The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Vikram Muralidhar Haridas - One of the best experts on this subject based on the ideXlab platform.
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reactive arthritis with Keratoderma Blennorrhagica
Internet Journal of Rheumatology and Clinical Immunology, 2015Co-Authors: Vikram Muralidhar HaridasAbstract:Reactive arthritis (ReA) or sterile penisme/topic-synovitis/">synovitis usually develops following a distant infection in the gut or gastrointestinal tract. The disease is predominant in men between 20 to 40 years of age. Keratoderma Blennorrhagica, which occurs as an additional feature of reactive arthritis, is the presence of scaly skin rashes on the hands and feet.
Vikas Majithia - One of the best experts on this subject based on the ideXlab platform.
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159 SUCCESSFUL USE OF INFLIXIMAB IN THE TREATMENT OF REITER'S SYNDROME: A CASE REPORT.
Journal of Investigative Medicine, 2006Co-Authors: H. Gill, Vikas MajithiaAbstract:Introduction Reiter9s syndrome is one of the reactive forms of spondyloarthropathies. The clinical syndrome consists of a triad of asymmetric oligoathritis, penisme/topic-urethritis/">urethritis, and conjunctivitis. It is also associated with characteristic mucocutaneous lesions. Various therapies used in the management are NSAIDs, antibiotics, and DMARDs such as SSZ or methotrexate. There is only 1 case report of successful treatment of Reiter9s syndrome with TNF-a blockers in an HIV+ patient. We report a case of Reiter9s syndrome treated successfully with infliximab. Case Report A 28-year-old white male presented with painful swelling of right elbow and ankle joints, penisme/topic-urethritis/">urethritis, and lesions involving skin of soles of feet and penis. No other joint was involved. He also complained of fatigue, fever, and mild sore throat, but, otherwise, his review of systems, past, social and family history was negative. He was sexually active with one partner and denied any history of sexually transmitted disease. Pertinent positives on physical examination were penisme/topic-synovitis/">synovitis of right elbow and ankle joints. He had extensive skin lesion on soles and penis consistent with Keratoderma Blennorrhagica and circinate balanitis. Laboratory workup was positive for a high WBC count of 13,700 cells/mm3, ESR of 82, and CRP of 11.1. Detailed workup of STDs, HIV, and systemic etiology was negative. Despite aggressive treatment with antibiotics, NSAIDS, prednisone, and methotrexate, he had persistent penisme/topic-synovitis/">synovitis and worsening of skin lesions. Due to severity and resistance of disease to the conventional treatment modalities, infliximab therapy was instituted, which resulted in complete resolution of arthritis and skin lesions within 6 weeks of infliximab therapy. Discussion and Conclusion There is a lot of evidence supporting the use of TNF-a blockers in other seronegative spondyloarthropathies, such as psoriatic arthritis and AS, but there is only 1 previous case report of its use in Reiter9s syndrome. Although this use is intuitive, there is a theoretical potential as well as animal data suggesting its possible benefit. The successful use of infliximab in this patient with Reiter9s syndrome as well as rapid improvement in severe skin lesions and arthritis suggests a significant role of TNF-a in the pathogenesis of this disease. This is an encouraging preliminary result, and we suggest that the use of TNF-a blockers in Reiter9s syndrome should be further investigated.
Richard M Keating - One of the best experts on this subject based on the ideXlab platform.
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Keratoderma Blennorrhagica as a result of reactive arthritis
2014Co-Authors: Richard M KeatingAbstract:Reactive arthritis (ReA) is an inflammatory arthritis within the larger category of spondyloarthropathies (SpA). Keratoderma Blennorrhagica is a cutaneous manifestation of ReA seen in about 10 % of patients with ReA. The characteristic features of KD include palm/sole hyperkeratotic plaques which begin as erythematous macules and vesicle and progress to pustules, papules, and then plaques. The lesions are difficult to distinguish from pustular psoriasis. Additional cutaneous features of ReA may include oral lesions, nail lesions, and circinate balanitis (men) or ulcerative penisme/topic-vulvitis/">vulvitis (women).
Masatoshi Fujishima - One of the best experts on this subject based on the ideXlab platform.
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Esophageal ulcer complicated by Reiter's syndrome. A case report.
Journal of Clinical Gastroenterology, 1992Co-Authors: Shotaro Nakamura, Mitsuo Iida, Kohrogi N, Atsuko Shimizu, Seizaburo Kashiwagi, Masatoshi FujishimaAbstract:: A 40-year-old woman with Reiter's syndrome had low-grade fever, a psoriasislike eruption on feet and hands, and multiple esophageal ulcers. She had Keratoderma Blennorrhagica, aseptic penisme/topic-vaginitis/">vaginitis, and ileosacral arthritis, but no ocular lesions. The patient was HLA-B27 negative. Radiographic and endoscopic examinations of the upper gastrointestinal (GI) tract showed multiple round or irregularly shaped small ulcers in the middle and distal portion of the esophagus. One month later, all esophageal ulcers disappeared spontaneously. A case like this of Reiter's syndrome with esophageal involvement has not been reported before.
R S Pattman - One of the best experts on this subject based on the ideXlab platform.
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reiter s syndrome and Keratoderma Blennorrhagica on glans penis is this unusual
International Journal of Std & Aids, 2002Co-Authors: D N Edirisinghe, K N Sankar, R S PattmanAbstract:Current teaching on Reiter's syndrome is that Keratoderma Blennorrhagica lesions appear characteristically on the soles of feet, although they can be seen on other parts of the body infrequently. We therefore thought that it would be interesting to report the case of Keratoderma Blennorrhagica lesions found on the glans penis of a circumcised patient with Reiter's syndrome.
