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Sundrarajan Mahalingam - One of the best experts on this subject based on the ideXlab platform.
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Biogenic approach for the synthesis of Ag-Au doped RuO2 nanoparticles in BMIM-PF6 ionic liquid medium: Structural characterization and its biocidal activity against pathogenic bacteria and HeLa cancerous cells
Journal of Molecular Liquids, 2020Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Mayakrishnan Arumugam, Sundrarajan MahalingamAbstract:Abstract In the present work, we focused on the eco-friendly and greener approach to the synthesis of silver–gold/ruthenium oxide (Ag-Au/RuO2) nanoparticles (NPs) using ethanolic leaf extracts of Justicia adhatoda with ionic liquid (IL) by the hydrothermal method. The 1-butyl-3-methylimidazolium hexafluorophosphate IL was used to control the particle growth during the synthesis of nanoparticles (NPs). The Justicia adhatoda leaves extracts contains vasicinone and N, N-Dimethylglycine which behaves capping and reducing agent. The synthesized NPs were characterized by different physicochemical analysis to confirm its formation. The average crystallite size of Ag-Au/RuO2 NP is 24 nm, as found from the X-ray diffraction results. Fourier transform infrared spectrum confirmed the Ru O peak at the range of 476 cm−1. The optical band gap of Ag-Au/RuO2 NP is 2.98 eV, it is confirmed by ultraviolet- diffuse reflectance spectrum result. SEM analysis of Ag-Au/RuO2 nanoparticle has a spherical like the structure of surface morphology. Energy-dispersive X-ray spectroscopy showed the composition of ruthenium, silver, gold, and oxygen present in the synthesized NPs. Ag–Au/RuO2 NPs revealed outstanding antibacterial activity against Escherichia coli and Staphylococcus aureus microbes. Furthermore, Ag–Au/RuO2 NPs exposed good anticancer properties against HeLa cancerous cell line. From the above results suggested Ag–Au/RuO2 NPs can be used in various applications in the biomedical field.
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facile biological synthetic strategy to morphologically aligned ceo2 zro2 core nanoparticles using Justicia adhatoda extract and ionic liquid enhancement of its bio medical properties
Journal of Photochemistry and Photobiology B-biology, 2018Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan MahalingamAbstract:In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size. GC-MS spectroscopy confirms the presence of vasicinone and N,N-Dimethylglycine present in the plant extract, which are capable of converting the corresponding metal ion precursor to CeO2/ZrO2 core metal oxide nanoparticles. In FTIR, the corresponding stretching for Ce-O and Zr-O bands indicated at 498 and 416cm-1 and Raman spectroscopy also supports typical stretching frequencies at 463 and 160cm-1. Band gap energy of the CeO2/ZrO2 core metal oxide is 3.37eV calculated from UV- DRS spectroscopy. The anti-bacterial studies performed against a set of bacterial strains the result showed that core metal oxide nanoparticles more susceptible to gram-positive (G+) bacteria than gram-negative (G-) bacteria. A unique feature of the antioxidant behaviors core metal oxides reduces the concentration of DPPH radical up to 89%. The CeO2/ZrO2 core metal oxide nanoparticles control the S. marcescent bio-film formation and restrict the quorum sensing. The toxicology behavior of CeO2/ZrO2 core metal oxide NPs is found due to the high oxygen site vacancies, ROS formation, smallest particle size and higher surface area. This type of green synthesis route may efficient and the core metal oxide nanoparticles will possess a good bio-medical agent in future.
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Facile biological synthetic strategy to morphologically aligned CeO2/ZrO2 core nanoparticles using Justicia adhatoda extract and ionic liquid: Enhancement of its bio-medical properties.
Journal of photochemistry and photobiology. B Biology, 2017Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan MahalingamAbstract:In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size. GC-MS spectroscopy confirms the presence of vasicinone and N,N-Dimethylglycine present in the plant extract, which are capable of converting the corresponding metal ion precursor to CeO2/ZrO2 core metal oxide nanoparticles. In FTIR, the corresponding stretching for Ce-O and Zr-O bands indicated at 498 and 416cm-1 and Raman spectroscopy also supports typical stretching frequencies at 463 and 160cm-1. Band gap energy of the CeO2/ZrO2 core metal oxide is 3.37eV calculated from UV- DRS spectroscopy. The anti-bacterial studies performed against a set of bacterial strains the result showed that core metal oxide nanoparticles more susceptible to gram-positive (G+) bacteria than gram-negative (G-) bacteria. A unique feature of the antioxidant behaviors core metal oxides reduces the concentration of DPPH radical up to 89%. The CeO2/ZrO2 core metal oxide nanoparticles control the S. marcescent bio-film formation and restrict the quorum sensing. The toxicology behavior of CeO2/ZrO2 core metal oxide NPs is found due to the high oxygen site vacancies, ROS formation, smallest particle size and higher surface area. This type of green synthesis route may efficient and the core metal oxide nanoparticles will possess a good bio-medical agent in future.
B. S. Sharath - One of the best experts on this subject based on the ideXlab platform.
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Cytotoxicity of zinc nanoparticles fabricated by Justicia adhatoda L. on root tips of Allium cepa L.—a model approach
Environmental science and pollution research international, 2015Co-Authors: Tarikere C. Taranath, Bheemanagouda N. Patil, T. U. Santosh, B. S. SharathAbstract:Zinc nanoparticles were synthesized using aqueous leaf extract of Justicia adhatoda L. The characterization of nanoparticles was done by ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), and high-resolution transmission electron microscopy (HR-TEM). The characteristic absorption peak of the UV spectrum was recorded at 379 nm. The FTIR data revealed the possible biomolecules involved in bioreduction and capping of zinc nanoparticles for efficient stabilization. AFM and HR-TEM images have shown that the size of zinc nanoparticles ranges from 55 to 83 nm and they are spherical in shape. The biogenic zinc nanoparticles were evaluated for their toxic effect on mitotic chromosomes of Allium cepa as a model system. Experiments were conducted in triplicate to assay the effect of 25, 50, 75, and 100 % of zinc nanoparticles on mitotic chromosomes at an interval of 6 h duration for 24 h. The investigation revealed that the mitotic index (MI) was decreased with increased concentration of zinc nanoparticles and exposure duration. The results revealed that zinc nanoparticles have induced abnormalities like anaphase bridge formation, diagonal anaphase, C-metaphase, sticky metaphase, laggards, and sticky anaphase at different percentages and times of exposure. It is evident from the observation that mitotic cell division becomes abortive at 100 % treatment of zinc nanoparticles.
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cytotoxicity of zinc nanoparticles fabricated by Justicia adhatoda l on root tips of allium cepa l a model approach
Environmental Science and Pollution Research, 2015Co-Authors: Tarikere C. Taranath, Bheemanagouda N. Patil, T. U. Santosh, B. S. SharathAbstract:Zinc nanoparticles were synthesized using aqueous leaf extract of Justicia adhatoda L. The characterization of nanoparticles was done by ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), and high-resolution transmission electron microscopy (HR-TEM). The characteristic absorption peak of the UV spectrum was recorded at 379 nm. The FTIR data revealed the possible biomolecules involved in bioreduction and capping of zinc nanoparticles for efficient stabilization. AFM and HR-TEM images have shown that the size of zinc nanoparticles ranges from 55 to 83 nm and they are spherical in shape. The biogenic zinc nanoparticles were evaluated for their toxic effect on mitotic chromosomes of Allium cepa as a model system. Experiments were conducted in triplicate to assay the effect of 25, 50, 75, and 100 % of zinc nanoparticles on mitotic chromosomes at an interval of 6 h duration for 24 h. The investigation revealed that the mitotic index (MI) was decreased with increased concentration of zinc nanoparticles and exposure duration. The results revealed that zinc nanoparticles have induced abnormalities like anaphase bridge formation, diagonal anaphase, C-metaphase, sticky metaphase, laggards, and sticky anaphase at different percentages and times of exposure. It is evident from the observation that mitotic cell division becomes abortive at 100 % treatment of zinc nanoparticles.
Nithya Pandiyan - One of the best experts on this subject based on the ideXlab platform.
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Biogenic approach for the synthesis of Ag-Au doped RuO2 nanoparticles in BMIM-PF6 ionic liquid medium: Structural characterization and its biocidal activity against pathogenic bacteria and HeLa cancerous cells
Journal of Molecular Liquids, 2020Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Mayakrishnan Arumugam, Sundrarajan MahalingamAbstract:Abstract In the present work, we focused on the eco-friendly and greener approach to the synthesis of silver–gold/ruthenium oxide (Ag-Au/RuO2) nanoparticles (NPs) using ethanolic leaf extracts of Justicia adhatoda with ionic liquid (IL) by the hydrothermal method. The 1-butyl-3-methylimidazolium hexafluorophosphate IL was used to control the particle growth during the synthesis of nanoparticles (NPs). The Justicia adhatoda leaves extracts contains vasicinone and N, N-Dimethylglycine which behaves capping and reducing agent. The synthesized NPs were characterized by different physicochemical analysis to confirm its formation. The average crystallite size of Ag-Au/RuO2 NP is 24 nm, as found from the X-ray diffraction results. Fourier transform infrared spectrum confirmed the Ru O peak at the range of 476 cm−1. The optical band gap of Ag-Au/RuO2 NP is 2.98 eV, it is confirmed by ultraviolet- diffuse reflectance spectrum result. SEM analysis of Ag-Au/RuO2 nanoparticle has a spherical like the structure of surface morphology. Energy-dispersive X-ray spectroscopy showed the composition of ruthenium, silver, gold, and oxygen present in the synthesized NPs. Ag–Au/RuO2 NPs revealed outstanding antibacterial activity against Escherichia coli and Staphylococcus aureus microbes. Furthermore, Ag–Au/RuO2 NPs exposed good anticancer properties against HeLa cancerous cell line. From the above results suggested Ag–Au/RuO2 NPs can be used in various applications in the biomedical field.
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facile biological synthetic strategy to morphologically aligned ceo2 zro2 core nanoparticles using Justicia adhatoda extract and ionic liquid enhancement of its bio medical properties
Journal of Photochemistry and Photobiology B-biology, 2018Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan MahalingamAbstract:In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size. GC-MS spectroscopy confirms the presence of vasicinone and N,N-Dimethylglycine present in the plant extract, which are capable of converting the corresponding metal ion precursor to CeO2/ZrO2 core metal oxide nanoparticles. In FTIR, the corresponding stretching for Ce-O and Zr-O bands indicated at 498 and 416cm-1 and Raman spectroscopy also supports typical stretching frequencies at 463 and 160cm-1. Band gap energy of the CeO2/ZrO2 core metal oxide is 3.37eV calculated from UV- DRS spectroscopy. The anti-bacterial studies performed against a set of bacterial strains the result showed that core metal oxide nanoparticles more susceptible to gram-positive (G+) bacteria than gram-negative (G-) bacteria. A unique feature of the antioxidant behaviors core metal oxides reduces the concentration of DPPH radical up to 89%. The CeO2/ZrO2 core metal oxide nanoparticles control the S. marcescent bio-film formation and restrict the quorum sensing. The toxicology behavior of CeO2/ZrO2 core metal oxide NPs is found due to the high oxygen site vacancies, ROS formation, smallest particle size and higher surface area. This type of green synthesis route may efficient and the core metal oxide nanoparticles will possess a good bio-medical agent in future.
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Facile biological synthetic strategy to morphologically aligned CeO2/ZrO2 core nanoparticles using Justicia adhatoda extract and ionic liquid: Enhancement of its bio-medical properties.
Journal of photochemistry and photobiology. B Biology, 2017Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan MahalingamAbstract:In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size. GC-MS spectroscopy confirms the presence of vasicinone and N,N-Dimethylglycine present in the plant extract, which are capable of converting the corresponding metal ion precursor to CeO2/ZrO2 core metal oxide nanoparticles. In FTIR, the corresponding stretching for Ce-O and Zr-O bands indicated at 498 and 416cm-1 and Raman spectroscopy also supports typical stretching frequencies at 463 and 160cm-1. Band gap energy of the CeO2/ZrO2 core metal oxide is 3.37eV calculated from UV- DRS spectroscopy. The anti-bacterial studies performed against a set of bacterial strains the result showed that core metal oxide nanoparticles more susceptible to gram-positive (G+) bacteria than gram-negative (G-) bacteria. A unique feature of the antioxidant behaviors core metal oxides reduces the concentration of DPPH radical up to 89%. The CeO2/ZrO2 core metal oxide nanoparticles control the S. marcescent bio-film formation and restrict the quorum sensing. The toxicology behavior of CeO2/ZrO2 core metal oxide NPs is found due to the high oxygen site vacancies, ROS formation, smallest particle size and higher surface area. This type of green synthesis route may efficient and the core metal oxide nanoparticles will possess a good bio-medical agent in future.
Tarikere C. Taranath - One of the best experts on this subject based on the ideXlab platform.
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Cytotoxicity of zinc nanoparticles fabricated by Justicia adhatoda L. on root tips of Allium cepa L.—a model approach
Environmental science and pollution research international, 2015Co-Authors: Tarikere C. Taranath, Bheemanagouda N. Patil, T. U. Santosh, B. S. SharathAbstract:Zinc nanoparticles were synthesized using aqueous leaf extract of Justicia adhatoda L. The characterization of nanoparticles was done by ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), and high-resolution transmission electron microscopy (HR-TEM). The characteristic absorption peak of the UV spectrum was recorded at 379 nm. The FTIR data revealed the possible biomolecules involved in bioreduction and capping of zinc nanoparticles for efficient stabilization. AFM and HR-TEM images have shown that the size of zinc nanoparticles ranges from 55 to 83 nm and they are spherical in shape. The biogenic zinc nanoparticles were evaluated for their toxic effect on mitotic chromosomes of Allium cepa as a model system. Experiments were conducted in triplicate to assay the effect of 25, 50, 75, and 100 % of zinc nanoparticles on mitotic chromosomes at an interval of 6 h duration for 24 h. The investigation revealed that the mitotic index (MI) was decreased with increased concentration of zinc nanoparticles and exposure duration. The results revealed that zinc nanoparticles have induced abnormalities like anaphase bridge formation, diagonal anaphase, C-metaphase, sticky metaphase, laggards, and sticky anaphase at different percentages and times of exposure. It is evident from the observation that mitotic cell division becomes abortive at 100 % treatment of zinc nanoparticles.
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cytotoxicity of zinc nanoparticles fabricated by Justicia adhatoda l on root tips of allium cepa l a model approach
Environmental Science and Pollution Research, 2015Co-Authors: Tarikere C. Taranath, Bheemanagouda N. Patil, T. U. Santosh, B. S. SharathAbstract:Zinc nanoparticles were synthesized using aqueous leaf extract of Justicia adhatoda L. The characterization of nanoparticles was done by ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), and high-resolution transmission electron microscopy (HR-TEM). The characteristic absorption peak of the UV spectrum was recorded at 379 nm. The FTIR data revealed the possible biomolecules involved in bioreduction and capping of zinc nanoparticles for efficient stabilization. AFM and HR-TEM images have shown that the size of zinc nanoparticles ranges from 55 to 83 nm and they are spherical in shape. The biogenic zinc nanoparticles were evaluated for their toxic effect on mitotic chromosomes of Allium cepa as a model system. Experiments were conducted in triplicate to assay the effect of 25, 50, 75, and 100 % of zinc nanoparticles on mitotic chromosomes at an interval of 6 h duration for 24 h. The investigation revealed that the mitotic index (MI) was decreased with increased concentration of zinc nanoparticles and exposure duration. The results revealed that zinc nanoparticles have induced abnormalities like anaphase bridge formation, diagonal anaphase, C-metaphase, sticky metaphase, laggards, and sticky anaphase at different percentages and times of exposure. It is evident from the observation that mitotic cell division becomes abortive at 100 % treatment of zinc nanoparticles.
Selvam Samayanan - One of the best experts on this subject based on the ideXlab platform.
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Biogenic approach for the synthesis of Ag-Au doped RuO2 nanoparticles in BMIM-PF6 ionic liquid medium: Structural characterization and its biocidal activity against pathogenic bacteria and HeLa cancerous cells
Journal of Molecular Liquids, 2020Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Mayakrishnan Arumugam, Sundrarajan MahalingamAbstract:Abstract In the present work, we focused on the eco-friendly and greener approach to the synthesis of silver–gold/ruthenium oxide (Ag-Au/RuO2) nanoparticles (NPs) using ethanolic leaf extracts of Justicia adhatoda with ionic liquid (IL) by the hydrothermal method. The 1-butyl-3-methylimidazolium hexafluorophosphate IL was used to control the particle growth during the synthesis of nanoparticles (NPs). The Justicia adhatoda leaves extracts contains vasicinone and N, N-Dimethylglycine which behaves capping and reducing agent. The synthesized NPs were characterized by different physicochemical analysis to confirm its formation. The average crystallite size of Ag-Au/RuO2 NP is 24 nm, as found from the X-ray diffraction results. Fourier transform infrared spectrum confirmed the Ru O peak at the range of 476 cm−1. The optical band gap of Ag-Au/RuO2 NP is 2.98 eV, it is confirmed by ultraviolet- diffuse reflectance spectrum result. SEM analysis of Ag-Au/RuO2 nanoparticle has a spherical like the structure of surface morphology. Energy-dispersive X-ray spectroscopy showed the composition of ruthenium, silver, gold, and oxygen present in the synthesized NPs. Ag–Au/RuO2 NPs revealed outstanding antibacterial activity against Escherichia coli and Staphylococcus aureus microbes. Furthermore, Ag–Au/RuO2 NPs exposed good anticancer properties against HeLa cancerous cell line. From the above results suggested Ag–Au/RuO2 NPs can be used in various applications in the biomedical field.
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facile biological synthetic strategy to morphologically aligned ceo2 zro2 core nanoparticles using Justicia adhatoda extract and ionic liquid enhancement of its bio medical properties
Journal of Photochemistry and Photobiology B-biology, 2018Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan MahalingamAbstract:In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size. GC-MS spectroscopy confirms the presence of vasicinone and N,N-Dimethylglycine present in the plant extract, which are capable of converting the corresponding metal ion precursor to CeO2/ZrO2 core metal oxide nanoparticles. In FTIR, the corresponding stretching for Ce-O and Zr-O bands indicated at 498 and 416cm-1 and Raman spectroscopy also supports typical stretching frequencies at 463 and 160cm-1. Band gap energy of the CeO2/ZrO2 core metal oxide is 3.37eV calculated from UV- DRS spectroscopy. The anti-bacterial studies performed against a set of bacterial strains the result showed that core metal oxide nanoparticles more susceptible to gram-positive (G+) bacteria than gram-negative (G-) bacteria. A unique feature of the antioxidant behaviors core metal oxides reduces the concentration of DPPH radical up to 89%. The CeO2/ZrO2 core metal oxide nanoparticles control the S. marcescent bio-film formation and restrict the quorum sensing. The toxicology behavior of CeO2/ZrO2 core metal oxide NPs is found due to the high oxygen site vacancies, ROS formation, smallest particle size and higher surface area. This type of green synthesis route may efficient and the core metal oxide nanoparticles will possess a good bio-medical agent in future.
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Facile biological synthetic strategy to morphologically aligned CeO2/ZrO2 core nanoparticles using Justicia adhatoda extract and ionic liquid: Enhancement of its bio-medical properties.
Journal of photochemistry and photobiology. B Biology, 2017Co-Authors: Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan MahalingamAbstract:In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size. GC-MS spectroscopy confirms the presence of vasicinone and N,N-Dimethylglycine present in the plant extract, which are capable of converting the corresponding metal ion precursor to CeO2/ZrO2 core metal oxide nanoparticles. In FTIR, the corresponding stretching for Ce-O and Zr-O bands indicated at 498 and 416cm-1 and Raman spectroscopy also supports typical stretching frequencies at 463 and 160cm-1. Band gap energy of the CeO2/ZrO2 core metal oxide is 3.37eV calculated from UV- DRS spectroscopy. The anti-bacterial studies performed against a set of bacterial strains the result showed that core metal oxide nanoparticles more susceptible to gram-positive (G+) bacteria than gram-negative (G-) bacteria. A unique feature of the antioxidant behaviors core metal oxides reduces the concentration of DPPH radical up to 89%. The CeO2/ZrO2 core metal oxide nanoparticles control the S. marcescent bio-film formation and restrict the quorum sensing. The toxicology behavior of CeO2/ZrO2 core metal oxide NPs is found due to the high oxygen site vacancies, ROS formation, smallest particle size and higher surface area. This type of green synthesis route may efficient and the core metal oxide nanoparticles will possess a good bio-medical agent in future.
