The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform
Y. Muraviev - One of the best experts on this subject based on the ideXlab platform.
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FRI0085 Social status of adult patients with childhood onset arthritis
Annals of the Rheumatic Diseases, 2020Co-Authors: N. Muravieva, Y. MuravievAbstract:Background Problems of social rehabilitation of adult patients with childhood onset arthritis are not well studied though very urgent. Objectives To assess social status of adult patients with childhood onset arthritis. Methods Analysis of database of adult patients with childhood onset arthritis. Activity of the disease (according to DAS28), functional class (FC) according Steinbrocker and social status of patients (education, work activity, marital status) were assessed. Results Database contains information on 210 adult patients with childhood onset arthritis: 157 women, 53 men in age from 16-64 (mean 24.6±8.3) years, with disease duration of 16.2±8.7 (1-50) years. Disease activity was found in 85.2% of patients (I – in 127, II – in 43, III – in 9), remission – in 31 (including non-medicamental - in 16 patients). The majority of patients (87.6%) had the II FC, 4 patients move in wheel-chair. Bone fractures were found in 8 patients, Joint Prosthetics – in 20 patients. Two patients have depraved vision on the level of color distinguishing. At present higher education was finished or in the process of continuation by 46 patients, special education was finished or in the process of continuation by 144 patients. Only school education is peculiar to 9.5% of patients. Out of those with full education (110 patients) 73 are working, while 37 patients are in dependence. 52 patients have family (94% - women), 34 patients (91% - women) have children: one – 25, two – 7, three - 1, six -1. Conclusions The majority of adult patients with childhood onset arthritis are socially adapted: 90% have (or continued) education; 66% with full education are working; every 4 th has family, every 6 th has a child. At the same time the third of patients do not work are not getting education and, consequently, need social rehabilitation. References Packham J.C., Hall M.A. Long-term follow-up of 246 adults with juvenile idiopathic arthritis: social function, relationships and sexual activity. Rheumatology, 2002, 41, 1440-1443. Disclosure of Interest None Declared
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AB0228 Arthritis with Childhood Onset in Adult Patients: Long-Term Outcomes and Social Adaptation
Annals of the Rheumatic Diseases, 2016Co-Authors: N. Muravieva, Y. MuravievAbstract:Background Follow-up care and social adaptation issues in adult patients with childhood onset arthritis are highly relevant, as the prognosis and long-term outcomes of the disease are not sufficiently studied. Objectives To assess long-term outcomes and social status of adults with childhood onset arthritis. Methods Establishment of the adult patients with childhood onset arthritis database, covering the period from 2003 year to 2015 year, allowed to analyze the disease activity, the radiographic stage and functional class (using Steinbrocker method ), complications, used pharmacotherapies, as well as social status (education, professional activity, marital status). Results The database includes 235 patients: 176 females, 59 males, mean age 27.7±8.0 years, disease duration 18.1±8.5 years. Persisting arthritis was found in 72% patients. Radiographic stage II was established in 139 patients, stage III – in 49, stage IV – in 47 patients. Functional class II predominates in the majority of patients. The most common disease-modifying anti-rheumatic drug (DMARD) used was methotrexate – in 73% of patients, each 3rd patient was taking sulfasalazine, each 4th - leflunomide, 15% of patients had never used whatever DMARDs. 53 patients were administered biologic drugs: 30 patients received 1, 16 patients – 2, 6 patients – 3, 1 patient received 4 of biologic drugs. Glucocorticoids (GCs) were administered in 55% of patients, more than 60% continue on GCs, including 42 patients using GCs for >10 years. Aseptic bone necrosis (predominantly of femoral head) was reported in 25% of patients. Bone fractures were documented in 8 patients. Joint Prosthetics were required in 23 patients: single Joint – in 9, 2 Joints – in 11, 3 Joints – in 2, 4 Joints - in one patient. Arterial hypertension, requiring medication, was found in 12 patients. Nanism was diagnosed in 27 patients, primary amenorrhea – in 11, secondary amenorrhea – in 2, steroid diabetes – in 2 patients. Light perception visual acuity was documented in 2 patients, poor vision was reported in 3 patients. Amyloidosis was found in 2 cases. At present higher education was finished or in the process of continuation by 49 patients (including 2 patients – in medical institute), special education was finished or in the process of continuation by 169 patients. Only school education has 17 patients. Out of those with full education (127 patients) 85 are working (including 2 rheumatologists and 1 pediatrician), while 42 patients are in dependence. 52 patients have family (93% - women), 36 patients (91% - women) have children: one – 27, two – 7, three – 1, six – 1. Conclusions Only 1/3 of adult patients with childhood onset arthritis have satisfactory long-term clinical outcomes; at the same time the majority of patients are well adapted socially. Disclosure of Interest None declared
N. Muravieva - One of the best experts on this subject based on the ideXlab platform.
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FRI0085 Social status of adult patients with childhood onset arthritis
Annals of the Rheumatic Diseases, 2020Co-Authors: N. Muravieva, Y. MuravievAbstract:Background Problems of social rehabilitation of adult patients with childhood onset arthritis are not well studied though very urgent. Objectives To assess social status of adult patients with childhood onset arthritis. Methods Analysis of database of adult patients with childhood onset arthritis. Activity of the disease (according to DAS28), functional class (FC) according Steinbrocker and social status of patients (education, work activity, marital status) were assessed. Results Database contains information on 210 adult patients with childhood onset arthritis: 157 women, 53 men in age from 16-64 (mean 24.6±8.3) years, with disease duration of 16.2±8.7 (1-50) years. Disease activity was found in 85.2% of patients (I – in 127, II – in 43, III – in 9), remission – in 31 (including non-medicamental - in 16 patients). The majority of patients (87.6%) had the II FC, 4 patients move in wheel-chair. Bone fractures were found in 8 patients, Joint Prosthetics – in 20 patients. Two patients have depraved vision on the level of color distinguishing. At present higher education was finished or in the process of continuation by 46 patients, special education was finished or in the process of continuation by 144 patients. Only school education is peculiar to 9.5% of patients. Out of those with full education (110 patients) 73 are working, while 37 patients are in dependence. 52 patients have family (94% - women), 34 patients (91% - women) have children: one – 25, two – 7, three - 1, six -1. Conclusions The majority of adult patients with childhood onset arthritis are socially adapted: 90% have (or continued) education; 66% with full education are working; every 4 th has family, every 6 th has a child. At the same time the third of patients do not work are not getting education and, consequently, need social rehabilitation. References Packham J.C., Hall M.A. Long-term follow-up of 246 adults with juvenile idiopathic arthritis: social function, relationships and sexual activity. Rheumatology, 2002, 41, 1440-1443. Disclosure of Interest None Declared
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AB0228 Arthritis with Childhood Onset in Adult Patients: Long-Term Outcomes and Social Adaptation
Annals of the Rheumatic Diseases, 2016Co-Authors: N. Muravieva, Y. MuravievAbstract:Background Follow-up care and social adaptation issues in adult patients with childhood onset arthritis are highly relevant, as the prognosis and long-term outcomes of the disease are not sufficiently studied. Objectives To assess long-term outcomes and social status of adults with childhood onset arthritis. Methods Establishment of the adult patients with childhood onset arthritis database, covering the period from 2003 year to 2015 year, allowed to analyze the disease activity, the radiographic stage and functional class (using Steinbrocker method ), complications, used pharmacotherapies, as well as social status (education, professional activity, marital status). Results The database includes 235 patients: 176 females, 59 males, mean age 27.7±8.0 years, disease duration 18.1±8.5 years. Persisting arthritis was found in 72% patients. Radiographic stage II was established in 139 patients, stage III – in 49, stage IV – in 47 patients. Functional class II predominates in the majority of patients. The most common disease-modifying anti-rheumatic drug (DMARD) used was methotrexate – in 73% of patients, each 3rd patient was taking sulfasalazine, each 4th - leflunomide, 15% of patients had never used whatever DMARDs. 53 patients were administered biologic drugs: 30 patients received 1, 16 patients – 2, 6 patients – 3, 1 patient received 4 of biologic drugs. Glucocorticoids (GCs) were administered in 55% of patients, more than 60% continue on GCs, including 42 patients using GCs for >10 years. Aseptic bone necrosis (predominantly of femoral head) was reported in 25% of patients. Bone fractures were documented in 8 patients. Joint Prosthetics were required in 23 patients: single Joint – in 9, 2 Joints – in 11, 3 Joints – in 2, 4 Joints - in one patient. Arterial hypertension, requiring medication, was found in 12 patients. Nanism was diagnosed in 27 patients, primary amenorrhea – in 11, secondary amenorrhea – in 2, steroid diabetes – in 2 patients. Light perception visual acuity was documented in 2 patients, poor vision was reported in 3 patients. Amyloidosis was found in 2 cases. At present higher education was finished or in the process of continuation by 49 patients (including 2 patients – in medical institute), special education was finished or in the process of continuation by 169 patients. Only school education has 17 patients. Out of those with full education (127 patients) 85 are working (including 2 rheumatologists and 1 pediatrician), while 42 patients are in dependence. 52 patients have family (93% - women), 36 patients (91% - women) have children: one – 27, two – 7, three – 1, six – 1. Conclusions Only 1/3 of adult patients with childhood onset arthritis have satisfactory long-term clinical outcomes; at the same time the majority of patients are well adapted socially. Disclosure of Interest None declared
Piotr Kowalczyk - One of the best experts on this subject based on the ideXlab platform.
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Influence of Bone Anisotropy on Stress Distribution and Optimum Shape of Cementless Femoral Implants
Engineering Transactions, 2020Co-Authors: Piotr KowalczykAbstract:Implant separation from bone tissue, resulting in the necessity for revision surgery, is a serious drawback of cement less total Joint replacement. Unnatural stress distribution around the implant is considered the main reason for the failure. Optimization of the implant properties, especially its geometric parameters, is believed to be the right way to improve reliability of Joint Prosthetics. Numerical models of femur-implant system enabling approximate analysis of stress distribution and shape optimization of implants suffer from numerous simplifications as, e.g., the assumption of bone isotropy, which may put in question reliability of the results obtained. In this paper, a numerical model including orthotropic properties of both cancellous and cortical bone is presented and influence of this assumption on results of the analysis and optimization is investigated.
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Design optimization of cementless femoral hip prostheses using finite element analysis.
Journal of Biomechanical Engineering-transactions of The Asme, 2001Co-Authors: Piotr KowalczykAbstract:Implant separation from bone tissue, resulting in the necessity for revision surgery, is a serious drawback of cementless total Joint replacement. Unnatural stress distribution around the implant is considered the main reason for the failure. Optimization of the implant properties, especially its geometric parameters, is believed to be the right way to improve reliability of Joint Prosthetics. An efficient numerical model of the femur-implant system is presented in the paper including the finite element formulation featuring computation of sensitivity gradients, parametric mesh generator, and a gradient-based optimization scheme. Numerical examples show results of shape optimization of an implant for two sets of design parameters and for the initial stability criterion taken as the optimization goal. The optimum shape appears to be relatively long and proximally porous-coated on about half of its length. The method can be flexibly adjusted to various implant types, stress- and displacement-based optimum criteria, and geometric design parameters.
A D Kalashnik - One of the best experts on this subject based on the ideXlab platform.
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Joint Prosthetics using carbon implants
Vestnik Rossiĭskoĭ akademii meditsinskikh nauk Rossiĭskaia akademiia meditsinskikh nauk, 1992Co-Authors: G S Iumashev, L L Silin, S B Brovkin, I N Lavrov, A D KalashnikAbstract:: A group of "Intost" materials based on carbon were developed by the I. M. Sechenov Moscow Medical Academy Jointly with the Research Institute of Graphite. After experimental studies the materials were authorized for use in clinical practice for implantation. A concept of the design of endoprostheses of the Joints from "Intost" was developed, on the basis of which unipolar combined endoprostheses of the hip Joint (127 cases), metatarsophalangeal articulation (27 cases), humeral and metacarpophalangeal articulations (two cases each), and condyles of the tibia (5 cases) were made and applied in clinical practice. A detailed analysis is given of ten years of experience gained with the use of the combined unipolar endoprosthesis of the hip Joint manufactured from "Intost-1" and "Intost-3". Long-term beneficial results were obtained in 95% of patients. Endoprosthesis is recommended for the treatment of fractures and false Joints of the neck of the femur in elderly and senile patients.
S. Monecke - One of the best experts on this subject based on the ideXlab platform.
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Molecular fingerprinting of Staphylococcus aureus from bone and Joint infections
European Journal of Clinical Microbiology & Infectious Diseases, 2010Co-Authors: C. Luedicke, P. Slickers, R. Ehricht, S. MoneckeAbstract:The objective of the study was to determine if a clonal complex (CC) of Staphylococcus aureus or certain virulence and adhesion factors were associated with infections of bones and prosthetic implants. One hundred and nineteen isolates were characterised using microarrays. There was no evidence for a single virulence factor or CC being causative for bone and implant infections. Isolates belonged to 20 different CCs, with CC8 (19.33%), CC45 (17.65%) and CC30 (12.61%) being dominant. Population structure and the relative abundances of virulence genes was similar to previously described isolates from healthy carriers. Differences to carrier isolates included a higher proportion of CC45, a lower proportion of CC15, as well as a higher abundance of sak (staphylokinase) among patient isolates. For 23 patients with infections of total knee or hip Prosthetics, it was possible to simultaneously obtain nasal swabs. Fifteen (65.2%) carried S. aureus in their anterior nares. In nine of them (39.1%), isolates from the infection site were identical to carriage isolates. This suggests an elevated risk of infection for S. aureus carriers and the possibility of endogenous infection in a high proportion of them. Therefore, the pre-operative screening and eradication of S. aureus in patients receiving total Joint Prosthetics should be considered.
