The Experts below are selected from a list of 5868 Experts worldwide ranked by ideXlab platform
Corrado Rubini - One of the best experts on this subject based on the ideXlab platform.
-
Calretinin expression in odontogenic cysts.
Journal of Endodontics, 2003Co-Authors: Adriano Piattelli, M Fioroni, Giovanna Iezzi, Corrado RubiniAbstract:Calretinin is a calcium-binding protein with a possible role as a calcium buffer, calcium-sensor, or regulator of apoptosis. Calretinin is expressed in neural tissue, is a specific marker of mesothelial cells, and has been demonstrated in the odontogenic epithelium during odontogenesis in rat molar tooth germs. Moreover, it has been found to be expressed in a high proportion of solid, unicystic, and multicystic ameloblastomas, whereas, on the contrary, no positive staining has been found in odontogenic Keratocysts, residual cysts, and dentigerous cysts. The purpose of this study was to evaluate calretinin expression in radicular cysts, follicular cysts, orthokeratinized Keratocysts, and parakeratinized Keratocysts. A total of 70 odontogenic cysts, 24 radicular cysts, 24 follicular cysts, and 22 odontogenic Keratocysts (10 orthokeratinized Keratocysts, 12 parakeratinized Keratocysts) were evaluated. All the radicular cysts, follicular cysts, and orthokeratinized Keratocysts were negative. However in 8 of 12 parakeratinized Keratocysts, there was a positivity to calretinin in the parabasal-intermediate layers of the cyst epithelium. This positivity to calretinin in the parabasal layers in parakeratinized Keratocysts, similar to that found for other markers like PCNA and p53, could point to an abnormal control of the cell cycle and could help to explain the differences in the clinical and pathologic behavior of odontogenic Keratocysts, in particular the differences found between orthokeratinized Keratocysts and parakeratinized Keratocysts.
Arley Silva Junior - One of the best experts on this subject based on the ideXlab platform.
-
Computerized Evaluation of the Immunoexpression of Ki-67 Protein in Odontogenic Keratocyst and Dentigerous Cyst
Head and Neck Pathology, 2019Co-Authors: Juliana Portes, Karin Soares Gonçalves Cunha, Licínio Esmeraldo Silva, Anna Karoline Fausto Silva, Danielle Castex Conde, Arley Silva JuniorAbstract:Evaluation and comparison of odontogenic Keratocysts and detigerous cysts immunoexpression and immunostaining intensities of Ki-67 antigen by assessing the whole extent of the epithelium (all epithelium layers in combination) and each layer individually. Ki-67 immunoexpression was evaluated in 15 odontogenic Keratocysts and 6 dentigerous cysts using automated methods and the Aperio Technologies Inc. computer system. No statistically significant differences were observed in immunoexpression nor in immunostaining intensities between both lesions. Also, no statistically significant differences were found between odontogenic Keratocysts from maxilla versus mandible nor primary versus recurrent. However, odontogenic Keratocyst showed a significantly higher cellular proliferation index in the suprabasal layers compared to the basal layer. Assessment of the cellular proliferation index through a computerized system enabled the evaluation of all epithelial tissue without field selection. The increased Ki-67 immunoexpression in suprabasal layers of odontogenic Keratocyst suggests a different biological behavior and more aggressive proliferation potential when compared to dentigerous cyst. The same result was found in recurrent odontogenic Keratocysts when compared with primary ones. The odontogenic Keratocysts of the maxilla and mandible have similar Ki-67 immunoexpression. The evaluation of cellular proliferation only by immunohistochemical analysis with Ki-67 antigen does not provide enough data to elucidate the biological behavior of odontogenic Keratocyst.
Adi Laurian - One of the best experts on this subject based on the ideXlab platform.
-
solid variant of odontogenic Keratocyst
Journal of Oral Pathology & Medicine, 2004Co-Authors: Marilena Vered, Amos Buchner, Dan Dayan, Moshe Shteif, Adi LaurianAbstract:A case of an unusual lesion from the maxilla is presented. Macroscopically, the lesion was solid and histologically consisted of ‘multiple separate Keratocysts’ of varying size that infiltrated into the surrounding bone and soft tissues. Panoramic image and CT scans showed a multilocular honeycomb ill-defined radiolucency with infiltration into the maxillary sinus and floor of orbit. This lesion should be differentiated from similar odontogenic lesions, such as keratoameloblastoma and papilliferous keratoameloblastoma. As there was no evidence of follicles, islands of ameloblastoma, or papilliferous structures in the entire specimen, the lesion could not be diagnosed as either a keratoameloblastoma or a papilliferous keratoameloblastoma. The invasive and destructive growth behavior, the histopathological features, and the histochemical pattern of the collagen stroma imply that this solid lesion is a neoplasia. It is suggested that the proper term for this lesion is solid variant of odontogenic Keratocyst.
Michael J. Cunningham - One of the best experts on this subject based on the ideXlab platform.
-
the odontogenic Keratocyst a 20 year clinicopathologic review
Laryngoscope, 1998Co-Authors: John G. Meara, Samir S. Shah, Michael J. CunninghamAbstract:The odontogenic Keratocyst (OKC) is a jaw cyst with a proclivity for local invasion and recurrence. This 20-year retrospective study was conducted to evaluate methods of treatment and recurrence rates. Forty-nine patients were identified with an average age at presentation of 39.5 years. The molar region of either the mandible or maxilla was the principal primary location; the maxillary antrum was also a common site. The majority of cysts were unilocular and associated with adjacent dentition. Initial therapy was typically enucleation with or without extraction of associated teeth; seven cases of recurrent or second primary odontogenic Keratocysts required more extensive surgery. Follow-up ranged from 1 to 15 years with an average duration of 4.3 years. The overall recurrence rate was 35%, and the average time to recurrence 4 years. A recurrence rate of 60% was documented for patients with basal cell nevus syndrome or a family history thereof. Long-term follow-up is necessary following initial OKC treatment. The high rate of recurrence in patients with documented or suspected basal cell nevus syndrome suggests the need for more aggressive initial surgical management in this selected patient population.
-
Odontogenic Keratocysts in the pediatric population.
Archives of otolaryngology--head & neck surgery, 1996Co-Authors: John G. Meara, Samir S. Shah, Michael J. CunninghamAbstract:Objective: To review the characteristics and treatment of odontogenic Keratocysts in the pediatric population at our institution in light of a comprehensive literature review of odontogenic Keratocysts in the general population in the hope of elucidating clinical, radiological, or pathological factors that would suggest a different therapeutic approach to odontogenic Keratocysts in the pediatric as opposed to the adult population. Design: A 19-year retrospective medical chart review of children with mandibular or maxillary masses of odontogenic Keratocyst origin. Setting: Two academic tertiary care institutions. Patients: Eleven children had pathologically confirmed odontogenic Keratocysts. Age at diagnosis ranged from 8 to 18 years (mean, 13.4 years). Results: A cystic mass with dentition displacement was characteristic clinically and radiographically. Treatment principally consisted of enucleation with or without extraction of teeth. Follow-up ranged from 1 to 8 years. Seven patients remained free of disease. Recurrences or second primary lesions occurred in 4 patients, all of whom had a family history of nevoid basal cell carcinoma syndrome or multiple cysts suggestive of this diagnosis. The maximum 8-year interval between initial treatment and recurrence is noteworthy. Conclusions: The diagnosis of odontogenic Keratocyst deserves consideration in children who have a mass of the mandible or maxilla. The clinical behavior of this lesion in its initial occurrence and response to conservative treatment seems to be similar to that reported in adults. Odontogenic Keratocysts, especially those that are multiple or recurrent, should alert the clinician to the possible underlying diagnosis of nevoid basal cell carcinoma syndrome. Arch Otolaryngol Head Neck Surg. 1996;122:725-728
Adriano Piattelli - One of the best experts on this subject based on the ideXlab platform.
-
Calretinin expression in odontogenic cysts.
Journal of Endodontics, 2003Co-Authors: Adriano Piattelli, M Fioroni, Giovanna Iezzi, Corrado RubiniAbstract:Calretinin is a calcium-binding protein with a possible role as a calcium buffer, calcium-sensor, or regulator of apoptosis. Calretinin is expressed in neural tissue, is a specific marker of mesothelial cells, and has been demonstrated in the odontogenic epithelium during odontogenesis in rat molar tooth germs. Moreover, it has been found to be expressed in a high proportion of solid, unicystic, and multicystic ameloblastomas, whereas, on the contrary, no positive staining has been found in odontogenic Keratocysts, residual cysts, and dentigerous cysts. The purpose of this study was to evaluate calretinin expression in radicular cysts, follicular cysts, orthokeratinized Keratocysts, and parakeratinized Keratocysts. A total of 70 odontogenic cysts, 24 radicular cysts, 24 follicular cysts, and 22 odontogenic Keratocysts (10 orthokeratinized Keratocysts, 12 parakeratinized Keratocysts) were evaluated. All the radicular cysts, follicular cysts, and orthokeratinized Keratocysts were negative. However in 8 of 12 parakeratinized Keratocysts, there was a positivity to calretinin in the parabasal-intermediate layers of the cyst epithelium. This positivity to calretinin in the parabasal layers in parakeratinized Keratocysts, similar to that found for other markers like PCNA and p53, could point to an abnormal control of the cell cycle and could help to explain the differences in the clinical and pathologic behavior of odontogenic Keratocysts, in particular the differences found between orthokeratinized Keratocysts and parakeratinized Keratocysts.
