Keratolysis

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Denise De Freitas - One of the best experts on this subject based on the ideXlab platform.

  • autoimmune Keratolysis in a patient with leukocytoclastic vasculitis unusual erythema elevatum diutinum with granulomatous pattern
    Cornea, 2001
    Co-Authors: Fabio Henrique Cacho Casanova, Rodrigo L Meirelles, Marcelo Tojar, Maria Cristina Martins, Moacir P Rigueiro, Denise De Freitas
    Abstract:

    Purpose Leukocytoclastic vasculitis (LCCV) is an immune complex-mediated, small vessel disease that is clinically characterized by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations of LCCV are rare. Methods We describe a patient with an unusual granulomatous pattern of erythema elevatum diutinum (EED) associated with autoimmune Keratolysis. Results We studied a 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular examination revealed bilateral superior corneal melting with perforation in the left eye and conjunctival thickening in both eyes, in association with a severe inflammatory reaction. Histopathologic examination of the conjunctiva revealed granulomatous vasculitis with neutrophilic infiltrate, giant cells, and fibroblastic proliferation. A punch biopsy taken from his skin showed similar characteristics that suggested EED; however, there were no giant cells. Conclusion To our knowledge, autoimmune Keratolysis secondary to cutaneous LCCV (EED) has not been described previously, and there has been no description of granulomatous reaction (in the conjunctiva) in EED.

  • Autoimmune Keratolysis in a patient with leukocytoclastic vasculitis - Unusual erythema elevatum diutinum with granulomatous pattern
    'Ovid Technologies (Wolters Kluwer Health)', 2001
    Co-Authors: Casanova Fhc, Meirelles R. L., Tojar M., Martins M. C., Rigueiro M. P., Denise De Freitas
    Abstract:

    Purpose. Leukocytoclastic vasculitis (LCCV) is an immune complex-mediated, small vessel disease that is clinically characterized by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations of LCCV are rare. Methods. We describe a patient with an unusual granulomatous pattern of erythema elevatum diutinum (EED) associated with autoimmune Keratolysis. Results. We studied a 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular examination revealed bilateral superior corneal melting with perforation in the left eye and conjunctival thickening in both eyes, in association with a severe inflammatory reaction. Histopathologic examination of the conjunctiva revealed granulomatous vasculitis with neutrophilic infiltrate, giant cells, and fibroblastic proliferation. A punch biopsy taken from his skin showed similar characteristics that suggested EED; however, there were no giant cells. Conclusion, To our knowledge, autoimmune Keratolysis secondary to cutaneous LCCV (EED) has not been described previously, and there has been no description of granulomatous reaction (in the conjunctiva) in EED.Universidade Federal de São Paulo, Paulista Sch Med, Dept Ophthalmol, São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Dept Ophthalmol, São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Dept Pathol, São Paulo, BrazilWeb of Scienc

  • Ceratólise auto-imune em paciente com vasculite leucocitoclástica: apresentação atípica de erythema elevatum diutinum com padrão granulomatoso Autoimmune Keratolysis in a patient with leucocytoclastic vasculitis: unusual erythema elevatum diutinum wi
    Conselho Brasileiro de Oftalmologia, 2000
    Co-Authors: Fabio Henrique Cacho Casanova, Rodrigo L Meirelles, Marcelo Tojar, Maria Cristina Martins, Moacir P Rigueiro, Denise De Freitas
    Abstract:

    Contexto: A vasculite leucocitoclástica é uma doença que acomete pequenos vasos mais comumente associada a distúrbios do tecido conectivo, caracterizada clinicamente pela presença de lesões purpúricas palpáveis. Manifestações oftalmológicas são raras. Objetivo: Descrever quadro clínico de paciente portador de vasculite leucocitoclástica como manifestação incomum de padrão granulomatoso do erythema elevatum diutinum (EED). Relato de Caso: Paciente de 64 anos, masculino, apresentando baixa de acuidade visual e aparecimento de lesões nodulares em mãos. Ao exame oftalmológico, evidenciou-se afinamento corneano superior bilateral com perfuração corneana do olho esquerdo e espessamento da conjuntiva limbar em ambos os olhos, associada a intensa atividade inflamatória. Exame anatomopatológico da conjuntiva revelou vasculite granulomatosa com intenso exsudato neutrofílico, células gigantes multinucleadas, além de proliferação fibroblástica. Exame anatomopatológico de biopsia da pele evidenciou alterações semelhantes compatíveis com EED, porém não foi visto célula gigante sugerindo lesão granulomatosa. Conclusão: Ceratólise auto-imune secundária a vasculite leucocitoclástica cutânea (EED) não havia sido descrito na literatura, tampouco encontramos referências sobre a reação granulomatosa (encontrada na conjuntiva) em EED.Purpose: Leucocytoclastic vasculitis is an immune complex-mediated, small vessel disease, that is characterized clinically by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations are rare. We describe a patient with an unusual granulomatous pattern of EED associated with autoimmune Keratolysis. Case Report: A 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular exami-nation presented bilateral superior corneal melting with perfuration in left eye and conjunctival thickness in both eyes, in association with severe inflammatory reaction. His-topathologic examination of the conjunctiva revealed gra-nulomatous vasculitis with neutrophilic infiltrate, giant cells and fibroblastic proliferation. A punch biopsy from skin showed similar characteristics suggesting EED, however there was no giant cell. Conclusion: To our knowledge, autoimmune Keratolysis secondary to cutaneous leucocytoclastic vasculitis (EED) has not previously been described, neither did we find a des-cription about granulomatous reaction (from conjunctiva) in EED

  • Autoimmune Keratolysis in a patient with leucocytoclastic vasculitis: unusual erythema elevatum diutinum with granulomatous pattern
    'FapUNIFESP (SciELO)', 2000
    Co-Authors: Casanova, Fábio Henrique Cacho, Meirelles R. L., Tojar Marcelo, Martins, Maria Cristina, Rigueiro, Moacyr Pezati, Denise De Freitas
    Abstract:

    Purpose: Leucocytoclastic vasculitis is an immune complex-mediated, small vessel disease, that is characterized clinically by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations are rare. We describe a patient with an unusual granulomatous pattern of EED associated with autoimmune Keratolysis. Case Report: A 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular exami-nation presented bilateral superior corneal melting with perfuration in left eye and conjunctival thickness in both eyes, in association with severe inflammatory reaction. His-topathologic examination of the conjunctiva revealed gra-nulomatous vasculitis with neutrophilic infiltrate, giant cells and fibroblastic proliferation. A punch biopsy from skin showed similar characteristics suggesting EED, however there was no giant cell. Conclusion: To our knowledge, autoimmune Keratolysis secondary to cutaneous leucocytoclastic vasculitis (EED) has not previously been described, neither did we find a des-cription about granulomatous reaction (from conjunctiva) in EED.Contexto: A vasculite leucocitoclástica é uma doença que acomete pequenos vasos mais comumente associada a distúrbios do tecido conectivo, caracterizada clinicamente pela presença de lesões purpúricas palpáveis. Manifestações oftalmológicas são raras. Objetivo: Descrever quadro clínico de paciente portador de vasculite leucocitoclástica como manifestação incomum de padrão granulomatoso do erythema elevatum diutinum (EED). Relato de Caso: Paciente de 64 anos, masculino, apresentando baixa de acuidade visual e aparecimento de lesões nodulares em mãos. Ao exame oftalmológico, evidenciou-se afinamento corneano superior bilateral com perfuração corneana do olho esquerdo e espessamento da conjuntiva limbar em ambos os olhos, associada a intensa atividade inflamatória. Exame anatomopatológico da conjuntiva revelou vasculite granulomatosa com intenso exsudato neutrofílico, células gigantes multinucleadas, além de proliferação fibroblástica. Exame anatomopatológico de biopsia da pele evidenciou alterações semelhantes compatíveis com EED, porém não foi visto célula gigante sugerindo lesão granulomatosa. Conclusão: Ceratólise auto-imune secundária a vasculite leucocitoclástica cutânea (EED) não havia sido descrito na literatura, tampouco encontramos referências sobre a reação granulomatosa (encontrada na conjuntiva) em EED.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de OftalmologiaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PatologiaUNIFESP, EPM, Depto. de OftalmologiaUNIFESP, EPM, Depto. de PatologiaSciEL

Anun Vongthongsri - One of the best experts on this subject based on the ideXlab platform.

  • Progressive Keratolysis with Pseudopterygium Associated with Erythema Elevatum Diutinum
    Ophthalmology, 2011
    Co-Authors: Kaevalin Lekhanont, Thanikan Patarakittam, Kanoktip Mantachote, Premjit Waiyawatjamai, Anun Vongthongsri
    Abstract:

    Objective To report a patient with a rare case of progressive Keratolysis with pseudopterygium associated with erythema elevatum diutinum (EED). Design Interventional case report and literature review. Participant One patient with ocular presentation of EED was identified. Methods A 64-year-old woman presented with recurrent pterygium and painful corneal thinning with impending perforation of the left eye. Examination revealed intensely inflamed pseudopterygium, paracentral and peripheral corneal ulcerations, and descemetocele with a pinpoint leakage. Main Outcome Measures Clinical course and laboratory and histopathologic findings. Results Disseminated skin lesions developed during hospital admission. Examination revealed multiple, well-demarcated, discrete, red to violaceous, firm nodules and plaques on the knuckles and dorsum of the hands, and the extensor surface of the forearms, elbows, knees, right ankle, and buttocks. A skin biopsy of the recent lesions showed a dense and diffuse inflammatory cell infiltration, predominantly neutrophilic infiltrates and nuclear dust (leukocytoclasis), located around small blood vessels in the dermis, consistent with the diagnosis of EED. The diagnosis of progressive Keratolysis with pseudopterygium associated with EED was made. Spontaneous, rapid resolution of both cutaneous and ocular lesions occurred after dapsone therapy. Conclusions Erythema elevatum diutinum is a rare, chronic, and recurrent disease that has both dermatologic and ocular manifestations. Peripheral ulcerative keratitis seems to be the most common ocular finding and may be the initial presenting feature of EED. Ophthalmologists should be aware of this rare entity in the differential diagnosis of ulcerative or nonulcerative peripheral keratitis. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Fabio Henrique Cacho Casanova - One of the best experts on this subject based on the ideXlab platform.

  • autoimmune Keratolysis in a patient with leukocytoclastic vasculitis unusual erythema elevatum diutinum with granulomatous pattern
    Cornea, 2001
    Co-Authors: Fabio Henrique Cacho Casanova, Rodrigo L Meirelles, Marcelo Tojar, Maria Cristina Martins, Moacir P Rigueiro, Denise De Freitas
    Abstract:

    Purpose Leukocytoclastic vasculitis (LCCV) is an immune complex-mediated, small vessel disease that is clinically characterized by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations of LCCV are rare. Methods We describe a patient with an unusual granulomatous pattern of erythema elevatum diutinum (EED) associated with autoimmune Keratolysis. Results We studied a 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular examination revealed bilateral superior corneal melting with perforation in the left eye and conjunctival thickening in both eyes, in association with a severe inflammatory reaction. Histopathologic examination of the conjunctiva revealed granulomatous vasculitis with neutrophilic infiltrate, giant cells, and fibroblastic proliferation. A punch biopsy taken from his skin showed similar characteristics that suggested EED; however, there were no giant cells. Conclusion To our knowledge, autoimmune Keratolysis secondary to cutaneous LCCV (EED) has not been described previously, and there has been no description of granulomatous reaction (in the conjunctiva) in EED.

  • Ceratólise auto-imune em paciente com vasculite leucocitoclástica: apresentação atípica de erythema elevatum diutinum com padrão granulomatoso Autoimmune Keratolysis in a patient with leucocytoclastic vasculitis: unusual erythema elevatum diutinum wi
    Conselho Brasileiro de Oftalmologia, 2000
    Co-Authors: Fabio Henrique Cacho Casanova, Rodrigo L Meirelles, Marcelo Tojar, Maria Cristina Martins, Moacir P Rigueiro, Denise De Freitas
    Abstract:

    Contexto: A vasculite leucocitoclástica é uma doença que acomete pequenos vasos mais comumente associada a distúrbios do tecido conectivo, caracterizada clinicamente pela presença de lesões purpúricas palpáveis. Manifestações oftalmológicas são raras. Objetivo: Descrever quadro clínico de paciente portador de vasculite leucocitoclástica como manifestação incomum de padrão granulomatoso do erythema elevatum diutinum (EED). Relato de Caso: Paciente de 64 anos, masculino, apresentando baixa de acuidade visual e aparecimento de lesões nodulares em mãos. Ao exame oftalmológico, evidenciou-se afinamento corneano superior bilateral com perfuração corneana do olho esquerdo e espessamento da conjuntiva limbar em ambos os olhos, associada a intensa atividade inflamatória. Exame anatomopatológico da conjuntiva revelou vasculite granulomatosa com intenso exsudato neutrofílico, células gigantes multinucleadas, além de proliferação fibroblástica. Exame anatomopatológico de biopsia da pele evidenciou alterações semelhantes compatíveis com EED, porém não foi visto célula gigante sugerindo lesão granulomatosa. Conclusão: Ceratólise auto-imune secundária a vasculite leucocitoclástica cutânea (EED) não havia sido descrito na literatura, tampouco encontramos referências sobre a reação granulomatosa (encontrada na conjuntiva) em EED.Purpose: Leucocytoclastic vasculitis is an immune complex-mediated, small vessel disease, that is characterized clinically by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations are rare. We describe a patient with an unusual granulomatous pattern of EED associated with autoimmune Keratolysis. Case Report: A 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular exami-nation presented bilateral superior corneal melting with perfuration in left eye and conjunctival thickness in both eyes, in association with severe inflammatory reaction. His-topathologic examination of the conjunctiva revealed gra-nulomatous vasculitis with neutrophilic infiltrate, giant cells and fibroblastic proliferation. A punch biopsy from skin showed similar characteristics suggesting EED, however there was no giant cell. Conclusion: To our knowledge, autoimmune Keratolysis secondary to cutaneous leucocytoclastic vasculitis (EED) has not previously been described, neither did we find a des-cription about granulomatous reaction (from conjunctiva) in EED

Moacir P Rigueiro - One of the best experts on this subject based on the ideXlab platform.

  • autoimmune Keratolysis in a patient with leukocytoclastic vasculitis unusual erythema elevatum diutinum with granulomatous pattern
    Cornea, 2001
    Co-Authors: Fabio Henrique Cacho Casanova, Rodrigo L Meirelles, Marcelo Tojar, Maria Cristina Martins, Moacir P Rigueiro, Denise De Freitas
    Abstract:

    Purpose Leukocytoclastic vasculitis (LCCV) is an immune complex-mediated, small vessel disease that is clinically characterized by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations of LCCV are rare. Methods We describe a patient with an unusual granulomatous pattern of erythema elevatum diutinum (EED) associated with autoimmune Keratolysis. Results We studied a 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular examination revealed bilateral superior corneal melting with perforation in the left eye and conjunctival thickening in both eyes, in association with a severe inflammatory reaction. Histopathologic examination of the conjunctiva revealed granulomatous vasculitis with neutrophilic infiltrate, giant cells, and fibroblastic proliferation. A punch biopsy taken from his skin showed similar characteristics that suggested EED; however, there were no giant cells. Conclusion To our knowledge, autoimmune Keratolysis secondary to cutaneous LCCV (EED) has not been described previously, and there has been no description of granulomatous reaction (in the conjunctiva) in EED.

  • Ceratólise auto-imune em paciente com vasculite leucocitoclástica: apresentação atípica de erythema elevatum diutinum com padrão granulomatoso Autoimmune Keratolysis in a patient with leucocytoclastic vasculitis: unusual erythema elevatum diutinum wi
    Conselho Brasileiro de Oftalmologia, 2000
    Co-Authors: Fabio Henrique Cacho Casanova, Rodrigo L Meirelles, Marcelo Tojar, Maria Cristina Martins, Moacir P Rigueiro, Denise De Freitas
    Abstract:

    Contexto: A vasculite leucocitoclástica é uma doença que acomete pequenos vasos mais comumente associada a distúrbios do tecido conectivo, caracterizada clinicamente pela presença de lesões purpúricas palpáveis. Manifestações oftalmológicas são raras. Objetivo: Descrever quadro clínico de paciente portador de vasculite leucocitoclástica como manifestação incomum de padrão granulomatoso do erythema elevatum diutinum (EED). Relato de Caso: Paciente de 64 anos, masculino, apresentando baixa de acuidade visual e aparecimento de lesões nodulares em mãos. Ao exame oftalmológico, evidenciou-se afinamento corneano superior bilateral com perfuração corneana do olho esquerdo e espessamento da conjuntiva limbar em ambos os olhos, associada a intensa atividade inflamatória. Exame anatomopatológico da conjuntiva revelou vasculite granulomatosa com intenso exsudato neutrofílico, células gigantes multinucleadas, além de proliferação fibroblástica. Exame anatomopatológico de biopsia da pele evidenciou alterações semelhantes compatíveis com EED, porém não foi visto célula gigante sugerindo lesão granulomatosa. Conclusão: Ceratólise auto-imune secundária a vasculite leucocitoclástica cutânea (EED) não havia sido descrito na literatura, tampouco encontramos referências sobre a reação granulomatosa (encontrada na conjuntiva) em EED.Purpose: Leucocytoclastic vasculitis is an immune complex-mediated, small vessel disease, that is characterized clinically by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations are rare. We describe a patient with an unusual granulomatous pattern of EED associated with autoimmune Keratolysis. Case Report: A 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular exami-nation presented bilateral superior corneal melting with perfuration in left eye and conjunctival thickness in both eyes, in association with severe inflammatory reaction. His-topathologic examination of the conjunctiva revealed gra-nulomatous vasculitis with neutrophilic infiltrate, giant cells and fibroblastic proliferation. A punch biopsy from skin showed similar characteristics suggesting EED, however there was no giant cell. Conclusion: To our knowledge, autoimmune Keratolysis secondary to cutaneous leucocytoclastic vasculitis (EED) has not previously been described, neither did we find a des-cription about granulomatous reaction (from conjunctiva) in EED

Maria Cristina Martins - One of the best experts on this subject based on the ideXlab platform.

  • autoimmune Keratolysis in a patient with leukocytoclastic vasculitis unusual erythema elevatum diutinum with granulomatous pattern
    Cornea, 2001
    Co-Authors: Fabio Henrique Cacho Casanova, Rodrigo L Meirelles, Marcelo Tojar, Maria Cristina Martins, Moacir P Rigueiro, Denise De Freitas
    Abstract:

    Purpose Leukocytoclastic vasculitis (LCCV) is an immune complex-mediated, small vessel disease that is clinically characterized by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations of LCCV are rare. Methods We describe a patient with an unusual granulomatous pattern of erythema elevatum diutinum (EED) associated with autoimmune Keratolysis. Results We studied a 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular examination revealed bilateral superior corneal melting with perforation in the left eye and conjunctival thickening in both eyes, in association with a severe inflammatory reaction. Histopathologic examination of the conjunctiva revealed granulomatous vasculitis with neutrophilic infiltrate, giant cells, and fibroblastic proliferation. A punch biopsy taken from his skin showed similar characteristics that suggested EED; however, there were no giant cells. Conclusion To our knowledge, autoimmune Keratolysis secondary to cutaneous LCCV (EED) has not been described previously, and there has been no description of granulomatous reaction (in the conjunctiva) in EED.

  • Ceratólise auto-imune em paciente com vasculite leucocitoclástica: apresentação atípica de erythema elevatum diutinum com padrão granulomatoso Autoimmune Keratolysis in a patient with leucocytoclastic vasculitis: unusual erythema elevatum diutinum wi
    Conselho Brasileiro de Oftalmologia, 2000
    Co-Authors: Fabio Henrique Cacho Casanova, Rodrigo L Meirelles, Marcelo Tojar, Maria Cristina Martins, Moacir P Rigueiro, Denise De Freitas
    Abstract:

    Contexto: A vasculite leucocitoclástica é uma doença que acomete pequenos vasos mais comumente associada a distúrbios do tecido conectivo, caracterizada clinicamente pela presença de lesões purpúricas palpáveis. Manifestações oftalmológicas são raras. Objetivo: Descrever quadro clínico de paciente portador de vasculite leucocitoclástica como manifestação incomum de padrão granulomatoso do erythema elevatum diutinum (EED). Relato de Caso: Paciente de 64 anos, masculino, apresentando baixa de acuidade visual e aparecimento de lesões nodulares em mãos. Ao exame oftalmológico, evidenciou-se afinamento corneano superior bilateral com perfuração corneana do olho esquerdo e espessamento da conjuntiva limbar em ambos os olhos, associada a intensa atividade inflamatória. Exame anatomopatológico da conjuntiva revelou vasculite granulomatosa com intenso exsudato neutrofílico, células gigantes multinucleadas, além de proliferação fibroblástica. Exame anatomopatológico de biopsia da pele evidenciou alterações semelhantes compatíveis com EED, porém não foi visto célula gigante sugerindo lesão granulomatosa. Conclusão: Ceratólise auto-imune secundária a vasculite leucocitoclástica cutânea (EED) não havia sido descrito na literatura, tampouco encontramos referências sobre a reação granulomatosa (encontrada na conjuntiva) em EED.Purpose: Leucocytoclastic vasculitis is an immune complex-mediated, small vessel disease, that is characterized clinically by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations are rare. We describe a patient with an unusual granulomatous pattern of EED associated with autoimmune Keratolysis. Case Report: A 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular exami-nation presented bilateral superior corneal melting with perfuration in left eye and conjunctival thickness in both eyes, in association with severe inflammatory reaction. His-topathologic examination of the conjunctiva revealed gra-nulomatous vasculitis with neutrophilic infiltrate, giant cells and fibroblastic proliferation. A punch biopsy from skin showed similar characteristics suggesting EED, however there was no giant cell. Conclusion: To our knowledge, autoimmune Keratolysis secondary to cutaneous leucocytoclastic vasculitis (EED) has not previously been described, neither did we find a des-cription about granulomatous reaction (from conjunctiva) in EED

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