The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
Cesar Chian - One of the best experts on this subject based on the ideXlab platform.
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acral Junctional Nevus versus acral lentiginous melanoma in situ a differential diagnosis that should be based on clinicopathologic correlation
Archives of Pathology & Laboratory Medicine, 2011Co-Authors: Francisco Bravo Puccio, Cesar ChianAbstract:Abstract Context.—Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and deceive pathologists dealing with such cases. Objectives.—To make pathologists aware of the histologic findings during early phases of acral lentiginous melanoma (including the in situ phase), to compare those findings with what is seen in acral Junctional Nevus, and to highlight their similarities and differences. This review will also emphasize the important clinical and dermatoscopic findings to be considered when diagnosing acral lentiginous melanoma. Data Sources.—Review of published articles on the epidemiology; the clinical, dermatoscopic, and histopathologic findings; and the molecular biology of acral lentiginous melanoma as well as the personal experience of the authors when dealing with such...
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Acral Junctional Nevus Versus Acral Lentiginous Melanoma In Situ: A Differential Diagnosis That Should Be Based on Clinicopathologic Correlation
Archives of Pathology & Laboratory Medicine, 2011Co-Authors: Francisco Bravo Puccio, Cesar ChianAbstract:Abstract Context.—Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and deceive pathologists dealing with such cases. Objectives.—To make pathologists aware of the histologic findings during early phases of acral lentiginous melanoma (including the in situ phase), to compare those findings with what is seen in acral Junctional Nevus, and to highlight their similarities and differences. This review will also emphasize the important clinical and dermatoscopic findings to be considered when diagnosing acral lentiginous melanoma. Data Sources.—Review of published articles on the epidemiology; the clinical, dermatoscopic, and histopathologic findings; and the molecular biology of acral lentiginous melanoma as well as the personal experience of the authors when dealing with such cases. Conclusions.—Acral lentiginous melanoma is a clinicopathologic entity with a clear-cut clinical picture: a diameter larger than 0.7 mm; ill-defined, darkly pigmented, flat lesion with irregular borders on acral locations; and the presence of mostly single-cell proliferations of melanocytes along the dermo-epidermal junction. Along with a few additional criteria, these findings should be sufficient to allow the pathologist to make the diagnosis and to recommend complete excision. Fluent communication between clinician and pathologist will facilitate a correct diagnosis.
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Acral Junctional Nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation.
Archives of pathology & laboratory medicine, 2011Co-Authors: Francisco Bravo Puccio, Cesar ChianAbstract:Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and deceive pathologists dealing with such cases. To make pathologists aware of the histologic findings during early phases of acral lentiginous melanoma (including the in situ phase), to compare those findings with what is seen in acral Junctional Nevus, and to highlight their similarities and differences. This review will also emphasize the important clinical and dermatoscopic findings to be considered when diagnosing acral lentiginous melanoma. Review of published articles on the epidemiology; the clinical, dermatoscopic, and histopathologic findings; and the molecular biology of acral lentiginous melanoma as well as the personal experience of the authors when dealing with such cases. Acral lentiginous melanoma is a clinicopathologic entity with a clear-cut clinical picture: a diameter larger than 0.7 mm; ill-defined, darkly pigmented, flat lesion with irregular borders on acral locations; and the presence of mostly single-cell proliferations of melanocytes along the dermo-epidermal junction. Along with a few additional criteria, these findings should be sufficient to allow the pathologist to make the diagnosis and to recommend complete excision. Fluent communication between clinician and pathologist will facilitate a correct diagnosis.
Francisco Bravo Puccio - One of the best experts on this subject based on the ideXlab platform.
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acral Junctional Nevus versus acral lentiginous melanoma in situ a differential diagnosis that should be based on clinicopathologic correlation
Archives of Pathology & Laboratory Medicine, 2011Co-Authors: Francisco Bravo Puccio, Cesar ChianAbstract:Abstract Context.—Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and deceive pathologists dealing with such cases. Objectives.—To make pathologists aware of the histologic findings during early phases of acral lentiginous melanoma (including the in situ phase), to compare those findings with what is seen in acral Junctional Nevus, and to highlight their similarities and differences. This review will also emphasize the important clinical and dermatoscopic findings to be considered when diagnosing acral lentiginous melanoma. Data Sources.—Review of published articles on the epidemiology; the clinical, dermatoscopic, and histopathologic findings; and the molecular biology of acral lentiginous melanoma as well as the personal experience of the authors when dealing with such...
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Acral Junctional Nevus Versus Acral Lentiginous Melanoma In Situ: A Differential Diagnosis That Should Be Based on Clinicopathologic Correlation
Archives of Pathology & Laboratory Medicine, 2011Co-Authors: Francisco Bravo Puccio, Cesar ChianAbstract:Abstract Context.—Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and deceive pathologists dealing with such cases. Objectives.—To make pathologists aware of the histologic findings during early phases of acral lentiginous melanoma (including the in situ phase), to compare those findings with what is seen in acral Junctional Nevus, and to highlight their similarities and differences. This review will also emphasize the important clinical and dermatoscopic findings to be considered when diagnosing acral lentiginous melanoma. Data Sources.—Review of published articles on the epidemiology; the clinical, dermatoscopic, and histopathologic findings; and the molecular biology of acral lentiginous melanoma as well as the personal experience of the authors when dealing with such cases. Conclusions.—Acral lentiginous melanoma is a clinicopathologic entity with a clear-cut clinical picture: a diameter larger than 0.7 mm; ill-defined, darkly pigmented, flat lesion with irregular borders on acral locations; and the presence of mostly single-cell proliferations of melanocytes along the dermo-epidermal junction. Along with a few additional criteria, these findings should be sufficient to allow the pathologist to make the diagnosis and to recommend complete excision. Fluent communication between clinician and pathologist will facilitate a correct diagnosis.
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Acral Junctional Nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation.
Archives of pathology & laboratory medicine, 2011Co-Authors: Francisco Bravo Puccio, Cesar ChianAbstract:Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and deceive pathologists dealing with such cases. To make pathologists aware of the histologic findings during early phases of acral lentiginous melanoma (including the in situ phase), to compare those findings with what is seen in acral Junctional Nevus, and to highlight their similarities and differences. This review will also emphasize the important clinical and dermatoscopic findings to be considered when diagnosing acral lentiginous melanoma. Review of published articles on the epidemiology; the clinical, dermatoscopic, and histopathologic findings; and the molecular biology of acral lentiginous melanoma as well as the personal experience of the authors when dealing with such cases. Acral lentiginous melanoma is a clinicopathologic entity with a clear-cut clinical picture: a diameter larger than 0.7 mm; ill-defined, darkly pigmented, flat lesion with irregular borders on acral locations; and the presence of mostly single-cell proliferations of melanocytes along the dermo-epidermal junction. Along with a few additional criteria, these findings should be sufficient to allow the pathologist to make the diagnosis and to recommend complete excision. Fluent communication between clinician and pathologist will facilitate a correct diagnosis.
Giuseppe Argenziano - One of the best experts on this subject based on the ideXlab platform.
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Flat pigmented macules on sun-damaged skin of the head/neck: Junctional Nevus, atypical lentiginous Nevus, or melanoma in situ?
Clinics in dermatology, 2014Co-Authors: Iris Zalaudek, Carlo Cota, Gerardo Ferrara, Elvira Moscarella, Pascale Guitera, Caterina Longo, Simonetta Piana, Giuseppe ArgenzianoAbstract:The clinical recognition of lentigo maligna (LM) in the mottled chronic sun-damaged skin can be challenging, because it shares many clinical features with other pigmented macules that commonly arise on sun-damaged skin. These include solar lentigo, flat seborrheic keratosis, and pigmented actinic keratosis, but almost never "Nevus." The reason Nevus is not included in the differential diagnosis of LM can be explained by the fact that the stereotypical appearance of a facial Nevus differs remarkably from that of an LM. Facial nevi in adults are usually nodular, dome-shaped, well-defined, and hypopigmented (i.e., intradermal Nevus of the Miescher type), whereas LM typically appears as a flat, ill-defined, and pigmented macule. Although this concept based on clinical observations sounds reasonable, clinicians apply it often only unconsciously and accept a given histopathologic diagnosis of a "Junctional or lentiginous Nevus" of a flat pigmented facial macule without the necessary criticism about its clinicopathologic validity.
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flat pigmented macules on sun damaged skin of the head neck Junctional Nevus atypical lentiginous Nevus or melanoma in situ
Clinics in Dermatology, 2014Co-Authors: Iris Zalaudek, Carlo Cota, Gerardo Ferrara, Elvira Moscarella, Pascale Guitera, Caterina Longo, Simonetta Piana, Giuseppe ArgenzianoAbstract:The clinical recognition of lentigo maligna (LM) in the mottled chronic sun-damaged skin can be challenging, because it shares many clinical features with other pigmented macules that commonly arise on sun-damaged skin. These include solar lentigo, flat seborrheic keratosis, and pigmented actinic keratosis, but almost never "Nevus." The reason Nevus is not included in the differential diagnosis of LM can be explained by the fact that the stereotypical appearance of a facial Nevus differs remarkably from that of an LM. Facial nevi in adults are usually nodular, dome-shaped, well-defined, and hypopigmented (i.e., intradermal Nevus of the Miescher type), whereas LM typically appears as a flat, ill-defined, and pigmented macule. Although this concept based on clinical observations sounds reasonable, clinicians apply it often only unconsciously and accept a given histopathologic diagnosis of a "Junctional or lentiginous Nevus" of a flat pigmented facial macule without the necessary criticism about its clinicopathologic validity.
Martin C Mihm - One of the best experts on this subject based on the ideXlab platform.
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Lentigo, Other Melanosis, and the Acquired Nevus
Melanocytic Lesions, 2014Co-Authors: Mai P. Hoang, Martin C MihmAbstract:In this chapter, benign pigmented lesions associated with increased melanin pigment in basal keratinocytes and mild increase in the number of melanocytes such as lentigo, psoralen and ultraviolet A lentigo, solar lentigo, cafe au lait macule, ink-spot lentigo, mucosal melanotic macule, vulvar melanosis, and Nevus spilus/speckled lentiginous Nevus are discussed. In addition, the common acquired nevi are a phenomenon of the epidermis and papillary dermis, and they can present as Junctional Nevus, compound Nevus, and dermal Nevus.
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Lentiginous melanoma: a histologic pattern of melanoma to be distinguished from lentiginous Nevus
Modern Pathology, 2005Co-Authors: Roy King, Paul B Googe, Robert N Page, Martin C MihmAbstract:Atypical lentiginous melanocytic proliferations in elderly patients continue to pose a diagnostic dilemma with lesions variably categorized as dysplastic Nevus, atypical Junctional Nevus, melanoma in situ (early or evolving) and premalignant melanosis. We present pigmented lesions from 16 patients (seven male and nine female) and with the exception of one case, all were older than 50 years of age. The anatomical sites included trunk (7), head and neck (6) and upper extremity (3). The clinical diagnosis was variable and included lentigo maligna, atypical Nevus, pigmented basal cell carcinoma, seborrheic keratosis and lentigo. The initial biopsies mimicked lentiginous Nevus or dysplastic Nevus and were characterized by a lentiginous proliferation of melanocytes at the dermoepidermal junction both as single cells and as small nests with areas of confluent growth, extending to the edges of the biopsy. The retiform epidermis was maintained and pagetoid spread of melanocytes was not prominent in hematoxylin- and eosin- stained sections. Dermal fibrosis was variably present and the melanocytic proliferation demonstrated cytological atypia. The subsequent re-excisions demonstrated similar atypical melanocytic proliferation occurring over a broad area flanking the prior biopsy sites. The diagnosis of melanoma was more easily recognized in the complete excision specimens. Immunohistochemical stains for Mitf and Mart-1 highlighted the extent of the basalar melanocytic proliferation as well as foci of pagetoid spread by melanocytes. Familiarity with this pattern of early melanoma should facilitate proper classification of lentiginous melanocytic proliferations in biopsies from older adults.
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Melanocytic lesions associated with dermatofibromas: a spectrum of lesions ranging from Junctional Nevus to malignant melanoma in situ
Modern Pathology, 2005Co-Authors: Roy King, Paul B Googe, Robert N Page, Martin C MihmAbstract:Dermatofibromas are common lesions that are often associated with epidermal hyperplasia and basal layer hyperpigmentation. A single case of lentiginous melanocytic hyperplasia overlying a dermatofibroma has been reported, however, nevi and melanoma have to the best of our knowledge, not been previously reported. We present 14 cases of melanocytic lesions associated with dermatofibromas. The clinical data and hematoxylin- and eosin- stained sections were obtained and formalin-fixed, paraffin-embedded tissue was immunostained with antibodies against S-100, Mart-1, Factor XIIIa, and CD117. There were nine females and five males ranging in age from 30 to 64 years and anatomic sites included back (five), arm (six), flank (two), and leg (one). The clinical diagnosis ranged from dermatofibroma to desmoplastic melanoma. Histologically, the melanocytic lesions included Junctional, compound, and dermal nevi, and malignant melanoma in situ . In four cases the dermal component appeared to merge with the dermatofibroma. In the case of the melanoma in situ , the dermatofibroma abutted the epidermis. Immunohistochemically, the melanocytic lesions were S-100/ Mart-1+, FXIIIa-, and the dermatofibromas were S-100/Mart-1−, FXIIIa+. Melanocytic neoplasia may appear in association with dermatofibromas. The fibrohistiocytic proliferation may be misinterpreted as a spindle or pleomorphic melanocytic process. Awareness of this association will aid in the correct diagnosis, and immunohistochemical studies will help in the differentiation of these two cell populations.
Iris Zalaudek - One of the best experts on this subject based on the ideXlab platform.
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Flat pigmented macules on sun-damaged skin of the head/neck: Junctional Nevus, atypical lentiginous Nevus, or melanoma in situ?
Clinics in dermatology, 2014Co-Authors: Iris Zalaudek, Carlo Cota, Gerardo Ferrara, Elvira Moscarella, Pascale Guitera, Caterina Longo, Simonetta Piana, Giuseppe ArgenzianoAbstract:The clinical recognition of lentigo maligna (LM) in the mottled chronic sun-damaged skin can be challenging, because it shares many clinical features with other pigmented macules that commonly arise on sun-damaged skin. These include solar lentigo, flat seborrheic keratosis, and pigmented actinic keratosis, but almost never "Nevus." The reason Nevus is not included in the differential diagnosis of LM can be explained by the fact that the stereotypical appearance of a facial Nevus differs remarkably from that of an LM. Facial nevi in adults are usually nodular, dome-shaped, well-defined, and hypopigmented (i.e., intradermal Nevus of the Miescher type), whereas LM typically appears as a flat, ill-defined, and pigmented macule. Although this concept based on clinical observations sounds reasonable, clinicians apply it often only unconsciously and accept a given histopathologic diagnosis of a "Junctional or lentiginous Nevus" of a flat pigmented facial macule without the necessary criticism about its clinicopathologic validity.
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flat pigmented macules on sun damaged skin of the head neck Junctional Nevus atypical lentiginous Nevus or melanoma in situ
Clinics in Dermatology, 2014Co-Authors: Iris Zalaudek, Carlo Cota, Gerardo Ferrara, Elvira Moscarella, Pascale Guitera, Caterina Longo, Simonetta Piana, Giuseppe ArgenzianoAbstract:The clinical recognition of lentigo maligna (LM) in the mottled chronic sun-damaged skin can be challenging, because it shares many clinical features with other pigmented macules that commonly arise on sun-damaged skin. These include solar lentigo, flat seborrheic keratosis, and pigmented actinic keratosis, but almost never "Nevus." The reason Nevus is not included in the differential diagnosis of LM can be explained by the fact that the stereotypical appearance of a facial Nevus differs remarkably from that of an LM. Facial nevi in adults are usually nodular, dome-shaped, well-defined, and hypopigmented (i.e., intradermal Nevus of the Miescher type), whereas LM typically appears as a flat, ill-defined, and pigmented macule. Although this concept based on clinical observations sounds reasonable, clinicians apply it often only unconsciously and accept a given histopathologic diagnosis of a "Junctional or lentiginous Nevus" of a flat pigmented facial macule without the necessary criticism about its clinicopathologic validity.
