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Kim Overvad - One of the best experts on this subject based on the ideXlab platform.
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adipose tissue content of alpha linolenic acid and the risk of Ischemic Stroke and Ischemic Stroke subtypes a danish case cohort study
PLOS ONE, 2018Co-Authors: Christian Sorensen Bork, Stine Krogh Veno, Soren Lundbyechristensen, Marianne Uhre Jakobsen, Anne Tjonneland, Philip C Calder, Kim OvervadAbstract:Background The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) may reduce the risk of cardiovascular disease. Objective We have investigated associations between the content of ALA in adipose tissue and the risk of Ischemic Stroke and its subtypes. Methods Incident cases of Ischemic Stroke among participants enrolled into the Danish Diet, Cancer and Health cohort (n = 57,053) were identified by linkage with the Danish National Patient Register. Subsequently, all potential cases were validated and classified into Ischemic Stroke subtypes. The fatty acid composition of adipose tissue was determined by gas chromatography in cases and in a randomly drawn sub-cohort (n = 3500). Statistical analyses were performed using weighted Cox regression. Results During a median of 13.4 years of follow-up, 1735 cases of total Ischemic Stroke were identified including 297 cases of large artery atherosclerosis, 772 cases of small-vessel occlusion, 99 cases of cardio-embolism, 91 cases with Stroke of other etiology and 476 cases with Stroke of undetermined etiology. The median content of ALA in adipose tissue within the sub-cohort was 0.84% (95% central range: 0.53–1.19%). Multivariable analyses showed a U-shaped association between adipose tissue content of ALA and the rate of total Ischemic Stroke, but this association was not statistically significant (p = 0.172). In analyses of Ischemic Stroke subtypes, we observed a statistically significant U-shaped association between ALA and the rate of Ischemic Stroke due to large artery atherosclerosis (p = 0.017), whereas no appreciable association was observed between ALA and the rate of small-vessel occlusion (p = 0.427). A positive but statistically non-significant association was observed between ALA and the rate of Ischemic Stroke due to cardio-embolism (p = 0.162). Conclusions The content of ALA in adipose tissue was statistically non-significantly U-shaped associated with risk of total Ischemic Stroke. For Ischemic Stroke subtypes a statistically significant, U-shaped association with large artery atherosclerosis was observed.
Yonghua Hu - One of the best experts on this subject based on the ideXlab platform.
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Study on the association between leukotriene A4 hydrolase gene polymorphism and Ischemic Stroke
Chinese journal of epidemiology, 2015Co-Authors: Yiqun Wu, Xun Tang, Dafang Chen, Jin Li, Tao Wu, Kai Fang, Shuai Li, Na Li, Yonghua HuAbstract:Objective To investigate the association between polymorphism of leukotriene A4 hydrolase (LTA4H) gene among Ischemic Stroke patients and the related subtypes in the discordant sib pairs. Methods Families including Ischemic Stroke patients and their siblings were recruited. Four single nucleotide polymorphisms (SNPs) of LTA4H as rs2072512, rs2540489, rs2540500 and rs6538697 were selected. Generalized estimating equation (GEE) was used to adjust for in-family correlation in the analysis of discordant sib pairs. Conditional logistic regression model and family based association test (FBAT) were both used to test the associations of LTA4H gene with Ischemic Stroke and its subtypes. Results In total, data from 356 discordant sib pairs from 234 Ischemic Stroke patient pedigrees were analyzed. Results of GEE showed that hypertension, diabetes mellitus and hyperlipoidemia were associated with Ischemic Stroke. According to the association test results, rs2540489 G allele was found to be associated with Ischemic Stroke, both in the additive model (OR=0.62, 95%CI: 0.41-0.94) and in the recessive model (OR=0.48, 95%CI: 0.23-1.02). For two main Ischemic Stroke subtypes, rs2540489 G allele was found to be associated with large-artery atherosclerosis Stroke in the additive model (OR=0.48, 95%CI: 0.24-0.95) and in the recessive model (OR=0.25, 95%CI: 0.07-0.93). After adjusting age, sex and other factors, the associations mentioned above, still existed. Conclusion rs2540489 polymorphism in LTA4H gene seemed to be associated with large-artery atherosclerosis Stroke. Key words: Ischemic Stroke; Leukotriene A4 hydrolase; Single nucleotide polymorphism; Genetic epidemiology
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association study between pde4d gene polymorphism and Ischemic Stroke
Journal of Peking University. Health sciences, 2013Co-Authors: Jinwei Wang, Dafang Chen, Yiqun Wu, Tao Wu, Kai Fang, Na Li, Zhiping Yu, Xueyin Wang, Yonghua HuAbstract:OBJECTIVE: To investigate the linkage and association between rs966221 (SNP 83) in PDE4D gene with Stroke and related traits in Ischemic Stroke families. METHODS: Ischemic Stroke families including Ischemic Stroke patients and their siblings and/or parents were recruited. Generalized estimating equation (GEE) was used to adjust for with-in family correlations and other potential confounding factors. Non-parameter linkage analysis and family based association test (FBAT) were applied to explore the relationship between rs966221 polymorphism and Ischemic Stroke together with its related traits. RESULTS: In the study 276 Ischemic Stroke families with totally 776 participants were enrolled. Apolipoprotein B (apoB), carotid intima media thickness (cIMT), high-density lipoprotein cholesterol and blood pressure were associated with Ischemic Stroke. In family based association test, after being adjusted for related chronic diseases, rs966221 C allele was found to be associated with cIMT in the dominant model (P=0.019), TT genotype (P=0.019) and CT genotype (P=0.007) were associated with cIMT significantly. After being adjusted for potential confounding factors, evidence of linkage was observed for rs966221 with apoB (P<0.001), high-sensitivity C-reactive protein (P=0.003) and systolic blood pressure (P=0.036). CONCLUSION: Abnormal serum lipid, blood pressure and increasing cIMT were associated with Ischemic Stroke, and linkage was observed for with apoB, high-sensitivity C-reactive protein, and systolic blood pressure; rs966221 C allele was probably associated with cIMT.
Christian Sorensen Bork - One of the best experts on this subject based on the ideXlab platform.
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adipose tissue content of alpha linolenic acid and the risk of Ischemic Stroke and Ischemic Stroke subtypes a danish case cohort study
PLOS ONE, 2018Co-Authors: Christian Sorensen Bork, Stine Krogh Veno, Soren Lundbyechristensen, Marianne Uhre Jakobsen, Anne Tjonneland, Philip C Calder, Kim OvervadAbstract:Background The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) may reduce the risk of cardiovascular disease. Objective We have investigated associations between the content of ALA in adipose tissue and the risk of Ischemic Stroke and its subtypes. Methods Incident cases of Ischemic Stroke among participants enrolled into the Danish Diet, Cancer and Health cohort (n = 57,053) were identified by linkage with the Danish National Patient Register. Subsequently, all potential cases were validated and classified into Ischemic Stroke subtypes. The fatty acid composition of adipose tissue was determined by gas chromatography in cases and in a randomly drawn sub-cohort (n = 3500). Statistical analyses were performed using weighted Cox regression. Results During a median of 13.4 years of follow-up, 1735 cases of total Ischemic Stroke were identified including 297 cases of large artery atherosclerosis, 772 cases of small-vessel occlusion, 99 cases of cardio-embolism, 91 cases with Stroke of other etiology and 476 cases with Stroke of undetermined etiology. The median content of ALA in adipose tissue within the sub-cohort was 0.84% (95% central range: 0.53–1.19%). Multivariable analyses showed a U-shaped association between adipose tissue content of ALA and the rate of total Ischemic Stroke, but this association was not statistically significant (p = 0.172). In analyses of Ischemic Stroke subtypes, we observed a statistically significant U-shaped association between ALA and the rate of Ischemic Stroke due to large artery atherosclerosis (p = 0.017), whereas no appreciable association was observed between ALA and the rate of small-vessel occlusion (p = 0.427). A positive but statistically non-significant association was observed between ALA and the rate of Ischemic Stroke due to cardio-embolism (p = 0.162). Conclusions The content of ALA in adipose tissue was statistically non-significantly U-shaped associated with risk of total Ischemic Stroke. For Ischemic Stroke subtypes a statistically significant, U-shaped association with large artery atherosclerosis was observed.
Yiqun Wu - One of the best experts on this subject based on the ideXlab platform.
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Study on the association between leukotriene A4 hydrolase gene polymorphism and Ischemic Stroke
Chinese journal of epidemiology, 2015Co-Authors: Yiqun Wu, Xun Tang, Dafang Chen, Jin Li, Tao Wu, Kai Fang, Shuai Li, Na Li, Yonghua HuAbstract:Objective To investigate the association between polymorphism of leukotriene A4 hydrolase (LTA4H) gene among Ischemic Stroke patients and the related subtypes in the discordant sib pairs. Methods Families including Ischemic Stroke patients and their siblings were recruited. Four single nucleotide polymorphisms (SNPs) of LTA4H as rs2072512, rs2540489, rs2540500 and rs6538697 were selected. Generalized estimating equation (GEE) was used to adjust for in-family correlation in the analysis of discordant sib pairs. Conditional logistic regression model and family based association test (FBAT) were both used to test the associations of LTA4H gene with Ischemic Stroke and its subtypes. Results In total, data from 356 discordant sib pairs from 234 Ischemic Stroke patient pedigrees were analyzed. Results of GEE showed that hypertension, diabetes mellitus and hyperlipoidemia were associated with Ischemic Stroke. According to the association test results, rs2540489 G allele was found to be associated with Ischemic Stroke, both in the additive model (OR=0.62, 95%CI: 0.41-0.94) and in the recessive model (OR=0.48, 95%CI: 0.23-1.02). For two main Ischemic Stroke subtypes, rs2540489 G allele was found to be associated with large-artery atherosclerosis Stroke in the additive model (OR=0.48, 95%CI: 0.24-0.95) and in the recessive model (OR=0.25, 95%CI: 0.07-0.93). After adjusting age, sex and other factors, the associations mentioned above, still existed. Conclusion rs2540489 polymorphism in LTA4H gene seemed to be associated with large-artery atherosclerosis Stroke. Key words: Ischemic Stroke; Leukotriene A4 hydrolase; Single nucleotide polymorphism; Genetic epidemiology
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association study between pde4d gene polymorphism and Ischemic Stroke
Journal of Peking University. Health sciences, 2013Co-Authors: Jinwei Wang, Dafang Chen, Yiqun Wu, Tao Wu, Kai Fang, Na Li, Zhiping Yu, Xueyin Wang, Yonghua HuAbstract:OBJECTIVE: To investigate the linkage and association between rs966221 (SNP 83) in PDE4D gene with Stroke and related traits in Ischemic Stroke families. METHODS: Ischemic Stroke families including Ischemic Stroke patients and their siblings and/or parents were recruited. Generalized estimating equation (GEE) was used to adjust for with-in family correlations and other potential confounding factors. Non-parameter linkage analysis and family based association test (FBAT) were applied to explore the relationship between rs966221 polymorphism and Ischemic Stroke together with its related traits. RESULTS: In the study 276 Ischemic Stroke families with totally 776 participants were enrolled. Apolipoprotein B (apoB), carotid intima media thickness (cIMT), high-density lipoprotein cholesterol and blood pressure were associated with Ischemic Stroke. In family based association test, after being adjusted for related chronic diseases, rs966221 C allele was found to be associated with cIMT in the dominant model (P=0.019), TT genotype (P=0.019) and CT genotype (P=0.007) were associated with cIMT significantly. After being adjusted for potential confounding factors, evidence of linkage was observed for rs966221 with apoB (P<0.001), high-sensitivity C-reactive protein (P=0.003) and systolic blood pressure (P=0.036). CONCLUSION: Abnormal serum lipid, blood pressure and increasing cIMT were associated with Ischemic Stroke, and linkage was observed for with apoB, high-sensitivity C-reactive protein, and systolic blood pressure; rs966221 C allele was probably associated with cIMT.
Dafang Chen - One of the best experts on this subject based on the ideXlab platform.
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Study on the association between leukotriene A4 hydrolase gene polymorphism and Ischemic Stroke
Chinese journal of epidemiology, 2015Co-Authors: Yiqun Wu, Xun Tang, Dafang Chen, Jin Li, Tao Wu, Kai Fang, Shuai Li, Na Li, Yonghua HuAbstract:Objective To investigate the association between polymorphism of leukotriene A4 hydrolase (LTA4H) gene among Ischemic Stroke patients and the related subtypes in the discordant sib pairs. Methods Families including Ischemic Stroke patients and their siblings were recruited. Four single nucleotide polymorphisms (SNPs) of LTA4H as rs2072512, rs2540489, rs2540500 and rs6538697 were selected. Generalized estimating equation (GEE) was used to adjust for in-family correlation in the analysis of discordant sib pairs. Conditional logistic regression model and family based association test (FBAT) were both used to test the associations of LTA4H gene with Ischemic Stroke and its subtypes. Results In total, data from 356 discordant sib pairs from 234 Ischemic Stroke patient pedigrees were analyzed. Results of GEE showed that hypertension, diabetes mellitus and hyperlipoidemia were associated with Ischemic Stroke. According to the association test results, rs2540489 G allele was found to be associated with Ischemic Stroke, both in the additive model (OR=0.62, 95%CI: 0.41-0.94) and in the recessive model (OR=0.48, 95%CI: 0.23-1.02). For two main Ischemic Stroke subtypes, rs2540489 G allele was found to be associated with large-artery atherosclerosis Stroke in the additive model (OR=0.48, 95%CI: 0.24-0.95) and in the recessive model (OR=0.25, 95%CI: 0.07-0.93). After adjusting age, sex and other factors, the associations mentioned above, still existed. Conclusion rs2540489 polymorphism in LTA4H gene seemed to be associated with large-artery atherosclerosis Stroke. Key words: Ischemic Stroke; Leukotriene A4 hydrolase; Single nucleotide polymorphism; Genetic epidemiology
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study on the association between leukotriene a4 hydrolase gene polymorphism and Ischemic Stroke
Chinese Journal of Endemiology, 2015Co-Authors: Kuo Liu, Xun Tang, Kai Fang, Dafang ChenAbstract:OBJECTIVE: To investigate the association between polymorphism of leukotriene A4 hydrolase (LTA4H) gene among Ischemic Stroke patients and the related subtypes in the discordant sib pairs. METHODS: Families including Ischemic Stroke patients and their siblings were recruited. Four single nucleotide polymorphisms (SNPs) of LTA4H as rs2072512, rs2540489, rs2540500 and rs6538697 were selected. Generalized estimating equation (GEE) was used to adjust for in-family correlation in the analysis of discordant sib pairs. Conditional logistic regression model and family based association test (FBAT) were both used to test the associations of LTA4H gene with Ischemic Stroke and its subtypes. RESULTS: In total, data from 356 discordant sib pairs from 234 Ischemic Stroke patient pedigrees were analyzed. Results of GEE showed that hypertension, diabetes mellitus and hyperlipoidemia were associated with Ischemic Stroke. According to the association test results, rs2540489 G allele was found to be associated with Ischemic Stroke, both in the additive model (OR = 0.62, 95% CI: 0.41-0.94) and in the recessive model (OR = 0.48, 95% CI: 0.23-1.02). For two main Ischemic Stroke subtypes, rs2540489 G allele was found to be associated with large-artery atherosclerosis Stroke in the additive model (OR = 0.48, 95% CI: 0.24-0.95) and in the recessive model (OR = 0.25, 95% CI: 0.07-0.93). After adjusting age, sex and other factors, the associations mentioned above, still existed. CONCLUSION: rs2540489 polymorphism in LTA4H gene seemed to be associated with large-artery atherosclerosis Stroke.
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association study between pde4d gene polymorphism and Ischemic Stroke
Journal of Peking University. Health sciences, 2013Co-Authors: Jinwei Wang, Dafang Chen, Yiqun Wu, Tao Wu, Kai Fang, Na Li, Zhiping Yu, Xueyin Wang, Yonghua HuAbstract:OBJECTIVE: To investigate the linkage and association between rs966221 (SNP 83) in PDE4D gene with Stroke and related traits in Ischemic Stroke families. METHODS: Ischemic Stroke families including Ischemic Stroke patients and their siblings and/or parents were recruited. Generalized estimating equation (GEE) was used to adjust for with-in family correlations and other potential confounding factors. Non-parameter linkage analysis and family based association test (FBAT) were applied to explore the relationship between rs966221 polymorphism and Ischemic Stroke together with its related traits. RESULTS: In the study 276 Ischemic Stroke families with totally 776 participants were enrolled. Apolipoprotein B (apoB), carotid intima media thickness (cIMT), high-density lipoprotein cholesterol and blood pressure were associated with Ischemic Stroke. In family based association test, after being adjusted for related chronic diseases, rs966221 C allele was found to be associated with cIMT in the dominant model (P=0.019), TT genotype (P=0.019) and CT genotype (P=0.007) were associated with cIMT significantly. After being adjusted for potential confounding factors, evidence of linkage was observed for rs966221 with apoB (P<0.001), high-sensitivity C-reactive protein (P=0.003) and systolic blood pressure (P=0.036). CONCLUSION: Abnormal serum lipid, blood pressure and increasing cIMT were associated with Ischemic Stroke, and linkage was observed for with apoB, high-sensitivity C-reactive protein, and systolic blood pressure; rs966221 C allele was probably associated with cIMT.
