The Experts below are selected from a list of 1851 Experts worldwide ranked by ideXlab platform

Xiong Guo - One of the best experts on this subject based on the ideXlab platform.

Mikko J. Lammi - One of the best experts on this subject based on the ideXlab platform.

Fuxing Pei - One of the best experts on this subject based on the ideXlab platform.

  • Total hip replacement in adult patients with severe Kashin-Beck Disease of the hip
    BMC musculoskeletal disorders, 2016
    Co-Authors: Xin Tang, Zongke Zhou, Bin Shen, Peng-de Kang, Jing Zhu, Fuxing Pei
    Abstract:

    The treatment of elderly patients with Kashin-Beck Disease (KBD) remains clinically challenging, and clinical data are very lacking. The aim of this study was to retrospectively evaluate pain and functional outcomes following total hip replacement in adult patients with severe KBD of the hip. Twenty-two patients (32 hips) with KBD underwent primary hip replacement and were followed for at least 2 years. Radiographic and Clinical assessments were evaluated for each patient at 2 and 4 weeks and at 3, 6 and 12 months after the operation and annually thereafter. The efficacy index included the visual analogue scale (VAS) score, Harris hip score, functional score for adult Tibetans with Kashin-Beck Disease (FSAT-KBD) and radiographic outcomes. The patients underwent a follow-up, and the mean follow-up time was 3.8 years. VAS scores significantly decreased within the first 6 months postoperatively. This decrease continued until the final follow-up (p 

  • Serum levels of M-CSF, RANKL and OPG in rats fed with Kashin-Beck Disease-affected diet.
    Journal of orthopaedic surgery and research, 2014
    Co-Authors: Denglu Yan, Fuxing Pei, Yancheng Song
    Abstract:

    Objective There were no studies on the macrophage colony-stimulating factor (M-CSF), receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG) in the pathogenesis of Kashin-Beck Disease (KBD). The objective of the present study was to investigate the serum M-CSF, RANKL and OPG in rats fed with KBD-affected diet.

  • Total knee arthroplasty in elderly patients with severe Kashin-Beck Disease of the knee
    International orthopaedics, 2013
    Co-Authors: Xin Tang, Zongke Zhou, Bin Shen, Peng-de Kang, Jing Yang, Fuxing Pei
    Abstract:

    Purpose The treatment of elderly KBD knee remains a significant clinical challenge, and clinical data are lacking. This study aimed to prospectively determine the functional outcomes of total knee arthroplasty (TKA) in adult patients with severe Kashin-Beck Disease (KBD) of the knee.

  • Selenium, iodine, and the relation with Kashin-Beck Disease.
    Nutrition (Burbank Los Angeles County Calif.), 2011
    Co-Authors: Yunfeng Yao, Fuxing Pei, Peng-de Kang
    Abstract:

    The etiology and pathogenesis of Kashin-Beck Disease (KBD) remain uncertain at present. A deficiency of selenium and iodine is considered common in KBD-affected areas. Supplying selenium and iodine for the prevention of KBD has been performed in the past few decades in affected areas in China. Supplying selenium and/or iodine has produced positive http://www.iciba.com/different/effects in most KBD-affected areas, but there are some affected areas where the effects have been unclear and supplementation with selenium and/or iodine has not eliminated this Disease. From animal and vitro experiments, we explore whether a deficiency of selenium and/or iodine may be the environmental factor causing KBD. KBD may have multiple etiologies. The role of selenium and iodine in KBD mainly involves antioxidation and maintenance of thyroid function according to the present review. Other important roles of selenium and iodine in KBD and a certain etiology of this Disease need further study.

  • Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck Disease (KBD) patients
    International orthopaedics, 2010
    Co-Authors: Rui Luo, Gang Liu, Wei Liu, Fuxing Pei, Zongke Zhou, Bin Shen, Peng-de Kang, Qibing Xie
    Abstract:

    The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck Disease. Adults (n = 168) with Kashin-Beck Disease were randomised in clusters to receive six week courses of celecoxib 200 mg once daily, meloxicam 7.5 mg once daily or paracetamol 300 mg three times daily. Efficacy assessments included overall joint pain intensity and Western Ontario and McMaster Universities Osteoarthritis Index subscales; tolerability was evaluated by adverse event and physician reporting. Celecoxib and meloxicam were efficacious in relieving pain and improving stiffness, but unable to improve physical function after six weeks. Paracetamol was efficacious in relieving pain, but unable to improve morning stiffness and physical function after six weeks. Celecoxib and meloxicam provide predictable and sustained relief from pain and stiffness. Paracetamol can relieve the pain. None of the treatments improved impaired physical function in Kashin-Beck Disease.

Françoise Begaux - One of the best experts on this subject based on the ideXlab platform.

  • Ethno-agricultural approach to the rural environment in the prevention of Kashin-Beck Disease
    International orthopaedics, 2001
    Co-Authors: François Malaisse, Françoise Mathieu, Eric Haubruge, Françoise Begaux
    Abstract:

    Kashin-Beck Disease occurs in several villages of Tibet; however, its local importance varies greatly. The ecoclimatological as well as the phytogeographical framework of the studied area are presented. An ecological approach based upon the ethno-ecosystem concept was carried out in the vicinity of each village. This study identifies 18 vegetation units on a structural basis; they were named for the dominant plants of each unit. Half of them belonged to the aquatic milieu. The different factors controlling their distribution were also identified. Particular attention will be paid to the links between man and the environment, particularly regarding alternative food intakes and water supply access.

  • The anatomical distribution of radiological abnormalities in Kashin-Beck Disease in Tibet.
    International orthopaedics, 2001
    Co-Authors: Maurice Hinsenkamp, Françoise Mathieu, Françoise Begaux, V. De Maertelaer, Eric Haubruge, C. Chasseur, F. Ryppens, M. Lepeire, Bernard Stallenberg
    Abstract:

    A radiological study of osteoarticular changes in Kashin-Beck Disease (KBD) was undertaken on the appendicular skeleton in 105 patients with KBD, in 31 healthy subjects living in an endemic area and in 30 healthy subjects living in a non-endemic area. The bone age was delayed in all three populations with no significant difference between the three studied Tibetan populations. Radiological changes occur in 56% of patients with KBD, and are usually bilateral. An analysis of the distribution of lesions shows a proximo-distal gradient. The changes are more common in the distal aspect of the limb and the lower limb is involved more commonly than the upper limb. The foot and ankle are involved in 89.5% of cases. The radiological changes and their distribution might be explained by the hypothesis of inhibition of angiogenesis by mycotoxins, exacerbated by chemical and physical environmental factors.

  • Epidemiological support for a multifactorial aetiology of Kashin-Beck Disease in Tibet.
    International orthopaedics, 2001
    Co-Authors: C. Suetens, Rodrigo Moreno-reyes, Françoise Mathieu, Françoise Begaux, Jean Neve, Eric Haubruge, C. Chasseur, M. C. Durand, Jean-baptiste Vanderpas
    Abstract:

    We carried out a cross-sectional study in 12 rural villages in order to identify the risk factors for Kashin-Beck Disease in Tibet. Children aged 5–15 years (n=575) were examined and their corresponding houses were visited. Samples were collected in order to study fungal contamination of stored grain and the organic matter content of drinking water. Multivariate analysis was performed using logistic regression and population attributable fractions were computed to estimate the impact of each factor. The following variables were independently associated with the Disease: age, gender, low socio-economic status, indicators of a poorly diversified diet, iodine deficiency and small water container size (with higher organic matter levels in small containers). Selenium deficiency was severe in all study subjects. The degree of fungal contamination of barley grain was related to the highest percentage of cases (65%) in a sample of the study population. Higher urinary iodine levels were not associated with decreasing prevalence rates when Alternaria sp. was isolated. The data that we report supports the hypothesis that Kashin-Beck Disease occurs as a consequence of oxidative damage to cartilage and bone cells when associated with decreased antioxidant defence. Another mechanism that may coexist is bone remodelling stimulated by thyroid hormones whose actions can be blocked by certain mycotoxins.

  • The prevalence of mycotoxins in Kashin-Beck Disease.
    International orthopaedics, 2001
    Co-Authors: Eric Haubruge, C. Suetens, Françoise Mathieu, Françoise Begaux, C. Chasseur, Catherine Debouck, V. Michel, Charles Gaspar, Marcel Rooze, Maurice Hinsenkamp
    Abstract:

    Mycotoxins are naturally occurring toxic chemical compounds produced by fungi infesting agricultural crops both during their growth and storage. Such secondary metabolites, when ingested, can produce toxic syndromes in humans. As it has been suggested that mycotoxins might be involved in the development of Kashin-Beck Disease (KBD), we undertook a survey of barley grains of KBD-affected families and non-affected families in that country. We found, by thin layer chromatography, a hitherto unknown metabolite of Alternaria sp. This was especially common on the barley grains of KBD-affected families.

  • Kashin-Beck Disease and drinking water in Central Tibet
    International orthopaedics, 2001
    Co-Authors: M. La Grange, C. Suetens, Françoise Mathieu, Françoise Begaux, M.-cl. Durand
    Abstract:

    A cross-sectional survey was carried out in order to study the relationship between Kashin-Beck Disease and drinking water. The average volume of the water containers was larger in families unaffected by the Disease. Organic material was measured by ultraviolet (UV) spectroscopy. The UV absorbency was significantly lower in drinking water of unaffected families. Thus, the organic material in drinking water may play a role in the pathogenesis of Kashin-Beck Disease.

Françoise Mathieu - One of the best experts on this subject based on the ideXlab platform.

  • Ethno-agricultural approach to the rural environment in the prevention of Kashin-Beck Disease
    International orthopaedics, 2001
    Co-Authors: François Malaisse, Françoise Mathieu, Eric Haubruge, Françoise Begaux
    Abstract:

    Kashin-Beck Disease occurs in several villages of Tibet; however, its local importance varies greatly. The ecoclimatological as well as the phytogeographical framework of the studied area are presented. An ecological approach based upon the ethno-ecosystem concept was carried out in the vicinity of each village. This study identifies 18 vegetation units on a structural basis; they were named for the dominant plants of each unit. Half of them belonged to the aquatic milieu. The different factors controlling their distribution were also identified. Particular attention will be paid to the links between man and the environment, particularly regarding alternative food intakes and water supply access.

  • The anatomical distribution of radiological abnormalities in Kashin-Beck Disease in Tibet.
    International orthopaedics, 2001
    Co-Authors: Maurice Hinsenkamp, Françoise Mathieu, Françoise Begaux, V. De Maertelaer, Eric Haubruge, C. Chasseur, F. Ryppens, M. Lepeire, Bernard Stallenberg
    Abstract:

    A radiological study of osteoarticular changes in Kashin-Beck Disease (KBD) was undertaken on the appendicular skeleton in 105 patients with KBD, in 31 healthy subjects living in an endemic area and in 30 healthy subjects living in a non-endemic area. The bone age was delayed in all three populations with no significant difference between the three studied Tibetan populations. Radiological changes occur in 56% of patients with KBD, and are usually bilateral. An analysis of the distribution of lesions shows a proximo-distal gradient. The changes are more common in the distal aspect of the limb and the lower limb is involved more commonly than the upper limb. The foot and ankle are involved in 89.5% of cases. The radiological changes and their distribution might be explained by the hypothesis of inhibition of angiogenesis by mycotoxins, exacerbated by chemical and physical environmental factors.

  • Epidemiological support for a multifactorial aetiology of Kashin-Beck Disease in Tibet.
    International orthopaedics, 2001
    Co-Authors: C. Suetens, Rodrigo Moreno-reyes, Françoise Mathieu, Françoise Begaux, Jean Neve, Eric Haubruge, C. Chasseur, M. C. Durand, Jean-baptiste Vanderpas
    Abstract:

    We carried out a cross-sectional study in 12 rural villages in order to identify the risk factors for Kashin-Beck Disease in Tibet. Children aged 5–15 years (n=575) were examined and their corresponding houses were visited. Samples were collected in order to study fungal contamination of stored grain and the organic matter content of drinking water. Multivariate analysis was performed using logistic regression and population attributable fractions were computed to estimate the impact of each factor. The following variables were independently associated with the Disease: age, gender, low socio-economic status, indicators of a poorly diversified diet, iodine deficiency and small water container size (with higher organic matter levels in small containers). Selenium deficiency was severe in all study subjects. The degree of fungal contamination of barley grain was related to the highest percentage of cases (65%) in a sample of the study population. Higher urinary iodine levels were not associated with decreasing prevalence rates when Alternaria sp. was isolated. The data that we report supports the hypothesis that Kashin-Beck Disease occurs as a consequence of oxidative damage to cartilage and bone cells when associated with decreased antioxidant defence. Another mechanism that may coexist is bone remodelling stimulated by thyroid hormones whose actions can be blocked by certain mycotoxins.

  • The prevalence of mycotoxins in Kashin-Beck Disease.
    International orthopaedics, 2001
    Co-Authors: Eric Haubruge, C. Suetens, Françoise Mathieu, Françoise Begaux, C. Chasseur, Catherine Debouck, V. Michel, Charles Gaspar, Marcel Rooze, Maurice Hinsenkamp
    Abstract:

    Mycotoxins are naturally occurring toxic chemical compounds produced by fungi infesting agricultural crops both during their growth and storage. Such secondary metabolites, when ingested, can produce toxic syndromes in humans. As it has been suggested that mycotoxins might be involved in the development of Kashin-Beck Disease (KBD), we undertook a survey of barley grains of KBD-affected families and non-affected families in that country. We found, by thin layer chromatography, a hitherto unknown metabolite of Alternaria sp. This was especially common on the barley grains of KBD-affected families.

  • Kashin-Beck Disease and drinking water in Central Tibet
    International orthopaedics, 2001
    Co-Authors: M. La Grange, C. Suetens, Françoise Mathieu, Françoise Begaux, M.-cl. Durand
    Abstract:

    A cross-sectional survey was carried out in order to study the relationship between Kashin-Beck Disease and drinking water. The average volume of the water containers was larger in families unaffected by the Disease. Organic material was measured by ultraviolet (UV) spectroscopy. The UV absorbency was significantly lower in drinking water of unaffected families. Thus, the organic material in drinking water may play a role in the pathogenesis of Kashin-Beck Disease.