The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
R. González-pérez - One of the best experts on this subject based on the ideXlab platform.
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Squamous Cell Carcinoma on Seborrheic Keratosis
Actas Dermo-Sifiliográficas, 2009Co-Authors: L. Carnero, R. Soloeta, N. Arbideb, R. González-pérezAbstract:To the Editor: Seborrheic Keratosis is one of the most common benign epidermal tumors in dermatologic clinical practice. Although the association between Seborrheic Keratosis and other skin tumors was first reported in 1932, its malignant transformation is very rare, with less than 20 published cases. We present the case of a patient with Seborrheic Keratosis that underwent transformation into an invasive squamous cell carcinoma. The patient was a 94-year-old woman who was seen in our outpatient clinic for a tumor on the abdomen that had been present for 30 years and that had increased in size over a period of months, causing pain and bleeding. On physical examination, a Seborrheic Keratosis with a maximum diameter of 12 cm was observed. On this lesion there were several hemorrhagic, lobulated tumors (Figure 1). Complete excision of the lesion was performed, with closure by tissue planes and primary suture under local anesthesia. Microscopic examination revealed different histological patterns within the same lesion (Figures 2 and 3), with images characteristic of ulcerated Seborrheic Keratosis, areas of transition between Seborrheic Keratosis and Bowen disease, and zones where Bowen disease infiltrated the dermis (invasive squamous cell carcinoma). The histological diagnosis was of invasive squamous cell carcinoma on Seborrheic Keratosis. Genotyping for human papillomavirus (HPV) was positive for type 59 in 1 of the 4 blocks sent. The patient remains disease-free after 1 year of follow-up in our clinic. Seborrheic Keratosis is rarely associated with other skin neoplasms such as basal cell or squamous cell carcinoma, Bowen disease, keratoacanthoma, or melanomas; in these cases it is most common to find that the lesion is adjacent to or contiguous with the other tumor.2,3 Malignant degeneration of Seborrheic Keratosis is very rare4 and, when this occurs, it usually develops as Bowen disease and
Giuseppe Argenziano - One of the best experts on this subject based on the ideXlab platform.
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clonal Seborrheic Keratosis dermoscopic and confocal microscopy characterization
Journal of The European Academy of Dermatology and Venereology, 2014Co-Authors: Caterina Longo, Iris Zalaudek, E Moscarella, A Lallas, Simonetta Piana, Giovanni Pellacani, Giuseppe ArgenzianoAbstract:Background The diagnosis of clonal Seborrheic Keratosis may be challenging clinically and histologically. Objective In our study, we describe the common aspects of this benign entity that show peculiar dermoscopic and confocal findings. Methods A total of nine clonal Seborrheic Keratosis were analyzed. Results Upon dermoscopy, it reveals the presence of globular-like structures and sharply demarcated borders whereas confocal microscopy displays the typical intraepidermal nesting of pigmented keratinocytes that permits to have a reliable in vivo diagnosis. Conclusions Dermoscopy and confocal microscopy permit to in vivo diagnose this variant of Seborrheic Keratosis.
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Clonal Seborrheic Keratosis: a dermoscopic pitfall.
Archives of dermatology, 2004Co-Authors: Iris Zalaudek, Gerardo Ferrara, Giuseppe ArgenzianoAbstract:We congratulate Hirata and coworkers for their report on the dermoscopic features of 2 cases of clonal Seborrheic Keratosis.We would like to add some comments based on our observation of a pigmented clonal Seborrheic Keratosis on the leg of a 72- year-old woman.
Per Westermark - One of the best experts on this subject based on the ideXlab platform.
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Amyloid in basal cell carcinoma and Seborrheic Keratosis.
Acta dermato-venereologica, 1994Co-Authors: Karen Ege Olsen, Per WestermarkAbstract:The frequency of amyloid substance was studied in two different types of skin tumours: basal cell carcinoma and Seborrheic Keratosis. In 9 out of 49 cases of Seborrheic Keratosis amyloid substance was found. In the basal cell carcinomas, 194 out of 260 cases showed amyloid deposits, a rate that is higher than that previously reported. The basal cell carcinoma material was further studied regarding the amount of amyloid, mitotic rate, degree of apoptosis and the age of the patients. There was no correlation between the amount of amyloid and the mitotic rate, or the degree of apoptosis. There was a slightly higher incidence of amyloid-positive cases among elderly patients.
L. Carnero - One of the best experts on this subject based on the ideXlab platform.
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Squamous Cell Carcinoma on Seborrheic Keratosis
Actas Dermo-Sifiliográficas, 2009Co-Authors: L. Carnero, R. Soloeta, N. Arbideb, R. González-pérezAbstract:To the Editor: Seborrheic Keratosis is one of the most common benign epidermal tumors in dermatologic clinical practice. Although the association between Seborrheic Keratosis and other skin tumors was first reported in 1932, its malignant transformation is very rare, with less than 20 published cases. We present the case of a patient with Seborrheic Keratosis that underwent transformation into an invasive squamous cell carcinoma. The patient was a 94-year-old woman who was seen in our outpatient clinic for a tumor on the abdomen that had been present for 30 years and that had increased in size over a period of months, causing pain and bleeding. On physical examination, a Seborrheic Keratosis with a maximum diameter of 12 cm was observed. On this lesion there were several hemorrhagic, lobulated tumors (Figure 1). Complete excision of the lesion was performed, with closure by tissue planes and primary suture under local anesthesia. Microscopic examination revealed different histological patterns within the same lesion (Figures 2 and 3), with images characteristic of ulcerated Seborrheic Keratosis, areas of transition between Seborrheic Keratosis and Bowen disease, and zones where Bowen disease infiltrated the dermis (invasive squamous cell carcinoma). The histological diagnosis was of invasive squamous cell carcinoma on Seborrheic Keratosis. Genotyping for human papillomavirus (HPV) was positive for type 59 in 1 of the 4 blocks sent. The patient remains disease-free after 1 year of follow-up in our clinic. Seborrheic Keratosis is rarely associated with other skin neoplasms such as basal cell or squamous cell carcinoma, Bowen disease, keratoacanthoma, or melanomas; in these cases it is most common to find that the lesion is adjacent to or contiguous with the other tumor.2,3 Malignant degeneration of Seborrheic Keratosis is very rare4 and, when this occurs, it usually develops as Bowen disease and
Karel Pizinger - One of the best experts on this subject based on the ideXlab platform.
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Regression of Seborrheic Keratosis in a dermoscopic follow-up series.
Journal of the American Academy of Dermatology, 2015Co-Authors: Tomas Fikrle, Karel PizingerAbstract:DERMOSCOPIC APPEARANCE The original dermoscopic examination clearly suggests Seborrheic Keratosis with pseudofollicular openings and horny pseudocysts (Fig 2, A). The two follow-up images beautifully capture the regression of the previous lesion (see Fig 2, B and C ). The diagnosis of Seborrheic Keratosis is still easily recognizable in the second image. Based on the last image with granular gray pigmentation, the exclusion of lentigo maligna is almost impossible; no dermoscopic structures typical for Seborrheic Keratosis are visible at this time.
