy (FNAB) for Iris Tumors. DESIGN: Retrospective, nonrandomized, single-center case series. PARTICIPANTS: One hundred eyes of 100 patients with diagnostically challenging Iris Tumors evaluated with FNAB. MAIN OUTCOME MEASURES: Biopsy technique and complications. RESULTS: Of more than 1400 patients referred with an Iris Tumor over a 24-year period, 100 underwent FNAB for diagnostic purposes. The median patient age was 44 years. The median basal dimension of the lesion was 9.0 mm and median thickness was 2.5 mm. A limbal entry with transaqueous approach parallel to the Iris was used in 100% of patients. Entry was from the superotemporal (52%) or inferotemporal (42%) direction. Needle gauge size was 22 (9%), 25 (55%), 27 (25%), or 30 (9%), depending on the friability and vascularity of the Tumor. Adequate Tumor sample was achieved in 99 eyes (99%). At the time of FNAB, the only immediate complication was partial hyphema (34%). Two weeks after FNAB, persistent hyphema was found in 6 eyes (6%), requiring surgical washout in 1 patient. There were no cases of recurrent hyphema, vitreous hemorrhage, prolonged hypotony, lens damage, endophthalmitis, or extraocular Tumor seeding. At mean follow-up of 5 years, there was no incident of Tumor recurrence on the Iris, along the needle tract, or on the corneal or epibulbar surface. CONCLUSIONS: Using our technique, FNAB for diagnostically challenging Iris Tumors can achieve high yield with relatively few complications.

Jerry A. Shields - One of the best experts on this subject based on the ideXlab platform.

  • Iris Melanoma in a Child Simulating Juvenile Xanthogranuloma.
    Middle East African journal of ophthalmology, 2018
    Co-Authors: Jerry A. Shields, Carol L. Shields, Sara E. Lally, Tatyana Milman, Ralph C. Eagle
    Abstract:

    An 8-year-old girl was referred for an amelanotic Iris Tumor believed to have enlarged slightly over 3 months, suspicious for juvenile xanthogranuloma (JXG). The affected right eye had a lightly pigmented, vascular Iris mass measuring 6 mm in basal dimension and 2 mm in thickness. There were no feeder vessels, seeding, inflammatory cells, or cutaneous abnormalities. Diagnostic fine needle aspiration biopsy (FNAB) was performed, revealing spindle B melanoma cells that were immunoreactive for melanocytic markers HMB45 and Melan-A. Complete Tumor resection by basal sector iridectomy was performed. Histopathology confirmed spindle B melanoma. At 14-years follow up, there has been no recurrence or metastasis and visual acuity remains 20/25. Iris melanoma can develop in children and clinically resemble nodular JXG.

  • Diffuse Anterior Retinoblastoma with Globe Salvage and Visual Preservation in 3 Consecutive Cases.
    Ophthalmology, 2015
    Co-Authors: Carol L. Shields, Sara E. Lally, Fairooz P. Manjandavida, Ann Leahey, Jerry A. Shields
    Abstract:

    Purpose Diffuse anterior retinoblastoma is an exquisitely rare variant of retinoblastoma in which the Tumor resides in the anterior segment of the eye, without apparent retinal involvement. Previously published cases have been managed with enucleation. We describe globe salvage and visual preservation in 3 consecutive cases using chemotherapy and radiotherapy. Design Retrospective case series. Participants Three children with diffuse anterior retinoblastoma. Methods Plaque radiotherapy plus intravenous chemotherapy. Main Outcome Measures Globe and vision preservation. Results The mean patient age at presentation elsewhere was 5.7 years (median, 7; range, 3–7 years). There were 2 white female patients and 1 African American male patient. The initial observation by parents/caregiver was reduced vision (n = 1), red eye (n = 1), or cloudy eye (n = 1), and the initial finding by physician was Iris Tumor (n = 2) or hyphema (n = 1). Referring diagnosis was Iris melanoma (n = 1), infectious endotheliitis (n = 1), and possible Tumor (nonspecified) (n = 1). At our evaluation, visual acuity was 20/50 to 20/60 (n = 2) and fix no follow (n = 1). In all cases, the opposite eye was normal. Mean intraocular pressure was 20 mm Hg (median, 16; range, 15–30 mmHg). Our examination revealed solid Iris Tumor (n = 3), ciliary body involvement (n = 2), and anterior chamber seeding (n = 3). In no case was there choroidal or retinal Tumor, vitreous seed or subretinal seed, or extrascleral extension. Clear corneal fine-needle aspiration biopsy confirmed the diagnosis as retinoblastoma in each case. Treatment included plaque radiotherapy (n = 3) plus additional systemic chemotherapy (n = 2). At mean follow-up of 35 months (median, 34; range, 20–51 months), there has been no recurrence, extrascleral extension, enucleation, metastasis, or death. In all 3 cases, cataract surgery was necessary at a mean interval of 16 months after complete and stable regression of retinoblastoma. Conclusions The rare diffuse anterior form of retinoblastoma can be managed with globe-salvaging alternatives and with visual preservation in selected cases.

  • juvenile xanthogranuloma involving the eye and ocular adnexa Tumor control visual outcomes and globe salvage in 30 patients
    Ophthalmology, 2015
    Co-Authors: Wasim A Samara, Jerry A. Shields, Ralph C. Eagle, Chloe T L Khoo, Emil Anthony T Say, Jarin Saktanasate, Carol L. Shields
    Abstract:

    Purpose To report clinical features and treatment outcomes of ocular juvenile xanthogranuloma (JXG). Design Retrospective case series. Participants There were 32 Tumors in 31 eyes of 30 patients with ocular JXG. Methods Review of medical records. Main Outcome Measures Tumor control, intraocular pressure (IOP), and visual acuity. Results The mean patient age at presentation was 51 months (median, 15 months; range, 1–443 months). Eye redness (12/30, 40%) and hyphema (4/30, 13%) were the most common presenting symptoms. Cutaneous JXG was concurrently present in 3 patients (3/30, 10%), and spinal JXG was present in 1 patient (1/30, 3%). The ocular tissue affected by JXG included the Iris (21/31, 68%), conjunctiva (6/31, 19%), eyelid (2/31, 6%), choroid (2/31, 6%), and orbit (1/31, 3%). Those with Iris JXG presented at a median age of 13 months compared with 30 months for those with conjunctival JXG. In the Iris JXG group, mean IOP was 19 mmHg (median, 18 mmHg; range, 11–30 mmHg) and hyphema was noted in 8 eyes (8/21, 38%). The Iris Tumor was nodular (16/21, 76%) or diffuse (5/21, 24%). Fine-needle aspiration biopsy was used in 10 cases and confirmed JXG cytologically in all cases. The Iris lesion was treated with topical (18/21, 86%) and/or periocular (4/21, 19%) corticosteroids. The eyelid, conjunctiva, and orbital JXG were treated with excisional biopsy in 5 patients (5/9, 56%), topical corticosteroids in 2 patients (2/9, 22%), and observation in 2 patients (2/9, 22%). Of 28 patients with a mean follow-up of 15 months (median, 6 months; range, 1–68 months), Tumor regression was achieved in all cases, without recurrence. Two patients were lost to follow-up. Upon follow-up of the Iris JXG group, visual acuity was stable or improved (18/19 patients, 95%) and IOP was controlled long-term without medication (14/21 patients, 74%). No eyes were managed with enucleation. Conclusions Ocular JXG preferentially affects the Iris and is often isolated without cutaneous involvement. Iris JXG responds to topical or periocular corticosteroids, often with stabilization or improvement of vision and IOP.

  • Fluorescein angiography of Iris juvenile xanthogranuloma.
    Journal of pediatric ophthalmology and strabismus, 2008
    Co-Authors: Carl J Danzig, Carol L. Shields, Arman Mashayekhi, Hormoz Ehya, Maria E. Manquez, Jerry A. Shields
    Abstract:

    A 3-year-old boy was referred because of the presence of a non-pigmented, highly vascular mass with tapioca appearance involving the superior portion of the left Iris. Iris fluorescein angiography revealed early hyperfluorescence of the Iris Tumor with diffuse, intense late leakage of dye throughout the entire Iris, not just in the region of the Tumor. Cytopathologic examination revealed Touton giant cells and the presence of histiocytes, confirming the diagnosis of Iris juvenile xanthogranuloma. The patient was prescribed topical prednisolone acetate, and the lesion resolved during the next 3 months. Fluorescein angiography may be useful in differentiating Iris juvenile xanthogranuloma from malignant or non-inflammatory benign Iris lesions.

  • fine needle aspiration biopsy of Iris Tumors in 100 consecutive cases technique and complications
    Ophthalmology, 2006
    Co-Authors: Carol L. Shields, Carl J Danzig, Arman Mashayekhi, Hormoz Ehya, Maria E. Manquez, Jerry A. Shields
    Abstract:

    OBJECTIVE: To evaluate the technique and complications of fine-needle aspiration biopsy (FNAB) for Iris Tumors. DESIGN: Retrospective, nonrandomized, single-center case series. PARTICIPANTS: One hundred eyes of 100 patients with diagnostically challenging Iris Tumors evaluated with FNAB. MAIN OUTCOME MEASURES: Biopsy technique and complications. RESULTS: Of more than 1400 patients referred with an Iris Tumor over a 24-year period, 100 underwent FNAB for diagnostic purposes. The median patient age was 44 years. The median basal dimension of the lesion was 9.0 mm and median thickness was 2.5 mm. A limbal entry with transaqueous approach parallel to the Iris was used in 100% of patients. Entry was from the superotemporal (52%) or inferotemporal (42%) direction. Needle gauge size was 22 (9%), 25 (55%), 27 (25%), or 30 (9%), depending on the friability and vascularity of the Tumor. Adequate Tumor sample was achieved in 99 eyes (99%). At the time of FNAB, the only immediate complication was partial hyphema (34%). Two weeks after FNAB, persistent hyphema was found in 6 eyes (6%), requiring surgical washout in 1 patient. There were no cases of recurrent hyphema, vitreous hemorrhage, prolonged hypotony, lens damage, endophthalmitis, or extraocular Tumor seeding. At mean follow-up of 5 years, there was no incident of Tumor recurrence on the Iris, along the needle tract, or on the corneal or epibulbar surface. CONCLUSIONS: Using our technique, FNAB for diagnostically challenging Iris Tumors can achieve high yield with relatively few complications.

Jinnan Cai - One of the best experts on this subject based on the ideXlab platform.

  • An Iris Tumor Secondary to Talaromyces Marneffei Infection in a Patient with AIDS and Syphilis.
    Ocular immunology and inflammation, 2021
    Co-Authors: Tingkun Shi, Jinnan Cai, Haoyu Chen
    Abstract:

    Purpose: To report a case of Iris Tumor secondary to Talaromyces marneffei infection in a patient with AIDS and syphilis.Case report: A 25-year-old man presented with gradual vision decrease in the right eye for 2 months. Ocular examination revealed best-corrected visual acuity (BCVA) of 0.12 and a vascularized and solid Tumor at inferotemporal Iris base in the right eye. There were some papulonecrotic skin lesions. Both serum treponema pallidum particle agglutination and human immunodeficiency virus antibody were positive. Non-target metagenome next-generation sequencing detected Talaromyces marneffei in the skin lesion and aqueous humor. After 8 weeks of oral voriconazole and fluconazole eyedrop treatment, the Iris Tumor completely subsided, and the BCVA improved to 1.0.Conclusion: Talaromyces marneffei infection may present as an Iris Tumor. Metagenome next-generation sequencing is helpful in diagnosis. Oral and topical anti-fungus therapy was sufficient to regress the disease without intraocular injection.

  • An Iris Tumor Secondary to Talaromyces Marneffei Infection in a Patient with AIDS and Syphilis.
    Ocular immunology and inflammation, 2021
    Co-Authors: Tingkun Shi, Jinnan Cai, Haoyu Chen
    Abstract:

    Purpose: To report a case of Iris Tumor secondary to Talaromyces marneffei infection in a patient with AIDS and syphilis.Case report: A 25-year-old man presented with gradual vision decrease in the...