Japanese Pharmacopoeia

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Okada S - One of the best experts on this subject based on the ideXlab platform.

  • Cholecalciferol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of cholecalciferol was examined for the preparation of "Cholecalciferol Reference Standard (Control 001)". Analytical data obtained were: melting point, 83.2 degrees C; UV and infrared spectra, the same as those of JP Cholecalciferol Reference Standard (Control 971), respectively; specific absorbance at 265 nm, E1ca1% = 478; optical rotation, [alpha]D20 = +108.6 degrees; thin-layer chromatography, no impurities were detected until 100 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.05%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Cholecalciferol Reference Standard (Control 001).

  • Alprostadil Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of Alprostadil was examined for the preparation of "Alprostadil Reference Standard (Control 001)". Analytical data obtained were: IR spectrum, same as that of the Alprostadil Reference Standard (Control 923); thin-layer chromatography, no impurities were detected until 20 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.2%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Alprostadil Reference Standard (Control 001).

  • Ergocalciferol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of ergocalciferol was examined for the preparation of "Ergocalciferol Reference Standard (Control 001)". Analytical data obtained were: melting point, 114.8 degrees C; UV and infrared spectra, the same as those of JP Ergocalciferol Reference Standard (Control 971); specific absorbance, E1ca1% = 471(265 nm); optical rotation, [alpha]D20 = +102.4 degrees; thin-layer chromatography, no impurities were detected until 100 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.1%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Ergocalciferol Reference Standard (Control 001).

  • Tocopherol Acetate Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2000
    Co-Authors: Iwata M, Maekawa K, Tanimoto T, Koide T, Saito H, Okada S
    Abstract:

    The raw material of tocopherol acetate was examined for the preparation of the "Tocopherol Acetate Reference Standard (Control 001)". Analytical data obtained were: IR spectrum, same as that of the Tocopherol Acetate Reference Standard (Control 974); specific absorbance, E/cm% (284 nm) = 43.7; thin-layer chromatography, no impurities were detected until 50 micrograms of the loaded raw material; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.6%; assay by HPLC, 101.7%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 001).

  • Tocopherol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2000
    Co-Authors: Iwata M, Maekawa K, Tanimoto T, Koide T, Saito H, Okada S
    Abstract:

    The raw material of tocopherol was tested for the preparation of "Tocopherol Reference Standard (Control 991)". Analytical data obtained were: IR spectrum, same as the Tocopherol Reference Standard (Control 941); specific absorbance, E/cm% (292 nm) = 72.9; thin-layer chromatography, no impurities were detected until 50.0 micrograms; high-performance liquid chromatography (HPLC), trace amounts of five impurities were detected and the total amount was estimated to be less than 1.4%; assay by HPLC, 99.9%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Standard (Control 991).

S Okada - One of the best experts on this subject based on the ideXlab platform.

  • dl-Camphor Reference Standard (Control 961) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 1997
    Co-Authors: A Kitajima, H Komatsu, K Maekawa, K Yoshii, T Tanimoto, Y Tagashira, S Okada
    Abstract:

    The raw material of dl-camphor was examined for the preparation of the "dl-Camphor Reference Standard (Control 961)" of National Institute of Health Sciences. Analytical data obtained are as follows: UV spectrum, lambda max = 290 nm; IR spectrum, the same as that of the present JP Camphor Reference Standard (Control 953); melting point, 179.1 degrees C; purity test by gas-chromatography (GC), three kinds of impurities were detected; assay by GC, 99.8%. Based on the above results, the candidate raw material was authorized as the dl-Camphor Reference standard (Control 961) National Institute of Health Sciences (Japanese Pharmacopoeia).

  • Tocopherol Acetate Reference Standard (Control 941) of the National Institute of Health Sciences
    Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1996
    Co-Authors: A Kitajima, H Komatsu, K Maekawa, K Yoshii, T Tanimoto, S Okada
    Abstract:

    The raw material of tocopherol acetate was tested for the preparation of the "Tocopherol Acetate Reference Standard (Control 941)". Analytical data obtained were as follows: infrared spectrum, the same as that of the Tocopherol Acetate Reference Standard (Control 919); specific absorbance, E1(1%)cm (284nm) = 44.5; thin-layer chromatography, no impurities were detected until 50.0 micrograms; high-performance liquid chromatography (HPLC), 2-3 impurities were detected and the amount was estimated to be about 1%; assay by HPLC, 100.8%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 941).

  • Ergocalciferol reference standard (Control 941) of the National Institute of Health Sciences
    Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1995
    Co-Authors: A Kitajima, H Komatsu, K Maekawa, K Yoshii, T Tanimoto, S Okada
    Abstract:

    The raw material for ergocalciferol was tested for preparation of the "Ergocalciferol Reference Standard (Control 941)". Analytical data obtained were as follows: melting point, 117.6 degrees C; UV and infrared spectra, the same as those for JP Cholecalciferol Reference Standard; specific absorbance, E1%1cm = 458 (265 nm); thin-layer chromatography and high-performance liquid chromatography (HPLC), no impurities were detected, respectively; assay, 100.6% by HPLC. Based on the above results, the candidate raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 941).

  • Cholecalciferol Reference Standard (Control 921) of National Institute of Health Sciences
    Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1993
    Co-Authors: W Izumi, H Komatsu, S Ishimitsu, A Kitajima, K Yoshii, S Okada
    Abstract:

    The raw material for cholecalciferol was tested for preparation of the "Cholecalciferol Reference Standard (Control 921)". Analytical data obtained were as follows: melting point, 89.9 degrees C; UV and infrared spectra, the same as those for JP Cholecalciferol Reference Standard (Control 901), respectively; specific absorbance at 265 nm E1%1 cm = 472.2; optical rotation, [alpha]20D = 107.1 degrees; thin-layer chromatography and high-performance liquid chromatography (HPLC), no impurities were detected; assay, 99.97% by HPLC. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 921).

  • Folic Acid Reference Standard (Control 921) of National Institute of Health Sciences
    Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1993
    Co-Authors: A Kitajima, S Ishimitsu, H Komatsu, K Yoshii, S Okada
    Abstract:

    Folic acid was tested for the preparation of "Folic Acid Reference Standard (Control 921)". The quality of the raw material was examined and compared with the previous Folic Acid Reference Standard (Control 862). Analytical data obtained were as follows: water content, 7.52%; free amines, 0.1%; infrared spectrum, the same as that of the JP Reference Standard; thin-layer chromatography, three impurities were detected; high-performance liquid chromatography (HPLC), two impurities were detected; assay, 101.2% by spectrophotometry at 550 nm and 100.4% by HPLC. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 921).

Tanimoto T - One of the best experts on this subject based on the ideXlab platform.

  • Alprostadil Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of Alprostadil was examined for the preparation of "Alprostadil Reference Standard (Control 001)". Analytical data obtained were: IR spectrum, same as that of the Alprostadil Reference Standard (Control 923); thin-layer chromatography, no impurities were detected until 20 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.2%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Alprostadil Reference Standard (Control 001).

  • Cholecalciferol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of cholecalciferol was examined for the preparation of "Cholecalciferol Reference Standard (Control 001)". Analytical data obtained were: melting point, 83.2 degrees C; UV and infrared spectra, the same as those of JP Cholecalciferol Reference Standard (Control 971), respectively; specific absorbance at 265 nm, E1ca1% = 478; optical rotation, [alpha]D20 = +108.6 degrees; thin-layer chromatography, no impurities were detected until 100 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.05%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Cholecalciferol Reference Standard (Control 001).

  • Ergocalciferol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of ergocalciferol was examined for the preparation of "Ergocalciferol Reference Standard (Control 001)". Analytical data obtained were: melting point, 114.8 degrees C; UV and infrared spectra, the same as those of JP Ergocalciferol Reference Standard (Control 971); specific absorbance, E1ca1% = 471(265 nm); optical rotation, [alpha]D20 = +102.4 degrees; thin-layer chromatography, no impurities were detected until 100 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.1%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Ergocalciferol Reference Standard (Control 001).

  • Tocopherol Acetate Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2000
    Co-Authors: Iwata M, Maekawa K, Tanimoto T, Koide T, Saito H, Okada S
    Abstract:

    The raw material of tocopherol acetate was examined for the preparation of the "Tocopherol Acetate Reference Standard (Control 001)". Analytical data obtained were: IR spectrum, same as that of the Tocopherol Acetate Reference Standard (Control 974); specific absorbance, E/cm% (284 nm) = 43.7; thin-layer chromatography, no impurities were detected until 50 micrograms of the loaded raw material; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.6%; assay by HPLC, 101.7%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 001).

  • Tocopherol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2000
    Co-Authors: Iwata M, Maekawa K, Tanimoto T, Koide T, Saito H, Okada S
    Abstract:

    The raw material of tocopherol was tested for the preparation of "Tocopherol Reference Standard (Control 991)". Analytical data obtained were: IR spectrum, same as the Tocopherol Reference Standard (Control 941); specific absorbance, E/cm% (292 nm) = 72.9; thin-layer chromatography, no impurities were detected until 50.0 micrograms; high-performance liquid chromatography (HPLC), trace amounts of five impurities were detected and the total amount was estimated to be less than 1.4%; assay by HPLC, 99.9%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Standard (Control 991).

T Tanimoto - One of the best experts on this subject based on the ideXlab platform.

  • Tocopherol Acetate Reference Standard (Control 021) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2003
    Co-Authors: Miho Murakami, Tatsuo Koide, Hiroyuki Saito, Yukiko Morita, T Tanimoto
    Abstract:

    The raw material of tocopherol acetate was examined for the preparation of the "Tocopherol Acetate Reference Standard (Control 021)", The analytical data obtained were: UV spectrum, lambda max of 278.5 and 284.8 nm and specific absorbance in ethanol at 284 nm = 42.9; IR spectrum, same as that of the Tocopherol Acetate Reference Standard (Control 001); thin-layer chromatography, no impurities were detected until 50 micrograms; high-performance liquid chromatography, total amount of impurities estimated to be less than 0.6%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Tocopherol Acetate Reference Standard (Control 021) of the National Institute of Health Sciences.

  • Cholecalciferol Reference Standard (Control 031) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2003
    Co-Authors: Miho Murakami, Tatsuo Koide, Hiroyuki Saito, Yukiko Morita, T Tanimoto
    Abstract:

    The raw material of cholecalciferol was examined for the preparation of the "Cholecalsiferol Reference Standard (Control 031)", The analytical data obtained were: melting point, 86.3 degrees C; UV spectrum, lambda max of 264.6 nm and specific absorbance in ethanol at 265 nm = 483.6; IR spectrum, same as that of the cholecalciferol Reference Standard (Control 003); optical rotation [alpha]20(D) = 105.1 degrees; thin-layer chromatography, one impurity was detected at 50 micrograms; high-performance liquid chromatography, total amount of impurities estimated to be less than 0.04%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Cholecalciferol Reference Standard (Control 031) of the National Institute of Health Sciences.

  • Ergocalciferol Reference Standard (Control 031) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2003
    Co-Authors: Miho Murakami, Tatsuo Koide, Hiroyuki Saito, Yukiko Morita, T Tanimoto
    Abstract:

    The raw material of ergocalciferol was examined for the preparation of the "Ergocalsiferol Reference Standard (Control 031)", The analytical data obtained were: melting point, 114.5 degrees C; UV spectrum, lambda max of 264.8 nm and specific absorbance in ethanol at 265 nm = 474.7; IR spectrum, same as that of the Ergocalciferol Reference Standard (Control 003); optical rotation, [alpha]20(D) = +104.6 degrees ; thin-layer chromatography, two impurities were detected at 50 micrograms; high-performance liquid chromatography, total amount of impurities estimated to be less than 0.04%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Ergocalciferol Reference Standard (Control 031) of the National Institute of Health Sciences.

  • Tocopherol Succinate Reference Standard (Control 021) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2002
    Co-Authors: Hiroyuki Saito, Tatsuo Koide, Miho Iwata, T Tanimoto
    Abstract:

    The raw material of tocopherol succinate was tested for the preparation of the "Tocopherol Succinate Reference Standard (Control 021)". Analytical data obtained were as follows: infrared spectrum, same as that of the Tocopherol Succinate Reference Standard (Control 981); specific absorbance, E1% 1 cm (286 nm) = 40.7; thin-layer chromatography, no impurities were detected until 50.0 micrograms; high-performance liquid chromatography (HPLC), four impurities were detected and the amount of tocopherol succinate was estimated to be 99.0%; loss on drying, 0.11%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 021).

  • dl-Camphor Reference Standard (Control 961) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 1997
    Co-Authors: A Kitajima, H Komatsu, K Maekawa, K Yoshii, T Tanimoto, Y Tagashira, S Okada
    Abstract:

    The raw material of dl-camphor was examined for the preparation of the "dl-Camphor Reference Standard (Control 961)" of National Institute of Health Sciences. Analytical data obtained are as follows: UV spectrum, lambda max = 290 nm; IR spectrum, the same as that of the present JP Camphor Reference Standard (Control 953); melting point, 179.1 degrees C; purity test by gas-chromatography (GC), three kinds of impurities were detected; assay by GC, 99.8%. Based on the above results, the candidate raw material was authorized as the dl-Camphor Reference standard (Control 961) National Institute of Health Sciences (Japanese Pharmacopoeia).

Maekawa K - One of the best experts on this subject based on the ideXlab platform.

  • Cholecalciferol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of cholecalciferol was examined for the preparation of "Cholecalciferol Reference Standard (Control 001)". Analytical data obtained were: melting point, 83.2 degrees C; UV and infrared spectra, the same as those of JP Cholecalciferol Reference Standard (Control 971), respectively; specific absorbance at 265 nm, E1ca1% = 478; optical rotation, [alpha]D20 = +108.6 degrees; thin-layer chromatography, no impurities were detected until 100 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.05%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Cholecalciferol Reference Standard (Control 001).

  • Alprostadil Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of Alprostadil was examined for the preparation of "Alprostadil Reference Standard (Control 001)". Analytical data obtained were: IR spectrum, same as that of the Alprostadil Reference Standard (Control 923); thin-layer chromatography, no impurities were detected until 20 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.2%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Alprostadil Reference Standard (Control 001).

  • Ergocalciferol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Maekawa K, Tanimoto T, Iwata M, Koide T, Saito H, Okada S
    Abstract:

    The raw material of ergocalciferol was examined for the preparation of "Ergocalciferol Reference Standard (Control 001)". Analytical data obtained were: melting point, 114.8 degrees C; UV and infrared spectra, the same as those of JP Ergocalciferol Reference Standard (Control 971); specific absorbance, E1ca1% = 471(265 nm); optical rotation, [alpha]D20 = +102.4 degrees; thin-layer chromatography, no impurities were detected until 100 micrograms; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.1%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Ergocalciferol Reference Standard (Control 001).

  • Tocopherol Acetate Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2000
    Co-Authors: Iwata M, Maekawa K, Tanimoto T, Koide T, Saito H, Okada S
    Abstract:

    The raw material of tocopherol acetate was examined for the preparation of the "Tocopherol Acetate Reference Standard (Control 001)". Analytical data obtained were: IR spectrum, same as that of the Tocopherol Acetate Reference Standard (Control 974); specific absorbance, E/cm% (284 nm) = 43.7; thin-layer chromatography, no impurities were detected until 50 micrograms of the loaded raw material; high-performance liquid chromatography (HPLC), total amount of impurities estimated to be less than 0.6%; assay by HPLC, 101.7%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 001).

  • Tocopherol Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2000
    Co-Authors: Iwata M, Maekawa K, Tanimoto T, Koide T, Saito H, Okada S
    Abstract:

    The raw material of tocopherol was tested for the preparation of "Tocopherol Reference Standard (Control 991)". Analytical data obtained were: IR spectrum, same as the Tocopherol Reference Standard (Control 941); specific absorbance, E/cm% (292 nm) = 72.9; thin-layer chromatography, no impurities were detected until 50.0 micrograms; high-performance liquid chromatography (HPLC), trace amounts of five impurities were detected and the total amount was estimated to be less than 1.4%; assay by HPLC, 99.9%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Standard (Control 991).

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