The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Maha M. Abdelrahman - One of the best experts on this subject based on the ideXlab platform.
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Mean centering of ratio spectra and successive derivative ratio spectrophotometric methods for determination of Isopropamide Iodide, trifluoperazine hydrochloride and trifluoperazine oxidative degradate
Journal of Saudi Chemical Society, 2016Co-Authors: Maha M. Abdelrahman, Eglal A. AbdelaleemAbstract:Abstract Two sensitive, selective and precise stability indicating methods for the determination of Isopropamide Iodide (ISO), trifluoperazine hydrochloride (TPZ) and trifluoperazine oxidative degradate (DEG) were developed and validated. Method A is a successive derivative ratio spectrophotometric one, which depends on the successive derivative of ratio spectra in two steps using 0.1 N HCl as a solvent and measuring TPZ at 250.4 and 257.2 nm, ISO at 223 and 228 nm and DEG at 210.6, 213 and 270.2 nm. Method B is mean centering of ratio spectra which depends on using the mean centered ratio spectra in two successive steps and measuring the mean centered values of the second ratio spectra at 322, 355 and 339 nm for TPZ, ISO and DEG, respectively. Factors affecting the developed methods were studied and optimized, moreover, they have been validated as per ICH guidelines and the results demonstrated that the suggested methods are reliable, reproducible and suitable for routine use with short analysis time. Statistical analysis of the two developed methods with the reported one using F- and Student’s t -test showed no significant difference regarding accuracy and precision.
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Spectrophotometric determination of Isopropamide Iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate.
Drug testing and analysis, 2010Co-Authors: Samah S. Abbas, Hala E. Zaazaa, Mohamed Abdelkawy, Maha M. AbdelrahmanAbstract:Four sensitive, selective and precise stability indicating methods for the determination of Isopropamide Iodide (ISO) and trifluoperazine hydrochloride (TPZ) in their binary mixture and in presence of trifluoperazine oxidative degradate (OXD). Method A is a derivative spectrophotometric one, where ISO was determined by first derivative (D(1)) at 226.4 nm while TPZ was determined by second derivative (D(2)) at 270.2 nm. Method B is the first derivative of the ratio spectra (DD(1)) spectrophotometric method, ISO can be determined by measuring the peak amplitude at 227.4 nm using 5 microg mL(-1) of OXD as a divisor, while TPZ can be determined by measuring the peak amplitude at 249.2 and 261.4 nm using 15 microg mL(-1) of ISO as a divisor. Method C is the isoabsorptive spectrophotometric method. This method allows determination of ISO and TPZ in their binary mixture by measuring total concentration of ISO and TPZ at their isoabsorptive point at lambda(229.8) nm (Aiso1) while TPZ concentration alone can be determined at lambda(max) 311.2 nm, then ISO concentration can be determined by subtraction. On the same basis TPZ can be determined in presence of ISO and OXD, where OXD concentration alone was determined by measuring the peak amplitude at lambda(281.6) and lambda(309.4) nm while total concentration of TPZ and OXD was determined at their isoabsorptive points at (Aiso2 = 270.2 nm), (Aiso3 = 310.6 nm) and (Aiso4 = 331.8 nm) then TPZ concentration was determined by subtraction. Method D is the multivariate calibration techniques [the classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS)], using the information contained in the absorption spectra of ISO, TPZ and OXD mixtures. The selectivity of the proposed methods was checked using laboratory prepared mixtures. The proposed methods have been successfully applied to the analysis of ISO and TPZ in pharmaceutical dosage form without interference from other dosage form additives and the results were statistically compared with the reported method.
Mohamed R Elghobashy - One of the best experts on this subject based on the ideXlab platform.
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smart electrochemical sensing platform for the simultaneous determination of psychotic disorder drugs Isopropamide Iodide and trifluoperazine hydrochloride
New Journal of Chemistry, 2018Co-Authors: Mona A Mohamed, Ahmed S Saad, Sara H Koshek, Mohamed R ElghobashyAbstract:A novel, simple and highly sensitive sensor for the simultaneous determination of Isopropamide Iodide (ISP) and trifluoperazine hydrochloride (TFP) was developed. A carbon paste electrode was modified with m-cresol purple (MCP) and carboxylated multiwalled carbon nanotubes (MWCNTs). Different techniques were used to characterize the nanostructure and performance of the sensor. Under the optimized experimental conditions, ISP and TFP showed linear responses over the ranges of 5.50 × 10−6–1.70 × 10−4 and 5.00 × 10−7–1.34 × 10−3 mol L−1, respectively. The detection limits for ISP and TFP were found to be 9.91 × 10−7 mol L−1 and 1.10 × 10−7 mol L−1, respectively. Satisfactory recoveries of analytes from these samples were demonstrated, indicating that the suggested sensor is highly suitable for clinical analysis, quality control and routine determination of ISP and TFP in pharmaceutical formulations and human fluids.
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Smart electrochemical sensing platform for the simultaneous determination of psychotic disorder drugs Isopropamide Iodide and trifluoperazine hydrochloride
New Journal of Chemistry, 2018Co-Authors: Mona A Mohamed, Ahmed S Saad, Sara H Koshek, Mohamed R ElghobashyAbstract:Schematic representation of carboxylation of multiwalled carbon nanotubes.
Hassan F. Askal - One of the best experts on this subject based on the ideXlab platform.
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Spectrophotometric determination of some pharmaceutical amides through charge—transfer complexation reactions
Journal of Pharmaceutical and Biomedical Analysis, 1991Co-Authors: Gamal A. Saleh, Hassan F. AskalAbstract:Abstract A spectrophotometric method is described for the assay of fenpipramide hydrochloride, Isopropamide Iodide, trimethobenzamide hydrochloride, morphazinamide hydrochloride and tolazamide. The method is based on the formation of a charge—transfer complex between the drug as n -donor and iodine, a ∂-acceptor. The product exhibits absorption maxima at 295 and 365 nm; measurements are made at 365 nm for fenpipramide and at 295 nm for the other compounds. Beer's law is obeyed in a concentration range of 1–120 μg ml −1 . The method is rapid, simple and sensitive and can be applied to the analysis of some commercial and laboratory prepared tablets without interference. A more detailed investigation of the complex was made with respect to its composition. association constant and free energy change.
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Spectrophotometric determination of some pharmaceutical amides through charge-transfer complexation reactions.
Journal of Pharmaceutical and Biomedical Analysis, 1991Co-Authors: Gamal A. Saleh, Hassan F. AskalAbstract:Abstract A spectrophotometric method is described for the assay of fenpipramide hydrochloride, Isopropamide Iodide, trimethobenzamide hydrochloride, morphazinamide hydrochloride and tolazamide. The method is based on the formation of a charge—transfer complex between the drug as n -donor and iodine, a ∂-acceptor. The product exhibits absorption maxima at 295 and 365 nm; measurements are made at 365 nm for fenpipramide and at 295 nm for the other compounds. Beer's law is obeyed in a concentration range of 1–120 μg ml −1 . The method is rapid, simple and sensitive and can be applied to the analysis of some commercial and laboratory prepared tablets without interference. A more detailed investigation of the complex was made with respect to its composition. association constant and free energy change.
Mona A Mohamed - One of the best experts on this subject based on the ideXlab platform.
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smart electrochemical sensing platform for the simultaneous determination of psychotic disorder drugs Isopropamide Iodide and trifluoperazine hydrochloride
New Journal of Chemistry, 2018Co-Authors: Mona A Mohamed, Ahmed S Saad, Sara H Koshek, Mohamed R ElghobashyAbstract:A novel, simple and highly sensitive sensor for the simultaneous determination of Isopropamide Iodide (ISP) and trifluoperazine hydrochloride (TFP) was developed. A carbon paste electrode was modified with m-cresol purple (MCP) and carboxylated multiwalled carbon nanotubes (MWCNTs). Different techniques were used to characterize the nanostructure and performance of the sensor. Under the optimized experimental conditions, ISP and TFP showed linear responses over the ranges of 5.50 × 10−6–1.70 × 10−4 and 5.00 × 10−7–1.34 × 10−3 mol L−1, respectively. The detection limits for ISP and TFP were found to be 9.91 × 10−7 mol L−1 and 1.10 × 10−7 mol L−1, respectively. Satisfactory recoveries of analytes from these samples were demonstrated, indicating that the suggested sensor is highly suitable for clinical analysis, quality control and routine determination of ISP and TFP in pharmaceutical formulations and human fluids.
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Smart electrochemical sensing platform for the simultaneous determination of psychotic disorder drugs Isopropamide Iodide and trifluoperazine hydrochloride
New Journal of Chemistry, 2018Co-Authors: Mona A Mohamed, Ahmed S Saad, Sara H Koshek, Mohamed R ElghobashyAbstract:Schematic representation of carboxylation of multiwalled carbon nanotubes.
Gamal A. Saleh - One of the best experts on this subject based on the ideXlab platform.
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Spectrophotometric determination of some pharmaceutical amides through charge—transfer complexation reactions
Journal of Pharmaceutical and Biomedical Analysis, 1991Co-Authors: Gamal A. Saleh, Hassan F. AskalAbstract:Abstract A spectrophotometric method is described for the assay of fenpipramide hydrochloride, Isopropamide Iodide, trimethobenzamide hydrochloride, morphazinamide hydrochloride and tolazamide. The method is based on the formation of a charge—transfer complex between the drug as n -donor and iodine, a ∂-acceptor. The product exhibits absorption maxima at 295 and 365 nm; measurements are made at 365 nm for fenpipramide and at 295 nm for the other compounds. Beer's law is obeyed in a concentration range of 1–120 μg ml −1 . The method is rapid, simple and sensitive and can be applied to the analysis of some commercial and laboratory prepared tablets without interference. A more detailed investigation of the complex was made with respect to its composition. association constant and free energy change.
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Spectrophotometric determination of some pharmaceutical amides through charge-transfer complexation reactions.
Journal of Pharmaceutical and Biomedical Analysis, 1991Co-Authors: Gamal A. Saleh, Hassan F. AskalAbstract:Abstract A spectrophotometric method is described for the assay of fenpipramide hydrochloride, Isopropamide Iodide, trimethobenzamide hydrochloride, morphazinamide hydrochloride and tolazamide. The method is based on the formation of a charge—transfer complex between the drug as n -donor and iodine, a ∂-acceptor. The product exhibits absorption maxima at 295 and 365 nm; measurements are made at 365 nm for fenpipramide and at 295 nm for the other compounds. Beer's law is obeyed in a concentration range of 1–120 μg ml −1 . The method is rapid, simple and sensitive and can be applied to the analysis of some commercial and laboratory prepared tablets without interference. A more detailed investigation of the complex was made with respect to its composition. association constant and free energy change.
