The Experts below are selected from a list of 35358 Experts worldwide ranked by ideXlab platform
J. Zach Hilt - One of the best experts on this subject based on the ideXlab platform.
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Targeted Iron Oxide Nanoparticles for the enhancement of radiation therapy
Biomaterials, 2016Co-Authors: Anastasia K. Hauser, Mihail I. Mitov, Emily F. Daley, Ronald C. Mcgarry, Kimberly W. Anderson, J. Zach HiltAbstract:To increase the efficacy of radiation, Iron Oxide Nanoparticles can be utilized for their ability to produce reactive oxygen species (ROS). Radiation therapy promotes leakage of electrons from the electron transport chain and leads to an increase in mitochondrial production of the superOxide anion which is converted to hydrogen perOxide by superOxide dismutase. Iron Oxide Nanoparticles can then catalyze the reaction from hydrogen perOxide to the highly reactive hydroxyl radical. Therefore, the overall aim of this project was to utilize Iron Oxide Nanoparticles conjugated to a cell penetrating peptide, TAT, to escape lysosomal encapsulation after internalization by cancer cells and catalyze hydroxyl radical formation. It was determined that TAT functionalized Iron Oxide Nanoparticles and uncoated Iron Oxide Nanoparticles resulted in permeabilization of the lysosomal membranes. Additionally, mitochondrial integrity was compromised when A549 cells were treated with both TAT-functionalized Nanoparticles and radiation. Pre-treatment with TAT-functionalized Nanoparticles also significantly increased the ROS generation associated with radiation. A long term viability study showed that TAT-functionalized Nanoparticles combined with radiation resulted in a synergistic combination treatment. This is likely due to the TAT-functionalized Nanoparticles sensitizing the cells to subsequent radiation therapy, because the Nanoparticles alone did not result in significant toxicities.
Ti-wen Sung - One of the best experts on this subject based on the ideXlab platform.
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Magnetic properties of monodisperse Iron Oxide Nanoparticles
Journal of Applied Physics, 2006Co-Authors: Chun-rong Lin, Ray-kuang Chiang, Jiun-shen Wang, Ti-wen SungAbstract:We have synthesized a set of monodisperse Iron Oxide Nanoparticles ranging from 7.8to17.9nm by thermal decomposition methods. Based on the evidence of high-resolution transmission electron microscopy, the Iron Oxide Nanoparticles appear as spherical dots with size standard deviations of less than 5%. Blocking temperatures of the set of Nanoparticles were measured by the zero-field-cooled magnetization measurements. The anisotropy energy constants are estimated from the measured blocking temperatures. The contribution from the surface anisotropy is the dominant factor of the higher anisotropy energy found. The saturation magnetization and coercive force HC (77K) are functions of the particle size and increase with the particle size.
Morteza Mahmoudi - One of the best experts on this subject based on the ideXlab platform.
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magnetic fluid hyperthermia focus on superparamagnetic Iron Oxide Nanoparticles
Advances in Colloid and Interface Science, 2011Co-Authors: Sophie Laurent, Silvio Dutz, Urs O Hafeli, Morteza MahmoudiAbstract:Due to their unique magnetic properties, excellent biocompatibility as well as multi-purpose biomedical potential (e.g., applications in cancer therapy and general drug delivery), superparamagnetic Iron Oxide Nanoparticles (SPIONs) are attracting increasing attention in both pharmaceutical and industrial communities. The precise control of the physiochemical properties of these magnetic systems is crucial for hyperthermia applications, as the induced heat is highly dependent on these properties. In this review, the limitations and recent advances in the development of superparamagnetic Iron Oxide Nanoparticles for hyperthermia are presented.
Niki Baccile - One of the best experts on this subject based on the ideXlab platform.
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Biocompatible GlycoNanoparticles by Grafting Sophorolipid Monolayers on Monodispersed Iron Oxide Nanoparticles
ACS Applied Bio Materials, 2019Co-Authors: Andrea Lassenberger, Andrea Scheberl, Krishna Chaithanya Batchu, Viviana Cristiglio, Isabelle Grillo, Erik Reimhult, Daniel Hermida-merino, Niki BaccileAbstract:This work presents the synthesis and characterization of sophorolipid-coated monodisperse Iron Oxide Nanoparticles. Sophorolipids are biological glycosylated amphiphiles produced by the yeast S. bombicola. In their open acidic form, sophorolipids have been used as a surface stabilizing agent for metal and metal Oxide Nanoparticles but with a poor control over size and structural properties. In this work, the COOH function of sophorolipids (SL) was modified with nitrodopamine (NDA), a catechol known for its high affinity to Iron ions. The resulting new form of sophorolipid–nitrodopamide (SL-NDA) was used as a surface ligand for monodisperse Iron Oxide Nanoparticles. We show by a combination of thermogravimetric analysis and small-angle X-ray and neutron scattering that Iron Oxide Nanoparticles (IONP) are stabilized by a single, high-density SL-NDA layer. This results in excellent colloidal stability under biologically relevant conditions, such as at high protein and salt concentrations. The IONP grafted wi...
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Sophorolipids-functionalized Iron Oxide Nanoparticles
Physical Chemistry Chemical Physics, 2013Co-Authors: Niki Baccile, Romain Noiville, Lorenzo Stievano, Inge Van BogaertAbstract:Functional Iron Oxide Nanoparticles (NP) have been synthesized in a one and a two-step method using a natural functional glycolipid belonging to the family of sophorolipids (SL). These compounds, whose open acidic form is highly suitable for nanoparticle stabilization, are readily obtained by a fermentation process of the yeast Candida bombicola (polymorph Starmerella bombicola) in large amounts. The final carbohydrate coated Iron Oxide Nanoparticles represent interesting potentially biocompatible materials for biomedical applications. According to the synthesis strategy, magnetic properties can eventually be tuned, thus putting in evidence the direct effect of the glycolipid on the final material's structure (maghemite and ferrihydrite have been obtained here). A combination of FT-IR, Dynamic Light Scattering (DLS) and UV-Vis experiments shows that SL complex the nanoparticle surface via their accessible COOH group thus forming stable colloids, whose hydrodynamic diameter mostly varies between 10 nm and 30 nm, both in water and in KCl-containing (0.01 M and 2 M) solutions. The materials can stand multiple filtration steps (up to 10) at different extents, where the largest recorded average aggregate size is 100 nm. In general, materials synthesized at T = 80 °C display better stability and smaller size distribution than those obtained at room temperature.
Juming Yao - One of the best experts on this subject based on the ideXlab platform.
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Ultrasonic-assisted preparation of monodisperse Iron Oxide Nanoparticles
Materials Letters, 2006Co-Authors: Guoqing Zhang, Q.k. Jiang, Lianyi Chen, Juming YaoAbstract:Abstract Monodisperse Iron Oxide Nanoparticles with 5–20 nm can be synthesized by an inexpensive and simple ultrasonic-assisted method at low temperature. This is based on the decomposition of Iron pentacarbonyl in cis–trans decalin. The high energy emitted by ultrasonic irradiation at a short time can promote the crystallization process simultaneously. At low temperature, these crystalline nucleuses can grow to monodisperse Nanoparticles. Effects of ultrasonic treatment, the concentration of surfactant and the refluxing time on the size and size distribution of Iron Oxide Nanoparticles were investigated. The morphology and crystal structure of Iron Oxide Nanoparticles obtained at different conditions were characterized by high-resolution transmission electron microscope, X-ray diffraction and selected area electron diffraction.
